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- All Subjects: psychology
- Creators: School of Social and Behavioral Sciences
- Creators: Lemery-Chalfant, Kathryn
Description
The interplay of genes and environment on children's development is a complex dynamic process. As behavior geneticists begin to model protective as well as risk factors, and interactive as well as main effect influences, development is elucidated. It was hypothesized that positive parenting, a quality home environment, and high family cohesion would moderate the heritability of three components of temperament: Effortful Control, Negative Affectivity, and Extraversion/Surgency. Participants were drawn from the Wisconsin Twin Project and consisted of 1573 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87). Higher order composites for the parenting and family environment moderators were formed from mother and father reports of Behavior Management Self-Assessment, Child Rearing Practices Report, Family Assessment Device, and Family Conflict Scale. Measures of the home environment (LEOS Living Environment Observation Scale and CHAOS Confusion, Hubbub, and Order Scale) were not composited due to the nature of the variables. Correlational analyses showed a majority of the temperament and environmental measures to be correlated (rs = -.49-.57). For Effortful Control, Negative Affectivity, and Extraversion/Surgency, estimates for the heritability and nonshared environment were 0.60 and 0.40, 0.80 and 0.20, and 0.59 and 0.41, respectively, with no significant main effects of the shared environment. Models incorporating environmental moderation of these estimates yielded parenting as a significant moderator for Negative Affectivity, LEOS for Effortful Control and Extraversion/Surgency, and CHAOS for Effortful Control and Extraversion/Surgency. Results suggest that the quality of the family environment may act as a permissive or determinative influence on the heritability and expression of temperament. Future analyses include the examination of interactive genetic influences. These findings underscore the importance of shared environment, and support the recent literature on the benefits of positive influences on children's development.
ContributorsKao, Karen (Author) / Bradley, Robert H. (Thesis advisor) / Lemery-Chalfant, Kathryn (Thesis advisor) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2011
Description
Externalizing behaviors are pervasive, widespread, and disruptive across a multitude of settings and developmental contexts. While the conventional diathesis-stress model typically measures the disordered end of the spectrum, studies that span the range of behavior, from externalizing to competence behaviors, are necessary to see the full picture. To that end, this study examined the additive and nonadditive relations of a dimension of parenting (ranging from warm to rejecting), and variants in dopamine, vasopressin, and neuropeptide-y receptor genes on externalizing/competence in a large sample of predominantly Caucasian twin children in toddlerhood, middle childhood, and early adolescence. Variants within each gene were hypothesized to increase biological susceptibility to both negative and positive environments. Consistent with prediction, warmth related to lower externalizing/higher competence at all ages. Earlier levels of externalizing/competence washed out the effect of parental warmth on future externalizing/competence with the exception of father warmth in toddlerhood marginally predicting change in externalizing/competence from toddlerhood to middle childhood. Warmth was a significant moderator of the heritability of behavior in middle childhood and early adolescence such that behavior was less heritable (mother report) and more heritable (father report) in low warmth environments. Interactions with warmth and the dopamine and vasopressin genes in middle childhood and early adolescence emphasize the moderational role gene variants play in relations between the rearing environment and child behavior. For dopamine, the long variant related to increased sensitivity to parent warmth such that the children displayed more externalizing behaviors when exposed to rejection but they also displayed more competence behaviors when exposed to high warmth. Vasopressin moderation was only present under conditions of parental warmth, not rejection. Interactions with neuropeptide-y and warmth were not significant. The picture that emerges is one of gene-environment interplay, wherein the influence of both parenting and child genotype each depend on the level of the other. As genetic research moves forward, gene variants previously implicated as conferring risk for disorder should be reexamined in conjunction with salient aspects of the environment on the full range of the behavioral outcome of interest.
