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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
The present study utilized longitudinal data from a high-risk community sample (n= 377; 166 trauma-exposed; 54% males; 52% children of alcoholics; 73% non-Hispanic/Latino Caucasian; 22% Hispanic/Latino; 5% other ethnicity) to test a series of hypotheses that may help explain the risk pathways that link traumatic stress, posttraumatic stress disorder (PTSD) symptomatology, and problematic alcohol and drug use. Specifically, this study examined whether pre-trauma substance use problems increase risk for trauma exposure (the high-risk hypothesis) or PTSD symptoms (the susceptibility hypothesis), whether PTSD symptoms increase risk for later alcohol/drug problems (the self-medication hypothesis), and whether the association between PTSD symptoms and alcohol/drug problems is due to shared risk factors (the shared vulnerability hypothesis). This study also examined the roles of gender and ethnicity in these pathways. A series of logistic and negative binomial regressions were performed in a path analysis framework. A composite pre-trauma family adversity variable was formed from measures of family conflict, family life stress, parental alcoholism, and other parent psychopathology. Results provided the strongest support for the self-medication hypothesis, such that PTSD symptoms predicted higher levels of later alcohol and drug problems among non-Hispanic/Latino Caucasian participants, over and above the influences of pre-trauma family adversity, pre-trauma substance use problems, trauma exposure, and demographic variables. Results partially supported the high-risk hypothesis, such that adolescent substance use problems had a marginally significant unique effect on risk for assaultive violence exposure but not on overall risk for trauma exposure. There was no support for the susceptibility hypothesis, as pre-trauma adolescent substance use problems did not significantly influence risk for PTSD diagnosis/symptoms over and above the influence of pre-trauma family adversity. Finally, there was little support for the shared vulnerability hypothesis. Neither trauma exposure nor preexisting family adversity accounted for the link between PTSD symptoms and later substance use problems. These results add to a growing body of literature in support of the self-medication hypothesis. Findings extend previous research by showing that PTSD symptoms may influence the development of alcohol and drug problems over and above the influence of trauma exposure itself, preexisting family risk factors, and baseline levels of substance use.
ContributorsHaller, Moira (Author) / Chassin, Laurie (Thesis advisor) / Davis, Mary (Committee member) / Pina, Armando (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2014
Description
Incidental learning of sequential information occurs in visual, auditory and tactile domains. It occurs throughout our lifetime and even in nonhuman species. It is likely to be one of the most important foundations for the development of normal learning. To date, there is no agreement as to how incidental learning occurs. The goal of the present set of experiments is to determine if visual sequential information is learned in terms of abstract rules or stimulus-specific details. Two experiments test the extent to which interaction with the stimuli can influence the information that is encoded by the learner. The results of both experiments support the claim that stimulus and domain specific details directly shape what is learned, through a process of tuning the neuromuscular systems involved in the interaction between the learner and the materials.
ContributorsMarsh, Elizabeth R (Author) / Glenberg, Arthur M. (Thesis advisor) / Amazeen, Eric (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2013
Description
Research has suggested that lonely people demonstrate distinct differences from nonlonely people in their behaviors, mood, and interpersonal experiences. Lonely people who are also enduring a chronic pain condition may be at an especially high risk for negative outcomes because of simultaneous issues such as stigma, mood disturbances, and pain-related disability. The current study examined chronic and transitory loneliness in a sample of 123 chronic pain patients. Participants completed daily diaries assessing the occurrence of positive and negative interpersonal events, appraisals of interpersonal events, pain, and mood. Multilevel modeling was used to examine effects of being a lonely person as well as having a lonely episode on daily life. Results indicated that both chronic and transitory loneliness were associated with more frequent negative and less frequent positive interpersonal events, higher levels of pain, more negative and less positive affect, and more stress and less enjoyment from social interactions. Loneliness did not affect reactivity to negative interpersonal events, but did influence responsivity to positive interpersonal events such that lonely people had greater boosts in enjoyment when experiencing more positive interpersonal events than usual. These findings suggest that both lonely people and individuals experiencing a lonely episode experience more negative consequences in their daily lives than nonlonely people. However, they can benefit from engaging in more frequent positive interpersonal events, which can help to inform future clinical interventions for lonely, chronic pain patients.
