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Multiple sclerosis is currently deemed the most common autoimmune disease. By definition, multiple sclerosis, known more commonly as MS, involves an immune-mediated process in which an abnormal response of the body’s immune system is directed against the central nervous system (“Definition of MS,” n.d.). Common treatment protocols call for daily,

Multiple sclerosis is currently deemed the most common autoimmune disease. By definition, multiple sclerosis, known more commonly as MS, involves an immune-mediated process in which an abnormal response of the body’s immune system is directed against the central nervous system (“Definition of MS,” n.d.). Common treatment protocols call for daily, monthly, or yearly disease-modifying medications. These drugs are taken indefinitely to stop the spread and appearance of new lesions, improve symptoms, and offer relief to the afflicted individuals. The necessity for patients to take these basic medical treatments is paramount, however, it should not be overlooked to make lifestyle changes as well. The purpose of this paper is to give a detailed understanding of multiple sclerosis, its etiology evolution, and medical advancements, while emphasizing the necessary transitions which must be made from a nutritional and lifestyle management standpoint. A brief focus will be placed on sleep, exercise, and stress management, with an emphasis on nutrition.
ContributorsDeets, Breanna L (Author) / Levinson, Simin (Thesis director) / Grant, Shauna (Committee member) / Department of Management and Entrepreneurship (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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With the rising prevalence of obesity and diabetes, novel treatments to help mitigate or prevent symptoms of these conditions are warranted. Prior studies have shown that fossilized plant materials found in soil lowers blood sugar in a mouse model of diabetes. The goal of this study is to determine whether

With the rising prevalence of obesity and diabetes, novel treatments to help mitigate or prevent symptoms of these conditions are warranted. Prior studies have shown that fossilized plant materials found in soil lowers blood sugar in a mouse model of diabetes. The goal of this study is to determine whether a similar organometallic complex (OMC) could prevent insulin resistance in the skeletal muscle brought on by chronic high fat intake by examining the protein expression of key enzymes in the insulin signaling pathway and examining glucoregulatory measures. Six-week-old periadolescent male Sprague-Dawley rats (n=42) were randomly chosen to be fed either a high fat diet (HFD) (20% protein, 20% carbohydrates [6.8% sucrose], 60% fat) or a standard chow diet (18.9% protein, 57.33% carbohydrates, 5% fat) for 10 weeks. Rats from each diet group were then randomly assigned to one of three doses of OMC (0, 0.6, 3.0 mg/mL), which was added to their drinking water and fasting blood glucose was measured at baseline and again at 10 weeks. After 10 weeks, rats were euthanized, and soleus muscle samples were isolated, snap-frozen, and stored at -80°C until analyses. Fasting plasma glucose was measured using a commercially available glucose oxidase kit. Following 6 and 10 weeks, HFD rats developed significant hyperglycemia (p<0.001 and p=0.025) compared to chow controls which was prevented by high dose OMC (p=0.021). After 10 weeks, there were significant differences in fasting serum insulin between diets (p=0.009) where levels were higher in HFD rats. No significant difference was seen in p-PI3K expression between groups. These results suggest that OMC could prevent insulin resistance by reducing hyperglycemia. Further studies are needed to characterize the effects of diet and OMC on the insulin signaling pathway in skeletal muscle, the main site of postprandial glucose disposal. This study was supported by a grant from Isagenix International LLC as well as funds from Barrett, the Honors College at Arizona State University, Tempe Campus.
ContributorsStarr, Ashlee (Author) / Sweazea, Karen (Thesis director) / Johnston, Carol (Committee member) / Hyatt, JP (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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Description
Childhood obesity is a worsening epidemic in the U.S. with substantial racial/ethnic and socioeconomic disparities. Community-based approaches are necessary to target populations that are disproportionately affected by childhood obesity. The current randomized controlled trial assessed the effects of Athletes for Life (AFL), a 12-week community-based nutrition education and physical activity

Childhood obesity is a worsening epidemic in the U.S. with substantial racial/ethnic and socioeconomic disparities. Community-based approaches are necessary to target populations that are disproportionately affected by childhood obesity. The current randomized controlled trial assessed the effects of Athletes for Life (AFL), a 12-week community-based nutrition education and physical activity program that aims to improve cardiovascular fitness and promote healthy eating among families in the South Phoenix region, relative to a control condition. One of the goals of the intervention was to increase participating children's intake of fruits/vegetables and reduce their sugar intake, measured by a parent-reported food-frequency questionnaire. Data were collected on 110 child participants aged 6-11 years old. Relative to baseline values, participants in the intervention reportedly increased their fruit intake frequency by 0.12 + 2.0 times per day, whereas the control group decreased their intake by 0.32 + 1.28 times per day (p=0.026). Participants in the intervention group also increased their vegetable intake by 0.21 + 0.65 times per day, whereas control participants decreased their intake by 0.05 + 0.72 times per day (p=0.019). Participants in the intervention group decreased their intake of sugar-sweetened beverage (SSB) intake by 0.22 + 0.62 times per day, whereas control participants decreased their intake of SSBs by 0.04 + 0.40 times per day, however, the change observed in SSB intake was not significant between groups. Lastly, frequency of sugar-laden food intake decreased by 0.86 + 1.10 times per day among the intervention group, whereas control participants increased their intake by 0.02 + 1.10 times per day (p=0.033). The AFL study may serve as a framework for future community-based interventions to promote health in underserved areas.
ContributorsCirjan, Ioana Alina (Author) / Vega-Lopez, Sonia (Thesis director) / Crespo, Noe (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
Attending college provides young adults with a major shift in environment from high school where many students are used to living at home with their parents or guardians. Students experience a newfound freedom once beginning their freshman year, especially if living in on-campus housing. Freshmen are known to gain weight

