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- All Subjects: Business
- All Subjects: Evolution
- Creators: School of Life Sciences
- Creators: Department of Supply Chain Management
- Creators: Samuelson, Melissa
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
- Resource Type: Text
Description
I'm a business major. As a matter of fact, I don't have a lot of opportunities to participate in projects where I can design and build things as my engineering friends do. In fact, I'm not good at building things. And perhaps that's why I soon figured out that Engineering school isn't for me. But business alone seems to be not enough; I crave for something new and exciting and there is nothing more satisfying than seeing a design on paper becoming a tangible product in hands. For that reason, I decided to join InnovationSpace after learning about the program from my professor and my friends who were in the program. My goal through the program is to deliver a product that people find useful, and hopefully, has an impact on their lives.
“InnovationSpace is an entrepreneurial joint venture among the Herberger Institute for Design and the Arts, Ira A. Fulton Schools of Engineering, W.P. Carey School of Business and the Julie Ann Wrigley Global Institute of Sustainability at Arizona State University. The goal […] is to develop products that create market value while serving real societal needs and minimizing impacts on the environment. Put simply, we seek to create products that are progressive, possible and profitable. At the same time, they must have a meaningful impact on the daily lives of ordinary people. InnovationSpace utilizes two fundamental strategies for creating sustainable innovation: a model of new product development known as Integrated Innovation and the emerging field of biomimicry.” — InnovationSpace program syllabus
The focus of the project outlined by Cisco is “to understand the needs of people who face physical, cognitive or sensory disabilities, and develop new products and services for them utilizing the potential of the new technologies called the Internet of Things.” In other words, I am challenged to leverage the Internet of Things technologies to develop a device that benefits individuals with disabilities.
The final product is an automated airport cart — Chariot. Based on stakeholders’ needs interviews, we find that visually impaired people experience difficulties navigating the airport when they need to travel. Many airports attempt to solve this problem by offering wheelchair. However, visually impaired people feel that they are treated unfairly and become dependent on the wheelchairs. Chariot strives to solve this problem by applying the same concept in autonomous vehicle to guide the users through the airport. The users receive their itinerary email that will link to the Chariot app on their phones. When they arrive at the airport, the users simply connect their phones with Chariot and information such as gate number and departure time will be updated in the cart so that Chariot can guide the users to the desired destination. Ultimately, Chariot aims to give visually impaired people more control over their lives.
“InnovationSpace is an entrepreneurial joint venture among the Herberger Institute for Design and the Arts, Ira A. Fulton Schools of Engineering, W.P. Carey School of Business and the Julie Ann Wrigley Global Institute of Sustainability at Arizona State University. The goal […] is to develop products that create market value while serving real societal needs and minimizing impacts on the environment. Put simply, we seek to create products that are progressive, possible and profitable. At the same time, they must have a meaningful impact on the daily lives of ordinary people. InnovationSpace utilizes two fundamental strategies for creating sustainable innovation: a model of new product development known as Integrated Innovation and the emerging field of biomimicry.” — InnovationSpace program syllabus
The focus of the project outlined by Cisco is “to understand the needs of people who face physical, cognitive or sensory disabilities, and develop new products and services for them utilizing the potential of the new technologies called the Internet of Things.” In other words, I am challenged to leverage the Internet of Things technologies to develop a device that benefits individuals with disabilities.
The final product is an automated airport cart — Chariot. Based on stakeholders’ needs interviews, we find that visually impaired people experience difficulties navigating the airport when they need to travel. Many airports attempt to solve this problem by offering wheelchair. However, visually impaired people feel that they are treated unfairly and become dependent on the wheelchairs. Chariot strives to solve this problem by applying the same concept in autonomous vehicle to guide the users through the airport. The users receive their itinerary email that will link to the Chariot app on their phones. When they arrive at the airport, the users simply connect their phones with Chariot and information such as gate number and departure time will be updated in the cart so that Chariot can guide the users to the desired destination. Ultimately, Chariot aims to give visually impaired people more control over their lives.