ContributorsDempsey, Laurie (Author) / Davis, Mary (Thesis advisor) / Zautra, Alex (Committee member) / Doane, Leah (Committee member) / Arizona State University (Publisher)
Created2012
Description
In rehabilitation settings, activity limitation can be a significant barrier to recovery. This study sought to examine the effects of state and trait level benefit finding, positive affect, and catastrophizing on activity limitation among individuals with a physician-confirmed diagnosis of either Osteoarthritis (OA), Fibromyalgia (FM), or a dual diagnosis of OA/FM. Participants (106 OA, 53 FM, and 101 OA/FM) who had no diagnosed autoimmune disorder, a pain rating above 20 on a 0-100 scale, and no involvement in litigation regarding their condition were recruited in the Phoenix metropolitan area for inclusion in the current study. After initial questionnaires were completed, participants were trained to complete daily diaries on a laptop computer and instructed to do so a half an hour before bed each night for 30 days. In each diary, participants rated their average daily pain, benefit finding, positive affect, catastrophizing, and activity limitation. A single item, "I thought about some of the good things that have come from living with my pain" was used to examine the broader construct of benefit finding. It was hypothesized that state and trait level benefit finding would have a direct relation with activity limitation and a partially mediated relationship, through positive affect. Multilevel modeling with SAS PROC MIXED revealed that benefit finding was not directly related to activity limitation. Increases in benefit finding were associated, however, with decreases in activity limitation through a significant mediated relationship with positive affect. Individuals who benefit find had a higher level of positive affect which was associated with decreased activity limitation. A suppression effect involving pain and benefit finding at the trait level was also found. Pain appeared to increase the predictive validity of the relation of benefit finding to activity limitation. These findings have important implications for rehabilitation psychologists and should embolden clinicians to encourage patients to increase positive affect by employing active approach-oriented coping strategies like benefit finding to reduce activity limitation.
ContributorsKinderdietz, Jeffrey Scott (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Barrera, Manuel (Committee member) / Okun, Morris (Committee member) / Arizona State University (Publisher)
Created2012
Description
The Hunger Games is one of the best representations of trauma and PTSD within a fictional work. While none of the characters are specifically diagnosed with PTSD, all of those who undergo the games put in place by the Capitol experience various forms of trauma and find various methods of coping. We see characters such as Haymitch or the morphling victors turn to drugs and alcohol for their survival. Further, we see characters such as Wiress and Annie who have incoherent speech and who struggle to put their thoughts into words. Finally, there are characters such as Peeta and Katniss who fight to hold onto the slightest bit of hope to try and remain in the present and avoid flashbacks and nightmares that return them to the horrors of the past. However, despite all of these symptoms of PTSD and trauma that are present through all three books of the series, one of the most important aspects of recovery from trauma that is demonstrated is the power of the ability to reconnect, to yourself, to family and friends and to others who have also experienced trauma. This social aspect of reconnecting relationships is the focus I would like to take for my thesis because I believe that it is one of the most powerful and the most healing aspect of trauma and PTSD. It is the most beneficial when those around you understand your experiences with PTSD and trauma and they are the ones who are able to help you the most in remaining in the present and wanting to continue living.
ContributorsWadhwa, Lipika (Author) / Hunter, Joel (Thesis director) / Matoka, Kimberly (Committee member) / Nelson, Peggy (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Department of English (Contributor)
Created2014-05
Description
Pediatric chronic pain is surprisingly common and impactful, prospectively predicting poorer mental and physical health outcomes. Internalizing symptoms represents one such outcome. It is the most common cluster of symptoms in children, it is related to poorer child functioning, and it has been linked to future functioning/psychopathology. The psychosocial mechanisms through which child pain may impact internalizing have yet to be fully elaborated, but withdrawal from social engagement with peers has been proposed as one possible mechanism. Additionally, sibling relationships may play a role in enhancing or diminishing a child’s social engagement while they are in pain. The current study aimed to examine whether child social engagement at age 8 mediates the relation between child chronic pain at age 8 and internalizing symptoms at age 9. Further, the study tested whether sibling warmth and sibling conflict act as moderators between child chronic pain and child social engagement. The physical and emotional health, quality of sibling relations, and extracurricular social engagement of 491 twin children from 247 families were assessed at age 8 and age 9 via surveys completed by the children’s primary caregivers. Findings showed that child pain at age 8 did not predict lower levels of social engagement, and social engagement did not predict child internalizing at age 9. Sibling warmth, but not conflict, significantly moderated the pain—social engagement relation. Together, these findings indicate that the relation between chronic pain and internalizing functions differently in children than in adults through a variety of cognitive, environmental, and social factors. More longitudinal research in this area will help establish changes in the relation between pain and internalizing from childhood into adulthood.
ContributorsRichards, Nicole Eve (Co-author) / Richards, Nicole (Co-author) / Davis, Mary (Thesis director) / Presson, Clark (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Art (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Nearly a decade of research has shown that high achieving students are at elevated risk for serious adjustment problems \u2014 including internalizing and externalizing symptoms and substance use. In this study, we examine the relationship among three types of risk factors, including parent expectations and criticism, self-reported perfectionism, and daily stressors, and internalizing symptoms, rule-breaking behaviors, and substance use.
