Matching Items (23)
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- All Subjects: psychology
- Genre: Masters Thesis
- Creators: Mickelson, Kristin
- Creators: Lemery-Chalfant, Kathryn
Description
The interplay of genes and environment on children's development is a complex dynamic process. As behavior geneticists begin to model protective as well as risk factors, and interactive as well as main effect influences, development is elucidated. It was hypothesized that positive parenting, a quality home environment, and high family cohesion would moderate the heritability of three components of temperament: Effortful Control, Negative Affectivity, and Extraversion/Surgency. Participants were drawn from the Wisconsin Twin Project and consisted of 1573 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87). Higher order composites for the parenting and family environment moderators were formed from mother and father reports of Behavior Management Self-Assessment, Child Rearing Practices Report, Family Assessment Device, and Family Conflict Scale. Measures of the home environment (LEOS Living Environment Observation Scale and CHAOS Confusion, Hubbub, and Order Scale) were not composited due to the nature of the variables. Correlational analyses showed a majority of the temperament and environmental measures to be correlated (rs = -.49-.57). For Effortful Control, Negative Affectivity, and Extraversion/Surgency, estimates for the heritability and nonshared environment were 0.60 and 0.40, 0.80 and 0.20, and 0.59 and 0.41, respectively, with no significant main effects of the shared environment. Models incorporating environmental moderation of these estimates yielded parenting as a significant moderator for Negative Affectivity, LEOS for Effortful Control and Extraversion/Surgency, and CHAOS for Effortful Control and Extraversion/Surgency. Results suggest that the quality of the family environment may act as a permissive or determinative influence on the heritability and expression of temperament. Future analyses include the examination of interactive genetic influences. These findings underscore the importance of shared environment, and support the recent literature on the benefits of positive influences on children's development.
ContributorsKao, Karen (Author) / Bradley, Robert H. (Thesis advisor) / Lemery-Chalfant, Kathryn (Thesis advisor) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2011
Description
The hypothalamus pituitary adrenal (HPA) axis and the human genome are important components of the biological etiology of externalizing disorders. By studying the associations between specific genetic variants, diurnal cortisol, and externalizing symptoms we can begin to unpack this complex etiology. It was hypothesized that genetic variants from the corticotropine releasing hormone receptor 1 (CRHR1), FK506 binding protein 51 (FKBP5), catechol-O-methyl transferase (COMT), and dopamine transporter (DAT1) genes and diurnal cortisol intercepts and slopes would separately predict externalizing symptoms. It was also hypothesized that genetic variants would moderate the association between cortisol and externalizing. Participants were 800 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87) participating in the Wisconsin Twin Project. Hierarchical Linear Modeling (HLM) was used to separate the variance associated with state and trait cortisol measured across three consecutive days and trait cortisol measures were used. There were no main effects of genes on externalizing symptoms. The evening cortisol intercept, the morning cortisol slope and the evening cortisol slope predicted externalizing, but only in boys, such that boys with higher cortisol and flatter slopes across the day also had more externalizing symptoms. The morning cortisol intercept and CRHR1 rs242924 interacted to predict externalizing in both boys and girls, with GG carriers significantly higher compared to TT carriers at one standard deviation below the mean of morning cortisol. For boys only there was a significant interaction between the DAT1 variable number tandem repeat (VNTR) and the afternoon slope and a significant slope for 9/9 carriers and 9/10 carriers such that when the slope was more steep, boys carrying a nine had fewer externalizing symptoms but when the slope was less steep, they had more. Results confirm a link between diurnal trait cortisol and externalizing in boys, as well as moderation of that association by genetic polymorphisms. This is the first study to empirically examine this association and should encourage further research on the biological etiology of externalizing disorder symptoms.