ContributorsNguyen, Khanh Hoang Tuan (Author) / Trujillo, Rhett (Thesis director) / Hedges, Craig (Committee member) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This paper consists of a literature review, wherein four papers surrounding Motivation Crowding Theory (MCT) were read and analyzed. The paper then goes into an analysis of a survey I conducted. The survey consisted of three main questions with three sub-questions for each, and all attempted to find a "limit" to MCT. However, results for the survey were ultimately inconclusive. The paper concludes with lessons learned in conducting research and surveys in particular, as well as a nod to the relevancy of MCT in business and personal applications.
ContributorsSmith, Mallory Anne (Author) / Reckers, Phil (Thesis director) / Samuelson, Melissa (Committee member) / Lowe, Jordan (Committee member) / School of Accountancy (Contributor) / Department of Information Systems (Contributor) / WPC Graduate Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Phenotypic evolution is an essential topic within the general field of evolution. Theoretically, the outcome of phenotypic evolution may be influenced by factors such as genetic background and the interaction of natural selection and genetic drift. To gain empirical evidence for testing the effects of those factors, we used eight long-term evolved Escherichia coli populations as a model system. These populations differ in terms of genetic background (different mutation rates) as well as bottleneck size (small- and large-magnitude). Specifically, we used a plate reader to measure three growth-related traits: maximum growth rate (umax), carrying capacity (Kc), and lag time (Lt) for 40 clones within each population. For each trait we quantified the change in mean per generation, the change in variance per generation, and the correlation coefficient between pairs of traits. Interestingly, we found that the small and large bottleneck populations of one background displayed clear, distinguishing trends that were not present within the populations of the other background. This leads to the conclusion that the influence of selection and drift on a population’s phenotypic outcomes is itself influenced by the genetic background of that population. Additionally, we found a strong positive correlation between umax and Kc within each of the high-mutation populations that was not consistent with our neutral expectation. However, the other two pairs did not exhibit a similar pattern. Our results provide a novel understanding in the relationship between the evolution of E. coli growth-related phenotypes and the population-genetic environment.
ContributorsGonzales, Jadon (Co-author, Co-author) / Lynch, Michael (Thesis director) / Ho, Wei-Chin (Committee member) / Geiler-Samerotte, Kerry (Committee member) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Humans have evolved in many ways. Just look at how life for mankind has changed over the past few decades. It is amazing how different life can be in just a short amount of time. While it is evident that we have impacts of the environment, it should be just as evident that we impact the animals around us. However, there are a few subtle ways in which we impact the evolution of life.
Through man-made structures, human interference, artificial lights at night, and electromagnetic fields we have caused animals and insects to evolve and fit these new environments. While we tail the world around us to convince ourselves, the animals also living in these environments need to adapt to survive. In this essay, I will discuss how the affects mentioned above have cause crows, moths, snails, bobcats, blackbirds, mosquitoes, elephants, diurnal animals, fireflies, dung beetles, birds and bats to evolve. The adaptations these organisms made were caused by the subtle ways in which we have impact the landscapes around us.
Through man-made structures, human interference, artificial lights at night, and electromagnetic fields we have caused animals and insects to evolve and fit these new environments. While we tail the world around us to convince ourselves, the animals also living in these environments need to adapt to survive. In this essay, I will discuss how the affects mentioned above have cause crows, moths, snails, bobcats, blackbirds, mosquitoes, elephants, diurnal animals, fireflies, dung beetles, birds and bats to evolve. The adaptations these organisms made were caused by the subtle ways in which we have impact the landscapes around us.
ContributorsFikse, Sydney D (Author) / Sterner, Beckett (Thesis director) / Pfeifer, Susanne (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
At the outset it may seem as if fields of business and history are two irreconcilable fields. However, careful study of both reveals that the two are far from dissimilar. After all, one cannot expect to conquer the world without impeccable logistics, and no organization succeeds without a competent culture. Two great civilizations rose to prominence because their supply chains and methodologies outstripped their contemporaries. The first is the Romans. Once a small village situated on the Italian Peninsula, Rome’s empire grew to encompass the entirety of the Mediterranean world during the first century CE. The second is the Mongols, nomadic horseman who formed the largest contiguous empire in history roughly twelve hundred years later. At its height, the Mongol civilization spanned from the Pacific Ocean in the east to the forests of Europe in the west.
