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- Creators: Ye, Jieping
- Creators: Computer Science and Engineering Program
Description
Sparsity has become an important modeling tool in areas such as genetics, signal and audio processing, medical image processing, etc. Via the penalization of l-1 norm based regularization, the structured sparse learning algorithms can produce highly accurate models while imposing various predefined structures on the data, such as feature groups or graphs. In this thesis, I first propose to solve a sparse learning model with a general group structure, where the predefined groups may overlap with each other. Then, I present three real world applications which can benefit from the group structured sparse learning technique. In the first application, I study the Alzheimer's Disease diagnosis problem using multi-modality neuroimaging data. In this dataset, not every subject has all data sources available, exhibiting an unique and challenging block-wise missing pattern. In the second application, I study the automatic annotation and retrieval of fruit-fly gene expression pattern images. Combined with the spatial information, sparse learning techniques can be used to construct effective representation of the expression images. In the third application, I present a new computational approach to annotate developmental stage for Drosophila embryos in the gene expression images. In addition, it provides a stage score that enables one to more finely annotate each embryo so that they are divided into early and late periods of development within standard stage demarcations. Stage scores help us to illuminate global gene activities and changes much better, and more refined stage annotations improve our ability to better interpret results when expression pattern matches are discovered between genes.
ContributorsYuan, Lei (Author) / Ye, Jieping (Thesis advisor) / Wang, Yalin (Committee member) / Xue, Guoliang (Committee member) / Kumar, Sudhir (Committee member) / Arizona State University (Publisher)
Created2013
Description
In most social networking websites, users are allowed to perform interactive activities. One of the fundamental features that these sites provide is to connecting with users of their kind. On one hand, this activity makes online connections visible and tangible; on the other hand, it enables the exploration of our connections and the expansion of our social networks easier. The aggregation of people who share common interests forms social groups, which are fundamental parts of our social lives. Social behavioral analysis at a group level is an active research area and attracts many interests from the industry. Challenges of my work mainly arise from the scale and complexity of user generated behavioral data. The multiple types of interactions, highly dynamic nature of social networking and the volatile user behavior suggest that these data are complex and big in general. Effective and efficient approaches are required to analyze and interpret such data. My work provide effective channels to help connect the like-minded and, furthermore, understand user behavior at a group level. The contributions of this dissertation are in threefold: (1) proposing novel representation of collective tagging knowledge via tag networks; (2) proposing the new information spreader identification problem in egocentric soical networks; (3) defining group profiling as a systematic approach to understanding social groups. In sum, the research proposes novel concepts and approaches for connecting the like-minded, enables the understanding of user groups, and exposes interesting research opportunities.
ContributorsWang, Xufei (Author) / Liu, Huan (Thesis advisor) / Kambhampati, Subbarao (Committee member) / Sundaram, Hari (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2013
Description
In blindness research, the corpus callosum (CC) is the most frequently studied sub-cortical structure, due to its important involvement in visual processing. While most callosal analyses from brain structural magnetic resonance images (MRI) are limited to the 2D mid-sagittal slice, we propose a novel framework to capture a complete set of 3D morphological differences in the corpus callosum between two groups of subjects. The CCs are segmented from whole brain T1-weighted MRI and modeled as 3D tetrahedral meshes. The callosal surface is divided into superior and inferior patches on which we compute a volumetric harmonic field by solving the Laplace's equation with Dirichlet boundary conditions. We adopt a refined tetrahedral mesh to compute the Laplacian operator, so our computation can achieve sub-voxel accuracy. Thickness is estimated by tracing the streamlines in the harmonic field. We combine areal changes found using surface tensor-based morphometry and thickness information into a vector at each vertex to be used as a metric for the statistical analysis. Group differences are assessed on this combined measure through Hotelling's T2 test. The method is applied to statistically compare three groups consisting of: congenitally blind (CB), late blind (LB; onset > 8 years old) and sighted (SC) subjects. Our results reveal significant differences in several regions of the CC between both blind groups and the sighted groups; and to a lesser extent between the LB and CB groups. These results demonstrate the crucial role of visual deprivation during the developmental period in reshaping the structural architecture of the CC.