Attending college provides young adults with a major shift in environment from high school where many students are used to living at home with their parents or guardians. Students experience a newfound freedom once beginning their freshman year, especially if living in on-campus housing. Freshmen are known to gain weight during this transitory period, and this has been partially attributed to changes in eating behaviors, which makes this a population of concern. College freshmen have significant autonomy over their food choices if not living at home, due to not having parents or guardians present. In the transition to college, freshmen are able to adopt new habits, healthy or unhealthy, which could make a large impact on their health habits for the rest of their lives; this is why the freshman population is an area of concern. RESULTS: None of the relationships between social connectedness and FF consumption were found to be statistically significant. Social connectedness was not significantly related to cross-sectional FF intake at the two different phases, or longitudinally between the two phases, even after adjustments were made. Additionally, there were no gender differences present in FF consumption or social connectedness at either phase. CONCLUSION: The lack of significant findings suggest that social connectedness might not be a reason college freshmen consume FF. Students might eat with others due to the convenience of living closely to them rather than as a means to socialize. Also, factors such as time constraints and cost might have played a larger role in why students consumed FF. Future research could involve similar studies using shorter questionnaires more tailored to eating behaviors, with more detailed measures of FF consumption (e.g. What specific FF meals did you consume?) and for a longer duration of time, to allow students to become more situated in their environment and have a better knowledge of all their food options. This study was an important contribution to the sparsely researched topic of social connectedness with a large and diverse sample studied longitudinally. It was also the only study of its kind to be performed on the college population, and had potential for future health implications in obesity and chronic conditions such as hypertension and type II diabetes. Further research is warranted to evaluate the relationship between social connectedness and other eating behaviors.
ContributorsBaca, Rachel (Author) / Bruening, Meg (Thesis director) / Brennhofer, Stephanie (Committee member) / School of Life Sciences (Contributor) / School of Nutrition and Health Promotion (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description

My project goes over the biology of chronic kidney disease, including what CKD is, definitions to understand, the prevalence of it, the signs and symptoms, and the main causes. Then I go over the nutrition guidelines of the disease and the nutrients important to regulate, including sodium, protein, fats and

My project goes over the biology of chronic kidney disease, including what CKD is, definitions to understand, the prevalence of it, the signs and symptoms, and the main causes. Then I go over the nutrition guidelines of the disease and the nutrients important to regulate, including sodium, protein, fats and whole grain carbohydrates, potassium, and phosphorus. Next, I write about recipes that I modify to be kidney-friendly and make nutrient analyses for each original recipe and each modified recipe. Finally, I made a video of myself cooking and trying two of the modified recipes.

ContributorsWickman, Skylar (Author) / Levinson, Simin (Thesis director) / Lehmann, Jessica (Committee member) / O'Keefe, Kelly (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / College of Health Solutions (Contributor)
Created2023-05
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Description

This paper outlines cumulative research on food deserts in relation to college students; namely, that there are communities classified as food deserts because significant numbers of the population lack access to grocery stores selling fresh produce or other goods normally called “healthy.” These areas are often also food swamps, or

This paper outlines cumulative research on food deserts in relation to college students; namely, that there are communities classified as food deserts because significant numbers of the population lack access to grocery stores selling fresh produce or other goods normally called “healthy.” These areas are often also food swamps, or areas with intense access to sugar-dense, high-fat foods. Research as a whole suggests that three, among many, things might primarily drive food insecurity for individuals caught in these food deserts: lack of access to a personal vehicle, low income or prohibitively expensive healthy foods, and personal education or culture (Wright, 2016). College students both fit into the geographical food deserts and are individuals who tend to have a worrying level of food insecurity (Kim, 2018). It is costly to make adjustments to entire environments to rid communities of food desert qualities, and it is not always effective as ending food insecurity or malnutrition; instead, it can be much more effective to focus on individuals within communities and help push cultures into a better direction. This project demonstrates that ASU students are experiencing food dissatisfaction and are in a food desert worthy of attention and action, and that students are motivated to see a solution. The solution that the paper focuses on is a food delivery system of fresh produce and foods for students. 


