Matching Items (9)
Filtering by

Clear all filters

136174-Thumbnail Image.png
Description
Schizophrenia affects 1.1% of the population worldwide. Schizophrenia is a complex, multifactorial disorder. Stress can trigger psychotic episodes and exacerbate schizophrenic symptoms. For humans, one gene implicated in stress and schizophrenia in humans is the early growth response 3 (EGR3). Patients with genomic variations in EGR3 have reduced levels of

Schizophrenia affects 1.1% of the population worldwide. Schizophrenia is a complex, multifactorial disorder. Stress can trigger psychotic episodes and exacerbate schizophrenic symptoms. For humans, one gene implicated in stress and schizophrenia in humans is the early growth response 3 (EGR3). Patients with genomic variations in EGR3 have reduced levels of EGR3 in the prefrontal brain region compared with healthy patients. Schizophrenic patients also have less serotonin 2A receptor (5HT2AR), which is coded by the gene Htr2a, in their prefrontal cortex. Mice that are Egr3-deficient also have decreased levels of 5HT2AR, suggesting that Egr3 may be involved in the regulation of 5HT2AR. The purpose of the experiment is to determine if EGR3 binds to the Htr2a gene promoter region by using a Chromatin immunoprecipitation (ChIP) assay. We will use ECS to increase EGR3 expression. Previously we have identified two upstream sites of interest where EGR3 potentially binds to the Htr2a gene, one which is distal and one proximal to the transcription start site. After ECS, increased binding is seen in the Htr2a distal region with EGR3 via the ChIP assay. Increased binding was not observed at either of the promoter sites; however, the t-test comparing the distal site of the ECS and the No ECS groups to have a p-value of 0.056, suggesting that increasing the number of animals (n=7) could possibly give a more accurate representation to test our hypothesis. However, the experiment still suggests increased expression and that EGR3 may bind to the distal site of Htr2a. Keywords: stress, environment, genetics, schizophrenia, EGR3, chromatin immunoprecipitation
ContributorsMishra, Abhinav (Author) / Buetow, Kenneth (Thesis director) / Gallitano, Amelia (Committee member) / Zhao, Xiuli (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Life Sciences (Contributor)
Created2015-05
133730-Thumbnail Image.png
Description
The concept of the Mediterranean Diet was described by Ancel Keys from the Seven Countries study, occurring in the 1960s. Unlike other diets, the Mediterranean Diet is a cultural tradition of nations surrounding the Mediterranean Sea. It involves the healthy pattern of food consumption and physical activity, which developed as

The concept of the Mediterranean Diet was described by Ancel Keys from the Seven Countries study, occurring in the 1960s. Unlike other diets, the Mediterranean Diet is a cultural tradition of nations surrounding the Mediterranean Sea. It involves the healthy pattern of food consumption and physical activity, which developed as an outcome of the locality's available food, other environmental resources, and overall cultural characteristics such as the polychromic time orientation of the Mediterranean nations. The Mediterranean Diet is a lifestyle structured around understanding a locality's natural conditions and resources and sustaining positive relationships between individuals, the community, and the components of their environment. The diet is largely plant based, where daily foods include grains, fruits, vegetables, olive oil, and dairy products. Seafood is eaten several times a week, while other animal products (poultry, meats, eggs) and sweets are eaten less often and in moderation. Alcohol, for those who drink it, is consumed several times a week. Research has shown a variety of health benefits from this diet. These benefits include preventing cardiovascular disease, certain cancers, Type 2 diabetes, Alzheimer's disease, age related macular degeneration of the eyes, kidney disease and osteoporosis. It also has been shown to improve conditions of metabolic syndrome, obesity, and depression. These favorable health outcomes are a result of the beneficial components within the foods commonly eaten. Fruits and vegetables are excellent sources of vitamins and minerals, which are needed to support cellular and overall organismal functioning, and nuts, vegetables, and fish also provide essential fatty acids like omega-3 and omega-6. The unifying component for all regions adhering to the Mediterranean Diet is the use of olive oil. Beyond being a healthy source of fat, it contains numerous chemical components with antioxidant properties. The Mediterranean region is an optimal region for olive tree growth and olive harvest, based on temperature and soil conditions. However, geographic differences, nutrient availability and age of olive trees can impact the quality of olive fruits and olive oil. Furthermore, climate change presents a challenge for sustaining the Mediterranean diet as it adds stress to plants and aquatic life environments. However, the diet shows promise of protecting the environment, as plant-based diets are found to have lower negative environmental impacts. In conclusion, the Mediterranean diet is an interconnected system of relationships that adapts to a locality's community, land, and climate.
ContributorsKaneris, Marianna Irene (Author) / Vitullo, Juliann (Thesis director) / Dal Martello, Chiara (Committee member) / Department of Psychology (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
137499-Thumbnail Image.png
Description
Faërie exists in the mythology and literature of northwestern Europe as a spiritual Otherworld, a land of immortal beauty just tangential to our own. This project explored multiple conceptions of Faërie and their common association with things that have been lost. The pattern that emerged is one in which the

