Matching Items (23)
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- All Subjects: Biomaterials
- All Subjects: Marketing
- Creators: Harrington Bioengineering Program
Description
The goal of this research project is to create a Mathcad template file capable of statistically modelling the effects of mean and standard deviation on a microparticle batch characterized by the log normal distribution model. Such a file can be applied during manufacturing to explore tolerances and increase cost and time effectiveness. Theoretical data for the time to 60% drug release and the slope and intercept of the log-log plot were collected and subjected to statistical analysis in JMP. Since the scope of this project focuses on microparticle surface degradation drug release with no drug diffusion, the characteristic variables relating to the slope (n = diffusional release exponent) and the intercept (k = kinetic constant) do not directly apply to the distribution model within the scope of the research. However, these variables are useful for analysis when the Mathcad template is applied to other types of drug release models.
ContributorsHan, Priscilla (Author) / Vernon, Brent (Thesis director) / Nickle, Jacob (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Cardiac tissue engineering is an emerging field that has the potential to regenerate and repair damaged cardiac tissues after myocardial infarction. Numerous studies have introduced hydrogel-based cardiac tissue constructs featuring suitable microenvironments for cell growth along with precise surface topographies for directed cell organization. Despite significant progress, previously developed cardiac tissue constructs have suffered from electrically insulated matrices and low cell retention. To address these drawbacks, we fabricated micropatterned hybrid hydrogel constructs (uniaxial microgrooves with 50 µm with) using a photocrosslinkable gelatin methacrylate (GelMA) hydrogel incorporated with gold nanorods (GNRs). The electrical impedance results revealed a lower impedance in the GelMA-GNR constructs versus the pure GelMA constructs. Superior electrical conductivity of GelMA-GNR hydrogels (due to incorporation of GNRs) enabled the hybrid tissue constructs to be externally stimulated using a pulse generator. Furthermore, GelMA-GNR tissue hydrogels were tested to investigate the biological characteristics of cultured cardiomyocytes. The F-actin fiber analysis results (area coverage and alignment indices) revealed higher directed (uniaxial) cytoskeleton organization of cardiac cells cultured on the GelMA-GNR hydrogel constructs in comparison to pure GelMA. Considerable increase in the coverage area of cardiac-specific markers (sarcomeric α-actinin and connexin 43) were observed on the GelMA-GNR hybrid constructs compared to pure GelMA hydrogels. Despite substantial dissimilarities in cell organization, both pure GelMA and hybrid GelMA-GNR hydrogel constructs provided a suitable microenvironment for synchronous beating of cardiomyocytes.
ContributorsMoore, Nathan Allen (Author) / Nikkhah, Mehdi (Thesis director) / Smith, Barbara (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Arizona State University students are currently out of the loop when it comes to hearing about events being held in their community. This is because there is no established service that provides an inclusive list of both on and near campus events. What's worse is that the current methods for event marketing rely heavily on who one knows. Currently, ASU students hear about events through word of mouth, email chains, Facebook pages, and posters around campus. Thankfully, there is now an event marketing method that is available to everyone. UniEvents is a newly developed event service that live-tracks events around ASU's Tempe campus. UniEvents consists of a webpage that accommodates all screen sizes and is accessible by all devices including smartphones, tablets, and desktop computers. The website offers a user-friendly interface and useful features. Students are able to scan through event listings on a calendar or they can use an interactive map to find events nearest to them. Furthermore, UniEvents also offers the option for users to submit events to be advertised through the service. This way, students and organizations can easily spread the word about events on campus. Through UniEvents, ASU students will finally be able to see a conclusive list of upcoming events in one convenient site. Students will be able to save time and hassle by not having to rely on numerous sources to learn about events. UniEvents is committed to help students learn about events and get involved in campus activities!
