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Description
Patients with schizophrenia have impaired cognitive flexibility, as evidenced by behaviors of perseveration. Cognitive impairments may be due to dysregulation of glutamate and/or loss of neuronal plasticity in the medial prefrontal cortex (mPFC). The purpose of these studies was to examine the effects of mGluR5 positive allosteric modulators (PAMs) alone

Patients with schizophrenia have impaired cognitive flexibility, as evidenced by behaviors of perseveration. Cognitive impairments may be due to dysregulation of glutamate and/or loss of neuronal plasticity in the medial prefrontal cortex (mPFC). The purpose of these studies was to examine the effects of mGluR5 positive allosteric modulators (PAMs) alone and in combination with the NMDAR antagonist MK-801, a pharmacological model of schizophrenia. An operant-based cognitive set-shifting task was utilized to assess cognitive flexibility, in vivo microdialysis procedures to measure extracellular glutamate levels in the mPFC, and diolistic labeling to assess the effects on dendritic spine density and morphology in the mPFC. Results revealed that chronic administration of the mGluR5 PAM CDPPB was able to significantly reduce the effects of chronically administered MK-801 on both behavioral perseveration and glutamate neurotransmission. Results also showed that CDPPB had no evidence of an effect on dendritic spine density or morphology, but the mGluR5 negative allosteric modulator fenobam caused significant increases in spine density and the frequency of occurrence of spines with smaller head diameters. Conclusions include that CDPPB is able to reverse MK-801 induced cognitive deficits as well as alterations in mPFC glutamate neurochemistry. The culmination of these studies add further support for targeting mGluR5 with PAMs as a novel mechanism to alleviate cognitive impairments in patients with schizophrenia.
ContributorsLaCrosse, Amber (Author) / Olive, Michael (Committee member) / Gallitano-Mendel, Amelia (Committee member) / Sanabria, Federico (Committee member) / Hammer, Ronald (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Destination image has been explored by studying various aspects of the process of forming a perception about an area and choosing to visit or not. This study uses a variety of theories from previous research which has focused on subsets of factors which influence the overall process to create a

Destination image has been explored by studying various aspects of the process of forming a perception about an area and choosing to visit or not. This study uses a variety of theories from previous research which has focused on subsets of factors which influence the overall process to create a model to organize the perception formation and decision making progress into one continuous and interrelated progression. Online questionnaires using Likert scale statements and questions were distributed to participants through Facebook in order to measure and test the model. A total of 266 questionnaires were completed and analyzed using t test, ANOVA, regression, factor analysis, and cluster analysis. The original model from the beginning of the study transformed with the removal of some variables and the alteration of others. The factors that were shown to influence perception of the destination were tourist type and knowledge of the country. Tourists who were more likely to seek new environments and had a higher level of knowledge of the country used in the marketing video had a better perception of the destination before and after the video. Obstacles for deciding to visit the destination were found to be long distances traveling and substitution of alternative destinations. The results show that marketing videos do create a positive change in the perception of the destination, but this alone is not likely enough to influence the decision to visit the destination. Marketing agencies should consider more ways of informing consumers of the destination in addition to commercials so that overall knowledge of the area can be improved. In addition, marketing agencies should target consumers that are interested in visiting new environments by using travel magazine subscriptions, international airline agencies and hotels, and social media groups.
ContributorsHugo, Nichole (Author) / Nyaupane, Gyan (Thesis advisor) / Andereck, Kathleen (Committee member) / Buzinde, Christine (Committee member) / Harrill, Rich (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Preoperative team briefings have been suggested to be important for improving team performance in the operating room. Many high risk environments have accepted team briefings; however healthcare has been slower to follow. While applying briefings in the operating room has shown positive benefits including improved communication and perceptions of teamwork,

Preoperative team briefings have been suggested to be important for improving team performance in the operating room. Many high risk environments have accepted team briefings; however healthcare has been slower to follow. While applying briefings in the operating room has shown positive benefits including improved communication and perceptions of teamwork, most research has only focused on feasibility of implementation and not on understanding how the quality of briefings can impact subsequent surgical procedures. Thus, there are no formal protocols or methodologies that have been developed.

The goal of this study was to relate specific characteristics of team briefings back to objective measures of team performance. The study employed cognitive interviews, prospective observations, and principle component regression to characterize and model the relationship between team briefing characteristics and non-routine events (NREs) in gynecological surgery. Interviews were conducted with 13 team members representing each role on the surgical team and data were collected for 24 pre-operative team briefings and 45 subsequent surgical cases. The findings revealed that variations within the team briefing are associated with differences in team-related outcomes, namely NREs, during the subsequent surgical procedures. Synthesis of the data highlighted three important trends which include the need to promote team communication during the briefing, the importance of attendance by all surgical team members, and the value of holding a briefing prior to each surgical procedure. These findings have implications for development of formal briefing protocols.