Both great civilizations achieved their empires due to their innovative supply chains, organizational tactics, and culture. Each, however, presented their own unique solutions to the problem of world conquest by capitalizing on their respective strengths. For the Romans, this meant placing an emphasis on infrastructure, adopting and modifying the technologies of other peoples, and instituting a culture that emphasized achievement and resilience among an aristocratic elite. The Mongol’s, however, focused on their force’s mobility rather than infrastructure, emphasized recruiting of outsiders to supplement their weakness, and developed a meritocratic system largely free of aristocratic structure. Both empires, however, emphasized the importance of each soldier as a self-sufficient unit to ease the strain of the overall supply chain.
These two civilizations therefore provide valuable insight for two diametrically opposed business environments. The first being manufacturing companies, with the need for rigid processes and investments in infrastructure not unlike the Romans. The second being startups with their need for speed and flexibility much like the Mongols. Thus, by examining the past modern companies gain valuable insights in how to structure their organizations for the future.
Both great civilizations achieved their empires due to their innovative supply chains, organizational tactics, and culture. Each, however, presented their own unique solutions to the problem of world conquest by capitalizing on their respective strengths. For the Romans, this meant placing an emphasis on infrastructure, adopting and modifying the technologies of other peoples, and instituting a culture that emphasized achievement and resilience among an aristocratic elite. The Mongol’s, however, focused on their force’s mobility rather than infrastructure, emphasized recruiting of outsiders to supplement their weakness, and developed a meritocratic system largely free of aristocratic structure. Both empires, however, emphasized the importance of each soldier as a self-sufficient unit to ease the strain of the overall supply chain.
These two civilizations therefore provide valuable insight for two diametrically opposed business environments. The first being manufacturing companies, with the need for rigid processes and investments in infrastructure not unlike the Romans. The second being startups with their need for speed and flexibility much like the Mongols. Thus, by examining the past modern companies gain valuable insights in how to structure their organizations for the future.
ContributorsCurtis, Alexander (Author) / Kellso, James (Thesis director) / Brettle, Adrian (Committee member) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Many factors are at play within the genome of an organism, contributing to much of the diversity and variation across the tree of life. While the genome is generally encoded by four nucleotides, A, C, T, and G, this code can be expanded. One particular mechanism that we examine in this thesis is modification of bases—more specifically, methylation of Adenine (m6A) within the GATC motif of Escherichia coli. These methylated adenines are especially important in a process called methyl-directed mismatch repair (MMR), a pathway responsible for repairing errors in the DNA sequence produced by replication. In this pathway, methylated adenines identify the parent strand and direct the repair proteins to correct the erroneous base in the daughter strand. While the primary role of methylated adenines at GATC sites is to direct the MMR pathway, this methylation has also been found to affect other processes, such as gene expression, the activity of transposable elements, and the timing of DNA replication. However, in the absence of MMR, the ability of these other processes to maintain adenine methylation and its targets is unknown.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.
To determine if the disruption of the MMR pathway results in the reduced conservation of methylated adenines as well as an increased tolerance for mutations that result in the loss or gain of new GATC sites, we surveyed individual clones isolated from experimentally evolving wild-type and MMR-deficient (mutL- ;conferring an 150x increase in mutation rate) populations of E. coli with whole-genome sequencing. Initial analysis revealed a lack of mutations affecting methylation sites (GATC tetranucleotides) in wild-type clones. However, the inherent low mutation rates conferred by the wild-type background render this result inconclusive, due to a lack of statistical power, and reveal a need for a more direct measure of changes in methylation status. Thus as a first step to comparative methylomics, we benchmarked four different methylation-calling pipelines on three biological replicates of the wildtype progenitor strain for our evolved populations.
While it is understood that these methylated sites play a role in the MMR pathway, it is not fully understood the full extent of their effect on the genome. Thus the goal of this thesis was to better understand the forces which maintain the genome, specifically concerning m6A within the GATC motif.
ContributorsBoyer, Gwyneth (Author) / Lynch, Michael (Thesis director) / Behringer, Megan (Committee member) / Geiler-Samerotte, Kerry (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Lactase persistence is the ability of adults to digest lactose in milk (Segurel & Bon, 2017). Mammals are generally distinguished by their mammary glands which gives females the ability to produce milk and feed their newborn children. The new born therefore requires the ability to breakdown the lactose in the milk to ensure its proper digestion (Segurel & Bon, 2017). Generally, humans lose the expression of lactase after weaning, which prevents them being able to breakdown lactose from dairy (Flatz, 1987).
