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Description
An analysis of university flight emissions, carbon neutrality goals, and the global impact of university sanctioned flight.
ContributorsKoehler, Megan Anne (Author) / Halden, Rolf (Thesis director) / Driver, Erin (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Plastics continue to benefit society in innumerable ways, even though recent public focus on plastics has centered mostly on human health and environmental concerns, including their endocrine-disrupting properties and the long-term pollution they represent. The benefits of plastics are particularly apparent in medicine and public health. Plastics are versatile, cost-effective, require less energy to produce than alternative materials like metal or glass, and can be manufactured to have many different properties. Due to these characteristics, polymers are used in diverse health applications like disposable syringes and intravenous bags, sterile packaging for medical instruments as well as in joint replacements, tissue engineering, etc. However, not all current uses of plastics are prudent and sustainable, as illustrated by the widespread, unwanted human exposure to endocrine-disrupting bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP), problems arising from the large quantities of plastic being disposed of, and depletion of non-renewable petroleum resources as a result of the ever-increasing mass production of plastic consumer articles. Using the health-care sector as example, this review concentrates on the benefits and downsides of plastics and identifies opportunities to change the composition and disposal practices of these invaluable polymers for a more sustainable future consumption. It highlights ongoing efforts to phase out DEHP and BPA in the health-care and food industry and discusses biodegradable options for plastic packaging, opportunities for reducing plastic medical waste, and recycling in medical facilities in the quest to reap a maximum of benefits from polymers without compromising human health or the environment in the process.
ContributorsNorth, Emily Jean (Co-author) / Halden, Rolf (Co-author, Thesis director) / Mikhail, Chester (Committee member) / Hurlbut, Ben (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Chemical Engineering Program (Contributor)
Created2013-05
Description
Current methods measuring the consumption of prescription and illicit drugs are often hampered by innate limitations, the data is slow and often restricted, which can impact the relevance and robustness of the associated data. Here, wastewater-based epidemiology (WBE) was applied as an alternative metric to measure trends in the consumption of twelve narcotics within a collegiate setting from January 2018 to May 2018 at a Southwestern U.S. university. The present follow-up study was designed to identify potential changes in the consumption patterns of prescription and illicit drugs as the academic year progressed. Samples were collected from two sites that capture nearly 100% of campus-generated wastewater. Seven consecutive 24-hour composite raw wastewater samples were collected each month (n = 68) from both locations. The study identified the average consumption of select narcotics, in units of mg/day/1000 persons in the following order: cocaine (528 ± 266), heroin (404 ± 315), methylphenidate (343 ± 396), amphetamine (308 ±105), ecstasy (MDMA; 114 ± 198), oxycodone (57 ± 28), methadone (58 ± 73), and codeine (84 ± 40). The consumption of oxycodone, methadone, heroin, and cocaine were identified as statistically lower in the Spring 2018 semester compared to the Fall 2017. Universities may need to increase drug education for the fall semester to lower the consumption of drugs in that semester. Data from this research encompasses both human health and the built environment by evaluating public health through collection of municipal wastewater, allowing public health officials rapid and robust narcotic consumption data while maintaining the anonymity of the students, faculty, and staff.
ContributorsCarlson, Alyssa Rose (Author) / Halden, Rolf (Thesis director) / Gushgari, Adam (Committee member) / School of Human Evolution & Social Change (Contributor) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The combined use of methamphetamine and opioids has been reported to be on the rise throughout the United States (U.S.). However, our knowledge of this phenomenon is largely based upon reported overdoses and overdose-related deaths, law enforcement seizures, and drug treatment records; data that are often slow, restricted, and only track a portion of the population participating in drug consumption activities. As an alternative, wastewater-based epidemiology (WBE) has the capability to track licit and illicit drug trends within an entire community, at a low cost and in near real-time, while providing anonymity to those contributing to the sewer shed. In this study, wastewater was collected from two Midwestern U.S. cities (2017-2019) and analyzed for the prevalence of methamphetamine and the opioids oxycodone, codeine, fentanyl, tramadol, hydrocodone, and hydromorphone. Monthly 24-hour time-weighted composite samples (n = 48) from each city were analyzed using isotope dilution liquid chromatography tandem mass spectrometry. Results showed that methamphetamine and total opioid consumption (milligram morphine equivalents) in City 1 were strongly correlated only in 2017 (Spearman rank order correlation coefficient, ρ = 0.78), the relationship driven by fentanyl, hydrocodone, and hydromorphone. For City 2, methamphetamine and total opioid consumption were strongly positively correlated during the entire study (ρ = 0.54), with the correlations driven by hydrocodone and hydromorphone. In both cities, hydrocodone and hydromorphone mass loads were highly correlated, suggesting a parent and metabolite relationship. WBE provides important insights into licit and illicit drug consumption patterns in near real-time as they evolve; important information for community stakeholders in municipalities across the U.S.