ContributorsDeegan, Taylor (Co-author) / Nguyen, Lilian (Co-author) / Ostrom, Lonnie (Thesis director) / Schlacter, John (Committee member) / Harrington Bioengineering Program (Contributor) / Economics Program in CLAS (Contributor) / Department of Information Systems (Contributor) / Department of Marketing (Contributor) / School of Accountancy (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis explores the task of creating industry-based marketing materials to assist academic programs in their recruitment of high school and community college students. With consistent reductions to public university budgets there is an increasing pressure on academic programs to raise their student enrollment figures, as student count is often cited as one of the most important statistics when making budget decisions. Many academic programs are ill-equipped to perform this task, however, as their personnel are not trained as recruiters, but rather as professors and industry professionals; furthermore, the university-level recruitment staff faces the impossible task of advertising every department's recruitment message. The Del E. Webb School of Construction has embarked upon a journey to create industry-based marketing materials to aid them in their recruitment efforts. Construction management (CM) has traditionally been viewed as a technology major relegated to vocational students and those not fit for baccalaureate programs. In recent years that perception has changed, however, as the industry has become increasingly complex and CM programs actively work to recruit students. In an attempt to increase that recruitment, the Del E. Webb School has created marketing materials that are signature to the program featuring the world's most widely-used building material, concrete, to create a keepsake for prospective students. This keepsake comes in the form of concrete replicas of the new ASU Pitchfork logo. These pitchforks are small and designed to be mass produced so that they can be handed out at recruitment events either on campus or in local schools. The Del E. Webb School had previously experimented with flexible rubber molds and flowable mixtures, such that the models could be easily cast and rapidly demolded and reset for casting. There were issues, however, as those pitchforks did not meet desired level of quality and were difficult to reproduce. This thesis thus describes an experimental program examining different casting and demolding regimens in an attempt to find the optimal way to create the pitchforks on a consistent basis. Following this, an operations manual for how to create the pitchforks was created in order to ensure that successive cohorts of construction students can reproduce the pitchforks in preparation for the School's annual recruitment events.
ContributorsErnzen, John Alexander (Author) / Wiezel, Avi (Thesis director) / Rogers, James (Committee member) / Barrett, The Honors College (Contributor) / Division of Educational Leadership and Innovation (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
Description
There has been a low rate of voter turnout in the U.S. in recent years, especially among young voters. In an effort to determine how to best encourage Americans to vote, emotional appeals and message frames were examined. The objective of this 2x2 study was to determine if positive or negative emotional appeals were more effective in changing voting behavior and if positively framed or negatively framed messages were more effective in changing voting behavior. An experiment was conducted via the Robert B. Cialdini Behavioral Research Lab at ASU, and each participant was shown a piece of voting communication that presented an emotional appeal and a message frame. It was found that, although the positive emotional appeals were not more effective than the negative emotional appeals in changing voting behavior, the positively framed messages were more effective than the negatively framed messages in changing voting behavior.
ContributorsSweeney, Erin Patrice (Author) / Eaton, Kate (Thesis director) / Brian, Jennifer (Committee member) / Department of Marketing (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This project aims to address the current protocol regarding the diagnosis and treatment of traumatic brain injury (TBI) in medical industries around the world. Although there are various methods used to qualitatively determine if TBI has occurred to a patient, this study attempts to aid in the creation of a system for quantitative measurement of TBI and its relative magnitude. Through a method of artificial evolution/selection called phage display, an antibody that binds highly specifically to a post-TBI upregulated brain chondroitin sulfate proteoglycan called neurocan has been identified. As TG1 Escheria Coli bacteria were infected with KM13 helper phage and M13 filamentous phage in conjunction, monovalent display of antibody fragments (ScFv) was performed. The ScFv bind directly to the neurocan and from screening, phage that produced ScFv's with higher affinity and specificity to neurocan were separated and purified. Future research aims to improve the ScFv characteristics through increased screening toward neurocan. The identification of a highly specific antibody could lead to improved targeting of neurocan post-TBI in-vivo, aiding researchers in quantitatively defining TBI by visualizing its magnitude.
