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- All Subjects: psychology
- Creators: Chassin, Laurie
Description
The present study tested the respective mediating effects of sensation seeking and initial level of response (LR) to negative, sedative alcohol effects on the relation between the density of familial history of alcoholism and adolescent alcohol use. Additionally, the present study tested the direct effect of LR to negative, sedative alcohol effects on adolescent drinking over and above the effects of sensation seeking; and also tested the moderating effect of sensation seeking on the relation between level of response negative, sedative alcohol effects and adolescent drinking. Specifically, OLS regression models first estimated the effects of sensation seeking, LR to negative, sedative alcohol effects, and their interaction on alcohol outcomes, over and above the influence of covariates. Indirect effects were then tested using the PRODCLIN method through RMediation. Analyses failed to support sensation seeking as a mediator in the relation between familial history of alcoholism and adolescent drinking, and as a moderator of the relation between LR and adolescent drinking. However, analyses did support a robust direct effect of LR to negative, sedative alcohol effects on adolescent alcohol involvement. A significant mediating effect of initial LR to negative, sedative alcohol effects on the relation between familial alcoholism and adolescent drinking was found, however failed to maintain significance in post-hoc analyses attenuating the downward bias of the measure of initial LR. Initial LR to negative, sedative alcohol effects continued to predict adolescent drinking after attenuating measure bias. These findings strengthen research on initial LR to negative, sedative alcohol effects as a risk for greater alcohol involvement in adolescence, and underscore the complexity of studying the familial transmission of alcoholism in adolescent populations
ContributorsPandika, Danielle (Author) / Chassin, Laurie (Thesis advisor) / Corbin, William (Committee member) / Aiken, Leona (Committee member) / Arizona State University (Publisher)
Created2015
Description
Internalizing symptoms are prevalent among adolescents, especially among Latinos, and can have negative consequences on health and development. Understanding the risk and protective factors leading to internalizing difficulties among Latino youth is critical. The current study sought to assess the effects of family risk and peer social rejection in the seventh grade on internalizing symptoms in the tenth grade, and the potential buffering effects of social support from family and from friends, among a sample of 749 Mexican American youth. Structural equation modeling was used to examine pathways from seventh grade family risk and peer social rejection to internalizing symptoms in the tenth grade. Perceived social support from family and perceived social support from friends were tested as moderators of these relations. Gender differences in these pathways were also assessed. Results showed that family risk did not predict tenth grade internalizing symptoms, but that peer social rejection predicted increased internalizing symptoms for girls. Furthermore, buffering effects were not confirmed; rather social support from both friends and family had no effect on the relation between family risk and internalizing symptoms, and high levels of social support from both sources amplified the effect of peer social rejection on internalizing symptoms. Secondary analyses suggested that at low levels of social support from both sources, peer social rejection predicted decreased internalizing symptoms for males. Limitations and implications for prevention and future research are discussed.
ContributorsJenchura, Emily C (Author) / Gonzales, Nancy (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Luecken, Linda (Committee member) / Arizona State University (Publisher)
Created2015
Description
Asian American (AA) adolescents and young adults are at risk for poor psychological adjustment and diminished health. Parental involvement and intergenerational gap in acculturation (IGA) have been independently associated with intergenerational acculturative conflict, a common stressor in the AA population. However, few studies have tested how the influence of parental involvement on intergenerational acculturative conflict/family cohesion and subsequent psychological adjustment may vary depending on IGA; and even fewer studies have investigated how such models apply to AA general health. The goals of the present study were, therefore, to identify pathways linking these acculturative family processes to AA young adult general health in a large sample of Filipino and Southeast Asian (SEA) families. Analyses utilized data from the Children of Immigrants Longitudinal Study (CILS; Portes & Rumbaut, 2001), a national longitudinal study of children from immigrant families. Results suggested that although Filipino and SEA families may differ in the acculturative processes that contribute to intergenerational acculturative conflict and family cohesion, depressive symptoms are an important mechanism through which these family outcomes in adolescence influence young adult general health outcomes in both Filipino and SEA families. This investigation serves to inform future programs aimed at providing targeted interventions for AAs at risk for long-term psychological disorders and physical health problems.
