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- Creators: Arizona State University
How Does Technology Development Influence the Assessment of Parkinson’s Disease? A Systematic Review
Description
Parkinson’s disease (PD) is a neurological disorder with complicated and disabling motor and non-motor symptoms. The pathology for PD is difficult and expensive. Furthermore, it depends on patient diaries and the neurologist’s subjective assessment of clinical scales. Objective, accurate, and continuous patient monitoring have become possible with the advancement in mobile and portable equipment. Consequently, a significant amount of work has been done to explore new cost-effective and subjective assessment methods or PD symptoms. For example, smart technologies, such as wearable sensors and optical motion capturing systems, have been used to analyze the symptoms of a PD patient to assess their disease progression and even to detect signs in their nascent stage for early diagnosis of PD.
This review focuses on the use of modern equipment for PD applications that were developed in the last decade. Four significant fields of research were identified: Assistance diagnosis, Prognosis or Monitoring of Symptoms and their Severity, Predicting Response to Treatment, and Assistance to Therapy or Rehabilitation. This study reviews the papers published between January 2008 and December 2018 in the following four databases: Pubmed Central, Science Direct, IEEE Xplore and MDPI. After removing unrelated articles, ones published in languages other than English, duplicate entries and other articles that did not fulfill the selection criteria, 778 papers were manually investigated and included in this review. A general overview of PD applications, devices used and aspects monitored for PD management is provided in this systematic review.
This review focuses on the use of modern equipment for PD applications that were developed in the last decade. Four significant fields of research were identified: Assistance diagnosis, Prognosis or Monitoring of Symptoms and their Severity, Predicting Response to Treatment, and Assistance to Therapy or Rehabilitation. This study reviews the papers published between January 2008 and December 2018 in the following four databases: Pubmed Central, Science Direct, IEEE Xplore and MDPI. After removing unrelated articles, ones published in languages other than English, duplicate entries and other articles that did not fulfill the selection criteria, 778 papers were manually investigated and included in this review. A general overview of PD applications, devices used and aspects monitored for PD management is provided in this systematic review.
ContributorsDeb, Ranadeep (Author) / Ogras, Umit Y. (Thesis advisor) / Shill, Holly (Committee member) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2019
Description
The world population is aging. Age-related disorders such as stroke and spinal cord injury are increasing rapidly, and such patients often suffer from mobility impairment. Wearable robotic exoskeletons are developed that serve as rehabilitation devices for these patients. In this thesis, a knee exoskeleton design with higher torque output compared to the first version, is designed and fabricated.
A series elastic actuator is one of the many actuation mechanisms employed in exoskeletons. In this mechanism a torsion spring is used between the actuator and human joint. It serves as torque sensor and energy buffer, making it compact and
safe.
A version of knee exoskeleton was developed using the SEA mechanism. It uses worm gear and spur gear combination to amplify the assistive torque generated from the DC motor. It weighs 1.57 kg and provides a maximum assistive torque of 11.26 N·m. It can be used as a rehabilitation device for patients affected with knee joint impairment.
A new version of exoskeleton design is proposed as an improvement over the first version. It consists of components such as brushless DC motor and planetary gear that are selected to meet the design requirements and biomechanical considerations. All the other components such as bevel gear and torsion spring are selected to be compatible with the exoskeleton. The frame of the exoskeleton is modeled in SolidWorks to be modular and easy to assemble. It is fabricated using sheet metal aluminum. It is designed to provide a maximum assistive torque of 23 N·m, two times over the present exoskeleton. A simple brace is 3D printed, making it easy to wear and use. It weighs 2.4 kg.
The exoskeleton is equipped with encoders that are used to measure spring deflection and motor angle. They act as sensors for precise control of the exoskeleton.
An impedance-based control is implemented using NI MyRIO, a FPGA based controller. The motor is controlled using a motor driver and powered using an external battery source. The bench tests and walking tests are presented. The new version of exoskeleton is compared with first version and state of the art devices.
A series elastic actuator is one of the many actuation mechanisms employed in exoskeletons. In this mechanism a torsion spring is used between the actuator and human joint. It serves as torque sensor and energy buffer, making it compact and
safe.
A version of knee exoskeleton was developed using the SEA mechanism. It uses worm gear and spur gear combination to amplify the assistive torque generated from the DC motor. It weighs 1.57 kg and provides a maximum assistive torque of 11.26 N·m. It can be used as a rehabilitation device for patients affected with knee joint impairment.