ContributorsO'Brien, T. Caitlin (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Eisenberg, Nancy (Committee member) / Enders, Craig (Committee member) / Nagoshi, Craig (Committee member) / Arizona State University (Publisher)
Created2011
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
The hypothalamus pituitary adrenal (HPA) axis and the human genome are important components of the biological etiology of externalizing disorders. By studying the associations between specific genetic variants, diurnal cortisol, and externalizing symptoms we can begin to unpack this complex etiology. It was hypothesized that genetic variants from the corticotropine releasing hormone receptor 1 (CRHR1), FK506 binding protein 51 (FKBP5), catechol-O-methyl transferase (COMT), and dopamine transporter (DAT1) genes and diurnal cortisol intercepts and slopes would separately predict externalizing symptoms. It was also hypothesized that genetic variants would moderate the association between cortisol and externalizing. Participants were 800 twins (51% boys), 88.5% Caucasian, M=7.93 years (SD=0.87) participating in the Wisconsin Twin Project. Hierarchical Linear Modeling (HLM) was used to separate the variance associated with state and trait cortisol measured across three consecutive days and trait cortisol measures were used. There were no main effects of genes on externalizing symptoms. The evening cortisol intercept, the morning cortisol slope and the evening cortisol slope predicted externalizing, but only in boys, such that boys with higher cortisol and flatter slopes across the day also had more externalizing symptoms. The morning cortisol intercept and CRHR1 rs242924 interacted to predict externalizing in both boys and girls, with GG carriers significantly higher compared to TT carriers at one standard deviation below the mean of morning cortisol. For boys only there was a significant interaction between the DAT1 variable number tandem repeat (VNTR) and the afternoon slope and a significant slope for 9/9 carriers and 9/10 carriers such that when the slope was more steep, boys carrying a nine had fewer externalizing symptoms but when the slope was less steep, they had more. Results confirm a link between diurnal trait cortisol and externalizing in boys, as well as moderation of that association by genetic polymorphisms. This is the first study to empirically examine this association and should encourage further research on the biological etiology of externalizing disorder symptoms.
ContributorsSwann, Gregory (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Doane-Sampey, Leah (Committee member) / Arizona State University (Publisher)
Created2012
Description
The present study tested the factor structure of the externalizing disorders (e.g. attention-deficit hyperactivity disorder (ADHD), conduct disorder (SE), and substance experimentation (SE) ) in adolescence. In addition, this study tested the influence of the GABRA2 gene on the factors of the externalizing spectrum. Confirmatory factor analyses were used to test the factor structure of the externalizing spectrum. Specifically, three competing alternate confirmatory factor analytic models were tested: a one-factor model where all disorders loaded onto a single externalizing factor, a two-factor model where CD and SE loaded onto one factor and ADHD loaded onto another, and a three-factor model, where all three disorders loaded onto separate factors. Structural equation modeling was used to test the effect of a GABRA2 SNP, rs279858, on the factors of the externalizing spectrum. Analyses revealed that a three-factor model of externalizing disorders with correlated factors fit the data best. Additionally, GABRA2 had a significant effect on the SE factor in adolescence, but not on the CD or ADHD factors. These findings demonstrate that the externalizing disorders in adolescence share commonalities but also have separate sources of systematic variance. Furthermore, biological mechanisms may act as a unique etiological factor in the development of adolescent substance experimentation.
ContributorsWang, Frances L (Author) / Chassin, Laurie (Thesis advisor) / Lemery-Chalfant, Kathryn (Committee member) / Geiser, Christian (Committee member) / Arizona State University (Publisher)
Created2012
Description
Perhaps by some ingrained sense of human preparedness, phobias are an outlier in the world of conditioning. Again and again, they are highlighted as the only thing which avoidance makes worse, rather than alleviates. My own fear of insects had reached its most severe level just as I began learning about phobias, and avoidance, in my undergraduate psychology courses. There, I learned that avoidance of the phobic stimulus \u2014 in my case, insects \u2014 seemed to be a fundamental element of maintaining a phobia, and I was more than guilty of it. Following this realization, I endeavored into what I would later come to call Stimulus Confrontation: A self-designed therapeutic course of action to overcome my fear. This thesis, then, is the record of this project. It weaves together my scholarly research on phobias with my own personal narrative concerning the employment of Stimulus Confrontation, beginning with the etymology and proposed etiologies of phobias, followed by an overview of contemporary treatment options available and a recounting of Stimulus Confrontation as applied to my own phobia. Told from her own perspective, English writer and journalist Jenny Diski's book, What I Don't Know About Animals, tells of her own arachnophobia, and includes an honest account of the fear and anxiety it caused for her, as well as her own journey to overcome it. Like my own, Diski's phobia \u2014 arachnophobia \u2014 had come to affect her everyday life. Prior to seeking treatment for her fear at the age of 58, Diski too had learned to avoid the thing which she so feared. Inspired by What I Don't Know About Animals, the personal anecdotes I have included throughout this thesis serve to elaborate upon my personal experience with my own insectophobia, and the cessation of avoidance that led to substantial progress in overcoming my fears. Throughout this thesis, I refer to this cessation of avoidance as Stimulus Confrontation, with the intention that following the same process I did may benefit others in overcoming their own specific phobias.
