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Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Incidental learning of sequential information occurs in visual, auditory and tactile domains. It occurs throughout our lifetime and even in nonhuman species. It is likely to be one of the most important foundations for the development of normal learning. To date, there is no agreement as to how incidental learning

Incidental learning of sequential information occurs in visual, auditory and tactile domains. It occurs throughout our lifetime and even in nonhuman species. It is likely to be one of the most important foundations for the development of normal learning. To date, there is no agreement as to how incidental learning occurs. The goal of the present set of experiments is to determine if visual sequential information is learned in terms of abstract rules or stimulus-specific details. Two experiments test the extent to which interaction with the stimuli can influence the information that is encoded by the learner. The results of both experiments support the claim that stimulus and domain specific details directly shape what is learned, through a process of tuning the neuromuscular systems involved in the interaction between the learner and the materials.
ContributorsMarsh, Elizabeth R (Author) / Glenberg, Arthur M. (Thesis advisor) / Amazeen, Eric (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Most people are experts in some area of information; however, they may not be knowledgeable about other closely related areas. How knowledge is generalized to hierarchically related categories was explored. Past work has found little to no generalization to categories closely related to learned categories. These results do not fit

Most people are experts in some area of information; however, they may not be knowledgeable about other closely related areas. How knowledge is generalized to hierarchically related categories was explored. Past work has found little to no generalization to categories closely related to learned categories. These results do not fit well with other work focusing on attention during and after category learning. The current work attempted to merge these two areas of by creating a category structure with the best chance to detect generalization. Participants learned order level bird categories and family level wading bird categories. Then participants completed multiple measures to test generalization to old wading bird categories, new wading bird categories, owl and raptor categories, and lizard categories. As expected, the generalization measures converged on a single overall pattern of generalization. No generalization was found, except for already learned categories. This pattern fits well with past work on generalization within a hierarchy, but do not fit well with theories of dimensional attention. Reasons why these findings do not match are discussed, as well as directions for future research.
ContributorsLancaster, Matthew E (Author) / Homa, Donald (Thesis advisor) / Glenberg, Arthur (Committee member) / Chi, Michelene (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2013
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Description
Research has suggested that lonely people demonstrate distinct differences from nonlonely people in their behaviors, mood, and interpersonal experiences. Lonely people who are also enduring a chronic pain condition may be at an especially high risk for negative outcomes because of simultaneous issues such as stigma, mood disturbances, and pain-related

Research has suggested that lonely people demonstrate distinct differences from nonlonely people in their behaviors, mood, and interpersonal experiences. Lonely people who are also enduring a chronic pain condition may be at an especially high risk for negative outcomes because of simultaneous issues such as stigma, mood disturbances, and pain-related disability. The current study examined chronic and transitory loneliness in a sample of 123 chronic pain patients. Participants completed daily diaries assessing the occurrence of positive and negative interpersonal events, appraisals of interpersonal events, pain, and mood. Multilevel modeling was used to examine effects of being a lonely person as well as having a lonely episode on daily life. Results indicated that both chronic and transitory loneliness were associated with more frequent negative and less frequent positive interpersonal events, higher levels of pain, more negative and less positive affect, and more stress and less enjoyment from social interactions. Loneliness did not affect reactivity to negative interpersonal events, but did influence responsivity to positive interpersonal events such that lonely people had greater boosts in enjoyment when experiencing more positive interpersonal events than usual. These findings suggest that both lonely people and individuals experiencing a lonely episode experience more negative consequences in their daily lives than nonlonely people. However, they can benefit from engaging in more frequent positive interpersonal events, which can help to inform future clinical interventions for lonely, chronic pain patients.
ContributorsDempsey, Laurie (Author) / Davis, Mary (Thesis advisor) / Zautra, Alex (Committee member) / Doane, Leah (Committee member) / Arizona State University (Publisher)
Created2012
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Description
In rehabilitation settings, activity limitation can be a significant barrier to recovery. This study sought to examine the effects of state and trait level benefit finding, positive affect, and catastrophizing on activity limitation among individuals with a physician-confirmed diagnosis of either Osteoarthritis (OA), Fibromyalgia (FM), or a dual diagnosis of