ContributorsClick, Kathleen Grace (Author) / Halden, Rolf (Thesis director) / Gushgari, Adam (Committee member) / Driver, Erin (Committee member) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Alzheimer’s disease (AD) is a neurodegenerative disease resulting in loss of cognitive function and is not considered part of the typical aging process. Recently, research is being conducted to study environmental effects on AD because the exact molecular mechanisms behind AD are not known. The associations between various toxins and AD have been mixed and unclear. In order to better understand the role of the environment and toxic substances on AD, we conducted a literature review and geospatial analysis of environmental, specifically wastewater, contaminants that have biological plausibility for increasing risk of development or exacerbation of AD. This literature review assisted us in selecting 10 wastewater toxic substances that displayed a mixed or one-sided relationship with the symptoms or prevalence of Alzheimer’s for our data analysis. We utilized data of toxic substances in wastewater treatment plants and compared them to the crude rate of AD in the different Census regions of the United States to test for possible linear relationships. Using data from the Targeted National Sewage Sludge Survey (TNSSS) and the Centers for Disease Control and Prevention (CDC), we developed an application using R Shiny to allow users to interactively visualize both datasets as choropleths of the United States and understand the importance of this area of research. Pearson’s correlation coefficient was calculated resulting in arsenic and cadmium displaying positive linear correlations with AD. Other analytes from this statistical analysis demonstrated mixed correlations with AD. This application and data analysis serve as a model in the methodology for further geospatial analysis on AD. Further data analysis and visualization at a lower level in terms of scope is necessary for more accurate and reliable evidence of a causal relationship between the wastewater substance analytes and AD.
GitHub Repository: https://github.com/komal-agrawal/AD_GIS.git
GitHub Repository: https://github.com/komal-agrawal/AD_GIS.git
ContributorsAgrawal, Komal (Author) / Scotch, Matthew (Thesis director) / Halden, Rolf (Committee member) / College of Health Solutions (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
With a rapidly decreasing amount of resources for construction, wood and bamboo have been suggested as renewable materials for increased use in the future to attain sustainability. Through a literature review, bamboo and wood growth, manufacturing and structural attributes were compared and then scored in a weighted matrix to determine the option that shows the higher rate of sustainability. In regards to the growth phase, which includes water usage, land usage, growth time, bamboo and wood showed similar characteristics overall, with wood scoring 1.11% higher than bamboo. Manufacturing, which captures the extraction and milling processes, is experiencing use of wood at levels four times those of bamboo, as bamboo production has not reached the efficiency of wood within the United States. Structural use proved to display bamboo’s power, as it scored 30% higher than wood. Overall, bamboo received a score 15% greater than that of wood, identifying this fast growing plant as the comparatively more sustainable construction material.
ContributorsThies, Jett Martin (Author) / Ward, Kristen (Thesis director) / Halden, Rolf (Committee member) / Industrial, Systems & Operations Engineering Prgm (Contributor) / Civil, Environmental and Sustainable Eng Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions. When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.
