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- All Subjects: Adaptation
- All Subjects: Podcast
- Creators: Hyatt, JP
- Creators: Kingsbury, Jeffrey
- Member of: Theses and Dissertations
Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about burnout and mental health in a conversational episode.
Disclaimer: Due to the COVID-19 global pandemic, the final outcomes of this project were impacted and limited. Therefore, the rough draft practice podcast session has been uploaded to accompany the written thesis portion as final recordings could not be recorded at this time.
DISCLAIMER: Due to the unexpected COVID-19 pandemic, the attached podcast is a draft recording in lieu of the final recording
Cellular hypertrophy is an anaerobically-based, adaptive process that mammalian skeletal muscle undergoes in response to damage resulting from unaccustomed force generation by the muscle. Hypertrophy allows for the muscle tissue to recover from the immediate injury and also to be rebuilt more capable of withstanding producing the same amount of force without injury, should it happen again. This means the end result of an adapted muscle is an overall more efficient tissue. The ability to regenerate after damage to the structure and function of the muscle tissue is a highly orchestrated event involving multiple steps and key events to occur. Most briefly, a mechanical load is attempted to be lifted but due to demanding a high amount of contractile force to lift, it causes microdamage to the structural and contractile elements of muscle fiber’s sarcomeres. In addition to an inflammatory response, satellite cells, as a part of a myogenic response, are activated to invade the fiber and then permanently reside inside to produce new proteins that will replace the damaged and necrotized proteins. This addition of cellular content, repeated over multiple times, results in the increased diameter of the fibers and manifests in the visual appearance of skeletal muscle hypertrophy. These steps have been listed off devoid of the contexts in which it takes for these to occur and will be addressed within this thesis.
Disclaimer: The initial goal of this project was to present this information as a podcast episode as a part of a series aimed at teaching the general public about human physiological adaptations. Due to the circumstances with COVID-19 we were unable to meet to make a final recording of the podcast episode. A recording of a practice session recorded earlier in the year has been uploaded instead and is therefore only a rough draft.
Our current understanding of the mitochondrial genome was revolutionized in 2015 with the discovery of short open reading frames (sORFs) that produced protein products called mitochondrial-derived peptides (MDPs). Interestingly, unlike other proteins produced by the organelle, these MDPs are not directly involved in the electron transport chain but rather serve the role of metabolic regulators. In particular, one of these peptides called MOTS-c has been shown to regulate glucose and fat metabolism in an AMPK-dependent manner. With its capacity to enter the mitochondria and impact gene expression, MOTS-c has also displayed the ability to increase aerobic exercise performance by triggering elevated synthesis of the HO-1 antioxidant. Overall these findings position MOTS-c as a promising treatment for metabolic diseases as well as a potential dietary supplement to boost ATP availability.
Due to the gender division of labor climate change will affect men and women differently. Policies and programs that do not take into account the needs and capacities of both men and women will fail to be effective and may worsen preexisting conditions that historically favor men. My research investigates the UN’s commitment towards gender mainstreaming. More specifically my objective is to understand how and to what extent the NAPAs from 49 countries integrate a gender dimension into their national climate adaptation policy. For the purpose of this research, I consider three interrelated issues: whether gender-specific needs and vulnerabilities were identified by the NAPA; if these needs and vulnerabilities were addressed by proposed adaptation projects; and in what forms women participated in the formulation of the NAPA. The scope of this research begins with an overview assessment of 49 NAPAs followed by a comparative assessment of NAPAs from four countries- Afghanistan, Bangladesh, Maldives, and Niger, and an in-depth analysis of Nepal’s NAPA, which incorporates field study. Nepal was chosen as a focus country due to its identification as being both inclusive and gender sensitive.
The method of inquiry consists of both quantitative and qualitative analysis, utilizing the quantitative measures of HDI and GII and the qualitative methods of content analysis and case study. The findings suggest that the response to the gender dimensions of climate change found in adaptation policies vary widely among the LDCs and the level of response is dependent upon social, cultural, economic, and political contexts within each LDC. Additionally, I find that gender mainstreaming techniques have not been fully integrated into the NAPA policy and processes, and have not been effective at promoting gender equality through adaptation strategies. Recommendations are provided in order to help mainstream gender in NAPAs as they continue to be developed, revised, and implemented.