In rehabilitation settings, activity limitation can be a significant barrier to recovery. This study sought to examine the effects of state and trait level benefit finding, positive affect, and catastrophizing on activity limitation among individuals with a physician-confirmed diagnosis of either Osteoarthritis (OA), Fibromyalgia (FM), or a dual diagnosis of OA/FM. Participants (106 OA, 53 FM, and 101 OA/FM) who had no diagnosed autoimmune disorder, a pain rating above 20 on a 0-100 scale, and no involvement in litigation regarding their condition were recruited in the Phoenix metropolitan area for inclusion in the current study. After initial questionnaires were completed, participants were trained to complete daily diaries on a laptop computer and instructed to do so a half an hour before bed each night for 30 days. In each diary, participants rated their average daily pain, benefit finding, positive affect, catastrophizing, and activity limitation. A single item, "I thought about some of the good things that have come from living with my pain" was used to examine the broader construct of benefit finding. It was hypothesized that state and trait level benefit finding would have a direct relation with activity limitation and a partially mediated relationship, through positive affect. Multilevel modeling with SAS PROC MIXED revealed that benefit finding was not directly related to activity limitation. Increases in benefit finding were associated, however, with decreases in activity limitation through a significant mediated relationship with positive affect. Individuals who benefit find had a higher level of positive affect which was associated with decreased activity limitation. A suppression effect involving pain and benefit finding at the trait level was also found. Pain appeared to increase the predictive validity of the relation of benefit finding to activity limitation. These findings have important implications for rehabilitation psychologists and should embolden clinicians to encourage patients to increase positive affect by employing active approach-oriented coping strategies like benefit finding to reduce activity limitation.
ContributorsKinderdietz, Jeffrey Scott (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Barrera, Manuel (Committee member) / Okun, Morris (Committee member) / Arizona State University (Publisher)
Created2012
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Description
It has been suggested that directed forgetting (DF) in the item-method paradigm results from selective rehearsal of R items and passive decay of F items. However, recent evidence suggested that the passive decay explanation is insufficient. The current experiments examined two theories of DF that assume an active forgetting process:

It has been suggested that directed forgetting (DF) in the item-method paradigm results from selective rehearsal of R items and passive decay of F items. However, recent evidence suggested that the passive decay explanation is insufficient. The current experiments examined two theories of DF that assume an active forgetting process: (1) attentional inhibition and (2) tagging and selective search (TSS). Across three experiments, the central tenets of these theories were evaluated. Experiment 1 included encoding manipulations in an attempt to distinguish between these competing theories, but the results were inconclusive. Experiments 2 and 3 examined the theories separately. The results from Experiment 2 supported a representation suppression account of attentional inhibition, while the evidence from Experiment 3 suggested that TSS was not a viable mechanism for DF. Overall, the results provide additional evidence that forgetting is due to an active process, and suggest this process may act to suppress the representations of F items.
ContributorsHansen, Whitney Anne (Author) / Goldinger, Stephen D. (Thesis advisor) / Azuma, Tamiko (Committee member) / Brewer, Gene (Committee member) / Homa, Donald (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Statistical word learning (SWL) has been proposed and tested as a powerful mechanism for word learning under referential ambiguity. Learners are adept at resolving word-referent ambiguity by calculating the co-occurrences between words and referents across ambiguous scenes. Despite the generalizability of such capacity, it is less clear which underlying factors

Statistical word learning (SWL) has been proposed and tested as a powerful mechanism for word learning under referential ambiguity. Learners are adept at resolving word-referent ambiguity by calculating the co-occurrences between words and referents across ambiguous scenes. Despite the generalizability of such capacity, it is less clear which underlying factors may play a role in SWL, such as learners’ language experience and individual differences of working memory. The current study therefore asked two questions: 1) How do learners of different language experience (monolinguals and bilinguals) approach SWL of different mapping types–when each referent has one name (1:1 mapping) or two names (2:1 mapping)? and 2) How do working memory capacities (spatial and phonological) play a role in SWL by mapping type? In this pre-registered study (OSF: https://osf.io/mte8s/), 69 English monolinguals and 88 bilinguals completed two SWL tasks (1:1 and 2:1 mapping), a symmetry span task indexing spatial working memory, and a listening span task indexing phonological working memory. Results showed no differences between monolinguals and bilinguals in SWL of both mapping types. However, spatial and phonological working memory positively predicted SWL regardless of language experience, but only in 1:1 mapping. The findings show a dissociation of working memory’s role in SWL of different mapping types. The study proposes a novel insight into a theoretical debate underlying statistical learning mechanisms: learners may adopt more explicit processes (i.e. hypothesis-testing) during 1:1 mapping but implicit processes (i.e. associative learning) during 2:1 mapping. Future studies can locate memory-related brain areas during SWL to test out the proposal.
ContributorsLi, Ye (Author) / Benitez, Viridiana (Thesis advisor) / Goldinger, Stephen (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2022
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Description
Although social cognitive deficits are considered a hallmark trait of schizophrenia, research on schizotypy and social cognition is inconsistent. The present study examines the associations among schizotypy, aberrant salience, and social cognition. Schizotypy and aberrant salience were assessed continuously using the Schizotypal Personality Questionnaire Brief Revised (SPQ-BR) and the Aberrant

