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- All Subjects: Applied physics
- Creators: Chamberlin, Ralph
Description
The challenge of radiation therapy is to maximize the dose to the tumor while simultaneously minimizing the dose elsewhere. Proton therapy is well suited to this challenge due to the way protons slow down in matter. As the proton slows down, the rate of energy loss per unit path length continuously increases leading to a sharp dose near the end of range. Unlike conventional radiation therapy, protons stop inside the patient, sparing tissue beyond the tumor. Proton therapy should be superior to existing modalities, however, because protons stop inside the patient, there is uncertainty in the range. “Range uncertainty” causes doctors to take a conservative approach in treatment planning, counteracting the advantages offered by proton therapy. Range uncertainty prevents proton therapy from reaching its full potential.
A new method of delivering protons, pencil-beam scanning (PBS), has become the new standard for treatment over the past few years. PBS utilizes magnets to raster scan a thin proton beam across the tumor at discrete locations and using many discrete pulses of typically 10 ms duration each. The depth is controlled by changing the beam energy. The discretization in time of the proton delivery allows for new methods of dose verification, however few devices have been developed which can meet the bandwidth demands of PBS.
In this work, two devices have been developed to perform dose verification and monitoring with an emphasis placed on fast response times. Measurements were performed at the Mayo Clinic. One detector addresses range uncertainty by measuring prompt gamma-rays emitted during treatment. The range detector presented in this work is able to measure the proton range in-vivo to within 1.1 mm at depths up to 11 cm in less than 500 ms and up to 7.5 cm in less than 200 ms. A beam fluence detector presented in this work is able to measure the position and shape of each beam spot. It is hoped that this work may lead to a further maturation of detection techniques in proton therapy, helping the treatment to reach its full potential to improve the outcomes in patients.
A new method of delivering protons, pencil-beam scanning (PBS), has become the new standard for treatment over the past few years. PBS utilizes magnets to raster scan a thin proton beam across the tumor at discrete locations and using many discrete pulses of typically 10 ms duration each. The depth is controlled by changing the beam energy. The discretization in time of the proton delivery allows for new methods of dose verification, however few devices have been developed which can meet the bandwidth demands of PBS.
In this work, two devices have been developed to perform dose verification and monitoring with an emphasis placed on fast response times. Measurements were performed at the Mayo Clinic. One detector addresses range uncertainty by measuring prompt gamma-rays emitted during treatment. The range detector presented in this work is able to measure the proton range in-vivo to within 1.1 mm at depths up to 11 cm in less than 500 ms and up to 7.5 cm in less than 200 ms. A beam fluence detector presented in this work is able to measure the position and shape of each beam spot. It is hoped that this work may lead to a further maturation of detection techniques in proton therapy, helping the treatment to reach its full potential to improve the outcomes in patients.
ContributorsHolmes, Jason M (Author) / Alarcon, Ricardo (Thesis advisor) / Bues, Martin (Committee member) / Galyaev, Eugene (Committee member) / Chamberlin, Ralph (Committee member) / Arizona State University (Publisher)
Created2019
Description
The work covered in this dissertation addresses two areas revolving around superconducting nanowire detector development. The first is regarding array architectureused for a large-scale system. The second involves operating under conditions that
allow for a linear response in a superconducting nanowire detector. This dissertation
provides the relevant theory, design, and measurements to characterize these detectors. The array architecture studied here utilizes a superconducting nanowire single
photon detector embedded in an LC resonant structure, allowing multiple pixels to
couple to a single transmission line and identify each one by a tuned characteristic frequency. The pixels in the array are DC-biased, allowing them to respond to absorbed
single photons and avoiding any dead time associated with RF biasing. Measured
results from a 16-pixel array based on chip components are analyzed. The development here directs this architecture towards integrating a proven 16-pixel design onto
a single substrate with the capacity to scale to a higher pixel count and integrate
into a broad range of applications. This text outlines the theory behind the proposed
linear operation regime and details the considerations needed to achieve a response.
The basic principle relies on the time-dependent change in kinetic inductance due to
an absorbed photon. Under the conditions discussed in the text, this would allow
for fast photon number resolution. However, without reaching those conditions, the
detector may still operate under a higher incident photon flux. Two device designs
are formulated and simulated, weighing the benefits and drawbacks of each approach.
One of the device designs uses an impedance-matching taper to minimize reflections
between the nanowire and 50 Ohm amplifier. The other design utilizes N parallel
nanowires spanning the length of a gap along a 50 Ohm transmission line path. The
tapered device is realized to a proof-of-principle stage and measured under conditions
that set a limit on the device’s linear response to optical power. The performance of this detector points to areas of improvement that are addressed or circumvented
in the parallel bridge design. Potential for future development is discussed for the
frequency multiplexed superconducting nanowire single photon detector array and
the linear mode detector.
ContributorsGlasby, Jacob (Author) / Mauskopf, Philip (Thesis advisor) / Chamberlin, Ralph (Committee member) / Schmidt, Kevin (Committee member) / Trichopoulos, Georgios (Committee member) / Arizona State University (Publisher)
Created2023