Matching Items (25)
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- All Subjects: psychology
- Creators: Sanabria, Federico
Description
Each year, millions of aging women will experience menopause, a transition from reproductive capability to reproductive senescence. In women, this transition is characterized by depleted ovarian follicles, declines in levels of sex hormones, and a dysregulation of gonadotrophin feedback loops. Consequently, menopause is accompanied by hot flashes, urogenital atrophy, cognitive decline, and other symptoms that reduce quality of life. To ameliorate these negative consequences, estrogen-containing hormone therapy is prescribed. Findings from clinical and pre-clinical research studies suggest that menopausal hormone therapies can benefit memory and associated neural substrates. However, findings are variable, with some studies reporting null or even detrimental cognitive and neurobiological effects of these therapies. Thus, at present, treatment options for optimal cognitive and brain health outcomes in menopausal women are limited. As such, elucidating factors that influence the cognitive and neurobiological effects of menopausal hormone therapy represents an important need relevant to every aging woman. To this end, work in this dissertation has supported the hypothesis that multiple factors, including post-treatment circulating estrogen levels, experimental handling, type of estrogen treatment, and estrogen receptor activity, can impact the realization of cognitive benefits with Premarin hormone therapy. We found that the dose-dependent working memory benefits of subcutaneous Premarin administration were potentially regulated by the ratios of circulating estrogens present following treatment (Chapter 2). When we administered Premarin orally, it impaired memory (Chapter 3). Follow-up studies revealed that this impairment was likely due to the handling associated with treatment administration and the task difficulty of the memory measurement used (Chapters 3 and 4). Further, we demonstrated that the unique cognitive impacts of estrogens that become increased in circulation following Premarin treatments, such as estrone (Chapter 5), and their interactions with the estrogen receptors (Chapter 6), may influence the realization of hormone therapy-induced cognitive benefits. Future directions include assessing the mnemonic effects of: 1) individual biologically relevant estrogens and 2) clinically-used bioidentical hormone therapy combinations of estrogens. Taken together, information gathered from these studies can inform the development of novel hormone therapies in which these parameters are optimized.
ContributorsEngler-Chiurazzi, Elizabeth (Author) / Bimonte-Nelson, Heather A. (Thesis advisor) / Sanabria, Federico (Committee member) / Olive, Michael F (Committee member) / Hoffman, Steven (Committee member) / Arizona State University (Publisher)
Created2013
Description
When a rolling ball exits a spiral tube, it typically maintains its final inertial state and travels along straight line in concordance with Newton's first law of motion. Yet, most people predict that the ball will curve, a "naive physics" misconception called the curvilinear impetus (CI) bias. In the current paper, we explore the ecological hypothesis that the CI bias arises from overgeneralization of correct motion of biological agents. Previous research has established that humans curve when exiting a spiral maze, and college students believe this motion is the same for balls and humans. The current paper consists of two follow up experiments. The first experiment tested the exiting behavior of rodents from a spiral rat maze. Though there were weaknesses in design and procedures of the maze, the findings support that rats do not behave like humans who exhibit the CI bias when exiting a spiral maze. These results are consistent with the CI bias being an overgeneralization of human motion, rather than generic biological motion. The second experiment tested physics teachers on their conception of how a humans and balls behave when exiting a spiral tube. Teachers demonstrated correct knowledge of the straight trajectory of a ball, but generalized the ball's behavior to human motion. Thus physics teachers exhibit the opposite bias from college students and presume that all motion is like inanimate motion. This evidence supports that this type of naive physics inertial bias is at least partly due to participants overgeneralizing both inanimate and animate motion to be the same, perhaps in an effort to minimize cognitive reference memory load. In short, physics training appears not to eliminate the bias, but rather to simply shift it from the presumption of stereotypical animate to stereotypical inanimate behavior.