ContributorsTanaka, Rika (Author) / Luecken, Linda J. (Thesis advisor) / Gonzales, Nancy (Committee member) / Doane Sampey, Leah (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2015
Description
The present study utilized longitudinal data from a high-risk community sample (n=254, 52.8% female, 47.2% children of alcoholics, 74% non-Hispanic Caucasian) to test questions concerning the effects of genetic risk, parental knowledge, and peer substance use on emerging adult substance use disorders (SUDs). Specifically, this study examined whether parental knowledge and peer substance use mediated the effects of parent alcohol use disorder (AUD) and genetic risk for behavioral undercontrol on SUD. The current study also examined whether genetic risk moderated effects of parental knowledge and peer substance use on risk for SUD. Finally, this study examined these questions over and above a genetic "control" which explained a large proportion of variance in the outcome, thereby providing a stricter test of environmental influences.
Analyses were performed in a path analysis framework. To test these research questions, the current study employed two polygenic risk scores. The first, a theory-based score, was formed using single-nucleotide polymorphisms (SNPs) from receptor systems implicated in the amplification of positive effects in the presence of new/exciting stimuli and/or pleasure derived from using substances. The second, an empirically-based score, was formed using a data-driven approach that explained a large amount of variance in SUDs. Together, these scores allowed the present study to test explanations for the relations among parent AUD, parental knowledge, peer substance use, and SUDs.
Results of the current study found that having parents with less knowledge or an AUD conferred greater risk for SUDs, but only for those at higher genetic risk for behavioral undercontrol. The current study replicated research findings suggesting that peer substance use mediated the effect of parental AUD on SUD. However, it adds to this literature by suggesting that some mechanism other than increased behavioral undercontrol explains relations among parental AUD, peer substance use, and emerging adult SUD. Taken together, these findings indicate that children of parents with AUDs comprise a particularly risky group, although likelihood of SUD within this group is not uniform. These findings also suggest that some of the most important environmental risk factors for SUDs exert effects that vary across level of genetic propensity.
Analyses were performed in a path analysis framework. To test these research questions, the current study employed two polygenic risk scores. The first, a theory-based score, was formed using single-nucleotide polymorphisms (SNPs) from receptor systems implicated in the amplification of positive effects in the presence of new/exciting stimuli and/or pleasure derived from using substances. The second, an empirically-based score, was formed using a data-driven approach that explained a large amount of variance in SUDs. Together, these scores allowed the present study to test explanations for the relations among parent AUD, parental knowledge, peer substance use, and SUDs.
Results of the current study found that having parents with less knowledge or an AUD conferred greater risk for SUDs, but only for those at higher genetic risk for behavioral undercontrol. The current study replicated research findings suggesting that peer substance use mediated the effect of parental AUD on SUD. However, it adds to this literature by suggesting that some mechanism other than increased behavioral undercontrol explains relations among parental AUD, peer substance use, and emerging adult SUD. Taken together, these findings indicate that children of parents with AUDs comprise a particularly risky group, although likelihood of SUD within this group is not uniform. These findings also suggest that some of the most important environmental risk factors for SUDs exert effects that vary across level of genetic propensity.
ContributorsBountress, Kaitlin (Author) / Chassin, Laurie (Thesis advisor) / Crnic, Keith (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / MacKinnon, David (Committee member) / Arizona State University (Publisher)
Created2015
Description
Comorbidity is a significant problem for current classification systems of psychopathology (i.e., DSM-V). One issue is that the underlying mechanisms shared among comorbid disorders are poorly understood, especially potential psychosocial mechanisms such as family dynamics. The current study used latent class analysis to empirically classify patterns of psychopathology within a large community sample of late adolescents (age 18-19) based on their lifetime psychological adjustment measured using the World Health Organization Composite International Diagnostic Interview. Videotaped family interactions of adolescents (age 16-17) and their parents were micro and macro coded and the resulting family dynamics were compared across the three empirically defined groups of psychological adjustment which emerged from the latent class analysis: 1) an early onset, persistent antisocial behavior class; 2) an emotionally distressed and substance using class; and 3) a typically developing class. It was found that some directly observed family dynamics, including parental monitoring, dyadic positive engagement and coercive engagement discriminated among empirically derived classes. It was also found that particular tasks better discriminated among classes with regard to specific family dynamics (e.g., family activity task best discriminated among classes on dyadic positive engagement). Overall, findings suggest that novel methodologies like latent class analysis can be useful in attempting to map underlying transdiagnostic mechanisms onto the current diagnostic framework. The findings also highlight the importance of taking many variables into consideration when attempting to understand how family dynamics are associated with psychological adjustment.
