Matching Items (25)
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- All Subjects: psychology
- Creators: School of Social and Behavioral Sciences
- Status: Published
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Perhaps by some ingrained sense of human preparedness, phobias are an outlier in the world of conditioning. Again and again, they are highlighted as the only thing which avoidance makes worse, rather than alleviates. My own fear of insects had reached its most severe level just as I began learning about phobias, and avoidance, in my undergraduate psychology courses. There, I learned that avoidance of the phobic stimulus \u2014 in my case, insects \u2014 seemed to be a fundamental element of maintaining a phobia, and I was more than guilty of it. Following this realization, I endeavored into what I would later come to call Stimulus Confrontation: A self-designed therapeutic course of action to overcome my fear. This thesis, then, is the record of this project. It weaves together my scholarly research on phobias with my own personal narrative concerning the employment of Stimulus Confrontation, beginning with the etymology and proposed etiologies of phobias, followed by an overview of contemporary treatment options available and a recounting of Stimulus Confrontation as applied to my own phobia. Told from her own perspective, English writer and journalist Jenny Diski's book, What I Don't Know About Animals, tells of her own arachnophobia, and includes an honest account of the fear and anxiety it caused for her, as well as her own journey to overcome it. Like my own, Diski's phobia \u2014 arachnophobia \u2014 had come to affect her everyday life. Prior to seeking treatment for her fear at the age of 58, Diski too had learned to avoid the thing which she so feared. Inspired by What I Don't Know About Animals, the personal anecdotes I have included throughout this thesis serve to elaborate upon my personal experience with my own insectophobia, and the cessation of avoidance that led to substantial progress in overcoming my fears. Throughout this thesis, I refer to this cessation of avoidance as Stimulus Confrontation, with the intention that following the same process I did may benefit others in overcoming their own specific phobias.
ContributorsKavanaugh, Ashley Marie (Author) / Gruber, Diane (Thesis director) / Lewis, Stephen (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
The purpose of this thesis is to examine the relationship between mental illness and capitalist consumer society. Many Americans are suffering from mental illness and there has to be something causing it besides a chemical imbalance in the brain. A capitalist society creates a set of expectations that conflict with human desires. The thesis takes a historical, economical, and psychological approach to answering the following question: Does a capitalist society make its citizens mentally sick? A brief history of capitalism over the past century is discussed, as well as a more in depth look at capitalism and the creation of neoliberalism during the 1980s. The psychological effects capitalism has on human beings is discussed for the majority of the thesis and focuses on ideas from the 1950s as well as the early 2000s. To show the effect capitalism has on modern day society, an analysis of a psychopharmaceutical drug commercial is given. The concluding thoughts attempt to offer solutions to the problems of human unhappiness in a consumer culture.
ContributorsSerki, Aisling Erin (Author) / Gruber, Diane (Thesis director) / Ramsey, Ramsey Eric (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
This correlational study investigated how adolescent's artistic style changed depending on their level of interest in art. The participants were 28 students from the 7th and 8th grade of Zuni Hills Elementary School. A survey was administered which measured, in regards to their artwork, the categories of interest, experimentation in subject, experimentation in material, abstract style, literal style, imagination, identity, emotion and storytelling. It was predicted that interest would have a significant positive relationship with abstract style and experimentation with subject. It was also predicted that interest would have a significant negative relationship with literal style and experimentation with material. Scores for all categories were compared and significant positive relations were found in regards to emotion, identity and storytelling. There was also a significant positive realtionship between interest and imagination as well as interest and emotion. These findings add to research about motivation in adolescent art through the means of expression of the self.
ContributorsAbeyta, Jennifer Lee (Author) / Miller, Paul (Thesis director) / Lewis, Stephen K. (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
A playwright behind the scenes of my personal struggle with PTSD, experience that caused it, and journey to healing from it. The playwright consists of deeper causes of PTSD and its effects, more than the average textbook can teach anyone. With the help of a couple people and Russ, a famous artist, I was able to grow and become stronger and show it all within my playwright. Enjoy the journey to healing of a person, a warrior who wanted to fight and made it through the night.
ContributorsCristobal, Nicky Desiree (Author) / Lewis, Stephen (Thesis director) / Zygutis, Linda (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
In this thesis, I will be discussing the similarities between Stoicism (as both an ancient Greek and Roman philosophy, as well as how it is interpreted in the modern age) and modern therapeutic methods; However, I will not be developing any type of novel theory as to how Stoicism can be used as one of those therapeutic methods by itself. That would require a degree of psychological and medical knowledge that I, as an undergraduate student, do not yet possess and do not have the authority to expand upon in a safe manner. What the goal of this thesis is, instead, is to draw and explore parallels between the ideals and principles of stoicism (such as eudaimonia, ethics, and relative asceticism) as compared to modern therapeutic techniques, like cognitive-behavioral and dialectical-behavioral therapies. I will draw direct parallels between Stoic philosophy and the therapeutic treatments commonly used to address the symptoms of two psychiatric issues (Bipolar Mood Disorder and Obsessive Compulsive Disorder). I will also be addressing a third psychiatric case study, as relating to Stoic philosophy - suicide, and how our view of it has changed and progressed,both through a Stoic lens as well as from a contemporary psychological viewpoint.