ContributorsSwann, Gregory (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Doane-Sampey, Leah (Committee member) / Arizona State University (Publisher)
Created2012
Description
The present study tested the factor structure of the externalizing disorders (e.g. attention-deficit hyperactivity disorder (ADHD), conduct disorder (SE), and substance experimentation (SE) ) in adolescence. In addition, this study tested the influence of the GABRA2 gene on the factors of the externalizing spectrum. Confirmatory factor analyses were used to test the factor structure of the externalizing spectrum. Specifically, three competing alternate confirmatory factor analytic models were tested: a one-factor model where all disorders loaded onto a single externalizing factor, a two-factor model where CD and SE loaded onto one factor and ADHD loaded onto another, and a three-factor model, where all three disorders loaded onto separate factors. Structural equation modeling was used to test the effect of a GABRA2 SNP, rs279858, on the factors of the externalizing spectrum. Analyses revealed that a three-factor model of externalizing disorders with correlated factors fit the data best. Additionally, GABRA2 had a significant effect on the SE factor in adolescence, but not on the CD or ADHD factors. These findings demonstrate that the externalizing disorders in adolescence share commonalities but also have separate sources of systematic variance. Furthermore, biological mechanisms may act as a unique etiological factor in the development of adolescent substance experimentation.
ContributorsWang, Frances L (Author) / Chassin, Laurie (Thesis advisor) / Lemery-Chalfant, Kathryn (Committee member) / Geiser, Christian (Committee member) / Arizona State University (Publisher)
Created2012
Description
How early life is experienced and perceived can greatly affect mental and physical health outcomes. An individual is greatly influenced by their first models of what social relationships look and feel like, and with time also learn how to survive when less favorable social experiences occur. The lessons learned may lead to healthy problem solving and resilience, or it may lead to unhealthy problem-solving habits that hinder well-being. Anxious thoughts and other mental health symptoms may accompany an individual long-term and hinder an essential need for a healthy life. The first main purpose of this thesis is to examine the impact of Adverse Childhood Experiences (ACEs) on mental health (anxiety symptoms), and on sleep quality (an essential need). The second purpose of my thesis is to investigate the impact of genetics on resilience, specifically, the mu-opioid receptor gene. The first hypothesis proposed ACEs that were perceived as more traumatic and occurred more frequently would be associated with more poor sleep quality symptoms. The second hypothesis predicted that anxiety symptoms would mediate the association. The third hypothesis (exploratory) suggested that an individual’s alleles for the mu-opioid receptor gene would moderate the mediation pathway. The study was conducted with 318 participants between the ages of 18 and 35 years old. The study demonstrated a direct effect for ACEs and sleep. Anxiety mediated the association between ACEs (exposure and severity) and sleep (insomnia, quality, sleepiness), suggesting that ACEs possibly increase feelings of anxiety which, in turn, lead to worse sleep outcomes. Finally, the moderated-mediation model with OPRM1 as the moderator, was not significant for the mediation pathway A; however, there was a significant interaction with anxiety and sleep symptoms.
ContributorsBailey, Elise (Author) / Mickelson, Kristin (Thesis advisor) / Burleson, Mary (Committee member) / Petrov, Megan (Committee member) / Arizona State University (Publisher)
Created2022
Description
With widespread increases in the use of electronic communication technology, cyber-sexual harassment (CSH) has been on the rise. Broadly defined, CSH is unwelcome and repeated conduct of a sexual nature performed through electronic technology. The prevalence of CSH reported in previous studies varies significantly due in part to inconsistencies in how CSH is defined and measured. Whereas four existing scales measuring aspects of CSH have been published, each has several limitations. This research aims to develop and psychometrically validate the Multidimensional Cyber-Sexual Harassment Experiences and Attitudes Scale for Victimization (MCSHEA-V), which taps into five key components of CSH, including: (1) gathering sexual information online, (2) image and video-based sexual harassment, (3) offensive comments or posts, (4) coercive behaviors, and (5) CSH attitudes. In Study 1, a sample of psychology graduate students and faculty (N = 13) evaluated the content validity of the MCSHEA-V items, leading to key improvements in item relevance, clarity, and wording. In Study 2, a sample of adult participants (N = 298) completed the initial version of the scale through the online survey platform, Prolific.co. Confirmatory factor analyses indicated the proposed 5-factor structure was a good fit, but exploratory factor analyses indicated the items represented an alternative 4-factor structure. Specifically, these items captured dyadic CSH behaviors, CSH behaviors that affect one’s reputation, perceptions of the seriousness of CSH, and CSH victim-blaming behaviors. In Study 3, an additional sample of adult participants (N = 207) was surveyed via Prolific.co. Separate confirmatory factor analyses indicated the 4-factor model was the best fit. Overall, the MCSHEA-V will contribute to a clearer understanding of the defining features and prevalence of CSH victimization and facilitate future research through the introduction of a psychometrically-validated measurement tool.
