Matching Items (2)
Filtering by
- All Subjects: Science history
- Creators: Broglio, Ronald
Description
Systems biology studies complex biological systems. It is an interdisciplinary field, with biologists working with non-biologists such as computer scientists, engineers, chemists, and mathematicians to address research problems applying systems’ perspectives. How these different researchers and their disciplines differently contributed to the advancement of this field over time is a question worth examining. Did systems biology become a systems-oriented science or a biology-oriented science from 1992 to 2013?
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
This project utilized computational tools to analyze large data sets and interpreted the results from historical and philosophical perspectives. Tools deployed were derived from scientometrics, corpus linguistics, text-based analysis, network analysis, and GIS analysis to analyze more than 9000 articles (metadata and text) on systems biology. The application of these tools to a HPS project represents a novel approach.
The dissertation shows that systems biology has transitioned from a more mathematical, computational, and engineering-oriented discipline focusing on modeling to a more biology-oriented discipline that uses modeling as a means to address real biological problems. Also, the results show that bioengineering and medical research has increased within systems biology. This is reflected in the increase of the centrality of biology-related concepts such as cancer, over time. The dissertation also compares the development of systems biology in China with some other parts of the world, and reveals regional differences, such as a unique trajectory of systems biology in China related to a focus on traditional Chinese medicine.
This dissertation adds to the historiography of modern biology where few studies have focused on systems biology compared with the history of molecular biology and evolutionary biology.
ContributorsZou, Yawen (Author) / Laubichler, Manfred (Thesis advisor) / Maienschein, Jane (Thesis advisor) / Creath, Richard (Committee member) / Ellison, Karin (Committee member) / Newfeld, Stuart (Committee member) / Arizona State University (Publisher)
Created2016
Description
At the beginning of the nineteenth century, there was no universal term to describe a person who practiced science. In 1833, the term “scientist” was proposed to recognize these individuals, but exactly who was represented by this term was still ambiguous. Supported by Bruno Latour’s theory of networks and hybridity, The Emerging Scientist takes a historical approach to analyze the different collectives of individuals who influenced the cultural perception of science and therefore aided in defining the role of the emerging scientist during the nineteenth century.
Each chapter focuses on a collective in the science network that influenced the development of the scientist across the changing scientific landscape of the nineteenth century. Through a study of William Small and Herbert Spencer, the first chapter investigates the informal clubs that prove to be highly influential due, in part, to the freedom individuals gain by being outside of formal institutions. Through an investigation of the lives and works of professional astronomer, Caroline Herschel, and physicist and mathematician, James Clerk Maxwell, chapter two analyzes the collective of professional practitioners of science to unveil the way in which scientific advancement actually occurred. Chapter three argues for the role of women in democratizing science and expanding the pool from which future scientists would come through a close analysis of Jane Marcet and Agnes Clerke, members of the collective of female popularizers of science. The final chapter examines how the collective of fictional depictions of science and the scientist ultimately are part of the cultural perception of the scientist through a close reading of Shelley’s Alastor; or, the Spirit of Solitude and Wilde’s The Picture of Dorian Gray. Ultimately, The Emerging Scientist aims to recreate the way science is studied in order to generate a more comprehensive understanding of the influences on developing science and the scientist during the nineteenth century.
Each chapter focuses on a collective in the science network that influenced the development of the scientist across the changing scientific landscape of the nineteenth century. Through a study of William Small and Herbert Spencer, the first chapter investigates the informal clubs that prove to be highly influential due, in part, to the freedom individuals gain by being outside of formal institutions. Through an investigation of the lives and works of professional astronomer, Caroline Herschel, and physicist and mathematician, James Clerk Maxwell, chapter two analyzes the collective of professional practitioners of science to unveil the way in which scientific advancement actually occurred. Chapter three argues for the role of women in democratizing science and expanding the pool from which future scientists would come through a close analysis of Jane Marcet and Agnes Clerke, members of the collective of female popularizers of science. The final chapter examines how the collective of fictional depictions of science and the scientist ultimately are part of the cultural perception of the scientist through a close reading of Shelley’s Alastor; or, the Spirit of Solitude and Wilde’s The Picture of Dorian Gray. Ultimately, The Emerging Scientist aims to recreate the way science is studied in order to generate a more comprehensive understanding of the influences on developing science and the scientist during the nineteenth century.
ContributorsSoutherly, Kaitlin (Author) / Lussier, Mark (Thesis advisor) / Broglio, Ronald (Committee member) / Bivona, Daniel (Committee member) / Arizona State University (Publisher)
Created2016