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- All Subjects: Behavioral psychology
- Creators: Robles-Sotelo, Elias
- Creators: Aiken, Leona S.
Description
Aging and the menopause transition are both intricately linked to cognitive changes
during mid-life and beyond. Clinical literature suggests the age at menopause onset can differentially impact cognitive status later in life. Yet, little is known about the relationship between behavioral and brain changes that occur during the transitional stage into the post-menopausal state. Much of the pre-clinical work evaluating an animal model of menopause involves ovariectomy in rodents; however, ovariectomy results in an abrupt loss of circulating hormones and ovarian tissue, limiting the ability to evaluate gradual follicular depletion. The 4-vinylcyclohexene diepoxide (VCD) model simulates transitional menopause in rodents by selectively depleting the immature ovarian follicle reserve and allowing animals to retain their follicle-deplete ovarian tissue, resulting in a profile similar to the majority of menopausal women. Here, Vehicle or VCD treatment was administered to ovary-intact adult and middle-aged Fischer-344 rats to assess the cognitive effects of transitional menopause via VCD-induced follicular depletion over time, as well as to understand potential interactions with age, with VCD treatment beginning at either six or twelve months of age. Results indicated that subjects that experience menopause onset at a younger age had impaired spatial working memory early in the transition to a follicle-deplete state. Moreover, in the mid- and post- menopause time points, VCD-induced follicular depletion amplified an age effect, whereby Middle-Aged VCD-treated animals had poorer spatial working and reference memory performance than Young VCD-treated animals. Correlations suggested that in middle age, animals with higher circulating estrogen levels tended to perform better on spatial memory tasks. Overall, these findings suggest that the age at menopause onset is a critical parameter to consider when evaluating learning and memory across the transition to reproductive senescence. From a translational perspective, this study informs the field with respect to how the age at menopause onset might impact cognition in menopausal women, as well as provides insight into time points to explore for the window of opportunity for hormone therapy during the menopause transition to attenuate age- and menopause- related cognitive decline, and produce healthy brain aging profiles in women who retain their ovaries throughout the lifespan.
during mid-life and beyond. Clinical literature suggests the age at menopause onset can differentially impact cognitive status later in life. Yet, little is known about the relationship between behavioral and brain changes that occur during the transitional stage into the post-menopausal state. Much of the pre-clinical work evaluating an animal model of menopause involves ovariectomy in rodents; however, ovariectomy results in an abrupt loss of circulating hormones and ovarian tissue, limiting the ability to evaluate gradual follicular depletion. The 4-vinylcyclohexene diepoxide (VCD) model simulates transitional menopause in rodents by selectively depleting the immature ovarian follicle reserve and allowing animals to retain their follicle-deplete ovarian tissue, resulting in a profile similar to the majority of menopausal women. Here, Vehicle or VCD treatment was administered to ovary-intact adult and middle-aged Fischer-344 rats to assess the cognitive effects of transitional menopause via VCD-induced follicular depletion over time, as well as to understand potential interactions with age, with VCD treatment beginning at either six or twelve months of age. Results indicated that subjects that experience menopause onset at a younger age had impaired spatial working memory early in the transition to a follicle-deplete state. Moreover, in the mid- and post- menopause time points, VCD-induced follicular depletion amplified an age effect, whereby Middle-Aged VCD-treated animals had poorer spatial working and reference memory performance than Young VCD-treated animals. Correlations suggested that in middle age, animals with higher circulating estrogen levels tended to perform better on spatial memory tasks. Overall, these findings suggest that the age at menopause onset is a critical parameter to consider when evaluating learning and memory across the transition to reproductive senescence. From a translational perspective, this study informs the field with respect to how the age at menopause onset might impact cognition in menopausal women, as well as provides insight into time points to explore for the window of opportunity for hormone therapy during the menopause transition to attenuate age- and menopause- related cognitive decline, and produce healthy brain aging profiles in women who retain their ovaries throughout the lifespan.