ContributorsZdrale, Gabriel (Author) / Mahant, Akhil (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05
Description
The production and incineration of single-use micropipette tips and disposable gloves, which are heavily used within laboratory facilities, generate large amounts of greenhouse gasses (GHGs) and accelerate climate change. Plastic waste that is not incinerated often is lost in the environment. The long degradation times associated with this waste exacerbates a variety of environmental problems such as substance runoff and ocean pollution. The objective of this study was to evaluate the efficacy of possible solutions for minimizing micropipette tip and disposable glove waste within laboratory spaces. It was hypothesized that simultaneously implementing the use of micropipette tip washers (MTWs) and energy-from-glove-waste programs (EGWs) would significantly reduce (p < 0.05) the average combined annual single-use plastic micropipette tip and nitrile glove waste (in kg) per square meter of laboratory space in the United States. ASU’s Biodesign Institute (BDI) was used as a case study to inform on the thousands of different laboratory facilities that exist all across the United States. Four separate research laboratories within the largest public university of the U.S. were sampled to assess the volume of plastic waste from single-use micropipette tips and gloves. Resultant data were used to represent the totality of single-use waste from the case study location and then extrapolated to all laboratory space in the United States. With the implementation of EGWs, annual BDI glove waste is reduced by 100% (0.47 ± 0.26 kg/m2; 35.5 ± 19.3 metric tons total) and annual BDI glove-related carbon emissions are reduced by ~5.01% (0.165 ± 0.09 kg/m2; 1.24 ± 0.68 metric tons total). With the implementation of MTWs, annual BDI micropipette tip waste is reduced by 92% (0.117 ± 0.03 kg/m2; 0.88 ± 0.25 metric tons total) and annual BDI tip-related carbon emissions are reduced by ~83.6% (4.04 ± 1.25 kg/m2; 30.5 ± 9.43 metric tons total). There was no significant difference (p = 0.06) observed between the mass of single-use waste (kg) in the sampled laboratory spaces before (x̄ = 47.1; σ = 43.3) and after (x̄ =0.070; σ = 0.033) the implementation of the solutions.When examining both solutions (MTWs & EGWs) implemented in conjunction with one another, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$7.92 ± $9.31/m2 (7,500 m2 of total wet laboratory space) or ~$60,000 ± $70,000 total. These savings represent ~15.77% of annual BDI spending on micropipette tips and nitrile gloves. The large error margins in these financial estimates create high uncertainty for whether or not BDI would see net savings from implementing both solutions simultaneously. However, when examining the implementation of only MTWs, the annual BDI financial savings (in regard to both purchasing and disposal costs) after the first year were determined to be ~$12.01 ± $6.79 kg/m2 or ~$91,000 ± $51,200 total. These savings represent ~23.92% of annual BDI spending on micropipette tips and nitrile gloves. The lower error margins for this estimate create a much higher likelihood of net savings for BDI. Extrapolating to all laboratory space in the United States, the total annual amount of plastic waste avoided with the implementation of the MTWs was identified as 8,130 ± 2,290 tons or 0.023% of all solid plastic waste produced in the United States in 2018. The total amount of nitrile waste avoided with the implementation of the EGWs was identified as 32,800 ± 17,900 tons or 0.36% of all rubber solid waste produced in the United States in 2018. The total amount of carbon emissions avoided with the implementation of the MTWs was identified as 281,000 ± 87,000 tons CO2eq or 5.4*10-4 % of all CO2eq GHG emissions produced in the United States in 2020. Both the micropipette tip washer and the glove waste avoidance program solutions can be easily integrated into existing laboratories without compromising the integrity of the activities taking place. Implemented on larger scales, these solutions hold the potential for significant single-use waste reduction.