ContributorsXu, Liang (Author) / Wang, Yalin (Thesis advisor) / Maciejewski, Ross (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2013
Description
In many fields one needs to build predictive models for a set of related machine learning tasks, such as information retrieval, computer vision and biomedical informatics. Traditionally these tasks are treated independently and the inference is done separately for each task, which ignores important connections among the tasks. Multi-task learning aims at simultaneously building models for all tasks in order to improve the generalization performance, leveraging inherent relatedness of these tasks. In this thesis, I firstly propose a clustered multi-task learning (CMTL) formulation, which simultaneously learns task models and performs task clustering. I provide theoretical analysis to establish the equivalence between the CMTL formulation and the alternating structure optimization, which learns a shared low-dimensional hypothesis space for different tasks. Then I present two real-world biomedical informatics applications which can benefit from multi-task learning. In the first application, I study the disease progression problem and present multi-task learning formulations for disease progression. In the formulations, the prediction at each point is a regression task and multiple tasks at different time points are learned simultaneously, leveraging the temporal smoothness among the tasks. The proposed formulations have been tested extensively on predicting the progression of the Alzheimer's disease, and experimental results demonstrate the effectiveness of the proposed models. In the second application, I present a novel data-driven framework for densifying the electronic medical records (EMR) to overcome the sparsity problem in predictive modeling using EMR. The densification of each patient is a learning task, and the proposed algorithm simultaneously densify all patients. As such, the densification of one patient leverages useful information from other patients.
ContributorsZhou, Jiayu (Author) / Ye, Jieping (Thesis advisor) / Mittelmann, Hans (Committee member) / Li, Baoxin (Committee member) / Wang, Yalin (Committee member) / Arizona State University (Publisher)
Created2014
Description
A myriad of social media services are emerging in recent years that allow people to communicate and express themselves conveniently and easily. The pervasive use of social media generates massive data at an unprecedented rate. It becomes increasingly difficult for online users to find relevant information or, in other words, exacerbates the information overload problem. Meanwhile, users in social media can be both passive content consumers and active content producers, causing the quality of user-generated content can vary dramatically from excellence to abuse or spam, which results in a problem of information credibility. Trust, providing evidence about with whom users can trust to share information and from whom users can accept information without additional verification, plays a crucial role in helping online users collect relevant and reliable information. It has been proven to be an effective way to mitigate information overload and credibility problems and has attracted increasing attention.
As the conceptual counterpart of trust, distrust could be as important as trust and its value has been widely recognized by social sciences in the physical world. However, little attention is paid on distrust in social media. Social media differs from the physical world - (1) its data is passively observed, large-scale, incomplete, noisy and embedded with rich heterogeneous sources; and (2) distrust is generally unavailable in social media. These unique properties of social media present novel challenges for computing distrust in social media: (1) passively observed social media data does not provide necessary information social scientists use to understand distrust, how can I understand distrust in social media? (2) distrust is usually invisible in social media, how can I make invisible distrust visible by leveraging unique properties of social media data? and (3) little is known about distrust and its role in social media applications, how can distrust help make difference in social media applications?
The chief objective of this dissertation is to figure out solutions to these challenges via innovative research and novel methods. In particular, computational tasks are designed to {\it understand distrust}, a innovative task, i.e., {\it predicting distrust} is proposed with novel frameworks to make invisible distrust visible, and principled approaches are develop to {\it apply distrust} in social media applications. Since distrust is a special type of negative links, I demonstrate the generalization of properties and algorithms of distrust to negative links, i.e., {\it generalizing findings of distrust}, which greatly expands the boundaries of research of distrust and largely broadens its applications in social media.
As the conceptual counterpart of trust, distrust could be as important as trust and its value has been widely recognized by social sciences in the physical world. However, little attention is paid on distrust in social media. Social media differs from the physical world - (1) its data is passively observed, large-scale, incomplete, noisy and embedded with rich heterogeneous sources; and (2) distrust is generally unavailable in social media. These unique properties of social media present novel challenges for computing distrust in social media: (1) passively observed social media data does not provide necessary information social scientists use to understand distrust, how can I understand distrust in social media? (2) distrust is usually invisible in social media, how can I make invisible distrust visible by leveraging unique properties of social media data? and (3) little is known about distrust and its role in social media applications, how can distrust help make difference in social media applications?
