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- All Subjects: Neuroscience
- Creators: Newbern, Jason
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Neurological manifestations may be more prominent and have a larger role in ankylosing spondylitis than previously thought. Ankylosing Spondylitis is a rheumatic disease primarily identified by its autoinflammatory characteristics and is highly associated with the HLA-B27 gene. While it’s cause is not yet fully understood and it’s symptoms widely vary, neurological impairment is not uncommon. The neurological manifestations of Ankylosing Spondylitis include but are not limited to pain sensitization, altered brain phenotype, and disrupted cardiac conduction. Central and peripheral nervous system involvement may be more significant than previously thought and have the potential to cause demyelinating diseases, spinal cord, and nerve root injuries. Altered connectivity throughout various regions within the brain further exemplify the need for a better understanding of the disease and better treatment development. Higher instances of depression and dementia were also reported and coincide with not only a less active lifestyle, but altered brain activity. Studies on cardiac conduction and arrhythmias in AS patients revealed parasympathetic and sympathetic nervous system dysregulation. These studies have explored the possibility of new targets for treatment involving cardiac mechanisms. Treatments for diseases of a similar suspected pathology, new prospective targets for therapy, and a more thorough understanding of current treatments for the disease may be the key in providing more substantial relief. By further investigation in the role of the nervous system in Ankylosing Spondylitis, the disease may become more manageable for patients and greatly increase quality of life in the future.
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Supply & Demand, the phrase speaks to the tango between college graduates seeking employment & employers seeking talent. Recruiters desire candidates with employability skills to lead, but report significant skill gaps among applicants. This thesis aims to (1) define the skills gap evidenced by employers, (2) determine students’ career preparedness, and (3) identify strategies to bridge the gap among undergraduate students as they prepare to join the workforce. Qualtrics, an experience management, and survey platform, was used to reach and collect information from nearly 1,200 students in order to quantitatively assess their career development skills and needs. As part of this thesis, I have partnered with the T.W. Lewis Center for Personal Development, a center of Barrett, The Honors College at Arizona State University in an effort to test and provide effective solutions to bridge the employability skills gap. Through this collaboration, we have constructed a Career Development Workshop Series for students using the data collected from students. The workshop was built to teach students about professional skill topics that they desired to learn about, but could not find on or off-campus. The Lewis Center Career Development Workshop is a 5-part series with topics ranging from negotiation and job interviewing to strength-building. In each workshop, an expert is selected as the guest speaker to share their experience and insights with students as they prepare for their career journeys. Guest speakers include CEOs, entrepreneurs, business executives, and more. The series is intended to deepen students’ business acumen, so they can enter the workforce with a sustainable advantage and ultimately supported the professional and personal growth of over 100 students. The series serves as an example of ways our university can improve its career development offerings to students. In an increasingly competitive labor market, the research collected and solutions presented are designed to empower students in their careers.
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Okur-Chung Neurodevelopmental syndrome (OCNDS) is a rare disorder characterized by hypotonia, developmental delay, dysmorphic features, and more. It is caused by pathogenic variants on CSNK2A1, the α subunit of protein kinase CK2. CK2 is considered a master regulator involved in many cell functions from cell differentiation and proliferation to apoptosis. Here, we create a potential zebrafish model of OCNDS with CK2 inhibition and characterize fibroblast cells with, K198R, D156E, and R47G variants of CSNK2A1. RNAseq results display a wide range of effects notably in the Myosin Protein superfamily, Insulin-like Growth Factor family, and in proteins related to mitochondrial function and cell metabolism. Factors in cell growth and metabolism across the nervous system and neuromuscular interactions appear to be most affected with similarities in markers to oncogenic states in some cases.