Although social cognitive deficits are considered a hallmark trait of schizophrenia, research on schizotypy and social cognition is inconsistent. The present study examines the associations among schizotypy, aberrant salience, and social cognition. Schizotypy and aberrant salience were assessed continuously using the Schizotypal Personality Questionnaire Brief Revised (SPQ-BR) and the Aberrant Salience Inventory (ASI). Social cognition was examined using The Awareness of Social Inference Test (TASIT), an audio-visual paradigm that taps into multiple domains of social cognition. Data from 849 undergraduate students was analyzed. Results indicated that schizotypy overall was not associated with social cognitive deficits. However, when schizotypy was analyzed dimensionally, positive schizotypy was associated with social cognitive impairments. Further, aberrant salience was revealed to be consistently associated with social cognitive impairments, except when positive schizotypy was included in the model. This suggests the possibility that positive schizotypy could mediate the association between aberrant salience and social cognition. Overall, this study highlights the importance of focusing on positive schizotypy and aberrant salience in future investigations of social cognitive difficulties in psychosis.
ContributorsArnett, Ciera (Author) / Karoly, Paul (Thesis advisor) / Corbin, William (Thesis advisor) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2021
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Description
Behavioral, electrophysiological, and neuroimaging evidence has demonstrated that multiple object tracking (MOT) tasks draw upon visual perception, attention, and working memory cognitive processes. Functional neuroimaging studies identified the middle temporal visual area (MT+/V5) as one of several brain regions associated with MOT in humans. MT+/V5 is thought to be responsible

Behavioral, electrophysiological, and neuroimaging evidence has demonstrated that multiple object tracking (MOT) tasks draw upon visual perception, attention, and working memory cognitive processes. Functional neuroimaging studies identified the middle temporal visual area (MT+/V5) as one of several brain regions associated with MOT in humans. MT+/V5 is thought to be responsible for processing motion from visual information, regulating smooth pursuit eye movements, and encoding memory for motion. However, it is unclear how MT+/V5 interacts with attention and working memory performance processes during MOT. To investigate this question, the right MT+/V5 region was identified in 14 neurotypical subjects using structural magnetic resonance imaging (sMRI). The right MT+/V5 was stimulated using intermittent theta-burst stimulation (iTBS), continuous theta-burst stimulation (cTBS), and sham transcranial magnetic stimulation (TMS) using a within-subjects design. Average MOT performance was measured before and 5-min, 30-min, and 60-min after each stimulation protocol. There was no significant difference in average MOT performance across time, regardless of the stimulation condition.
ContributorsAlucard, Myles (Author) / Duran, Nicholas (Thesis advisor, Committee member) / Brewer, Gene (Thesis advisor, Committee member) / Burleson, Mary (Committee member) / Arizona State University (Publisher)
Created2023
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Description
Stereotype humor is a highly prevalent but particularly divisive phenomenon, with the potential for both negative and positive social implications. While highly subjective, interpretations of stereotype humor's subtext (support/challenge of stereotype) have major implications for reactions to this type of humor. This experimental study (N = 104) represents a novel

Stereotype humor is a highly prevalent but particularly divisive phenomenon, with the potential for both negative and positive social implications. While highly subjective, interpretations of stereotype humor's subtext (support/challenge of stereotype) have major implications for reactions to this type of humor. This experimental study (N = 104) represents a novel investigation of the effect of two facets of stereotype humor, explicitness of stereotyping and stereotype distortion, on judgments of stereotype endorsement (support) versus subversion (challenge) in memes about four different groups (Asian, Hispanic, Irish, White) and associated group stereotypes. In this completely within-subjects design, participants viewed several memes about the target groups which varied systematically by the two factors of interest and provided judgments of stereotype endorsement versus subversion, ratings of funniness, and ratings of offensiveness. Multilevel models were used to determine the effect of explicitness, distortion, and their interaction, as well as target group, on judgements of stereotype humor while accounting for nesting of responses within participants. Results showed that stereotype distortion (e.g., exaggeration) and explicit stereotyping (e.g., overtly linking group to stereotype) both significantly predicted greater ratings of subversion. Unexpectedly, stereotype distortion also predicted greater levels of offense. Interestingly, marginalized group membership (i.e., Asian, Hispanic) significantly predicted lower ratings of subversion, lower funny ratings, and higher offense ratings. Findings highlight the significant role of explicitness and distortion when considering how individuals interpret the subtext of stereotype humor. Furthermore, findings underscore the major influence of group status on judgments and social implications of this type of humor. Overall, this study contributes to a better understanding of the mechanisms by which individuals interpret stereotype humor, providing valuable insights for promoting better intergroup relations and communication.
ContributorsLangley, Erika Beatrice (Author) / Shiota, Michelle (Thesis advisor) / Neuberg, Steven (Committee member) / Maddox, Keith (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2024