ContributorsDye, Rosaline (Author) / Mcbeath, Michael K (Thesis advisor) / Sanabria, Federico (Committee member) / Megowan, Colleen (Committee member) / Arizona State University (Publisher)
Created2013
Description
The development of self-regulation is believed to play a crucial role in predicting later psychopathology and is believed to begin in early childhood. The early postpartum period is particularly important in laying the groundwork for later self-regulation as infants' dispositional traits interact with caregivers' co-regulatory behaviors to produce the earliest forms of self-regulation. Moreover, although emerging literature suggests that infants' exposure to maternal stress even before birth may be integral in determining children's self-regulatory capacities, the complex pathways that characterize these developmental processes remain unclear. The current study considers the complex, transactional processes in a high-risk, Mexican American sample. Data were collected from 305 Mexican American infants and their mothers during prenatal, 6- and 12-week home interviews. Mother self-reports of stress were obtained prenatally between 34-37 weeks gestation. Mother reports of infant temperamental negativity and surgency were obtained at 6-weeks as were observed global ratings of maternal sensitivity during a structured peek-a-boo task. Microcoded ratings of infants' engagement orienting and self-comforting behaviors were obtained during the 12-week peek-a-boo task. Study findings suggest that self-comforting and orienting behaviors help to modulate infants' experiences of distress, and also that prenatal stress influences infants' engagement in each of those regulatory behaviors, both directly by influence tendencies to engage in orienting behaviors and indirectly by programming higher levels of infant negativity and surgency, both of which may confer risk for later regulatory disadvantage. Advancing our understandings about the nature of these developmental pathways could have significant implications for targets of early intervention in this high-risk population.
ContributorsLin, Betty (Author) / Crnic, Keith A (Thesis advisor) / Lemery-Chalfant, Kathryn S (Committee member) / Mackinnon, David P (Committee member) / Arizona State University (Publisher)
Created2013
Description
The brain is a fundamental target of the stress response that promotes adaptation and survival but the repeated activation of the stress response has the potential alter cognition, emotion, and motivation, key functions of the limbic system. Three structures of the limbic system in particular, the hippocampus, medial prefrontal cortex (mPFC), and amygdala, are of special interest due to documented structural changes and their implication in post-traumatic stress disorder (PTSD). One of many notable chronic stress-induced changes include dendritic arbor restructuring, which reflect plasticity patterns in parallel with the direction of alterations observed in functional imaging studies in PTSD patients. For instance, chronic stress produces dendritic retraction in the hippocampus and mPFC, but dendritic hypertrophy in the amygdala, consistent with functional imaging in patients with PTSD. Some have hypothesized that these limbic region's modifications contribute to one's susceptibility to develop PTSD following a traumatic event. Consequently, we used a familiar chronic stress procedure in a rat model to create a vulnerable brain that might develop traits consistent with PTSD when presented with a challenge. In adult male rats, chronic stress by wire mesh restraint (6h/d/21d) was followed by a variety of behavioral tasks including radial arm water maze (RAWM), fear conditioning and extinction, and fear memory reconsolidation to determine chronic stress effects on behaviors mediated by these limbic structures. In chapter 2, we corroborated past findings that chronic stress caused hippocampal CA3 dendritic retraction. Importantly, we present new findings that CA3 dendritic retraction corresponded with poor spatial memory in the RAWM and that these outcomes reversed after a recovery period. In chapter 3, we also showed that chronic stress impaired mPFC-mediated extinction memory, findings that others have reported. Using carefully assessed behavior, we present new findings that chronic stress impacted nonassociative fear by enhancing contextual fear during extinction that generalized to a new context. Moreover, the generalization behavior corresponded with enhanced functional activation in the hippocampus and amygdala during fear extinction memory retrieval. In chapter 5, we showed for the first time that chronic stress enhanced amygdala functional activation during fear memory retrieval, i.e., reactivation. Moreover, these enhanced fear memories were resistant to protein synthesis interference to disrupt a previously formed memory, called reconsolidation in a novel attempt to weaken chronic stress enhanced traumatic memory. Collectively, these studies demonstrated the plastic and dynamic effects of chronic stress on limbic neurocircuitry implicated in PTSD. We showed that chronic stress created a structural and functional imbalance across the hippocampus, mPFC, and amygdala, which lead to a PTSD-like phenotype with persistent and exaggerated fear following fear conditioning. These behavioral disruptions in conjunction with morphological and functional imaging data reflect a chronic stress-induced imbalance between hippocampal and mPFC regulation in favor of amygdala function overdrive, and supports a novel approach for traumatic memory processing in PTSD.