The chief objective of this dissertation is to figure out solutions to these challenges via innovative research and novel methods. In particular, computational tasks are designed to {\it understand distrust}, a innovative task, i.e., {\it predicting distrust} is proposed with novel frameworks to make invisible distrust visible, and principled approaches are develop to {\it apply distrust} in social media applications. Since distrust is a special type of negative links, I demonstrate the generalization of properties and algorithms of distrust to negative links, i.e., {\it generalizing findings of distrust}, which greatly expands the boundaries of research of distrust and largely broadens its applications in social media.
ContributorsTang, Jiliang (Author) / Liu, Huan (Thesis advisor) / Xue, Guoliang (Committee member) / Ye, Jieping (Committee member) / Aggarwal, Charu (Committee member) / Arizona State University (Publisher)
Created2015
Description
The rapid urban expansion has greatly extended the physical boundary of our living area, along with a large number of POIs (points of interest) being developed. A POI is a specific location (e.g., hotel, restaurant, theater, mall) that a user may find useful or interesting. When exploring the city and neighborhood, the increasing number of POIs could enrich people's daily life, providing them with more choices of life experience than before, while at the same time also brings the problem of "curse of choices", resulting in the difficulty for a user to make a satisfied decision on "where to go" in an efficient way. Personalized POI recommendation is a task proposed on purpose of helping users filter out uninteresting POIs and reduce time in decision making, which could also benefit virtual marketing.
Developing POI recommender systems requires observation of human mobility w.r.t. real-world POIs, which is infeasible with traditional mobile data. However, the recent development of location-based social networks (LBSNs) provides such observation. Typical location-based social networking sites allow users to "check in" at POIs with smartphones, leave tips and share that experience with their online friends. The increasing number of LBSN users has generated large amounts of LBSN data, providing an unprecedented opportunity to study human mobility for personalized POI recommendation in spatial, temporal, social, and content aspects.
Different from recommender systems in other categories, e.g., movie recommendation in NetFlix, friend recommendation in dating websites, item recommendation in online shopping sites, personalized POI recommendation on LBSNs has its unique challenges due to the stochastic property of human mobility and the mobile behavior indications provided by LBSN information layout. The strong correlations between geographical POI information and other LBSN information result in three major human mobile properties, i.e., geo-social correlations, geo-temporal patterns, and geo-content indications, which are neither observed in other recommender systems, nor exploited in current POI recommendation. In this dissertation, we investigate these properties on LBSNs, and propose personalized POI recommendation models accordingly. The performance evaluated on real-world LBSN datasets validates the power of these properties in capturing user mobility, and demonstrates the ability of our models for personalized POI recommendation.
Developing POI recommender systems requires observation of human mobility w.r.t. real-world POIs, which is infeasible with traditional mobile data. However, the recent development of location-based social networks (LBSNs) provides such observation. Typical location-based social networking sites allow users to "check in" at POIs with smartphones, leave tips and share that experience with their online friends. The increasing number of LBSN users has generated large amounts of LBSN data, providing an unprecedented opportunity to study human mobility for personalized POI recommendation in spatial, temporal, social, and content aspects.
Different from recommender systems in other categories, e.g., movie recommendation in NetFlix, friend recommendation in dating websites, item recommendation in online shopping sites, personalized POI recommendation on LBSNs has its unique challenges due to the stochastic property of human mobility and the mobile behavior indications provided by LBSN information layout. The strong correlations between geographical POI information and other LBSN information result in three major human mobile properties, i.e., geo-social correlations, geo-temporal patterns, and geo-content indications, which are neither observed in other recommender systems, nor exploited in current POI recommendation. In this dissertation, we investigate these properties on LBSNs, and propose personalized POI recommendation models accordingly. The performance evaluated on real-world LBSN datasets validates the power of these properties in capturing user mobility, and demonstrates the ability of our models for personalized POI recommendation.