ContributorsKoebele, Stephanie Victoria (Author) / Bimonte-Nelson, Heather A. (Thesis advisor) / Aiken, Leona S. (Committee member) / Conrad, Cheryl D. (Committee member) / Wynne, Clive DL (Committee member) / Arizona State University (Publisher)
Created2015
Description
Loss aversion manifests as a decision bias in which avoiding losses is preferred over acquiring rewards and can drastically alter an individual’s decision-making by overweighting potential losses relative to gains of equal magnitude. Consequently, individuals may require greater positive compensation to offset potential losses, exhibit contradictory choice preferences, or even avoid the decision entirely; and this behavior may be ascribed to an over-reliance on automatic, unconscious (intuitive) judgments rather than initiating analytic reasoning more capable of objectively evaluating outcomes.
Religion (specifically Christianity) is the topic of focus, as preliminary evidence suggests an individual’s intuitive inclinations positively correlate with and predict religious beliefs. Moreover, self-reported religious beliefs significantly differed as a function of inducing either intuitive or reflective mindsets. Therefore, the purpose of this experiment was to test the hypothesis that religious participants will display significantly greater levels of loss aversion than nonreligious participants.
This hypothesis extends from a previous study relating large-scale cultural and religious differences with loss aversion. While their results revealed religious orthodoxy strongly influenced loss aversion, the parameters elicited may be less stable as only two lottery questions were asked and religion was determined by cultural demographics. This study used the same design, but with a total of ten lotteries and a more detailed investigation into individual religious factors.
While loss aversion coefficients replicated the overall behavioral effect (Median θ = 2.6), independent sample, Mann-Whitney U tests did not yield any significant differences between Christian and Nonreligious participants (p > 0.05); nor did any of the religious factors examined account for a significant amount of variability.
This study attempted to add to current knowledge by further conflating the relationship between religiosity and adaptive decision strategies susceptible to errant and inconsistent behavior. While the hypotheses were unsupported, a null finding is still important, and future research re-testing this association or introducing causational designs may prove more fruitful in understanding these complex relationships.
Religion (specifically Christianity) is the topic of focus, as preliminary evidence suggests an individual’s intuitive inclinations positively correlate with and predict religious beliefs. Moreover, self-reported religious beliefs significantly differed as a function of inducing either intuitive or reflective mindsets. Therefore, the purpose of this experiment was to test the hypothesis that religious participants will display significantly greater levels of loss aversion than nonreligious participants.
This hypothesis extends from a previous study relating large-scale cultural and religious differences with loss aversion. While their results revealed religious orthodoxy strongly influenced loss aversion, the parameters elicited may be less stable as only two lottery questions were asked and religion was determined by cultural demographics. This study used the same design, but with a total of ten lotteries and a more detailed investigation into individual religious factors.
While loss aversion coefficients replicated the overall behavioral effect (Median θ = 2.6), independent sample, Mann-Whitney U tests did not yield any significant differences between Christian and Nonreligious participants (p > 0.05); nor did any of the religious factors examined account for a significant amount of variability.
This study attempted to add to current knowledge by further conflating the relationship between religiosity and adaptive decision strategies susceptible to errant and inconsistent behavior. While the hypotheses were unsupported, a null finding is still important, and future research re-testing this association or introducing causational designs may prove more fruitful in understanding these complex relationships.
ContributorsHowatt, Brian (Author) / Robles-Sotelo, Elias (Thesis advisor) / Vargas, Perla (Committee member) / Neal, Tess (Committee member) / Arizona State University (Publisher)
Created2017
Description
Magnocellular-Dorsal pathway’s function had been related to reading ability, and visual perceptual learning can effectively increase the function of this neural pathway. Previous researches training people with a traditional dot motion paradigm and an integrated visual perceptual training “video game” called Ultimeyes pro, all showed improvement with regard to people’s reading performance. This research used 2 paradigms in 2 groups in order to compare the 2 paradigms’ effect on improving people’s reading ability. We also measured participants’ critical flicker fusion threshold (CFFT), which is related to word decoding ability. The result did not show significant improvement of reading performance in each group, but overall the reading speed improved significantly. The result for CFFT in each group only showed significant improvement among people who trained with Ultimeyes pro. This result supports that the beneficial effect of visual perceptual learning training on people’s reading ability, and it suggests that Ultimeyes pro is more efficient than the traditional dot motion paradigm, and might have more application value.
ContributorsZhou, Tianyou (Author) / Nanez, Jose E (Thesis advisor) / Robles-Sotelo, Elias (Committee member) / Duran, Nicholas (Committee member) / Arizona State University (Publisher)
Created2015