ContributorsWheeler, Brittany (Author) / Hall, Deborah (Thesis advisor) / Mickelson, Kristin (Committee member) / Burleson, Mary (Committee member) / Arizona State University (Publisher)
Created2022
Description
Background: Premature infants may be at risk for lower effortful control, and subsequent lower academic achievement, peer competence, and emotional and physical wellness throughout the lifespan. However, because prematurity is related to obstetrical and neonatal complications, it is unclear what may drive the effect. Effortful control also has a strong heritable component; therefore, environmental factors during pregnancy and the neonatal period may interact with genetic factors to predict effortful control development. In this study, I aimed to dissect the influences of genetics, prematurity, and neonatal and obstetrical complications on the development of effortful control from 12 months to 10 years using a twin cohort. Methods: This study used data from the Arizona Twin Project, an ongoing longitudinal study of approximately 350 pairs of twins. Twins were primarily Hispanic/Latinx (23.8%-27.1%) and non-Hispanic/Latinx White (53.2%-57.8%), and families ranged in socioeconomic status with around one-third falling below or near the poverty line. Of the twins, 62.6% were born prematurely. Effortful control was assessed via parent report at six waves. Results: There was not a significant relationship between gestational age and effortful control regardless of whether obstetrical and neonatal complications were controlled for. Biometric twin modeling revealed that the attentional focusing subdomain of effortful control was highly heritable. Gestational age did not moderate genetic and environmental estimates. Conclusions: The findings help inform the risk assessment of prematurity and provide evidence for differing etiology of each subdomain of effortful control and the strong role of genetics in effortful control development.
ContributorsPickett, Janna (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Su, Jinni (Committee member) / Eggum, Natalie D (Committee member) / Arizona State University (Publisher)
Created2023
Description
Although adverse events cannot always be prevented, the negative outcomes on development can potentially be modified by considering methods of fostering positive emotional and behavioral responses. The study examined biopsychosocial health outcomes in the presence of uncontrollable adverse childhood events with the goal of identifying a potential intervention to increase resilience, health, and safe behaviors among at-risk children. It was hypothesized that adverse events can result in positive biopsychosocial outcomes in the presence of high scores on the Positive Emotion, Engagement, Relationships, Meaning, and Accomplishments (PERMA) model of well-being, self-efficacy, gratitude, and the ability to envision a positive future self. The study retrospectively examined adverse childhood events and present behavioral, emotional, and physical health outcomes. Participant (n = 685) data were analyzed using Hayes PROCESS (v3.5) to test all components of the moderation model. Results suggest that as adverse events increase, health adversity also increases. However, those with high intrapersonal strengths showed better health outcomes. Through understanding intrapersonal pathways in the presence of adverse events, the study can potentially identify mechanisms important for promoting resilient outcomes in childhood that could cascade into adulthood.
ContributorsBraunstein, Bailey Marie (Author) / Mickelson, Kristin (Thesis advisor) / Hall, Deborah (Committee member) / Lindstrom-Johnson, Sarah (Committee member) / Arizona State University (Publisher)
Created2022
Description
The COVID-19 pandemic has affected many aspects of daily life due to social distancing guidelines, including physical exercise. Prior research indicates that physical activity is a potent resilience factor against stress’ impact on mental health. Further, research suggests that social integration and participation positively contributes to mental well-being. Yet, one aspect of physical activity that may be particularly impacted by social distancing guidelines is the social context. It is unclear if those who participated in social physical activity prior to the COVID pandemic are more impacted by the restrictions placed on these behaviors. In a sample of 519 adults in the United States, the current longitudinal study examined whether participation in social physical activity, compared to individual physical activity, moderates the influence of pandemic stress on mental health and whether there are gender differences between men and women in these associations. Study results indicated physical activity did benefit mental health during the COVID pandemic. However, greater social physical activity did not buffer against the negative impact of stress. Future research should examine other variables potentially influencing these relationships, and examine them under non-pandemic conditions.