As a result of drawing these parallels, this thesis will also explore some of the more modern uses of Stoicism - for example, those discussed in A Guide To The Good Life by William B Irvine, and Stoic Warriors by Nancy Sherman. Irvine focuses primarily on the use of Stoicism to avoid the factors of“chronic dissatisfaction” that afflict much of our modern-day lives - an absence of control, unhappiness, and erroneous personal values, to name a few. Sherman takes a more targeted approach - the application of Stoic philosophy to the workings of the military mentality and instinct. Sherman explores how being “Stoic” is taught as a part of military bearing, specifically when serving in the American forces. Stoic values are used to create a culture of discipline and self-control in the military - as Sherman puts it, “The idea that one’s happiness could depend solely on one’s own virtue, and that one’s agency and control might be bulletproof, appealed to [them]” (Sherman, 11). These authors’ perspectives are just two examples of how Stoicism can be applied in the modern age, as will be shown in further detail in subsequent sections.
As a result of drawing these parallels, this thesis will also explore some of the more modern uses of Stoicism - for example, those discussed in A Guide To The Good Life by William B Irvine, and Stoic Warriors by Nancy Sherman. Irvine focuses primarily on the use of Stoicism to avoid the factors of“chronic dissatisfaction” that afflict much of our modern-day lives - an absence of control, unhappiness, and erroneous personal values, to name a few. Sherman takes a more targeted approach - the application of Stoic philosophy to the workings of the military mentality and instinct. Sherman explores how being “Stoic” is taught as a part of military bearing, specifically when serving in the American forces. Stoic values are used to create a culture of discipline and self-control in the military - as Sherman puts it, “The idea that one’s happiness could depend solely on one’s own virtue, and that one’s agency and control might be bulletproof, appealed to [them]” (Sherman, 11). These authors’ perspectives are just two examples of how Stoicism can be applied in the modern age, as will be shown in further detail in subsequent sections.
ContributorsSimpson, Naomi (Author) / Lynch, John (Thesis director) / O'Neill, Joseph (Committee member) / School of Music (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This study was been influenced from the perspective of clinical psychology. The main research question was: What personality traits and/or characteristics (in this case emotional characteristics) can influence dating violence? Aspects such as gender, age, sexual orientation, and current relationship status were considered. Given the evolving culture of relationship dominance, it has been difficult to detect when, and if, people can become potential victims of relationship violence.
Results of the dating violence assessments were reported as well as the results of a personality assessment. The comparisons between the three relationship assessments were inconclusive. This research should be taken as a guidance into the factors of dating violence by taking into consideration the characteristics and personalities of potential victims. It can also be seen as a snapshot of the current time period on the topic of relationship violence and its ideas and its prevalence.
The research conducted was at Arizona State University in three psychology classes. The results included participants relationships, abuse screening scores, and personality assessments. The True Colors personality test showed that the majority of the participants were associated with being emotion driven.
Results of the dating violence assessments were reported as well as the results of a personality assessment. The comparisons between the three relationship assessments were inconclusive. This research should be taken as a guidance into the factors of dating violence by taking into consideration the characteristics and personalities of potential victims. It can also be seen as a snapshot of the current time period on the topic of relationship violence and its ideas and its prevalence.
The research conducted was at Arizona State University in three psychology classes. The results included participants relationships, abuse screening scores, and personality assessments. The True Colors personality test showed that the majority of the participants were associated with being emotion driven.
ContributorsValadez, Saily (Author) / Lewis, Stephen (Thesis director) / Roberts, Nicole (Committee member) / Division of Teacher Preparation (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The purpose of this project is to raise awareness for children with social anxiety. As a book directed to children around the age of 12, it will give them a character they can relate to, so they can feel less alone. Throughout the story, the main character experiences symptoms of social anxiety and is subject to events that exacerbate those symptoms. Despite her challenges, the main character is able to effectively cope with her social anxiety through her own hard work, and help from her family members, teachers, and peers. The intent is to show children with social anxiety that, contrary to what their disorder makes them feel, they are special and have the capacity to develop skills that are relevant to their talents and interests, and overcome their fears. They should know that parents, teachers, and peers will be there to help and support them and will not judge them as harshly as they suspect. The supporting characters in this story show how a strong support base can influence the success of children with social anxiety. By the end of the story, the main character still has social anxiety, but has gained confidence and her symptoms are less severe. This illustrates that, although social anxiety cannot simply be overcome—that is, it doesn’t go away completely—it can be effectively managed with assistance from close others, and perseverance.
ContributorsDillard, Bethlehem (Author) / Lewis, Stephen (Thesis director) / Gaffney, Cynthia (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Abstract White matter thickness correlates with various mental illness. Commissure white matter tracts are responsible for interconnecting the same cortical area in both hemispheres. Injury to the brain can result in thinning and shrinkage even collapsing and detachment of the white matter tracts' myelin sheaths. Injury can affect cognitive function and time points are essential for therapeutic intervention. Research is beginning to identify gradual long-term neurodegenerative effects. With the advancement of brain imaging technology, we know that Wallerian degeneration has a significant negative impact on the white matter tracts throughout the brain (Johnson, Stewart, & Smith, 2013). If major tracts become injured like, the corpus callosum, then it can affect interhemispheric communication. Once myelin is damaged the axon becomes vulnerable, and the mechanisms of nerve recovery are not well known. Myelin sheath recovery has been studied in hopes to proliferate the oligodendrocytes that make up for the atrophied myelin. Neurotoxic chemicals released at activation of macrophages which hinders the brains ability to proliferate myelin protein needed for myelin differentiation adequately. In the central nervous system myelin has mechanisms to recover. Neurogenesis is a naturally occurring recovery mechanism seen after brain injury. Understanding the time points in which brain recovery occurs is important for treatment of diffuse injuries that cannot be identified through some imaging techniques. To better understand critical timepoints of natural recovery after brain injury can allow further investigation for early intervention to promote adequate recovery.
ContributorsLiptow, Kristen Ashley (Author) / Neisewander, Janet (Thesis director) / Law, L. Matthew (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12