A new version of exoskeleton design is proposed as an improvement over the first version. It consists of components such as brushless DC motor and planetary gear that are selected to meet the design requirements and biomechanical considerations. All the other components such as bevel gear and torsion spring are selected to be compatible with the exoskeleton. The frame of the exoskeleton is modeled in SolidWorks to be modular and easy to assemble. It is fabricated using sheet metal aluminum. It is designed to provide a maximum assistive torque of 23 N·m, two times over the present exoskeleton. A simple brace is 3D printed, making it easy to wear and use. It weighs 2.4 kg.
The exoskeleton is equipped with encoders that are used to measure spring deflection and motor angle. They act as sensors for precise control of the exoskeleton.
An impedance-based control is implemented using NI MyRIO, a FPGA based controller. The motor is controlled using a motor driver and powered using an external battery source. The bench tests and walking tests are presented. The new version of exoskeleton is compared with first version and state of the art devices.
ContributorsJhawar, Vaibhav (Author) / Zhang, Wenlong (Thesis advisor) / Sugar, Thomas G. (Committee member) / Lee, Hyunglae (Committee member) / Marvi, Hamidreza (Committee member) / Arizona State University (Publisher)
Created2018
Description
Stress is one of the critical factors in daily lives, as it has a profound impact onperformance at work and decision-making processes. With the development of IoT
technology, smart wearables can handle diverse operations, including networking and
recording biometric signals. Also, it has become easier for individual users to selfdetect stress with recorded data since these wearables as well as their accompanying
smartphones now have data processing capability. Edge computing on such devices
enables real-time feedback and in turn preemptive identification of reactions to stress.
This can provide an opportunity to prevent more severe consequences that might
result if stress is unaddressed. From a system perspective, leveraging edge computing
allows saving energy such as network bandwidth and latency since it processes data in
proximity to the data source. It can also strengthen privacy by implementing stress
prediction at local devices without transferring personal information to the public
cloud.
This thesis presents a framework for real-time stress prediction using Fitbit and
machine learning with the support from cloud computing. Fitbit is a wearable tracker
that records biometric measurements using optical sensors on the wrist. It also provides developers with platforms to design custom applications. I developed an application for the Fitbit and the user’s accompanying mobile device to collect heart rate
fluctuations and corresponding stress levels entered by users. I also established the
dataset collected from police cadets during their academy training program. Machine
learning classifiers for stress prediction are built using classic models and TensorFlow
in the cloud. Lastly, the classifiers are optimized using model compression techniques
for deploying them on the smartphones and analyzed how efficiently stress prediction
can be performed on the edge.
ContributorsSim, Sang-Hun (Author) / Zhao, Ming (Thesis advisor) / Roberts, Nicole (Committee member) / Zou, Jia (Committee member) / Arizona State University (Publisher)
Created2022
Description
With the extensive technological progress made in the areas of drives, sensors and processing, exoskeletons and other wearable devices have become more feasible. However, the stringent requirements in regards to size and weight continue to exert a strong influence on the system-wide design of these devices and present many obstacles to a successful solution. On the other hand, while the area of controls has seen a significant amount of progress, there also remains a large potential for improvements. This dissertation approaches the design and control of wearable devices from a systems perspective and provides a framework to successfully overcome the often-encountered obstacles with optimal solutions. The electronics, drive and control system design for the HeSA hip exoskeleton project and APEx hip exoskeleton project are presented as examples of how this framework is used to design wearable devices. In the area of control algorithms, a real-time implementation of the Fast Fourier Transform (FFT) is presented as an alternative approach to extracting amplitude and frequency information of a time varying signal. In comparison to the peak search method (PSM), the FFT allows extracting basic gait signal information at a faster rate because time windows can be chosen to be less than the fundamental gait frequency. The FFT is implemented on a 16-bit processor and the results show the real-time detection of amplitude and frequency coefficients at an update rate of 50Hz. Finally, a novel neural networks based approach to detecting human gait activities is presented. Existing neural networks often require vast amounts of data along with significant computer resources. Using Neural Ordinary Differential Equations (Neural ODEs) it is possible to distinguish between seven different daily activities using a significantly smaller data set, lower system resources and a time window of only 0.1 seconds.
