Matching Items (19)
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- All Subjects: development
- All Subjects: feminism
- Creators: School of Social and Behavioral Sciences
- Status: Published
Description
Bexarotene (Targretin®) is an FDA approved drug used to treat cutaneous T-cell lymphoma (CTCL), as well as off-label treatments for various cancers and neurodegenerative diseases. Previous research has indicated that bexarotene has a specific affinity for retinoid X receptors (RXR), which allows bexarotene to act as a ligand-activated-transcription factor and in return control cell differentiation and proliferation. Bexarotene targets RXR homodimerization to drive transcription of tumor suppressing genes; however, adverse reactions occur simultaneously when bound to other nuclear receptors. In this study, we used novel bexarotene analogs throughout 5 iterations synthesized in the laboratory of Dr. Wagner to test for their potency and ability to bind RXR. The aim of our study is to quantitatively measure RXR homodimerization driven by bexarotene analogs using a yeast two-hybrid system. Our results suggests there to be several compounds with higher protein activity than bexarotene, particularly in generations 3.0 and 5.0. This higher affinity for RXR homodimers may help scientists identify a compound that will minimize adverse effects and toxicity of bexarotene and serve as a better cancer treatment alternative.
ContributorsSeto, David Hua (Author) / Marshall, Pamela (Thesis director) / Wagner, Carl (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Natural Sciences (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2015-05
Description
Bexarotene is a commercially produced drug commonly known as Targetin presecribed to treat cutaneous T-cell lymphoma (CTCL). Bex mimics the actions of natural 9-cis retinoic acid in the body, which are derived from Vitamin A in the diet and boost the immune system. Bex has been shown to be effective in the treatment of multiple types of cancer, including lung cancer. However, the disadvantages of using Bex include increased instances of hypothyroidism and excessive concentrations of blood triglycerides. If an analog of Bex can be developed which retains high affinity RXR binding similar to the 9-cis retinoic acid while exhibiting less interference for heterodimerization pathways, it would be of great clinical significance in improving the quality of life for patients with CTCL. This thesis will detail the biological profiling of additional novel (Generation Two) analogs, which are currently in submission for publication, as well as that of Generation Three analogs. The results from these studies reveal that specific alterations in the core structure of the Bex "parent" compound structure can have dramatic effects in modifying the biological activity of RXR agonists.
ContributorsYang, Joanna (Author) / Jurutka, Peter (Thesis director) / Wagner, Carl (Committee member) / Hibler, Elizabeth (Committee member) / Barrett, The Honors College (Contributor)
Created2012-05
Description
Menstruation curricula in elementary schools presents an opportunity to better examine the early teachings about menstruation, as this is often the first time that young people learn about gender difference within school sanctioned curricula. A closer examination of this pedagogical moment from the perspective of educators helps us to understand the dissemination of the shame narrative present in menstrual socialization. Six teachers were interviewed about their experiences with administering the menstrual health curriculum in elementary schools across a large southwest metropolitan area. A discourse analysis of these interviews was completed in order to find themes of language used surrounding menstrual health curriculum. Themes of shame, legislative restrictions on sex education curriculum and personal narratives surrounding menstruation are discussed in addition to the current neo-liberal structure of public health curriculum. Future research into alternative modes of education on menstruation is proposed.
ContributorsGonzalez, Jaqueline Jean (Author) / Fahs, Breanne (Thesis director) / Grzanka, Patrick (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
This research study evaluated the effects of early childhood environment and the influence parenting style has on the life outcomes among university students who varied in psychopathic traits; demonstrating evidence to show students who scored highly in measures of psychopathy used antisocial success seeking strategies to attain common life goals. This study examined the prospect of parenting styles and childhood environment as possible influences on important differences between psychopaths who become involved in the American legal system and those who do not. These differences were identified by asking participants to describe how often they engage in success seeking behaviors by using either prosocial or antisocial methods. Results were based on a hierarchical regression analysis and illustrated psychopathy as a significant predictor for utilizing antisocial success seeking strategic behavior. Such strategies include lying on job applications, accepting credit for the work of others, or winning a competition by cheating. In contrast, our Model determined that parental influence based on measures of paternal and maternal warmth, financial support, and physical and emotional abuse, did not significantly predict either prosocial success seeking strategies or antisocial success seeking strategies. Possible trends relating to childhood environment were identified but were undoubtedly restricted due to the evidently small sample size in this study. Conclusions into this investigation affirm the necessity for additional research into this view of psychopathy and how some psychopaths may be able to utilize their unique traits to their advantage.