ContributorsGao, Huiji (Author) / Liu, Huan (Thesis advisor) / Xue, Guoliang (Committee member) / Ye, Jieping (Committee member) / Caverlee, James (Committee member) / Arizona State University (Publisher)
Created2014
Description
This thesis proposed a novel approach to establish the trust model in a social network scenario based on users' emails. Email is one of the most important social connections nowadays. By analyzing email exchange activities among users, a social network trust model can be established to judge the trust rate between each two users. The whole trust checking process is divided into two steps: local checking and remote checking. Local checking directly contacts the email server to calculate the trust rate based on user's own email communication history. Remote checking is a distributed computing process to get help from user's social network friends and built the trust rate together. The email-based trust model is built upon a cloud computing framework called MobiCloud. Inside MobiCloud, each user occupies a virtual machine which can directly communicate with others. Based on this feature, the distributed trust model is implemented as a combination of local analysis and remote analysis in the cloud. Experiment results show that the trust evaluation model can give accurate trust rate even in a small scale social network which does not have lots of social connections. With this trust model, the security in both social network services and email communication could be improved.
ContributorsZhong, Yunji (Author) / Huang, Dijiang (Thesis advisor) / Dasgupta, Partha (Committee member) / Syrotiuk, Violet (Committee member) / Arizona State University (Publisher)
Created2011
Description
Genes have widely different pertinences to the etiology and pathology of diseases. Thus, they can be ranked according to their disease-significance on a genomic scale, which is the subject of gene prioritization. Given a set of genes known to be related to a disease, it is reasonable to use them as a basis to determine the significance of other candidate genes, which will then be ranked based on the association they exhibit with respect to the given set of known genes. Experimental and computational data of various kinds have different reliability and relevance to a disease under study. This work presents a gene prioritization method based on integrated biological networks that incorporates and models the various levels of relevance and reliability of diverse sources. The method is shown to achieve significantly higher performance as compared to two well-known gene prioritization algorithms. Essentially, no bias in the performance was seen as it was applied to diseases of diverse ethnology, e.g., monogenic, polygenic and cancer. The method was highly stable and robust against significant levels of noise in the data. Biological networks are often sparse, which can impede the operation of associationbased gene prioritization algorithms such as the one presented here from a computational perspective. As a potential approach to overcome this limitation, we explore the value that transcription factor binding sites can have in elucidating suitable targets. Transcription factors are needed for the expression of most genes, especially in higher organisms and hence genes can be associated via their genetic regulatory properties. While each transcription factor recognizes specific DNA sequence patterns, such patterns are mostly unknown for many transcription factors. Even those that are known are inconsistently reported in the literature, implying a potentially high level of inaccuracy. We developed computational methods for prediction and improvement of transcription factor binding patterns. Tests performed on the improvement method by employing synthetic patterns under various conditions showed that the method is very robust and the patterns produced invariably converge to nearly identical series of patterns. Preliminary tests were conducted to incorporate knowledge from transcription factor binding sites into our networkbased model for prioritization, with encouraging results. Genes have widely different pertinences to the etiology and pathology of diseases. Thus, they can be ranked according to their disease-significance on a genomic scale, which is the subject of gene prioritization. Given a set of genes known to be related to a disease, it is reasonable to use them as a basis to determine the significance of other candidate genes, which will then be ranked based on the association they exhibit with respect to the given set of known genes. Experimental and computational data of various kinds have different reliability and relevance to a disease under study. This work presents a gene prioritization method based on integrated biological networks that incorporates and models the various levels of relevance and reliability of diverse sources. The method is shown to achieve significantly higher performance as compared to two well-known gene prioritization algorithms. Essentially, no bias in the performance was seen as it was applied to diseases of diverse ethnology, e.g., monogenic, polygenic and cancer. The method was highly stable and robust against significant levels of noise in the data. Biological networks are often sparse, which can impede the operation of associationbased gene prioritization algorithms such as the one presented here from a computational perspective. As a potential approach to overcome this limitation, we explore the value that transcription factor binding sites can have in elucidating suitable targets. Transcription factors are needed for the expression of most genes, especially in higher organisms and hence genes can be associated via their genetic regulatory properties. While each transcription factor recognizes specific DNA sequence patterns, such patterns are mostly unknown for many transcription factors. Even those that are known are inconsistently reported in the literature, implying a potentially high level of inaccuracy. We developed computational methods for prediction and improvement of transcription factor binding patterns. Tests performed on the improvement method by employing synthetic patterns under various conditions showed that the method is very robust and the patterns produced invariably converge to nearly identical series of patterns. Preliminary tests were conducted to incorporate knowledge from transcription factor binding sites into our networkbased model for prioritization, with encouraging results. To validate these approaches in a disease-specific context, we built a schizophreniaspecific network based on the inferred associations and performed a comprehensive prioritization of human genes with respect to the disease. These results are expected to be validated empirically, but computational validation using known targets are very positive.