ContributorsSeelig, Timothy Scott (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
The purpose of this study was to examine the history of pilgrimage tourism and its marketability to a modern consumer. It was also to examine the role of government in promoting tourism activities. Through a case study on el Camino de Santiago and the Xunta de Galicia, I discovered a market gap and created a communications strategy aimed towards closing the gap and smoothing demand fluctuation. Target market research indicated consumer interest and supported the marketing strategy. The study was conducted through historical, statistical, ethnographic, and psychographic research and analysis. The major findings of this study were that the American consumer is not as religiously motivated to travel as their European counterparts. However, they find many other aspects of the pilgrimage experience very appealing. Their lack of interest in the religious aspect of travel experiences segments them into a group that can potentially help flatten demand fluctuation amid Holy Years along el Camino de Santiago. The modernization of the pilgrimage contributes to its movement away from pious tourism towards secular tourism and offers an opportunity for an untapped market to support pilgrimage tourism economies.
ContributorsPowers, Molly Kathleen (Author) / Eaton, John (Thesis director) / Eaton, Kate (Committee member) / School of International Letters and Cultures (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
There is an increasing interest in developing thermo-responsive polymers for treating aneurysms. In this thesis project, the potential for poly(NIPAAm-co-JAAm-co-HEMA-Acrylate) (PNJHAc) as a treatment method for brain aneurysms was investigated. Five different batches of polymer were synthesized, purified, lyophilized, and characterized using nuclear magnetic resonance and cloud point techniques over the course of several months. Two were tested in aneurysm models. Of these five batches, there were two that showed promise as liquid embolic agents for endovascular embolization.
ContributorsLoui, Michelle (Author) / Vernon, Brent (Thesis director) / Pal, Amrita (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Top Cup plans on opening its doors by 2020 in Gilbert, Arizona. This differentiation strategy goes into depth about the steps needed to properly and efficiently introduce Top Cup to the coffee industry. A market analysis determined that Top Cup’s ideal consumer is to be described as the “sophisticated” customer between the ages of 18-54. They are described as affluent, working professionals who value quality and will spend on luxury items. Considering that Top Cup is advertising its high-quality products, a zip analysis was performed on 85293 to validate the practicality of targeting this market segment. 64% of the population residing in this zip code, labeled Boomburbs, encompass the same appeals as the ideal consumer Top Cup should seek. Top Cup’s mission is to serve consumers the best quality premium coffee products in an ambience-centric environment. By utilizing a product value strategy and expert-recommended strategy, Top Cup can access higher margins of profit in their asking price. The implementation of a pub-themed coffee shop will differentiate Top Cup from industry competitors and provide a unique experience to consumers on a daily basis.
ContributorsJaber, Ranine (Co-author, Co-author) / Eaton, Kate (Thesis director) / Schlacter, John (Committee member) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This study seeks to understand what design factors best aid in the elicitation of behaviors, specifically disclosure behaviors, from one party to another with the intent to provide some form of service. I looked at the medical industry to see how to create the best possible quality of care all while ensuring that the patient information is collected accurately and quickly. With healthcare in the United States becoming increasingly expensive along with the multitude of people seeking attention, the time that physicians have is scare. This scarcity can affect the type and quality of care that a patient would receive. Therefore, creating an online form to gather patient data would reduce time so long as the information was collected via a trusted method and patients were honest in their disclosure. The quality of the face-to-face time in a physician’s office would increase with increased honesty from patients, as the physician would be able to properly prepare for the appointment. This study examines whether screen lighting and typeface could influence a patient's disclosure of problem behaviors, such as smoking or drinking, the patient's rating of the importance of honesty, and the patient's perceptions of privacy and confidentiality during the disclosure. The results showed that Sans Serif [Arial] typeface was more effective in eliciting problem behavior disclosure. Perceptions and disclosure in relation to background color did not yield overwhelming results either way.
ContributorsScheetz, Taylor Renee (Author) / Eaton, Kate (Thesis director) / Eaton, John (Committee member) / Department of Marketing (Contributor) / Economics Program in CLAS (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05