Matching Items (19)
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- All Subjects: Politics
- All Subjects: development
- Creators: School of Social and Behavioral Sciences
- Creators: Woodall, Gina
- Status: Published
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
A study on the effectiveness of different graphic design elements, such as color and shape, in political communication over a digital medium. The study was conducted through an online survey of young adults (18-25 years old). Participants' preferences for the design elements are compared to their online and offline political participation and their primary sources for political information.
ContributorsRyan, Daiquiri Ice (Author) / Lennon, Tara (Thesis director) / Woodall, Gina (Committee member) / Blyler, Lisa (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / School of Politics and Global Studies (Contributor)
Created2014-05
Description
We were interested in whether or not certain demographics, such as gender, age, education level, and academic major, would affect an individual's political awareness. In particular, we hypothesized that Political Science majors would have a higher level of political awareness than Non-Political Science majors. In an in-person survey, we asked participants on the Arizona State University, Tempe campus a series of nine questions measuring government structure and procedure, current politics, and policy issues. Our findings concluded that, within our sample: 1) on average, Political Science majors outperformed Non-Political Science majors 2) education level appears to be positively associated with political awareness 3) like education, age appears to be positively associated with political awareness, however, there seemed to be a peak at 21 years of age 4) males outperformed females, as suggested by research studying the gender gap in political knowledge. Because our sample population was not randomly selected, and this report focuses on descriptive statistics, we cannot generalize or comment on our findings' statistical significance. However, many of our findings are supported by current research and, with further specification, may be of interest to university officials who seek to measure the political knowledge and awareness of various demographic groups on campus.
ContributorsTaylor, Kaela (Co-author) / Leung, Emily (Co-author) / Lennon, Tara (Thesis director) / Woodall, Gina (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / School of International Letters and Cultures (Contributor) / School of Politics and Global Studies (Contributor) / Department of Information Systems (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
This thesis explores a method of how political information could be distributed to the public and asks the question, what is the best way to provide voters with all of the information they need to cast an informed vote? It involved the creation of a website, www.azleglive.info, which republishes state legislative data in interactive and visually condensed formats and asked users to compare it to the existing Arizona State Legislature website on the metrics of depth of information, usability, and clarity. It also asked what resources users would utilize in order to cast a vote in the next election. Ultimately, the majority of users determined that the new website added needed usability and clarity to available legislative information, but that both websites would be useful when voting. In conclusion, the responsibility of disseminating useful information to voters is most likely to be effective when distributed among a variety of sources.
ContributorsJosephson, Zachary (Co-author) / Umaretiya, Amy (Co-author) / Jones, Ruth (Thesis director) / Woodall, Gina (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / School of Politics and Global Studies (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The contemporary Democratic Party has departed from their roots protecting working-class issues in favor of neoliberal ideology protecting the professional class; however, recent surges in progressive campaigns demonstrate the desire to move past this elitist ideology for New Deal-like policies, namely, young people. By utilizing the works of Thomas Frank and Anand Giridharadas to analyze the faults of the DNC, I then make case for the path forward that is more inclusive of young people and older members Black, Indigenous, Latino, Asian, and LGBTQ+ communities with progressive policies to "bringing the party home."
ContributorsThompson, Makayla Lynn (Author) / Gruber, Diane (Thesis director) / Ron, Amit (Committee member) / School of Social and Behavioral Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This study aims to gain a better understanding of the potential influence that perceived levels of attractiveness impose on individuals’ perceptions of male and female candidates’ competency and favorability. I utilized a quasi-experimental design that had a total of 603 respondents, all of which were current students at Arizona State University. The experimental design of the study consisted of the same pre-test, and post-test questionnaire, with a randomly assigned experimental group viewing a video regarding the halo effect, and a randomly assigned control group viewing a neutral video with no comment on attractiveness and its inherent effects. The results demonstrate insignificant findings in regard to candidate favorability and attractiveness, but one significant finding revealed itself in regard to competency. Hypothesis 6 (H6) identified an unexpected, yet statistically significant finding when concerning the ‘above average’ female candidate and respondents’ perception of her competency. This suggests that individuals may be more inclined to favorably perceive the competency of an attractive female candidate when they are aware of their implicit biases that accompany increased levels of attractiveness. This study offers insight into whether perceived level of attractiveness affects evaluations of male and female politicians.