ContributorsKavanaugh, Ashley Marie (Author) / Gruber, Diane (Thesis director) / Lewis, Stephen (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
The purpose of this thesis is to examine the relationship between mental illness and capitalist consumer society. Many Americans are suffering from mental illness and there has to be something causing it besides a chemical imbalance in the brain. A capitalist society creates a set of expectations that conflict with human desires. The thesis takes a historical, economical, and psychological approach to answering the following question: Does a capitalist society make its citizens mentally sick? A brief history of capitalism over the past century is discussed, as well as a more in depth look at capitalism and the creation of neoliberalism during the 1980s. The psychological effects capitalism has on human beings is discussed for the majority of the thesis and focuses on ideas from the 1950s as well as the early 2000s. To show the effect capitalism has on modern day society, an analysis of a psychopharmaceutical drug commercial is given. The concluding thoughts attempt to offer solutions to the problems of human unhappiness in a consumer culture.
ContributorsSerki, Aisling Erin (Author) / Gruber, Diane (Thesis director) / Ramsey, Ramsey Eric (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
This correlational study investigated how adolescent's artistic style changed depending on their level of interest in art. The participants were 28 students from the 7th and 8th grade of Zuni Hills Elementary School. A survey was administered which measured, in regards to their artwork, the categories of interest, experimentation in subject, experimentation in material, abstract style, literal style, imagination, identity, emotion and storytelling. It was predicted that interest would have a significant positive relationship with abstract style and experimentation with subject. It was also predicted that interest would have a significant negative relationship with literal style and experimentation with material. Scores for all categories were compared and significant positive relations were found in regards to emotion, identity and storytelling. There was also a significant positive realtionship between interest and imagination as well as interest and emotion. These findings add to research about motivation in adolescent art through the means of expression of the self.
ContributorsAbeyta, Jennifer Lee (Author) / Miller, Paul (Thesis director) / Lewis, Stephen K. (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
A playwright behind the scenes of my personal struggle with PTSD, experience that caused it, and journey to healing from it. The playwright consists of deeper causes of PTSD and its effects, more than the average textbook can teach anyone. With the help of a couple people and Russ, a famous artist, I was able to grow and become stronger and show it all within my playwright. Enjoy the journey to healing of a person, a warrior who wanted to fight and made it through the night.
ContributorsCristobal, Nicky Desiree (Author) / Lewis, Stephen (Thesis director) / Zygutis, Linda (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Attention-deficit/hyperactivity disorder (ADHD) is a common developmental disorder characterized by symptoms of impulsivity, inattention, and hyperactivity that interfere with development. Given the lasting academic and social deficits associated with ADHD symptoms, it is critical to study the risk factors of this disorder and possible factors that could protect against its development. Therefore, the current study investigated the potential role of social support from parents, siblings, teachers, and peers as promotive and protective factors against the development of ADHD symptoms for children at familial risk of developing ADHD symptoms. Participants included 903 twins (30.5% monozygotic twins, 35.9% same-sex dizygotic twins, 31.7% opposite-sex dizygotic twins) from the longitudinal Arizona Twin Project. Children (51.6% female) were assessed for social support and ADHD symptoms at age 8 (M = 8.42, SD = 0.68) and for ADHD symptoms at age 9 (M = 9.71, SD = 0.93). Children’s familial risk for developing ADHD symptoms was assessed as a function of their cotwin’s symptom status at age 8 and the pair’s zygosity. Mixed model regression analyses indicated that familial risk was a robust predictor of ADHD symptoms. Further, peer acceptance was found to operate as a promotive factor against the development of ADHD symptoms, with some evidence for positive parenting as a promotive factor, as well. None of the forms of social support were found to be protective factors for children at familial risk of developing ADHD symptoms. Bivariate twin analyses revealed that peer acceptance and ADHD were related for both genetic and environmental reasons, suggesting that children’s heritable behaviors influence their peer acceptance. Future directions may include examining additional factors as possible moderators of familial risk of developing ADHD symptoms.
ContributorsHawkins, Jessica Kathryn (Author) / Lemery-Chalfant, Kathryn (Thesis director) / Miadich, Samantha (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12