As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of developing AD. Familial AD, which makes up less than 1% of all AD cases, is caused by autosomal dominant gene mutations and has almost 100% penetrance. Genetic risk factors are believed to make up about 49%-79% of the risk in sporadic cases. Many different genetic risk factors for both familial and sporadic AD have been identified, but there is still much work to be done in the field of AD, especially in non-Caucasian populations. This review summarizes the three major genes responsible for familial AD, namely APP, PSEN1 and PSEN2. Also discussed are seven identified genetic risk factors for sporadic AD, single nucleotide polymorphisms in the APOE, ABCA7, NEDD9, CASS4, PTK2B, CLU, and PICALM genes. An overview of the main function of the proteins associated with the genes is given, along with the supposed connection to AD pathology.

Suicide is one of the leading causes of death worldwide and statistical analysis of suicide by profession reveals that physicians and veterinarians experience abnormally high suicide rates. This paper seeks to provide a comprehensive literature review over what some general theories of suicide are, why these professions exhibit high suicide rates, what assistance is currently being provided, and where do these assistance efforts succeed or fail. Moreover, this paper addresses what advancements may be made within these fields to further combat suicide in physicians and veterinarians. To achieve this, general theories behind suicide, risk factors unique to or heavily prevalent in these professions, and current assistance efforts are read, organized, and summarized.<br/><br/>A summary of these risk factors includes stress and mental health disorders accumulated through school and work, personal and professional isolation, access to lethal substances, suicide contagion, exposure to euthanasia, and the role of perfectionism. There are several assistance efforts in place with the most successful ones being highly personalized, but many are still underutilized. Moreover, the stigma of suicide pervades these professions and is addressed by several researchers as something to combat or prevent. Going forward, it is hopeful that not only will more assistance efforts will be created and provided for physicians and veterinarians suffering from suicidal tendencies, but efforts to reduce the stigma of suicide be implemented and utilized as soon as possible.

This project consisted of creating at-home lesson plan activities for middle school sixth-grade students centered around environmental education topics. The lesson plan activities were informal for students to do at home by themselves or alongside their parents. I focused on Environmental Education topics such as awareness, animal and plant life so that students can learn more about the environments that surround them. Environmental Education invites students to look closer at the environment surrounding them while also helping them develop a sense of place and respect for their environment. My lesson plan activities encouraged students to go outside and learn more about their surroundings, developing an awareness and an appreciation for their natural setting. After implementing the lessons, I surveyed the students on the following 1) engagement: was the activity enjoyable 2) knowledge: what did you learn? and 3) the ease of the activity directions: what challenges did they face. After collecting the surveys, I analyzed them to see what went well, and changes I would make to future activities.

Businesses, as with other sectors in society, are not yet taking sufficient action towards achieving sustainability. The United Nations recently agreed upon a set of Sustainable Development Goals (SDGs), which if properly harnessed, provide a framework (so far lacking) for businesses to meaningfully drive transformations to sustainability. This paper proposes to operationalize the SDGs for businesses through a progressive framework for action with three discrete levels: communication, tactical, and strategic. Within the tactical and strategic levels, several innovative approaches are discussed and illustrated. The challenges of design and measurement as well as opportunities for accountability and the social side of Sustainability, together call for transdisciplinary, collective action. This paper demonstrates feasible pathways and approaches for businesses to take corporate social responsibility to the next level and utilize the SDG framework informed by sustainability science to support transformations towards the achievement of sustainability.