Pre-operative team briefings are beneficial for team performance in the operating room. Future research will be needed to continue understanding this relationship between how briefings are conducted and team performance to establish more consistent approaches and as well as for the continuing assessment of team briefings and other similar team-related events in the operating room.
ContributorsHildebrand, Emily A (Author) / Branaghan, Russell J (Thesis advisor) / Cooke, Nancy J. (Committee member) / Hallbeck, M. Susan (Committee member) / Bekki, Jennifer M (Committee member) / Blocker, Renaldo C (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The unpleasant bitter taste found in many nutritious vegetables may deter their consumption. While bitterness suppression by prototypical tastants is well-studied in the chemical and pharmacological fields, mechanisms to reduce the bitterness of foods such as vegetables remain to be elucidated. Here tastants representing the taste primaries of

The unpleasant bitter taste found in many nutritious vegetables may deter their consumption. While bitterness suppression by prototypical tastants is well-studied in the chemical and pharmacological fields, mechanisms to reduce the bitterness of foods such as vegetables remain to be elucidated. Here tastants representing the taste primaries of salty and sweet were investigated as potential bitterness suppressors of three types of Brassicaceae vegetables. The secondary aim of these studies was to determine whether the bitter masking agents were differentially effective for bitter-sensitive and bitter-insensitive individuals. In all experiments, participants rated vegetables plain and with the addition of tastants. In Experiments 1-3, sucrose and NNS suppressed the bitterness of broccoli, Brussels sprouts, and cauliflower, whereas NaCl did not. Varying concentrations of NaCl and sucrose were introduced in Experiment 4 to assess the dose-dependency of the effects. While sucrose was a robust bitterness suppressor, NaCl suppressed bitterness only for participants who perceived the plain Brussels sprouts as highly bitter. Experiment 5, through the implementation of a rigorous control condition, determined that some but not all of this effect can be accounted for by regression to the mean. Individual variability in taste perception as determined by sampling of aqueous bitter, salty, and sweet solutions did not influence the degree of suppression by NaCl or sucrose. Consumption of vegetables is deterred by their bitter taste. Utilizing tastants to mask bitterness, a technique that preserves endogenous nutrients, can circumvent this issue. Sucrose is a robust bitter suppressor whereas the efficacy of NaCl is dependent upon bitterness perception of the plain vegetables.
ContributorsWilkie, Lynn Melissa (Author) / Capaldi Phillips, Elizabeth D (Thesis advisor) / Cohen, Adam (Committee member) / Johnston, Carol (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Working with participants in schools for highly gifted students, this study asked adolescents to create a digital story to address the prompt, "How has your life changed since coming to this school?" Participant interviews were conducted in an attempt to determine how gifted students view their educational experiences and how

Working with participants in schools for highly gifted students, this study asked adolescents to create a digital story to address the prompt, "How has your life changed since coming to this school?" Participant interviews were conducted in an attempt to determine how gifted students view their educational experiences and how those experiences influence the current development of self-identity. Digital story creation and photo elicitation methods were chosen in an effort to remove researcher bias and allow participant voices to be heard more accurately. Parent and educator interviews were also conducted. Data analysis was completed using narrative construction methods. Findings include several themes among participant self-identity influences including how labels affect participant's view of themselves, perfectionism and competitive drive function in each gifted child, necessity of intellectual challenge, appropriate learning environment helps to create self-confidence and self-identity, and grades are more important than learning for knowledge.
ContributorsHart, Courtney Brook (Author) / Ganesh, Tirupalavanam G. (Thesis advisor) / Margolis, Eric (Thesis advisor) / Sandlin, Jennifer (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Scholars have contemplated gender differences in negotiations for a number of years. Recently, attention has been directed to the early stages of a negotiation, particularly the propensity to initiate a negotiation. Indeed, there is evidence that men are significantly more likely than women to initiate a negotiation (Small, Gelfand, Babcock,