ContributorsRaghuraman, Vidya (Author) / Gailey, Tim (Co-author) / Hailey, Lauren (Co-author) / Reyes, Marina (Co-author) / Byrne, Jared (Thesis director) / Satpathy, Asish (Committee member) / Balven, Rachel (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Marketing (Contributor) / The Design School (Contributor)
Created2022-05
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Description

The purpose of this project was to garner a greater understanding of the form, function, and uses of school as well as community gardens. Worldwide, school and community gardens are used to promote health, nutrition, and some aspects of education. I wished to extend my knowledge of these gardens to

The purpose of this project was to garner a greater understanding of the form, function, and uses of school as well as community gardens. Worldwide, school and community gardens are used to promote health, nutrition, and some aspects of education. I wished to extend my knowledge of these gardens to greater lengths by building and incorporating a school garden in a community that was underderserving. Along the way I also sought to better my understanding of how to help communities through the knowledge and aid of experts and other community members. By doing this, I would hopefully both improve that community as well as understand the difficulties and problems that stand in the way of greater school garden incorporation.

ContributorsMitrius, Jake (Author) / Adamson, Joni (Thesis director) / Aggarwal, Rhimjim (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
Description
Cancer is an ever-relevant disease with many genetic, social, environmental, and behavioral risk factors. One factor which has been garnering interest is the impact of nutrition on cancer. As a disease process, cancer is primarily driven by an accumulation of genetic aberrations. Recent epidemiological, pre-clinical, and clinical studies have demonstrated

Cancer is an ever-relevant disease with many genetic, social, environmental, and behavioral risk factors. One factor which has been garnering interest is the impact of nutrition on cancer. As a disease process, cancer is primarily driven by an accumulation of genetic aberrations. Recent epidemiological, pre-clinical, and clinical studies have demonstrated various impacts of bioactive food molecules on the promotion or prevention of these oncogenic mutations. This work explores several of these molecules and their relation to cancer prevention and provides a sample meal plan, which highlights many additional molecules that are currently being studied.
ContributorsCurtin, Elise (Author) / Don, Rachael (Thesis director) / Compton, Carolyn (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-05
Description
Optimizing the microbiome to improve gut health has become a prominent research topic that aids in relieving stomach issues through nutrition and the introduction of beneficial bacteria. By incorporating a few gut-healthy foods into the diets of developing children, I hope to decrease their chances of developing pediatric diseases and

Optimizing the microbiome to improve gut health has become a prominent research topic that aids in relieving stomach issues through nutrition and the introduction of beneficial bacteria. By incorporating a few gut-healthy foods into the diets of developing children, I hope to decrease their chances of developing pediatric diseases and experiencing stomach problems as they grow older. The purpose of this cookbook is to use ingredients that are beneficial to the gut microbiome and incorporate them into healthy recipes that children can easily understand and create themselves. Additionally, many factors influence the fluctuation of the gut microbiome, one of which is nutrition, so it is important to maintain a diet rich in foods beneficial to the gut microbiome because it can prevent the onset of certain pediatric diseases. By including gut-healthy recipes in a cookbook targeted towards kids, they can gain independence, engage in a bonding activity with their parents, and be guided into creating and consuming things that are good for their gut and will benefit their health in the future. There are also many benefits for children who use this cookbook, such as developing healthy habits and preventing common disorders like obesity, IBS, and IBD. However, the overarching goal is to create a fun and engaging way for kids to prioritize good gut health for a healthy future. I hope that through this cookbook, kids can take control of their diet and engage in an activity that I enjoyed as a child.
ContributorsThex, Sophia (Author) / Dixon, Kathleen (Thesis director) / Mayol-Kreiser, Sandra (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description

Chutneys are a form of Indian condiment that can be made in many different flavors and paired with various foods. However, the availability of chutneys in the United States is very limited and many people have not tried them before. With this observation in mind, we founded A2Z Chutneys, which

Chutneys are a form of Indian condiment that can be made in many different flavors and paired with various foods. However, the availability of chutneys in the United States is very limited and many people have not tried them before. With this observation in mind, we founded A2Z Chutneys, which is a business that aims to distribute a variety of organic and locally produced chutneys. Through the Founders Lab program, A2Z Chutneys was created and research was conducted to justify the viability of our business. We were able to gather and interpret data from potential customers, which allowed us to identify a target market. Additionally, time was spent identifying and creating a variety of authentic and unique chutneys that have proven to be desired. This report demonstrates and outlines the feasibility of A2Z Chutneys in providing unique and desirable flavors to the population.

ContributorsPatel, Javin (Author) / Macha, Sankshay (Co-author) / Byrne, Jared (Thesis director) / Patel, Manish (Committee member) / Pierce, John (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Politics and Global Studies (Contributor) / School of Life Sciences (Contributor)
Created2023-05