ContributorsLee, Jang (Author) / Gonzalez, Graciela (Thesis advisor) / Ye, Jieping (Committee member) / Davulcu, Hasan (Committee member) / Gallitano-Mendel, Amelia (Committee member) / Arizona State University (Publisher)
Created2011
Description
Detecting anatomical structures, such as the carina, the pulmonary trunk and the aortic arch, is an important step in designing a CAD system of detection Pulmonary Embolism. The presented CAD system gets rid of the high-level prior defined knowledge to become a system which can easily extend to detect other anatomic structures. The system is based on a machine learning algorithm --- AdaBoost and a general feature --- Haar. This study emphasizes on off-line and on-line AdaBoost learning. And in on-line AdaBoost, the thesis further deals with extremely imbalanced condition. The thesis first reviews several knowledge-based detection methods, which are relied on human being's understanding of the relationship between anatomic structures. Then the thesis introduces a classic off-line AdaBoost learning. The thesis applies different cascading scheme, namely multi-exit cascading scheme. The comparison between the two methods will be provided and discussed. Both of the off-line AdaBoost methods have problems in memory usage and time consuming. Off-line AdaBoost methods need to store all the training samples and the dataset need to be set before training. The dataset cannot be enlarged dynamically. Different training dataset requires retraining the whole process. The retraining is very time consuming and even not realistic. To deal with the shortcomings of off-line learning, the study exploited on-line AdaBoost learning approach. The thesis proposed a novel pool based on-line method with Kalman filters and histogram to better represent the distribution of the samples' weight. Analysis of the performance, the stability and the computational complexity will be provided in the thesis. Furthermore, the original on-line AdaBoost performs badly in imbalanced conditions, which occur frequently in medical image processing. In image dataset, positive samples are limited and negative samples are countless. A novel Self-Adaptive Asymmetric On-line Boosting method is presented. The method utilized a new asymmetric loss criterion with self-adaptability according to the ratio of exposed positive and negative samples and it has an advanced rule to update sample's importance weight taking account of both classification result and sample's label. Compared to traditional on-line AdaBoost Learning method, the new method can achieve far more accuracy in imbalanced conditions.
ContributorsWu, Hong (Author) / Liang, Jianming (Thesis advisor) / Farin, Gerald (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2011
Description
Rapid advance in sensor and information technology has resulted in both spatially and temporally data-rich environment, which creates a pressing need for us to develop novel statistical methods and the associated computational tools to extract intelligent knowledge and informative patterns from these massive datasets. The statistical challenges for addressing these massive datasets lay in their complex structures, such as high-dimensionality, hierarchy, multi-modality, heterogeneity and data uncertainty. Besides the statistical challenges, the associated computational approaches are also considered essential in achieving efficiency, effectiveness, as well as the numerical stability in practice. On the other hand, some recent developments in statistics and machine learning, such as sparse learning, transfer learning, and some traditional methodologies which still hold potential, such as multi-level models, all shed lights on addressing these complex datasets in a statistically powerful and computationally efficient way. In this dissertation, we identify four kinds of general complex datasets, including "high-dimensional datasets", "hierarchically-structured datasets", "multimodality datasets" and "data uncertainties", which are ubiquitous in many domains, such as biology, medicine, neuroscience, health care delivery, manufacturing, etc. We depict the development of novel statistical models to analyze complex datasets which fall under these four categories, and we show how these models can be applied to some real-world applications, such as Alzheimer's disease research, nursing care process, and manufacturing.
ContributorsHuang, Shuai (Author) / Li, Jing (Thesis advisor) / Askin, Ronald (Committee member) / Ye, Jieping (Committee member) / Runger, George C. (Committee member) / Arizona State University (Publisher)
Created2012