Perfectionism and daily stressors (e.g., relationship stress and hours of sleep) were significantly associated with internalizing symptoms and rule-breaking behaviors for both males and females across schools. Our findings suggest that there may be a unique interplay among perfectionism, relationship stress, and hours of sleep for students attending high achieving schools. Future research should attempt to tease apart the interactions among these risk factors and determine whether interventions should address them as separate, modifiable dimensions or treat them in a holistic manner.
Perfectionism and daily stressors (e.g., relationship stress and hours of sleep) were significantly associated with internalizing symptoms and rule-breaking behaviors for both males and females across schools. Our findings suggest that there may be a unique interplay among perfectionism, relationship stress, and hours of sleep for students attending high achieving schools. Future research should attempt to tease apart the interactions among these risk factors and determine whether interventions should address them as separate, modifiable dimensions or treat them in a holistic manner.
ContributorsSciabica, Kyra Nicole (Author) / Luthar, Suniya (Thesis director) / Glenberg, Arthur (Committee member) / Department of English (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Asthma is one of the most common chronic diseases affecting children, and investigators have identified a number of risk factors that worsen asthma symptoms. Most prior studies have concluded that there is an association between one risk factor, poor sleep quality, and asthma; however, whether sleep quality predicts future asthma symptoms, asthma symptoms predict future sleep quality, or the relation is reciprocal is still unclear. The methodology of studies examining the asthma-sleep association has consisted of actigraphy and parent report to determine children's sleep duration and sleep efficiency, and lung function assessments with a spirometer on the participants to determine children's overall lung function. The purpose of the proposed study is to determine the strength of the cross-sectional and longitudinal associations between indicators of sleep quality and asthma. The proposed study plans to use a combination of actigraphy, sleep diaries, and lung function assessments using a spirometer to determine sleep quality and lung function, respectively. Future directions include determining the directionality of the association between sleep quality and asthma as well as strength of association.
ContributorsLacy, Kordell Reggie (Author) / Davis, Mary (Thesis director) / Miadich, Samantha (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Higher education institutions have increasingly sought to diversify the ethnic makeup of freshmen classes (Covarrubias, Herrmann, & Fryberg, 2016) and rates of Latinx college attendance have been rising (Hall, Nishina, & Lewis, 2017). However, despite comparable levels of earned-credits, Latinx students have lower rates of college completion (Contreras & Contreras, 2015). One potential explanation may be disproportionate increases in stress, and in particular, discrimination experiences reported by Latinx students during the transition from high school to college (Hunyh & Fuligni, 2012). As such, the aim of the current study was to examine whether everyday discrimination in high school and college were associated with changes in adolescent well-being and academic adjustment over the college transition in a sample of Latinx adolescents. Study participants were 209 Latinx adolescents (85.1% Mexican descent, 62.1% 2nd generation; 35.6% male; Mage= 17.59) who completed questionnaire assessments during the spring or summer before entering college (T1) and again during the first semester of college (T2; 88.5% retention). In both high school and college, participants completed a modified version of the Everyday Discrimination Scale (T1 α=.88, T2 α=.89; Williams et al., 1997). Dependent variables included internalizing symptoms in college (depressive symptoms {α = .95}, anxiety symptoms {α = .88}, stress symptoms {α = .94}; DASS; Lovibond & Lovibond, 1995), and institutional records of college GPA. Correlation and regression analyses were conducted in SPSS 23 to examine associations between discrimination experiences (high school and college) and college internalizing symptoms and GPA, controlling for high school levels. Other covariates included immigrant generation status, sex, parent education (as a proxy for socioeconomic status), and whether the participant attended the focal higher education institution. Zero order correlations (Table 1) revealed that greater reports of discrimination in high school and college were associated with higher depressive symptoms, higher anxiety symptoms, higher stress, but not GPA in college (Table 1; all ps <.05). In multivariate analyses and after adjusting for covariates similar patterns emerged (Table 2). Greater reports of discrimination in college were associated with higher depressive symptoms (β = .18, p < .05), anxiety symptoms (β = .19, p <.05) and stress (β = .18, p <.05), but not GPA (β = -.04, ns). Everyday experiences of discrimination in high school were not significantly associated with college outcomes. In summary, our findings suggest that discrimination experiences among Latinx students in college, but not high school, are associated with increases in internalizing symptoms, including depression, anxiety and stress. Interestingly, discrimination experiences in high school and college were not associated with academic achievement in the first semester of college. Such findings suggest that higher education institutions should focus on global indicators of well-being during the Latinx college transition and seek to implement programs to: a) reduce stress associated with engaging in diverse college environments and b) reduce discrimination experiences on college campuses. Future research is needed for replication of these results and should also seek to further explore the trajectories of internalizing symptoms beyond the first semester of college.
ContributorsSills, Jessica (Author) / Doane, Leah (Thesis director) / Perez, Marisol (Committee member) / Castro, Saul (Committee member) / Department of English (Contributor, Contributor) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05