ContributorsMahant, Akhil (Author) / Zdrale, Gabriel (Co-author) / Halden, Rolf (Thesis director) / Biyani, Nivedita (Committee member) / Driver, Erin (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2022-05
Description
This dissertation critically evaluated methodologies and devices for assessing and protecting the health of human populations, with particular emphasis on groundwater remediation and the use of wastewater-based epidemiology (WBE) to inform population health. A meta-analysis and assessment of laboratory-scale treatability studies for removing chlorinated solvents from groundwater found that sediment microcosms operated as continuous-flow columns are preferable to batch bottles when seeking to emulate with high fidelity the complex conditions prevailing in the subsurface in contaminated aquifers (Chapter 2). Compared to monitoring at the field-scale, use of column microcosms also showed (i) improved chemical speciation, and (ii) qualitative predictability of field parameters (Chapter 3). Monitoring of glucocorticoid hormones in wastewater of a university campus showed (i) elevated stress levels particularly at the start of the semester, (ii) on weekdays relative to weekend days (p = 0.05) (161 ± 42 μg d-1 per person, 122 ± 54 μg d-1 per person; p ≤ 0.05), and (iii) a positive association between levels of stress hormones and nicotine (rs: 0.49) and caffeine (0.63) consumption in this student population (Chapter 4). Also, (i) alcohol consumption determined by WBE was in line with literature estimates for this young sub-population (11.3 ± 7.5 g d-1 per person vs. 10.1 ± 0.8 g d-1 per person), whereas caffeine and nicotine uses were below (114 ± 49 g d-1 per person, 178 ± 19 g d-1 per person; 627 ± 219 g d-1 per person, 927 ± 243 g d-1 per person). The introduction of a novel continuous in situ sampler to WBE brought noted benefits relative to traditional time-integrated sampling, including (i) a higher sample coverage (93% vs. 3%), (ii) an ability to captured short-term analyte pulses (e.g., heroin, fentanyl, norbuprenorphine, and methadone), and (iii) an overall higher mass capture for drugs of abuse like morphine, fentanyl, methamphetamine, amphetamine, and the opioid antagonist metabolite norbuprenorphine (p ≤ 0.01). Methods and devices developed in this work are poised to find applications in the remediation sector and in human health assessments.
ContributorsDriver, Erin Michelle (Author) / Halden, Rolf (Thesis advisor) / Conroy-Ben, Otakuye (Committee member) / Kavazanjian, Edward (Committee member) / Krajmalnik-Brown, Rosa (Committee member) / Arizona State University (Publisher)
Created2018
Description
Arsenic (As) and chromium (Cr) occur naturally in AZ surface and groundwaters, pose different health impacts, and exhibit different treatment efficacies. Hexavalent chromium (Cr(VI)) has newly recognized human health concerns, and State and Federal agencies are evaluating a low Cr(VI)-specific maximum contaminant level (MCL) for drinking water. Occurrence of Cr and As in municipal drinking waters and industrial cooling tower waters was quantified by grab samples and compared with sampling results obtained from a new passive sampler developed specifically for Cr(VI). Cr(VI) and As concentrations in groundwater used for cooling tower make-up water concentrations were ~3 ppb and ~4 ppb, respectively, and were concentrated significantly in blowdown water (~20 ppb and ~40 ppb). Based upon pending Cr(VI), As, and other metal regulations, these blowdown waters will need routine monitoring and treatment. Cr(VI) concentrations in a water treatment plant (WTP) raw and finished water samples varied from 0.5 and 2 ppb for grab samples collected every 4 hours for 7 consecutive days using an ISCO sampler. The development of an ion exchange (IX) based passive sampler was validated in the field at the WTP and yielded an average exposure within 1 standard deviation of ISCO sampler grab data. Sampling at both the WTP and cooling towers suggested sources of Cr(III) from treatment chemicals or wood preservatives may exist. Since both facilities use chlorine oxidants, I quantified the apparent (pH=5) second-order rate constant for aqueous chlorine (HOCl/OCl-) with Cr(III) to form Cr(VI) as 0.7 M-1s-1. Under typical conditions (2 ppb Cr(III) ; 2 mg/L Cl2) the half-life for the conversion of Cr(III) to the more toxic form Cr(VI) is 4.7 hours. The occurrence studies in AZ and CA show the Cr(VI) and As treatment of groundwaters will be required to meet stringent Cr(VI) regulations. IX technologies, both strong base anion (SBA) and weak base anion (WBA) resin types were screened (and compared) for Cr removal. The SBA IX process for As removal was optimized by utilizing a reactive iron coagulation and filtration (RCF) process to treat spent IX brine, which was then reused to for SBA resin regeneration.
ContributorsBowen, Alexandra (Author) / Paul, Westerhoff K. (Thesis advisor) / Hristovski, Kiril (Committee member) / Halden, Rolf (Committee member) / Arizona State University (Publisher)
Created2014