ContributorsHoffman, Ann (Author) / Conrad, Cheryl D. (Thesis advisor) / Olive, M. Foster (Committee member) / Hammer, Jr., Ronald P. (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2013
Description
Patients with schizophrenia have impaired cognitive flexibility, as evidenced by behaviors of perseveration. Cognitive impairments may be due to dysregulation of glutamate and/or loss of neuronal plasticity in the medial prefrontal cortex (mPFC). The purpose of these studies was to examine the effects of mGluR5 positive allosteric modulators (PAMs) alone and in combination with the NMDAR antagonist MK-801, a pharmacological model of schizophrenia. An operant-based cognitive set-shifting task was utilized to assess cognitive flexibility, in vivo microdialysis procedures to measure extracellular glutamate levels in the mPFC, and diolistic labeling to assess the effects on dendritic spine density and morphology in the mPFC. Results revealed that chronic administration of the mGluR5 PAM CDPPB was able to significantly reduce the effects of chronically administered MK-801 on both behavioral perseveration and glutamate neurotransmission. Results also showed that CDPPB had no evidence of an effect on dendritic spine density or morphology, but the mGluR5 negative allosteric modulator fenobam caused significant increases in spine density and the frequency of occurrence of spines with smaller head diameters. Conclusions include that CDPPB is able to reverse MK-801 induced cognitive deficits as well as alterations in mPFC glutamate neurochemistry. The culmination of these studies add further support for targeting mGluR5 with PAMs as a novel mechanism to alleviate cognitive impairments in patients with schizophrenia.
ContributorsLaCrosse, Amber (Author) / Olive, Michael (Committee member) / Gallitano-Mendel, Amelia (Committee member) / Sanabria, Federico (Committee member) / Hammer, Ronald (Committee member) / Arizona State University (Publisher)
Created2014
Description
The unpleasant bitter taste found in many nutritious vegetables may deter their consumption. While bitterness suppression by prototypical tastants is well-studied in the chemical and pharmacological fields, mechanisms to reduce the bitterness of foods such as vegetables remain to be elucidated. Here tastants representing the taste primaries of salty and sweet were investigated as potential bitterness suppressors of three types of Brassicaceae vegetables. The secondary aim of these studies was to determine whether the bitter masking agents were differentially effective for bitter-sensitive and bitter-insensitive individuals. In all experiments, participants rated vegetables plain and with the addition of tastants. In Experiments 1-3, sucrose and NNS suppressed the bitterness of broccoli, Brussels sprouts, and cauliflower, whereas NaCl did not. Varying concentrations of NaCl and sucrose were introduced in Experiment 4 to assess the dose-dependency of the effects. While sucrose was a robust bitterness suppressor, NaCl suppressed bitterness only for participants who perceived the plain Brussels sprouts as highly bitter. Experiment 5, through the implementation of a rigorous control condition, determined that some but not all of this effect can be accounted for by regression to the mean. Individual variability in taste perception as determined by sampling of aqueous bitter, salty, and sweet solutions did not influence the degree of suppression by NaCl or sucrose. Consumption of vegetables is deterred by their bitter taste. Utilizing tastants to mask bitterness, a technique that preserves endogenous nutrients, can circumvent this issue. Sucrose is a robust bitter suppressor whereas the efficacy of NaCl is dependent upon bitterness perception of the plain vegetables.