ContributorsMcSweeney, Christy Anne (Author) / Black, Candace J. (Thesis director) / Pardini, Dustin A. (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The steroid hormone 20-hydroxyecdysone (20E) controls molting in arthropods. The timing of 20E production, and subsequent developmental transitions, is regulated by a variety of factors including nutrition and photoperiod. Environmental factors, such as temperature, play a critical role in regulation as well. The increasing prevalence of urban heat islands (UHI), or areas with elevated temperature due to retained heat by built structures, in response to rapid urbanization has made it critical to understand how organisms respond to elevating global temperatures. Some arthropods, such as the Western black widow spider, Latrodectus hesperus, appear to thrive under UHI conditions, but the physiological mechanism underlying their success has not been explored. Recently, we have shown that L. hesperus, a troublesome urban pest, in fact responds to urban heat island conditions in Phoenix, AZ with delayed development, reduced body mass, and increased mortality. Here we look at the relationship between 20E levels and development in spiderlings reared under desert (27ᵒC), intermediate (30ᵒC), and urban (33ᵒC) temperatures, filling a noticeable gap in not only understanding ecdysteroids’ role in arachnid development but how incremental changes in environmental conditions affect the regulation of this process. Developmental progression and hemolymph 20E titers were recorded for several families of spiders collected from across the urban Phoenix area with data spanning from day 55 to 75 of development, focusing on the second developmental instar. We found that 33°C, but not 30°C, led to 1) a significantly higher production of 20E throughout development, 2) a reduced and delayed molt-inducing 20E peak, and 3) noticeable reductions in growth rate and mass. At 30°C, a variable response is seen in molt timing, without the negative impacts on size and mortality as seen at 33°C, suggesting that at UHI temperatures, the optimal developmental temperature threshold has been surpassed.
ContributorsMoen, Claire Elizabeth (Author) / Hackney-Price, Jennifer (Thesis director) / Johnson, J. Chadwick (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The story of Sor Juana Ines de la Cruz is one of a woman who defied the odds of her time. Sor Juana was a nun born in the 1600's in Mexico. From an early start, she had an endless passion for knowledge and always strove to learn as much as she could. She went on to become a nun at the Convent of Santa Paula and used her intellect to advocate for women's rights. Though met with opposition, she wrote many poems, letters, and even plays which included her strong push for women's equality. However, the name Sor Juana Ines de la Cruz is almost never mentioned in popular feminist discourse, despite Sor Juana being credited as one of the first feminist authors. This paper works to not only tell the story of Sor Juana Ines de la Cruz in detail, but also works to answer the question, "Why do people not know about Sor Juana". By diving into the origins of the Feminist movement in the United States, the dark underbelly of Feminism is uncovered. Primarily, the topic of how racism in feminism has plague the civil rights movement, what damage has been done to people of color because of feminism's history, and how does that pertain to modern day feminism and Sor Juana. By telling her story through both written and visual aids, the voice of Sor Juana Ines de la Cruz is no longer silenced but free to tell her tale and move a generation.
ContributorsParker, Natalie (Author) / Devine, Theresa (Thesis director) / Walker, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Four hundred years after the word "virtuous," came to be associated with a woman's sexuality, today's female adolescent seemingly has everything. Yet, there is a psychological civil war raging in the psyche of the 21st century young American female because her mind is divided against itself due to the conflicting instructions of who and what she should be. She has so many choices; it is easy to become overwhelmed by them. Today's female youth is threatened. She communicates more and more, but her ability to express herself is inhibited because she is unsure of how to develop an authentic sense of self. It is a hermeneutic understanding of communication and what it means to be "virtuous" that can free young women to cultivate authentic self and continue to make decisions that support such a lifestyle. It is the aim of this thesis to reclaim the word "virtuous" for the benefit of today's young women. Deeper understanding of hermeneutics and communication allow us to view this word in a different light and read the entirety of Proverbs 31 as feminists. Young women have always faced challenges in adolescence, but a return to classical wisdom and philosophy will equip them to further advance themselves and their communities, rather than forcing them into a life of speaking tongue twisters. The virtuous young woman does not know what the future holds, but armed with the lessons of tradition and the fire of hope, she may speak a virtuous magic over the world with a tongue fit for the challenge.