Scholars have contemplated gender differences in negotiations for a number of years. Recently, attention has been directed to the early stages of a negotiation, particularly the propensity to initiate a negotiation. Indeed, there is evidence that men are significantly more likely than women to initiate a negotiation (Small, Gelfand, Babcock, & Gettman, 2007). In an effort to unpack these findings, the present mixed method study partially replicates the quantitative lab study by Small and her colleagues (2007) to explore gender differences and then extends this work with qualitative interviews to examine the rationales underlying the propensity to negotiate. In the quantitative phase of this study, undergraduate students were invited to complete a task in which they could earn between $3 and $10 in addition to course extra credit. All participants were offered $3 and could earn up to $10 if they initiated a negotiation for more money. The qualitative phase of this study included follow-up qualitative interviews to explore the reasons women and men chose to initiate or avoid a negotiation. Quantitative results demonstrate no significant gender differences in the propensity to negotiate. However, qualitative findings reveal trends suggesting that women maintained higher evaluations of money but lower probabilities of attaining more money during the negotiation. Findings support that clear gender differences exist with regard to perceived risks and the value in the decision to negotiate. Thus, findings suggest that gender differences in the propensity to negotiate are more complex than which can be quantitatively measured using a simple ask-no ask dichotomy.
ContributorsLeier, Cassaundra Renee (Author) / Alberts, Jess (Thesis advisor) / Miller, Katherine (Committee member) / Hinshaw, Art (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Intermittent social defeat stress produces vulnerability to drugs of abuse, a phenomena known as cross-sensitization, which is proceeded by a corresponding upregulation of ventral tegmental area (VTA) mu-opioid receptors (MORs). Since VTA MORs are implicated in the expression of psychostimulant sensitization, they may also mediate social stress-induced vulnerability to drugs

Intermittent social defeat stress produces vulnerability to drugs of abuse, a phenomena known as cross-sensitization, which is proceeded by a corresponding upregulation of ventral tegmental area (VTA) mu-opioid receptors (MORs). Since VTA MORs are implicated in the expression of psychostimulant sensitization, they may also mediate social stress-induced vulnerability to drugs of abuse. Social stress and drugs of abuse increase mesolimbic brain-derived neurotrophic factor (BDNF) signaling with its receptor, tropomyosin-related kinase B (TrkB). These studies examined whether VTA MOR signaling is important for the behavioral and cellular consequences of social stress. First, the function of VTA MORs in the behavioral consequences of intermittent social defeat stress was investigated. Lentivirus-mediated knockdown of VTA MORs prevented social stress-induced cross-sensitization, as well as stress-induced social avoidance and weight gain deficits. Next it was examined whether VTA MOR expression is critical for stress-induced alterations in the mesocorticolimbic circuit. At the time cross-sensitization was known to occur, lentivirus-mediated knockdown of VTA MORs prevented stress-induced increases in VTA BDNF and its receptor, TrkB in the nucleus accumbens (NAc), and attenuated NAc expression of delta FosB. There was no effect of either stress or virus on BDNF expression in the prefrontal cortex. Since social stress-induced upregulation of VTA MORs is necessary for consequences of social stress, next activity dependent changes in AKT, a downstream target of MOR stimulation associated with sensitization to psychostimulant drugs, were investigated. Using fluorescent immunohistochemical double labeling for the active form of AKT (pAKT) and markers of either GABA or dopamine neurons in the VTA, it was determined that social stress significantly increased the expression of pAKT in GABA, but not dopamine neurons, and that this effect was dependent on VTA MOR expression. Moreover, intra-VTA inhibition of pAKT during stress prevented stress-induced weight gain deficits, while acute inhibition of VTA pAKT blocked the expression of cross-sensitization in subjects that had previously exhibited sensitized locomotor activity. Together these results suggest that social stress upregulates MORs on VTA GABA neurons, resulting in AKT phosphorylation, and that increased VTA MOR-pAKT signaling may represent a novel therapeutic target for the intervention of substance abuse disorders.
ContributorsJohnston, Caitlin (Author) / Hammer, Ronald P. (Thesis advisor) / Nikulina, Ella M. (Thesis advisor) / Neisewander, Janet L. (Committee member) / Wu, Jie (Committee member) / Olive, Michael F. (Committee member) / Arizona State University (Publisher)
Created2015
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Description
When consumers make experiential purchases, they often have to decide between experiences that contain many or few features. Contrary to prior research demonstrating that consumers prefer feature-rich products before consumption but feature-poor products after consumption, the author reveals a reversal of this effect for experiences. Specifically, the author hypothesizes and