Faërie exists in the mythology and literature of northwestern Europe as a spiritual Otherworld, a land of immortal beauty just tangential to our own. This project explored multiple conceptions of Faërie and their common association with things that have been lost. The pattern that emerged is one in which the Otherworld is not merely linked to lost things, but becomes a way of preserving and rediscovering them. Faërie embodies the hope that things lost live on, and can be found again.
ContributorsBell, Andrew Roos (Author) / Baldini, Cajsa (Thesis director) / Maring, Heather (Committee member) / Foy, Joseph (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / Department of English (Contributor)
Created2013-05
137791-Thumbnail Image.png
Description
This study examines sustainable development concerns as an essential part of the Costa Rican national identity. Interviews with ecotourism industry workers and an analysis of pertinent news articles shine light on the Costa Rican citizen's perspective of sustainable development, showing that in spite of current initiatives industry workers still have

This study examines sustainable development concerns as an essential part of the Costa Rican national identity. Interviews with ecotourism industry workers and an analysis of pertinent news articles shine light on the Costa Rican citizen's perspective of sustainable development, showing that in spite of current initiatives industry workers still have unmet environmental and economic concerns, and that the general public is both passionately interested and personally invested in the topic.
ContributorsHoward, Kalyn Marie (Author) / Puleo, Thomas (Thesis director) / Larson, Elizabeth (Committee member) / Hunter, Joel (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Politics and Global Studies (Contributor)
Created2013-05
147516-Thumbnail Image.png
Description

Lithium ion batteries are quintessential components of modern life. They are used to power smart devices — phones, tablets, laptops, and are rapidly becoming major elements in the automotive industry. Demand projections for lithium are skyrocketing with production struggling to keep up pace. This drive is due mostly to the

Lithium ion batteries are quintessential components of modern life. They are used to power smart devices — phones, tablets, laptops, and are rapidly becoming major elements in the automotive industry. Demand projections for lithium are skyrocketing with production struggling to keep up pace. This drive is due mostly to the rapid adoption of electric vehicles; sales of electric vehicles in 2020 are more than double what they were only a year prior. With such staggering growth it is important to understand how lithium is sourced and what that means for the environment. Will production even be capable of meeting the demand as more industries make use of this valuable element? How will the environmental impact of lithium affect growth? This thesis attempts to answer these questions as the world looks to a decade of rapid growth for lithium ion batteries.

ContributorsMelton, John (Author) / Brian, Jennifer (Thesis director) / Karwat, Darshawn (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Water affordability is a critical issue for rural and tribal communities in Northern Arizona. However, measuring affordability in these communities can be extremely challenging due to a lack of accessible data and several unique, structural, barriers. This thesis evaluates both the challenges and opportunities for measuring water affordability in the

Water affordability is a critical issue for rural and tribal communities in Northern Arizona. However, measuring affordability in these communities can be extremely challenging due to a lack of accessible data and several unique, structural, barriers. This thesis evaluates both the challenges and opportunities for measuring water affordability in the City of Show Low and the Hopi Nation and explores potential solutions to improve measurement accessibility. Using a mixed-methods approach, the study found that data necessary to measure water affordability is often unavailable or difficult to collect in rural and tribal systems, and limited resources, personnel & capacity, as well as sociocultural and political factors within these areas further hinder their ability to assess affordability. Additionally, analysis of existing resources and initiatives for assessing water affordability in these communities revealed several limitations that must be addressed to improve measurement accessibility. The study suggests that several actions can be taken at the state and federal levels to improve the ability of small and rural systems to study water affordability in Northern Arizona. These actions include conducting a state-wide water affordability assessment, improving existing guidebooks and resources specifically for rural and tribal systems, providing low-cost consultants to assist in utility management, detailed federal review of SRF funding application requirements, and oversight on new allocations following the recent historic investment in the SRF. Overall, this thesis highlights the challenges faced by rural and tribal communities in measuring water affordability and provides recommendations for policymakers and stakeholders to improve measurement accessibility. By advocating for policy changes and addressing limitations in existing resources, this research aims to improve water affordability in Northern Arizona and beyond.

