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Description
Restraint stress is the most commonly used laboratory stressor. It is difficult to characterize as psychological or physical, because past studies show psychological features, but the nature of confinement adds a physical dimension. This was the first study to investigate how experience with restraint stress affects brain response to the next stress without a physical burden. Pair-housed adult male rats were transported to a novel context and restrained or left undisturbed (6hr). The next day, rats were returned to the same context and were either restrained or left undisturbed in the context (n=8/group). After 90min, rats were euthanized to determine functional activation in limbic structures using Fos immunohistochemistry and to measure HPA axis reactivity through blood serum corticosterone levels. Regardless of day 1 experience, context exposure on day 2 enhanced Fos expression in CA1 and CA3 of the hippocampus, basolateral amygdala, and central amygdala. Conversely, other regions and corticosterone levels demonstrated modulation from the previous day's experience. Specifically, rats that were placed back into the restraint context but not restrained on day 2 showed enhanced Fos expression in the dentate gyrus suprapyramidal blade (DGSup), and infralimbic cortex (IL). Also Fos expression was attenuated in rats that received two restraint exposures in the IL and medial amygdala (MEA), suggesting habituation. Only the DG infrapyramidal blade (DGInf) showed enhanced Fos expression to restraint on day 2 without influence of the previous day. While context predominately directed Fos activation, prior experience with restraint influenced Fos expression in the DGSup, IL, MEA and corticosterone levels to support restraint having psychological components.
ContributorsAnouti, P. Danya (Author) / Conrad, D. Cheryl (Thesis director) / Hammer, Ronald (Committee member) / Hoffman, N. Ann (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Prospective memory is defined as the process of remembering to do something at a particular point in the future after first forming a conscious intention. There are three types of prospective memory intentions; event-based, time-based and activity-based intentions. Research has suggested that activity-based is one of the dominant prospective memory failures that people self-report yet there is little research on this area of prospective memory. The current study focuses on how activity-based PM is influenced by the association between the match of internal context and intended action. According to previous research, similar context between intention formation and retrieval has been shown to facilitate prospective memory, which increases the execution of intentions. Based on literature, we hypothesized that there would be higher intention completion when the internal context matches the intended action to be completed in the future. Results showed that internal context affected activity-based intention completion significantly. However the interaction between internal context and the intended action did not significantly affect intention completion. Although we did not get the hypothesized interaction, the means do cross over showing the interaction pattern is there. We decided to treat this as a pilot study and replicate it with a well-powered experiment consisting of 560 valid participants.
ContributorsEdrington, Alexis Adele (Author) / Brewer, Gene (Thesis director) / Presson, Clark (Committee member) / McClure, Samuel (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2015-12