ContributorsKaneris, Marianna Irene (Author) / Mickelson, Kristin (Thesis advisor) / Hall, Deborah (Committee member) / Mean, Lindsey (Committee member) / Arizona State University (Publisher)
Created2022
Description
Given the prevalence and severity of dating violence (DV) in our World, uncovering the long-term effects of DV is pivotal. This thesis provides information about how prior DV impacts a survivor’s future relationships. First, understanding the association between prior DV and current relationship satisfaction. Next, suggesting potential moderators between DV and current relationship satisfaction in forms of resilience. Tangible resilience strategies such as seeking therapy and obtaining an order of protection were assessed as potential moderators. As well as one’s attachment style as a predictor of how one overcomes prior DV and impacts current relationship satisfaction. A study was conducted with 218 participants from both the United States and international countries. Prior DV was a predictor of relationship satisfaction, however in the adverse way as predicted. Survivors of prior dating violence reported higher levels of current relationship satisfaction. Tangible resilience and secure attachment style were both significant moderators of the relationship between prior DV and current relationship satisfaction. These results present new ways to face the challenge of overcoming the repercussions of DV for survivors. As well as provide hope and support to all survivors of DV that their past does not have to impact their future.
ContributorsGraham, Kaylyn (Author) / Mickelson, Kristin (Thesis advisor) / Randall, Ashley (Committee member) / Burleson, Mary (Committee member) / Arizona State University (Publisher)
Created2022
Description
Aggressive and violent behavior is expressed differently across development, but for some adolescents, this behavior leads to criminal justice involvement through arrests and incarceration. Further, according to the biopsychosocial model, aggressive behavior is influenced by both genetics and the environment. This study sought to examine the differential impacts of early childhood environmental cumulative risk and genetic risk on the developmental cascade from middle childhood behavioral aggression and lack of control to adolescent antisocial behavior or callous-unemotional traits, to emerging adult involvement with the criminal justice system, and whether the effects of risk were mitigated by receiving the Family Check-Up (FCU) prevention program in childhood. The sample included high-risk youth (N = 731; 50% female, 50% White, 28% Black, 13% Hispanic, 9% Indigenous, Native Hawaiian, or Asian; of these 13% were multiracial; Mincome = $28,993; representative 515 genotyped) involved in a randomized-controlled trial of the Family Check-Up and followed longitudinally across 11 waves from ages 2 through 19 years. Behavioral measures included parent-report of behavioral aggression and observational lack of control in middle childhood, self-report of antisocial behavior and callous-unemotional (CU) traits in adolescence, and self-report of involvement with the legal system at age 19. Results of longitudinal structural equation modeling (SEM) supported a developmental cascade from middle childhood behavioral aggression to antisocial behavior in adolescence to legal system involvement. Early cumulative environmental risk and polygenic risk tolerance (RT PGS) significantly predicted involvement with the legal system at age 19, while RT PGS also predicted antisocial behavior in adolescence. Further, intervention effects were found for the FCU, such that the FCU disrupted the effects of RT PGS and middle childhood aggression on antisocial behavior and CU traits in adolescence. This study showed that the FCU can mitigate polygenic risk, supporting the benefit of early psychosocial prevention programs. Importantly, this study showed initial evidence that prevention programs targeting early childhood conduct problems could potentially reduce rates of justice system involvement, including arrests and incarceration, by the age of 19.
ContributorsOstner, Savannah Grace (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Davis, Mary C (Committee member) / Arizona State University (Publisher)
Created2024