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"Wide adaptation" is an agricultural concept often employed and seldom closely examined. Norman E. Borlaug, while working for the Rockefeller Foundation (RF) on an agricultural project in Mexico in the 1950s, discovered that some tropical wheat varieties could be grown over broad geographic regions, not just in Central and South

"Wide adaptation" is an agricultural concept often employed and seldom closely examined. Norman E. Borlaug, while working for the Rockefeller Foundation (RF) on an agricultural project in Mexico in the 1950s, discovered that some tropical wheat varieties could be grown over broad geographic regions, not just in Central and South America but also in the Middle East and South Asia. He called this wide, or broad, adaptation, which scientists generally define as a plant type that has high yields throughout diverse environments. Borlaug soon made wide adaptation as a core pillar of his international wheat program. Borlaug's wheat program rapidly expanded in the 1960s, and he and his colleagues from the RF heavily promoted wide adaptation and the increased use of fertilizers in the Middle East and India. These events led to the green revolution, when several countries rapidly increased their wheat production. Indian wheat cultivation changed radically in the 1960s due to new technologies and policy reforms introduced during the green revolution, and farmers' adoption of 'technology packages' of modern seeds, fertilizer, and irrigation.

Just prior to the green revolution, Indian wheat scientists adopted Borlaug’s new plant breeding philosophy—that varieties should have as wide an adaptation as possible. But Borlaug and Indian wheat scientists also argued that wide adaptation could be achieved by selecting only plants that did well in high fertility and irrigated environments. Scientists claimed, in many cases erroneously, that widely adapted varieties still produced high yields in marginal, or resource poor, areas. Many people have criticized the green revolution for its unequal spread of benefits, but none of these critiques address wide adaptation—the core tenant held by Indian wheat scientists to justify their focus on highly productive land while ignoring marginal and rainfed agriculture. My dissertation describes Borlaug and the RF's research program in wide adaptation, Borlaug's involvement in the Indian wheat program, and internal debates about wide adaptation and selection under favorable environments among Indian scientists. It argues that scientists leveraged the concept of wide adaptation to justify a particular regime of research focused on high production agriculture, and that the footprints of this regime are still present in Indian agriculture.
ContributorsBaranski, Marcin (Author) / Kinzig, Ann P. (Thesis advisor) / Mathur, Prem N. (Committee member) / Eakin, Hallie (Committee member) / Sarewitz, Daniel (Committee member) / Wetmore, Jameson (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Atrial fibrillation (AF) is the most common abnormal heart rhythm, affecting

nearly 2% of the world’s population at a cost of $26 Billion in the United States annually, and incalculable costs worldwide. AF causes no symptoms for some people. However, others with AF experience uncomfortable symptoms including palpitations, breathlessness, dizziness, and

Atrial fibrillation (AF) is the most common abnormal heart rhythm, affecting

nearly 2% of the world’s population at a cost of $26 Billion in the United States annually, and incalculable costs worldwide. AF causes no symptoms for some people. However, others with AF experience uncomfortable symptoms including palpitations, breathlessness, dizziness, and fatigue. AF can severely diminish quality of life for both AF sufferers and their loved ones. Beyond uncomfortable symptoms, AF is also linked to congestive heart failure and stroke, both of which can cause premature death. Medications often fail to control AF, leading patients and healthcare providers to seek other cures, including catheter ablation. To date, catheter ablation has yielded uneven results, but garners much attention in research and innovation in pursuit of a cure for AF. This dissertation examines the historical development and contemporary practices of AF ablation to identify opportunities to improve the innovation system for the disease. First, I trace the history of AF and AF ablation knowledge from the 2nd century B.C.E. through the present. This historical look identifies patterns of knowledge co-development between science, technology, and technique, as well as publication patterns impacting knowledge dissemination. Second, I examine the current practices of AF ablation knowledge translation from the perspective of clinical practitioners to characterize the demand-side of knowledge translation in real-world practice. Demand-side knowledge translation occurs in nested patterns, and requires data, experience, and trust in order to incorporate knowledge into a practice paradigm. Third, I use social network mapping and analysis to represent the full AF ablation knowledge-practice system and identify

opportunities to modify research and innovation practice in AF ablation based on i

measures of centrality and power. Finally, I outline six linked recommendations using raw data capture during ablation procedures and open big data analytics, coupled with multi-stakeholder social networking approaches, to maximize innovation potential in AF ablation research and practice.
ContributorsRoss, Heather M (Author) / Hackett, Edward J (Thesis advisor) / Hurlbut, James B (Thesis advisor) / Sarewitz, Daniel (Committee member) / Miller, Clark A. (Committee member) / Arizona State University (Publisher)
Created2016