ContributorsPanza, Kaitlyn E (Author) / Dishion, Thomas J (Thesis advisor) / Crnic, Keith A (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2015
Description
Although research has documented robust prospective relationships between externalizing symptomatology and subsequent binge drinking among adolescents, the extent to which internalizing symptoms increase risk for drinking remains controversial. In particular, the role of anxiety as a predictor of binge drinking remains unclear. Recent evidence suggests that one possible reason for these mixed findings is that separate dimensions of anxiety may differentially confer risk for alcohol use. The present study tested two dimensions of anxiety - worry and physiological anxiety -- as predictors of binge drinking in a longitudinal study of juvenile delinquents. Overall, results indicate that worry and physiological anxiety showed differential relations with drinking behavior. In general, worry was protective against alcohol use, whereas physiological anxiety conferred risk for binge drinking, but both effects were conditional on levels of offending. Implications for future research examining the role of anxiety in predicting drinking behavior among youth are discussed.
ContributorsNichter, Brandon (Author) / Chassin, Laurie (Thesis advisor) / Barrera, Manuel (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2014
Description
ADHD is a childhood neurobehavioral disorder characterized by inordinate levels of hyperactivity, inattention and impulsivity. The inability to withhold a reinforced response, or response inhibition capacity (RIC), is one aspect of impulsivity associated with ADHD. The first goal of this dissertation was to evaluate the fixed minimum interval (FMI) schedule as a method for assessing RIC. Chapter 2 showed that latencies were substantially more sensitive than FMI-derived estimates of RIC to the effects of pre-feeding and changes in rate and magnitude of reinforcement. Chapter 3 examined the ability of the FMI to discriminate between spontaneously hypertensive rats (SHR), an animal model of ADHD, and Wistar Kyoto (WKY) controls. Results from Chapter 3 showed that RIC was not substantially different between SHR and WKY rats. However, latencies were significantly shorter for SHRs than for WKYs suggesting incentive motivation differed between strains. The second goal of this dissertation was to examine the sensitivity of the SHR to nicotine. ADHD is a risk factor for tobacco dependence. The goal of Chapters 4 and 5 was to determine whether the SHR provided a model of ADHD-related tobacco sensitivity. Chapter 4 examined nicotine's locomotor and rewarding effects in adolescent SHRs using the conditioned place preference (CPP) procedure. SHRs developed CPP to the highest nicotine dose tested and were sensitive to nicotine's locomotor-enhancing properties. WKY controls did not develop CPP to any nicotine dose tested and were not sensitive to nicotine's locomotor properties. However, it is likely that nicotine effects were obscured by a pseudo-conditioning to saline in WKYs. Chapter 5 demonstrated that SHRs were more active than WKYs in the open-field but not in the Rotorat apparatus. Results also showed that SHRs and WKYs were both sensitive to nicotine's locomotor sensitizing effects. However, WKYs were more sensitive than SHRs to nicotine's locomotor suppressing effects. Collectively, results from Chapters 4 and 5 show that SHRs are sensitive to the rewarding and locomotor-enhancing properties of nicotine. However, more research is necessary to confirm that SHRs are a suitable model for studying ADHD-related tobacco use.
ContributorsWatterson, Elizabeth (Author) / Sanabria, Federico (Thesis advisor) / Olive, Foster (Thesis advisor) / Chassin, Laurie (Committee member) / Neisewander, Janet (Committee member) / Arizona State University (Publisher)
Created2015
Description
Longitudinal data from European-American (EA) and Mexican-American (MA) families (n = 179 mothers, fathers, and youth; 41% MA) was used to test a bio-psycho-cultural model of the effect of non-responsive parenting on externalizing problems in young adult offspring through the effect on the stress response system. Parenting behavior (acceptance, rejection, harsh discipline) was assessed when children were in late childhood (12-13 years), cortisol samples were collected during late adolescence (18-19 years), and externalizing problems were measured in young adulthood (21-22 years). Latent profile analyses were used to examine patterns of parenting behavior in EA and MA families. A path analysis framework was used to examine how non-responsive parenting interacted with acceptance to predict adolescent stress response and subsequent externalizing problems in EA and MA young adults. Results showed different patterns of parenting behavior in EA versus MA families, with MA families demonstrating a profile of high acceptance and high non-responsiveness at higher rates than EA families. In MA families, youth adherence to the traditional cultural value of familismo related to more positive perceptions of parenting behavior. Across ethnic groups, parent rejection only predicted higher externalizing problems in young adults when acceptance was high. The effect of parent harsh discipline on offspring stress response differed by ethnicity. In MA families, harsh discipline predicted dysregulated stress response in youth when acceptance was low. In EA families, harsh discipline did not relate to youth stress response. Overall, results increase the understanding of normative and adaptive parenting behaviors in MA families. Findings inform the development of culturally-competent parenting-focused interventions that can better prevent dysregulated stress response and externalizing behavior problems in ethnically diverse youth.
