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Overexpression of AVP1 (Arabidopsis vacuolar pyrophosphatase), a type I H+ pyrophosphatase, results in greater biomass, possibly due to a function in sucrose transport within the phloem. Overexpression of the phloem lipid-associated family protein (PLAFP) was shown to increase the number of vascular bundles in Arabidopsis. Could these two phenotypes complement

Overexpression of AVP1 (Arabidopsis vacuolar pyrophosphatase), a type I H+ pyrophosphatase, results in greater biomass, possibly due to a function in sucrose transport within the phloem. Overexpression of the phloem lipid-associated family protein (PLAFP) was shown to increase the number of vascular bundles in Arabidopsis. Could these two phenotypes complement one another additively? In this work, double mutants overexpressing both AVP1 and PLAFP were characterized. These double mutants have enhanced biomass, greater leaf area, and a larger number of vascular bundles than the single mutant lines. Overexpression of PLAFP does not result in any increase in rhizosphere acidification capacity.
ContributorsWilson, Sean (Co-author) / Furstenau, Tara (Co-author) / Gaxiola, Roberto (Thesis director) / Mason, Hugh (Committee member) / Wojciechowski, Martin (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2014-05
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This thesis concerns the adoption of health information technology in the medical sector, specifically electronic health records (EHRs). EHRs have been seen as a great benefit to the healthcare system and will improve the quality of patient care. The federal government, has seen the benefit EHRs can offer, has been

This thesis concerns the adoption of health information technology in the medical sector, specifically electronic health records (EHRs). EHRs have been seen as a great benefit to the healthcare system and will improve the quality of patient care. The federal government, has seen the benefit EHRs can offer, has been advocating the use and adoption of EHR for nearly a decade now. They have created policies that guide medical providers on how to implement EHRs. However, this thesis concerns the attitudes medical providers in Phoenix have towards government implementation. By interviewing these individuals and cross-referencing their answers with the literature this thesis wants to discover the pitfalls of federal government policy toward EHR implementation and EHR implementation in general. What this thesis found was that there are pitfalls that the federal government has failed to address including loss of provider productivity, lack of interoperability, and workflow improvement. However, the providers do say there is still a place for government to be involved in the implementation of EHR.
ContributorsKaldawi, Nicholas Emad (Author) / Lewis, Paul (Thesis director) / Cortese, Denis (Committee member) / Jones, Ruth (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2013-05
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Description
Electronic Health Records: Suggestions for Future Use explores how EHRs are currently being used in the clinical setting and in the research setting. This paper provides suggestions for how EHRs should be used in the future, so that patient centered health care is optimized while maintaining efficiency. Additionally, the thesis

Electronic Health Records: Suggestions for Future Use explores how EHRs are currently being used in the clinical setting and in the research setting. This paper provides suggestions for how EHRs should be used in the future, so that patient centered health care is optimized while maintaining efficiency. Additionally, the thesis discusses why privacy is viewed as an innate human right in society as well as why it is specifically valued in the healthcare setting. The value of privacy significantly impacts how EHRs are currently used, and the more automated EHR systems become, the more likely it is that the privacy of patients is threatened. It was concluded that the healthcare industry can improve EHR use in future clinical and research settings, while upholding privacy laws.
ContributorsPhillips, Emily (Co-author) / Waldman, Lauren (Co-author) / Brian, Jennifer (Thesis director) / Mason, Hugh (Committee member) / Department of English (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
Climate change has the potential to reduce the amount of land that is suitable for crop growth. Such changes may cause food shortages, which would most likely disproportionately affect the poorest regions of the world. While GMO crops showed potential to increase crop yield and agricultural efficiency, significant public pushback

Climate change has the potential to reduce the amount of land that is suitable for crop growth. Such changes may cause food shortages, which would most likely disproportionately affect the poorest regions of the world. While GMO crops showed potential to increase crop yield and agricultural efficiency, significant public pushback has led to a search for alternative methods to generate similar results. Compounds produced by bacteria, such as 2,3-butanediol, offer a potential way to change the phenotypes of plants without the deliberate genomic changes involved in the development of GMOs which are often the subject of great controversy. These compounds influence how plants grow and function. Through precise application, the compounds could be used to improve crop yield and stress tolerance. While these effects are not completely understood, they may be due to changes in transcription and translation of certain proteins, the microbiome surrounding the plants and its interactions with the compounds, or other unknown factors. The compound 2,3-butanediol appears to increase biomass, lead to larger root systems and more root hairs, and increase germination rates in a variety of plants. All these traits are favorable for producing higher yields and enduring stress conditions. The phenotypes induced by this compound are similar to plants engineered to over express a type I proton pyrophosphatase. Plants treated with 2,3-butanediol offer a potential option to achieve the benefits of GMO crops without the attached social stigma.
ContributorsOlson, Erik Jon (Co-author) / Olson, Erik (Co-author) / Gaxiola, Roberto (Thesis director) / Mason, Hugh (Committee member) / Riley, James (Committee member) / School of Life Sciences (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
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Description
The traditional model of assessing and treating behavioral health (BH) and physical health (PH) in silos is inadequate for supporting whole-person health and wellness. The integration of BH and PH may result in better care quality, patient-provider experiences, outcomes, and reduced costs. Cross-organizational health data sharing between BH and PH

The traditional model of assessing and treating behavioral health (BH) and physical health (PH) in silos is inadequate for supporting whole-person health and wellness. The integration of BH and PH may result in better care quality, patient-provider experiences, outcomes, and reduced costs. Cross-organizational health data sharing between BH and PH providers is critical to patients with BH conditions (BHCs). In the last few decades, many initiatives -including health information exchange organizations- have facilitated cross-organizational health data sharing. The current challenge is affording meaningful consent and ensuring patient privacy, two of the core requirements for advancing the adoption and use of health information technology (HIT) in the US. The Office of the National Coordinator for HIT (ONC) recommends that patients should be given granular control beyond the “share all” or “share none” approach widely used currently in consent practices. But there is no consensus on the variables relevant to promote granularity in data sharing to honor privacy satisfaction for patients. As a result, existing granular data sharing (GDS) studies use ad-hoc and non-standardized approaches to implement or investigate patient data sharing preferences. Novel informatics methods were proposed and piloted to support patient-driven GDS and to validate the suitability and applicability of such methods in clinical environments. The hypotheses were: H1) the variables recommended by the ONC are relevant to support GDS; H2) there is diversity in medical record sharing preferences of individuals with BHCs; and H3) the most frequently used sensitive data taxonomy captures sensitive data sharing preferences of patients with BHCs. Findings validated the study hypotheses by proposing an innovative standards-based GDS framework, validating the framework with the design and pilot testing of a clinical decision support system with 209 patients with BHCs, validating with patients the adequacy of the most frequently used sensitive data taxonomy, and systematically exploring data privacy views and data sharing perceptions of patients with BHCs. This research built the foundations for a new generation of future data segmentation methods and tools that advances the vision of the ONC of creating standards-based, interoperable models to share sensitive health information in compliance with patients’ data privacy preferences.
ContributorsKarway, George K (Author) / Grando, Adela Maria (Thesis advisor) / Murcko, Anita C (Committee member) / Franczak, Michael (Committee member) / Arizona State University (Publisher)
Created2022