ContributorsHeminger, Grant (Author) / Sorensen, Kathryn (Thesis director) / Johnson, Michael Kotutwa (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Department of Psychology (Contributor) / School of Politics and Global Studies (Contributor)
Created2023-05
Description

Food waste is a crucial issue in stores, restaurants and other institutions. Specifically, there is a high amount of food waste in grocery stores, especially in the produce section. As a result, environmental damage occurs, and many individuals struggle to have food in their homes. This thesis will analyze the

Food waste is a crucial issue in stores, restaurants and other institutions. Specifically, there is a high amount of food waste in grocery stores, especially in the produce section. As a result, environmental damage occurs, and many individuals struggle to have food in their homes. This thesis will analyze the cause, quantity, and effect of this waste, and how it can be changed or mitigated. An overarching question was posed to analyze these causes and effects of waste, asking how does the amount of produce waste that occurs in Scottsdale, Arizona contribute to environmental issues and what is being done to remedy this issue? As this is a difficult question to answer on its own, the research was broken down into two more answerable questions, which are Why does produce get wasted in grocery stores? How much of this occurs? and What remedies already exist to limit/reduce this waste? These questions are important because they contribute to knowledge and understanding about food waste, consumer waste, as well as the overall environmental impact of being wasteful. It is also important for both retailers and consumers to understand that waste has an immense and negative impact on the environment and contributes to climate change, and that taking steps to reduce this waste is essential.

ContributorsPagnillo, Mary (Author) / Haglund, LaDawn (Thesis director) / Holman, Christine (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Social Transformation (Contributor) / School of Politics and Global Studies (Contributor)
Created2023-05
Description

Mining is a key component of both the Brazilian and Chilean economies and accounts for an outsized share of these countries’ exports. Yet, it is a common target for environmental criticism, especially due to its impacts on local populations and ecosystems. Brazil and Chile have adopted markedly different trade strategies

Mining is a key component of both the Brazilian and Chilean economies and accounts for an outsized share of these countries’ exports. Yet, it is a common target for environmental criticism, especially due to its impacts on local populations and ecosystems. Brazil and Chile have adopted markedly different trade strategies over the past three decades, most notably with regards to their involvement in international trade agreements. This paper investigates how these differences in trade policy since 1990 have affected the sustainability of each country’s mining sector by identifying and comparing the channels through which free trade agreements influence the environmental impacts of resource extraction.

ContributorsKopek, Justin (Author) / Sheriff, Glenn (Thesis director) / Goodman, Glen (Committee member) / Barrett, The Honors College (Contributor) / Economics Program in CLAS (Contributor) / School of Politics and Global Studies (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / School of International Letters and Cultures (Contributor)
Created2023-05
166225-Thumbnail Image.png
Description
What is the correct response towards the world being set on fire? Climate change is a global emergency that can cause many emotions within people, including climate anxiety and ecological grief. While both of these emotions are valid responses to the global emergency humanity is facing, it is essential that

What is the correct response towards the world being set on fire? Climate change is a global emergency that can cause many emotions within people, including climate anxiety and ecological grief. While both of these emotions are valid responses to the global emergency humanity is facing, it is essential that environmentalists and humanitarians throughout the world hold on to hope when addressing this crisis. It is also essential that they tend to their mental health as they work to tend to the world. My thesis describes my journey in working to promote hope in the environmental movement and the framework for a global mental health study I am conducting on environmentalists. Inner sustainability (the practice of taking care of one's mental health) and outer sustainability (the practice of taking care of the world) need to coexist in order for any movement to truly be sustainable.
ContributorsDarira, Saiarchana (Author) / Pipe, Teri (Thesis director) / Krasnow, Aaron (Committee member) / Barrett, The Honors College (Contributor) / Thunderbird School of Global Management (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / Department of Psychology (Contributor) / School of Sustainability (Contributor)
Created2022-05