When consumers make experiential purchases, they often have to decide between experiences that contain many or few features. Contrary to prior research demonstrating that consumers prefer feature-rich products before consumption but feature-poor products after consumption, the author reveals a reversal of this effect for experiences. Specifically, the author hypothesizes and finds that consumers prefer feature-poor experiences before consumption (a phenomenon denoted as `feature apprehension') but prefer feature-rich experiences after consumption. This feature apprehension occurs before consumption because consumers are concerned with the uncertainty associated with attaining a satisfying outcome from the experience. Manipulating the temporal distance with which consumers view the experience can attenuate this effect. Additionally, locus of control and social signaling moderate consumers' post-consumption preference for feature-rich experiences. The author proposes several recommendations for consumers and providers of experiences.
ContributorsMiller, Chadwick Justin (Author) / Samper, Adriana (Thesis advisor) / Mandel, Naomi (Thesis advisor) / Sinha, Rajiv K (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Siblings are a salient part of family life; however, few studies have explored the role of siblings on youths' cultural development and educational expectations. In the current dissertation, two studies address this gap in the literature by using longitudinal data from 246 Mexican-origin sibling pairs and their mothers and fathers.

Siblings are a salient part of family life; however, few studies have explored the role of siblings on youths' cultural development and educational expectations. In the current dissertation, two studies address this gap in the literature by using longitudinal data from 246 Mexican-origin sibling pairs and their mothers and fathers. The first study examined how older siblings' cultural orientations and values uniquely contribute to younger siblings' cultural orientations and values from late adolescence to young adulthood, after accounting for mothers' and fathers' cultural orientations and values; further, it was explored the role of sibling modeling and sibling characteristics as moderators of these associations. Findings revealed that older siblings' cultural orientations and values contribute to younger siblings' cultural orientations and values from late adolescence into young adulthood. Specifically, under conditions of high sibling modeling, younger siblings reported higher levels of Anglo orientation and familism values. Whereas, fathers' orientations were positively associated with younger siblings' Anglo and Mexican orientations and mothers' values were predictive of younger siblings' familism values. Together, the findings suggest that siblings and parents play different roles in youths' cultural development.

The second study explored the reciprocal associations between older and younger siblings' educational expectations from early/middle adolescence to middle/late adolescence and from middle/late adolescence to young adulthood. In this study it was tested the moderating role of family immigrant context and sibling characteristics in the association between older and younger siblings' educational expectations. Findings revealed that older siblings' educational expectations at T1 predicted younger siblings' educational expectations at T2. Further, older siblings' educational expectations at T2 continued to influence younger siblings' educational expectations at T3, and younger siblings' educational expectations at T2 also predicted older siblings' educational expectations at T3. Family immigrant context moderated the association from older siblings' educational expectations at T2 to younger siblings' educational expectations at T3, such that the association was significant for immigrant-born families, but not for U.S.-born/Mixed-status families. Our study highlights the value of siblings' roles, particularly in immigrant families, as youth make important decisions about their educational pursuits.
ContributorsRodríguez De Jesús, Sue Annie (Author) / Updegraff, Kimberly A (Thesis advisor) / Bradley, Robert H (Committee member) / Iida, Masumi (Committee member) / Umaña-Taylor, Adriana J. (Committee member) / Arizona State University (Publisher)
Created2015
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Description
The dissertation examines treatment services received by youth on probation in the Maricopa County, Arizona. The project focuses on three primary issues: 1) the factors associated with receiving treatment services while on probation, 2) the factors associated with receiving treatment services through different funding streams, and 3) whether treatment services

The dissertation examines treatment services received by youth on probation in the Maricopa County, Arizona. The project focuses on three primary issues: 1) the factors associated with receiving treatment services while on probation, 2) the factors associated with receiving treatment services through different funding streams, and 3) whether treatment services and specific characteristics of treatment services, particularly the funding source, influence recidivism outcomes of youth. To answer these questions the research used data obtained from the Maricopa County Juvenile Probation Department from July 2012 thru August 2014. Multivariate regression, along with statistical techniques to control for selection bias, were used to identify the factors associated with receiving treatment services, the factors associated with the funding source of treatment services, and the effect of treatment services on recidivism. The findings from the current dissertation suggest that the receipt of treatment services is not equal across groups, and particularly that minorities are less likely to receive treatment services compared to their White counterparts. Additionally, the findings reveal that certain characteristics of youth and the type of treatment service received influence the funding source, but the source of funding does not influence the effectiveness of the treatment services. Finally, using propensity score matching, the current dissertation found that treatment services were effective in reducing recidivism while under probation supervision and 6 months after probation supervision has ended. Implications for policy and research are discussed in light of these findings.
ContributorsWhite, Clair, Ph.D (Author) / Shafer, Michael (Thesis advisor) / Ready, Justin (Committee member) / Wang, Xia (Committee member) / Arizona State University (Publisher)
Created2015