ContributorsWilkie, Lynn Melissa (Author) / Capaldi Phillips, Elizabeth D (Thesis advisor) / Cohen, Adam (Committee member) / Johnston, Carol (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2014
Description
Comorbidity is a significant problem for current classification systems of psychopathology (i.e., DSM-V). One issue is that the underlying mechanisms shared among comorbid disorders are poorly understood, especially potential psychosocial mechanisms such as family dynamics. The current study used latent class analysis to empirically classify patterns of psychopathology within a large community sample of late adolescents (age 18-19) based on their lifetime psychological adjustment measured using the World Health Organization Composite International Diagnostic Interview. Videotaped family interactions of adolescents (age 16-17) and their parents were micro and macro coded and the resulting family dynamics were compared across the three empirically defined groups of psychological adjustment which emerged from the latent class analysis: 1) an early onset, persistent antisocial behavior class; 2) an emotionally distressed and substance using class; and 3) a typically developing class. It was found that some directly observed family dynamics, including parental monitoring, dyadic positive engagement and coercive engagement discriminated among empirically derived classes. It was also found that particular tasks better discriminated among classes with regard to specific family dynamics (e.g., family activity task best discriminated among classes on dyadic positive engagement). Overall, findings suggest that novel methodologies like latent class analysis can be useful in attempting to map underlying transdiagnostic mechanisms onto the current diagnostic framework. The findings also highlight the importance of taking many variables into consideration when attempting to understand how family dynamics are associated with psychological adjustment.
ContributorsPanza, Kaitlyn E (Author) / Dishion, Thomas J (Thesis advisor) / Crnic, Keith A (Committee member) / Tein, Jenn-Yun (Committee member) / Arizona State University (Publisher)
Created2015
Description
Globally, addiction to stimulants such as methamphetamine (METH) remains a significant public health problem. Despite decades of research, no approved anti-relapse medications for METH or any illicit stimulant exist, and current treatment approaches suffer from high relapse rates. Recently, synthetic cathinones have also emerged as popular abused stimulants, leading to numerous incidences of toxicity and death. However, contrary to traditional illicit stimulants, very little is known about their addiction potential. Given the high relapse rates and lack of approved medications for METH addiction, chapters 2 and 3 of this dissertation assessed three different glutamate receptor ligands as potential anti-relapse medications following METH intravenous self-administration (IVSA) in rats. In chapters 4 through 7, using both IVSA and intracranial self-stimulation (ICSS) procedures, experiments assessed abuse liability of the popular synthetic cathinones 3,4-Methylenedioxypyrovalerone (MDPV) , methylone, α-pyrrolidinovalerophenone (α-PVP) and 4-methylethylcathinone (4-MEC). Results from these seminal studies suggest that these drugs possess similar abuse potential to traditional illicit stimulants such as METH, cocaine, and 3,4-methylenedioxymethamphetamine (MDMA). Finally, studies outlined in chapter 8 assessed the potential neurotoxic or adverse cognitive effects of METH and MDPV following IVSA procedures for the purpose of identifying potential novel pharmacotherapeutic targets. However, results of these final studies did not reveal neurotoxic or adverse cognitive effects when using similar IVSA procedural parameters that were sufficient for establishing addiction potential, suggesting that these parameters do not allow for sufficient drug intake to produce similar neurotoxicity or cognitive deficits reported in humans. Thus, these models may be inadequate for fully modeling the adverse neural and psychological consequences of stimulant addiction. Together, these studies support the notion for continued research into the abuse liability and toxicity of METH and synthetic cathinones and suggest that refinements to traditional IVSA models are needed for both more effective assessment of potential cognitive and neural deficits induced by these drugs and screening of potentially clinically efficacious pharmacotherapeutics.