ContributorsAndrade, Madison Antoinette (Author) / Woodall, Gina (Thesis director) / Kenney, Patrick (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
This research study evaluated the effects of early childhood environment and the influence parenting style has on the life outcomes among university students who varied in psychopathic traits; demonstrating evidence to show students who scored highly in measures of psychopathy used antisocial success seeking strategies to attain common life goals. This study examined the prospect of parenting styles and childhood environment as possible influences on important differences between psychopaths who become involved in the American legal system and those who do not. These differences were identified by asking participants to describe how often they engage in success seeking behaviors by using either prosocial or antisocial methods. Results were based on a hierarchical regression analysis and illustrated psychopathy as a significant predictor for utilizing antisocial success seeking strategic behavior. Such strategies include lying on job applications, accepting credit for the work of others, or winning a competition by cheating. In contrast, our Model determined that parental influence based on measures of paternal and maternal warmth, financial support, and physical and emotional abuse, did not significantly predict either prosocial success seeking strategies or antisocial success seeking strategies. Possible trends relating to childhood environment were identified but were undoubtedly restricted due to the evidently small sample size in this study. Conclusions into this investigation affirm the necessity for additional research into this view of psychopathy and how some psychopaths may be able to utilize their unique traits to their advantage.
ContributorsMcSweeney, Christy Anne (Author) / Black, Candace J. (Thesis director) / Pardini, Dustin A. (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The steroid hormone 20-hydroxyecdysone (20E) controls molting in arthropods. The timing of 20E production, and subsequent developmental transitions, is regulated by a variety of factors including nutrition and photoperiod. Environmental factors, such as temperature, play a critical role in regulation as well. The increasing prevalence of urban heat islands (UHI), or areas with elevated temperature due to retained heat by built structures, in response to rapid urbanization has made it critical to understand how organisms respond to elevating global temperatures. Some arthropods, such as the Western black widow spider, Latrodectus hesperus, appear to thrive under UHI conditions, but the physiological mechanism underlying their success has not been explored. Recently, we have shown that L. hesperus, a troublesome urban pest, in fact responds to urban heat island conditions in Phoenix, AZ with delayed development, reduced body mass, and increased mortality. Here we look at the relationship between 20E levels and development in spiderlings reared under desert (27ᵒC), intermediate (30ᵒC), and urban (33ᵒC) temperatures, filling a noticeable gap in not only understanding ecdysteroids’ role in arachnid development but how incremental changes in environmental conditions affect the regulation of this process. Developmental progression and hemolymph 20E titers were recorded for several families of spiders collected from across the urban Phoenix area with data spanning from day 55 to 75 of development, focusing on the second developmental instar. We found that 33°C, but not 30°C, led to 1) a significantly higher production of 20E throughout development, 2) a reduced and delayed molt-inducing 20E peak, and 3) noticeable reductions in growth rate and mass. At 30°C, a variable response is seen in molt timing, without the negative impacts on size and mortality as seen at 33°C, suggesting that at UHI temperatures, the optimal developmental temperature threshold has been surpassed.
ContributorsMoen, Claire Elizabeth (Author) / Hackney-Price, Jennifer (Thesis director) / Johnson, J. Chadwick (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
In this undergraduate thesis, I explore the relationship between politics and popular culture through an ethnography of Justice League Arizona, a cosplay ensemble devoted to costumed civic activism. While existing scholarship addresses cosplay ensembles and political theory, there is very little that examines how the act of cosplay can be a form of politics and what the impact of that interpretation has on both individuals and the community at large. Through both participant observation and interviews with members of the ensemble, I discovered that cosplay has the ability to intensify aspects of the self, the ability to expose new aspects of the self, and the ability to bring one closer to a particular character. I also found cosplay to be political through the sensibility and situated knowledge that proves to be in practice during cosplay, ultimately having the power to be used as a form of political resistance.
ContributorsBurrus, Ella Rene (Author) / Mack, Robert (Thesis director) / Behl, Natasha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Herberger Institute for Design and the Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12