ContributorsMahrer, Nicole Eva (Author) / Luecken, Linda (Thesis advisor) / Wolchik, Sharlene (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Pina, Armando (Committee member) / Arizona State University (Publisher)
Created2015
Description
Research has consistently shown that gay/lesbian/bisexual (GLB) or sexual minority youth are at an increased risk for adverse outcomes resulting from the stress caused by continual exposure to negative events (e.g., victimization, discrimination). The present study used a nationally representative sample of adolescents to test mechanisms that may be responsible for the differences in offending behaviors among sexual minority and heterosexual adolescents. Specifically, this study tested whether bisexual adolescents received less maternal support than did heterosexual adolescents because of their sexual orientation, thus increasing the likelihood that they run away from home. This study then examined whether the greater likelihood that bisexual adolescents running away would lead to them committing a significantly higher variety of income-based offenses, but not a significantly higher variety of aggression-based offenses. This study tested the hypothesized mediation model using two separate indicators of sexual orientation measured at two different time points, modeled outcomes in two ways, as well as estimated the models separately for boys and girls. Structural equation modeling was used to test the hypothesized direct and indirect relations. Results showed support for maternal support and running away mediating the relations between sexual orientation and offending behaviors for the model predicting the likelihood of committing either an aggressive or an income offense, but only for girls who identified as bisexual in early adulthood. Results did not support these relations for the other models, suggesting that bisexual females have unique needs when it comes to prevention and intervention. Results also highlight the need for a greater understanding of sexual orientation measurement methodology.
ContributorsMansion, Andre (Author) / Chassin, Laurie (Thesis advisor) / Barrera, Manuel (Committee member) / Grimm, Kevin J. (Committee member) / Toomey, Russell B (Committee member) / Arizona State University (Publisher)
Created2018
Description
Time-to-event analysis or equivalently, survival analysis deals with two variables simultaneously: when (time information) an event occurs and whether an event occurrence is observed or not during the observation period (censoring information). In behavioral and social sciences, the event of interest usually does not lead to a terminal state such as death. Other outcomes after the event can be collected and thus, the survival variable can be considered as a predictor as well as an outcome in a study. One example of a case where the survival variable serves as a predictor as well as an outcome is a survival-mediator model. In a single survival-mediator model an independent variable, X predicts a survival variable, M which in turn, predicts a continuous outcome, Y. The survival-mediator model consists of two regression equations: X predicting M (M-regression), and M and X simultaneously predicting Y (Y-regression). To estimate the regression coefficients of the survival-mediator model, Cox regression is used for the M-regression. Ordinary least squares regression is used for the Y-regression using complete case analysis assuming censored data in M are missing completely at random so that the Y-regression is unbiased. In this dissertation research, different measures for the indirect effect were proposed and a simulation study was conducted to compare performance of different indirect effect test methods. Bias-corrected bootstrapping produced high Type I error rates as well as low parameter coverage rates in some conditions. In contrast, the Sobel test produced low Type I error rates as well as high parameter coverage rates in some conditions. The bootstrap of the natural indirect effect produced low Type I error and low statistical power when the censoring proportion was non-zero. Percentile bootstrapping, distribution of the product and the joint-significance test showed best performance. Statistical analysis of the survival-mediator model is discussed. Two indirect effect measures, the ab-product and the natural indirect effect are compared and discussed. Limitations and future directions of the simulation study are discussed. Last, interpretation of the survival-mediator model for a made-up empirical data set is provided to clarify the meaning of the quantities in the survival-mediator model.
ContributorsKim, Han Joe (Author) / Mackinnon, David P. (Thesis advisor) / Tein, Jenn-Yun (Thesis advisor) / West, Stephen G. (Committee member) / Grimm, Kevin J. (Committee member) / Arizona State University (Publisher)
Created2017