Filtering by
- All Subjects: Renewable Energy
- Creators: Chemical Engineering Program
Targeting Tumors: Inclusion of Functional Groups on Ion-Containing Block Copolymers to Combat Cancer
The FDA-approved drug bexarotene has been predominantly utilized for the treatment of cutaneous T-cell lymphoma (CTLC), but has shown promise as an off label treatment for various other cancers as well as Alzheimer's disease (AD). However, harmful side effects such as hypothyroidism have catalyzed a search for alternative rexinoids which retain similar levels of RXR agonism while reducing the undesirable effects incurred by bexarotene. This honors thesis outlines the steps taken to design and synthesize novel analogues of the selective retinoid-X-receptor (RXR) agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). Corresponding NMR spectra indicates the successful construction of four novel compounds which are structurally similar to known, biologically-evaluated rexinoids that have induced fewer side effects while stimulating greater levels of RXR selectivity as compared to bexarotene. Future In vitro analyses of these four analogues coupled with the recognized efficacy of their parent compounds demonstrate the chemotherapeutic potential of structurally modified bexarotene analogues
This thesis explores the investigation of the project “Designing for a Post-Diesel Engine World”, a collaborative experiment between organizations within Arizona State University and an undisclosed company. This investigation includes the analysis of various renewable energy technologies and their potential to replace industrial diesel engines as used in the company’s business. In order to be competitive with diesel engines, the technology should match or exceed diesel in power output, have reduced environmental impact, and meet other criteria standards as determined by the company. The team defined the final selection criteria as: low environmental impact, high efficiency, high power, and high technology readiness level. I served as the lead Hydrogen Fuel Cell Researcher and originally hypothesized that PEM fuel cells would be the most viable solution. Results of the analysis led to PEM fuel cells and Li-ion batteries being top contenders, and the team developed a hybrid solution incorporating both of these technologies in a technical and strategic solution. The resulting solution design from this project has the potential to be modified and implemented in various industries and reduce overall anthropogenic emissions from industrial processes.
Chemistry has always played a foundational role in the synthesis of pharmaceuticals. With the rapid growth of the global population, the health and medical needs have also rapidly increased. In order to provide drugs capable of mediating symptoms and curing diseases, organic chemistry provides drug derivatives utilizing a limited number of chemical building blocks and privileged structures. Of these limited building blocks, this project explores Late–stage C–H functionalization of (iso)quinolines using abundant metal catalysis in order to achieve site-selective molecular modification.