ContributorsWatterson, Lucas (Author) / Olive, Michael F (Thesis advisor) / Czyzyk, Traci (Committee member) / Neisewander, Janet (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2014
Description
Postpartum depression (PPD) is a significant public health concern affecting up to half a million U.S. women annually. Mexican-American women experience substantially higher rates of PPD, and represent an underserved population with significant health disparities that put these women and their infants at greater risk for substantial psychological and developmental difficulties. The current study utilized data on perceived stress, depression, maternal parenting behavior, and infant social-emotional and cognitive development from 214 Mexican-American mother-infant dyads. The first analysis approach utilized a latent intercept (LI) model to examine how overall mean levels and within-person deviations of perceived stress, depressive symptoms, and maternal parenting behavior are related across the postpartum period. Results indicated large, positive between- and within-person correlations between perceived stress and depression. Neither perceived stress nor depressive symptoms were found to have significant between- or within-person associations with the parenting variables. The second analysis approach utilized an autoregressive cross-lagged model with tests of mediation to identify underlying mechanisms among perceived stress, postpartum depressive symptoms, and maternal parenting behavior in the prediction of infant social-emotional and cognitive development. Results indicated that increased depressive symptoms at 12- and 18-weeks were associated with subsequent reports of increased perceived stress at 18- and 24-weeks, respectively. Perceived stress at 12-weeks was found to be negatively associated with subsequent non-hostility at 18-weeks, and both sensitivity and non-hostility were found to be associated with infant cognitive development and social-emotional competencies at 12 months of age (52-weeks), but not with social-emotional problems. The results of the mediation analyses showed that non-hostility at 18- and 24-weeks significantly mediated the association between perceived stress at 12-weeks and infant cognitive development and social-emotional competencies at 52-weeks. The findings extend research that sensitive parenting in early childhood is as important to the development of cognitive ability, social behavior, and emotion regulation in ethnic minority cultures as it is in majority culture families; that maternal perceptions of stress may spillover into parenting behavior, resulting in increased hostility and negatively influencing infant cognitive and social-emotional development; and that symptoms of depressed mood may influence the experience of stress.
ContributorsCiciolla, Lucia (Author) / Crnic, Keith A (Thesis advisor) / West, Stephen G. (Thesis advisor) / Luecken, Linda J. (Committee member) / Presson, Clark C. (Committee member) / Arizona State University (Publisher)
Created2014
Description
Maternal intrusiveness is an important predictor of child mental health problems. Evidence links high levels of maternal intrusiveness to later infant negativity, and child internalizing problems. However, children also influence the manner in which parents interact with them. For example, infants that show more negative emotionality elicit less positive parenting in their caregivers. Infant affect is also associated with later child internalizing difficulties. Although previous research has demonstrated that maternal intrusiveness is related to infant affect and child internalizing symptomatology, and that infant affect is a predictor of internalizing problems and parenting, no studies have looked at the transactional relations between early maternal intrusiveness and infant affect, and whether these relations in infancy predict later childhood internalizing symptomatology. The present study investigates young children's risk for internalizing problems as a function of the interplay between maternal intrusiveness and infant affect during the early infancy period in a low-income, Mexican-American sample. Participants included 323 Mexican-American women and their infants. Data were collected when the infants were 12, 18, 24, and 52 weeks old. Mothers were asked to interact with their infants in semi-structured tasks, and mother and infant behaviors were coded at 12, 18, and 24 weeks. Maternal intrusiveness was globally rated, and duration of infant negative- and positive affect was recorded. Mother reports of child Internalizing symptomatology were obtained at 52 weeks. Findings suggest that there are transactional relations between early maternal intrusiveness and infant negative affect, while the relations between infant positive affect and maternal intrusiveness are unidirectional, in that infant positivity influences parenting but not vice versa. Further, findings also imply that neither maternal intrusiveness, nor infant affect, influence later toddler internalizing symptomatology. Identifying risk processes in a Mexican-American sample adds to our understanding of emerging infant difficulties in this population, and may have implications for early interventions.
ContributorsRystad, Ida A (Author) / Crnic, Keith A (Thesis advisor) / Enders, Craig (Committee member) / Bradley, Robert (Committee member) / Arizona State University (Publisher)
Created2014