ContributorsBoehler, Alexander (Author) / Sugar, Thomas (Thesis advisor) / Redkar, Sangram (Committee member) / Hollander, Kevin (Committee member) / Arizona State University (Publisher)
Created2021
Description
With more people falling every year it is more important to continue to track everyday activity as well as follow the progress that someone is making over time. As well as at risk subjects, athletes are also wanting to track their activity as well as improve in finer control of their motions and abilities. To improve someone’s balance, strength, flexibility, and more someone can now start to use different biological sensors to help live a healthier and better lifestyle. To build different sensors requires materials that are comfortable to wear and accurate in collecting data. Graphene has been considered a wonder material that is used in many different applications which allow circuits and devices to use the flexible and durable material to conduct electricity. This paper shows multiple different tests and 36 trials of using graphene as a device which measures pressure that can be used to analyze gait patterns. These tests involve walking on a dual force plate treadmill for 90 continuous seconds with the graphene strip in the heel of the shoe wirelessly transmitting data to be recorded. The initial tests show that graphene will pick up noise and that graphene can start to deteriorate without proper protection. When looking at subject 1 there is less than .01 seconds of error between the graphene circuit and the ground truth. The ground truth was collected simultaneously, and the t-tests and ANOVA tests showed that there is no statistical difference between the graphene system and the ground truth. These tests also showed a 96.7% reproducibility score. There are limitations as seen in the later subjects, but these limitations can be overcome by further protecting the graphene and replacing the strip when it starts to show signs of deterioration which will allow graphene to be used in everyday bio wearable devices.
ContributorsSweeten, William (Author) / Lockhart, Thurmon (Thesis advisor) / Arquiza, Jose Apollo (Committee member) / Soangra, Rahul (Committee member) / Arizona State University (Publisher)
Created2022
Description
Wearable assistive devices have been greatly improved thanks to advancements made in soft robotics, even creation soft extra arms for paralyzed patients. Grasping remains an active area of research of soft extra limbs. Soft robotics allow the creation of grippers that due to their inherit compliance making them lightweight, safer for human interactions, more robust in unknown environments and simpler to control than their rigid counterparts. A current problem in soft robotics is the lack of seamless integration of soft grippers into wearable devices, which is in part due to the use of elastomeric materials used for the creation of most of these grippers. This work introduces fabric-reinforced textile actuators (FRTA). The selection of materials, design logic of the fabric reinforcement layer and fabrication method are discussed. The relationship between the fabric reinforcement characteristics and the actuator deformation is studied and experimentally verified. The FRTA are made of a combination of a hyper-elastic fabric material with a stiffer fabric reinforcement on top. In this thesis, the design, fabrication, and evaluation of FRTAs are explored. It is shown that by varying the geometry of the reinforcement layer, a variety of motion can be achieve such as axial extension, radial expansion, bending, and twisting along its central axis. Multi-segmented actuators can be created by tailoring different sections of fabric-reinforcements together in order to generate a combination of motions to perform specific tasks. The applicability of this actuators for soft grippers is demonstrated by designing and providing preliminary evaluation of an anthropomorphic soft robotic hand capable of grasping daily living objects of various size and shapes.
ContributorsLopez Arellano, Francisco Javier (Author) / Santello, Marco (Thesis advisor) / Zhang, Wenlong (Thesis advisor) / Buneo, Christopher (Committee member) / Arizona State University (Publisher)
Created2019
Description
Movement disorders are becoming one of the leading causes of functional disability due to aging populations and extended life expectancy. Diagnosis, treatment, and rehabilitation currently depend on the behavior observed in a clinical environment. After the patient leaves the clinic, there is no standard approach to continuously monitor the patient and report potential problems. Furthermore, self-recording is inconvenient and unreliable. To address these challenges, wearable health monitoring is emerging as an effective way to augment clinical care for movement disorders.
Wearable devices are being used in many health, fitness, and activity monitoring applications. However, their widespread adoption has been hindered by several adaptation and technical challenges. First, conventional rigid devices are uncomfortable to wear for long periods. Second, wearable devices must operate under very low-energy budgets due to their small battery capacities. Small batteries create a need for frequent recharging, which in turn leads users to stop using them. Third, the usefulness of wearable devices must be demonstrated through high impact applications such that users can get value out of them.