My research is focused on the people of Turkana, a human pastoral population inhabiting Northwest Kenya. The people of Turkana are Nilotic people that are native to the Turkana district. There are currently no conclusive studies done on evidence for genetic lactase persistence in Turkana. Therefore, my research will be on the evolution of lactase persistence in the people of Turkana. The goal of this project is to investigate the evolutionary history of two genes with known involvement in lactase persistence, LCT and MCM6, in the Turkana. Variants in these genes have previously been identified to result in the ability to digest lactose post-weaning age. Furthermore, an additional study found that a closely related population to the Turkana, the Massai, showed stronger signals of recent selection for lactase persistence than Europeans in these genes. My goal is to characterize known variants associated with lactase persistence by calculating their allele frequencies in the Turkana and conduct selection scans to determine if LCT/MCM6 show signatures of positive selection. In doing this, we conducted a pilot study consisting of 10 female Turkana individuals and 10 females from four different populations from the 1000 genomes project namely: the Yoruba in Ibadan, Nigeria (YRI); Luhya in Webuye, Kenya; Utah Residents with Northern and Western European Ancestry (CEU); and the Southern Han Chinese. The allele frequency calculation suggested that the CEU (Utah Residents with Northern and Western European Ancestry) population had a higher lactase persistence associated allele frequency than all the other populations analyzed here, including the Turkana population. Our Tajima’s D calculations and analysis suggested that both the Turkana population and the four haplotype map populations shows signatures of positive selection in the same region. The iHS selection scans we conducted to detect signatures of positive selection on all five populations showed that the Southern Han Chinese (CHS), the LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations had stronger signatures of positive selection than the Turkana population. The LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations showed the strongest signatures of positive selection in this region. This project serves as a first step in the investigation of lactase persistence in the Turkana population and its evolution over time.
My research is focused on the people of Turkana, a human pastoral population inhabiting Northwest Kenya. The people of Turkana are Nilotic people that are native to the Turkana district. There are currently no conclusive studies done on evidence for genetic lactase persistence in Turkana. Therefore, my research will be on the evolution of lactase persistence in the people of Turkana. The goal of this project is to investigate the evolutionary history of two genes with known involvement in lactase persistence, LCT and MCM6, in the Turkana. Variants in these genes have previously been identified to result in the ability to digest lactose post-weaning age. Furthermore, an additional study found that a closely related population to the Turkana, the Massai, showed stronger signals of recent selection for lactase persistence than Europeans in these genes. My goal is to characterize known variants associated with lactase persistence by calculating their allele frequencies in the Turkana and conduct selection scans to determine if LCT/MCM6 show signatures of positive selection. In doing this, we conducted a pilot study consisting of 10 female Turkana individuals and 10 females from four different populations from the 1000 genomes project namely: the Yoruba in Ibadan, Nigeria (YRI); Luhya in Webuye, Kenya; Utah Residents with Northern and Western European Ancestry (CEU); and the Southern Han Chinese. The allele frequency calculation suggested that the CEU (Utah Residents with Northern and Western European Ancestry) population had a higher lactase persistence associated allele frequency than all the other populations analyzed here, including the Turkana population. Our Tajima’s D calculations and analysis suggested that both the Turkana population and the four haplotype map populations shows signatures of positive selection in the same region. The iHS selection scans we conducted to detect signatures of positive selection on all five populations showed that the Southern Han Chinese (CHS), the LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations had stronger signatures of positive selection than the Turkana population. The LWK (Luhya in Webuye, Kenya) and the YRI (Yoruba in Ibadan, Nigeria) populations showed the strongest signatures of positive selection in this region. This project serves as a first step in the investigation of lactase persistence in the Turkana population and its evolution over time.