ContributorsNichols, Hannah May (Author) / Ramsey, Ramsey Eric (Thesis director) / Gaffney, Cynthia (Committee member) / Watrous, Lisa (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
As a writer and reader of young adult (YA) literature, I find it is impossible to ignore the rise of traditional masculinity within new, adolescent heroines. In the 21st century, readers have seen the rise of supposedly strong female characters—heroines who carry assault rifles and avoid their emotions. By relinquishing their emotions and their flaws, these heroines have sacrificed the qualities about themselves that initially made them appear so interesting. My desire to see more realistic heroines like myself developed into a creative fiction project that follows and acknowledges the voices of feminine heroines. I call these protagonists “female strong.” My project—a collection of linked short stories—is peopled with the types of heroines that are severely lacking in YA novels and in the film industry. In my own short stories, I have embraced the narratives about young women who are both strong and emotional. I wanted to create memorable female characters that the reader could root for simply because of their feminine strength, even if their flaws were naivety, or lack of confidence, or even if they failed to achieve their resolution in the end. Female-strong characters are vital because they present a view of women who aren’t purely fantasy; they are placed in the real and are feminine, too. In other words, they don’t have to be a gorgeous, knockout model who can kick butt; instead, they can derive strength from their intellect, or their intuition, or perhaps even from their emotion.
ContributorsGoldsmith, Ilyssa Sallie (Author) / Gruber, Diane (Thesis director) / Amparano, Julie (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This research explores how to best communicate positive body images to women. This project was intended to improve a blog I created my freshmen year in college called You're Not A Potato where I used original illustrations to tell a narrative about body image issues. The thesis begins with an historical overview of body image issues and finds that women have been dealing with high levels of body dissatisfaction since the Victorian era. The thesis then recaps the role of traditional media as well as contemporary social media and the role they play in imposing rigid beauty ideals on women's bodies. After an analysis of social media culture, it becomes evident women still communicate about their bodies in a negative manner, not only towards themselves, but towards others. To address this issue, I define the Body Positive movement and explore how public figures are using social media to implement Body Positivity. To conclude this project, I utilize my new-found knowledge in body positive communication by impacting my university campus community. I started a "You're Not a Potato" Campaign for Body Pride week with the help of the ASU Wellness Team and designed and facilitated several engaging programs that reflected the values of the Body Positive movement to our students. Through this research, I discovered how our appearance-based culture has stolen self-confidence from young women today, but by the end of this project, I explain how we can attempt to rebuild our culture by effectively communicating self-love and body acceptance in our online and physical communities.
ContributorsMouton, Brianna Anais (Author) / Gruber, Diane (Thesis director) / Taylor, Jameien (Committee member) / Manninen, Bertha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
My thesis argues Romanticism and feminism are utopian allies, and Romanticism, understood as a philosophical movement, should be recognized as an essential aspect of critical feminist theory. I claim feminism must be understood as holding an undischarged utopian potential, liberated and inspired by a dynamic neo-Romanticism. This critical discourse gives birth to Romantic-feminism, which reinterprets Romantic works and rereads feminist theory, cultivating their shared revolutionary aspirations. While the claim that feminism buoys Romanticism—potentially creating a space for a singularly genuine kind of Romantic thought—is fairly bold, the core of this project rests upon an argument of even greater magnitude: feminism is as in need of Romanticism as Romanticism is in need of feminism. In fact, feminism is in desperate want of the revolutionary, aesthetic, and utopian vision of Romanticism, and a reinvented, reinvigorated feminism capable of confronting grave contemporary issues will not be possible without philosophical and artistic Romantic influence. A dynamic and progressive feminism not only betters Romantic texts, but provides the only possible condition for the realization of genuine revolution within Romanticism as a whole . As such, the second half of this project focuses on close readings of three poems by 19th-century women: “On Being Cautioned Against Walking on an Headland Overlooking the Sea because it was Frequented by a Lunatic” by Charlotte Smith, “The Lily” by Mary Tighe, and “Lines of Life” by Letitia Elizabeth Landon. Approaching these Romantic works will necessitate an openness and welcoming of both tradition and the strange, a critical emphasis on intersectional feminist concerns, an innovative critique of modernity informed by Marxist and socialist thought, a willingness to transform (the text, the self, and the world), and revolutionary and utopian desires.
ContributorsGosse, Raelynn (Author) / Ramsey, Ramsey Eric (Thesis director) / Mann, Annika (Committee member) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05