This dissertation presents solutions to solving the challenges faced by wearable devices. First, it presents an open-source hardware/software platform for wearable health monitoring. The proposed platform uses flexible hybrid electronics to enable devices that conform to the shape of the user’s body. Second, it proposes an algorithm to enable recharge-free operation of wearable devices that harvest energy from the environment. The proposed solution maximizes the performance of the wearable device under minimum energy constraints. The results of the proposed algorithm are, on average, within 3% of the optimal solution computed offline. Third, a comprehensive framework for human activity recognition (HAR), one of the first steps towards a solution for movement disorders is presented. It starts with an online learning framework for HAR. Experiments on a low power IoT device (TI-CC2650 MCU) with twenty-two users show 95% accuracy in identifying seven activities and their transitions with less than 12.5 mW power consumption. The online learning framework is accompanied by a transfer learning approach for HAR that determines the number of neural network layers to transfer among uses to enable efficient online learning. Next, a technique to co-optimize the accuracy and active time of wearable applications by utilizing multiple design points with different energy-accuracy trade-offs is presented. The proposed technique switches between the design points at runtime to maximize a generalized objective function under tight harvested energy budget constraints. Finally, we present the first ultra-low-energy hardware accelerator that makes it practical to perform HAR on energy harvested from wearable devices. The accelerator consumes 22.4 microjoules per operation using a commercial 65 nm technology. In summary, the solutions presented in this dissertation can enable the wider adoption of wearable devices.
Wearable devices are being used in many health, fitness, and activity monitoring applications. However, their widespread adoption has been hindered by several adaptation and technical challenges. First, conventional rigid devices are uncomfortable to wear for long periods. Second, wearable devices must operate under very low-energy budgets due to their small battery capacities. Small batteries create a need for frequent recharging, which in turn leads users to stop using them. Third, the usefulness of wearable devices must be demonstrated through high impact applications such that users can get value out of them.
This dissertation presents solutions to solving the challenges faced by wearable devices. First, it presents an open-source hardware/software platform for wearable health monitoring. The proposed platform uses flexible hybrid electronics to enable devices that conform to the shape of the user’s body. Second, it proposes an algorithm to enable recharge-free operation of wearable devices that harvest energy from the environment. The proposed solution maximizes the performance of the wearable device under minimum energy constraints. The results of the proposed algorithm are, on average, within 3% of the optimal solution computed offline. Third, a comprehensive framework for human activity recognition (HAR), one of the first steps towards a solution for movement disorders is presented. It starts with an online learning framework for HAR. Experiments on a low power IoT device (TI-CC2650 MCU) with twenty-two users show 95% accuracy in identifying seven activities and their transitions with less than 12.5 mW power consumption. The online learning framework is accompanied by a transfer learning approach for HAR that determines the number of neural network layers to transfer among uses to enable efficient online learning. Next, a technique to co-optimize the accuracy and active time of wearable applications by utilizing multiple design points with different energy-accuracy trade-offs is presented. The proposed technique switches between the design points at runtime to maximize a generalized objective function under tight harvested energy budget constraints. Finally, we present the first ultra-low-energy hardware accelerator that makes it practical to perform HAR on energy harvested from wearable devices. The accelerator consumes 22.4 microjoules per operation using a commercial 65 nm technology. In summary, the solutions presented in this dissertation can enable the wider adoption of wearable devices.
ContributorsBhat, Ganapati (Author) / Ogras, Umit Y. (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Nedić, Angelia (Committee member) / Marculescu, Radu (Committee member) / Arizona State University (Publisher)
Created2020
Description
Current exosuit technologies utilizing soft inflatable actuators for gait assistance have drawbacks of having slow dynamics and limited portability. The first part of this thesis focuses on addressing the aforementioned issues by using inflatable actuator composites (IAC) and a portable pneumatic source. Design, fabrication and finite element modeling of the IAC are presented. Volume optimization of the IAC is done by varying its internal volume using finite element methods. A portable air source for use in pneumatically actuated wearable devices is also presented. Evaluation of the system is carried out by analyzing its maximum pressure and flow output. Electro-pneumatic setup, design and fabrication of the developed air source are also shown. To provide assistance to the user using the exosuit in appropriate gait phases, a gait detection system is needed. In the second part of this thesis, a gait sensing system utilizing soft fabric based inflatable sensors embedded in a silicone based shoe insole is developed. Design, fabrication and mechanical characterization of the soft gait detection sensors are given. In addition, integration of the sensors, each capable of measuring loads of 700N in a silicone based shoe insole is also shown along with its possible application in detection of various gait phases. Finally, a possible integration of the actuators, air source and gait detection shoes in making of a portable soft exosuit for knee assistance is given.
Contributorspoddar, souvik (Author) / Zhang, Wenlong (Thesis advisor) / Lee, Hyunglae (Committee member) / Marvi, Hamidreza (Committee member) / Arizona State University (Publisher)
Created2020