ContributorsJobe, Ndey Bassin (Author) / Wilson Sayres, Melissa (Thesis director) / Paaijmans, Krijn (Committee member) / Taravella, Angela (Committee member) / School of Earth and Space Exploration (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Executive compensation is broken into two parts: one fixed and one variable. The fixed component of executive compensation is the annual salary and the variable components are performance-based incentives. Clawback provisions of executive compensation are designed to require executives to return performance-based, variable compensation that was erroneously awarded in the year of a misstatement. This research shows the need for the use of a new clawback provision that combines aspects of the two currently in regulation. In our current federal regulation, there are two clawback provisions in play: Section 304 of Sarbanes-Oxley and section 954 of The Dodd\u2014Frank Wall Street Reform and Consumer Protection Act. This paper argues for the use of an optimal clawback provision that combines aspects of both the current SOX provision and the Dodd-Frank provision, by integrating the principles of loss aversion and narcissism. These two factors are important to consider when designing a clawback provision, as it is generally accepted that average individuals are loss averse and executives are becoming increasingly narcissistic. Therefore, when attempting to mitigate the risk of a leader keeping erroneously awarded executive compensation, the decision making factors of narcissism and loss aversion must be taken into account. Additionally, this paper predicts how compensation structures will shift post-implementation. Through a survey analyzing the level of both loss- aversion and narcissism in respondents, the research question justifies the principle that people are loss averse and that a subset of the population show narcissistic tendencies. Both loss aversion and narcissism drove the results to suggest there are benefits to both clawback provisions and that a new provision that combines elements of both is most beneficial in mitigating the risk of executives receiving erroneously awarded compensation. I concluded the most optimal clawback provision is mandatory for all public companies (Dodd-Frank), targets all executives (Dodd-Frank), and requires the recuperation of the entire bonus, not just that which was in excess of what should have been received (SOX).
ContributorsLarscheid, Elizabeth (Author) / Samuelson, Melissa (Thesis director) / Casas-Arce, Pablo (Committee member) / WPC Graduate Programs (Contributor) / School of Accountancy (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Since its discovery in 1524, many people have characterized the vermiform appendix. Charles Darwin considered the human appendix to be a vestige and a useless structure. Others at the time opposed this hypothesis. However, Darwin's hypothesis became prevalent one until recently when there became a renewed interest in the appendix because of advancements in microscopes, knowledge of the immune system, and phylogenetics. In this review, I will argue that the vermiform appendix, although still not completely understood, has important functions. First, I will give the anatomy of the appendix. I will discuss the comparative anatomy between different animals and also primates. I will address the effects of appendicitis and appendectomy. I will give background on vestigial structures and will discuss if the appendix is a vestige. Following, I will review the evolution of the appendix. Finally, I will argue that the function of the appendix is as an immune organ, including discussion of gut-associated lymphoid tissue (GALT), development of lymphoid follicles in GALT and their comparison within different organs, Immunoglobulin A (IgA) function in the gut, biofilms as evidence that the appendix is a safe-house for beneficial bacteria, re-inoculation of the bowel, and protection against recurring infection. I will conclude with future studies that should be conducted to further our understanding of the vermiform appendix.
ContributorsPrestwich, Shelby Elizabeth (Author) / Cartwright, Reed (Thesis director) / Lynch, John (Committee member) / Furstenau, Tara (Committee member) / School of Geographical Sciences and Urban Planning (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Currently, Arizona State University's West Campus offers students a Bachelor's of Science degree in Forensics. This degree program has been at ASU's West campus for over three years now and is at its capacity of 300 students due to limitations on lab space. In order to support the growth and provide students with a valuable experience, the Math and Natural Sciences department seeks to create a "fee-for-service" enterprise within the Forensics division. This new lab called the Arizona State University Forensic Science Center (ASU-FSC) would serve city, county, state, and federal government agencies. The mission of the ASU-FSC is to provide robust, accurate and efficient forensic services while leading innovation in research and education in forensics for Arizona, the Southwest and the country. The School of Natural Science and Mathematics has sought help from W. P. Carey School of Business students to analyze the possibility of adding a Forensics fee-for-service lab to ASU West campus. The deliverables from this report will provide a comprehensive marketing, supply chain and financial review of all aspects of the business, and will aid in the decision making process for the creation of the Arizona State University Forensic Science Center.
ContributorsBlackburn, Amy (Co-author) / Snyder, Emily (Co-author) / Dong, Tim (Co-author) / Trujillo, Rhett (Thesis director) / Ferry, Lara (Committee member) / W. P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor) / Department of Marketing (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05