Matching Items (45)
Description
Science fiction themed video games, specifically Role Playing Games (RPGs) like Deus Ex: Human Revolution (DX:HR), that focus on an emerging technology, contain features that help to better inform anticipatory governance. In a game like DX:HR, players vicariously experience human-enhancement technology and its societal effects through their in-game character. Acting as the character, the player explores the topic of human-enhancement technology in various ways, including dialogue with non-player characters (NPCs) and decisions that directly affect the game's world. Because Deus Ex: Human Revolution and games similar to it, allow players to explore and think about the technology itself, the stances on it, and its potential societal effects, they facilitate the anticipatory governance process. In this paper I postulate a theory of anticipatory gaming, which asserts that video games inform the anticipatory governance process for an emerging technology. To demonstrate this theory I examine the parts of the anticipatory governance process and demonstrate RPG's ability to inform it, through a case study of Deus Ex: Human Revolution.
ContributorsShedd, Jesse Bernard (Author) / Wetmore, Jameson (Thesis director) / Fisher, Erik (Committee member) / McKnight, John Carter (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2013-05
Description
Laboratory automation systems have seen a lot of technological advances in recent times. As a result, the software that is written for them are becoming increasingly sophisticated. Existing software architectures and standards are targeted to a wider domain of software development and need to be customized in order to use them for developing software for laboratory automation systems. This thesis proposes an architecture that is based on existing software architectural paradigms and is specifically tailored to developing software for a laboratory automation system. The architecture is based on fairly autonomous software components that can be distributed across multiple computers. The components in the architecture make use of asynchronous communication methodologies that are facilitated by passing messages between one another. The architecture can be used to develop software that is distributed, responsive and thread-safe. The thesis also proposes a framework that has been developed to implement the ideas proposed by the architecture. The framework is used to develop software that is scalable, distributed, responsive and thread-safe. The framework currently has components to control very commonly used laboratory automation devices such as mechanical stages, cameras, and also to do common laboratory automation functionalities such as imaging.
ContributorsKuppuswamy, Venkataramanan (Author) / Meldrum, Deirdre (Thesis advisor) / Collofello, James (Thesis advisor) / Sarjoughian, Hessam S. (Committee member) / Johnson, Roger (Committee member) / Arizona State University (Publisher)
Created2012
Description
Single cell analysis has become increasingly important in understanding disease onset, progression, treatment and prognosis, especially when applied to cancer where cellular responses are highly heterogeneous. Through the advent of single cell computerized tomography (Cell-CT), researchers and clinicians now have the ability to obtain high resolution three-dimensional (3D) reconstructions of single cells. Yet to date, no live-cell compatible version of the technology exists. In this thesis, a microfluidic chip with the ability to rotate live single cells in hydrodynamic microvortices about an axis parallel to the optical focal plane has been demonstrated. The chip utilizes a novel 3D microchamber design arranged beneath a main channel creating flow detachment into the chamber, producing recirculating flow conditions. Single cells are flowed through the main channel, held in the center of the microvortex by an optical trap, and rotated by the forces induced by the recirculating fluid flow. Computational fluid dynamics (CFD) was employed to optimize the geometry of the microchamber. Two methods for the fabrication of the 3D microchamber were devised: anisotropic etching of silicon and backside diffuser photolithography (BDPL). First, the optimization of the silicon etching conditions was demonstrated through design of experiment (DOE). In addition, a non-conventional method of soft-lithography was demonstrated which incorporates the use of two positive molds, one of the main channel and the other of the microchambers, compressed together during replication to produce a single ultra-thin (<200 µm) negative used for device assembly. Second, methods for using thick negative photoresists such as SU-8 with BDPL have been developed which include a new simple and effective method for promoting the adhesion of SU-8 to glass. An assembly method that bonds two individual ultra-thin (<100 µm) replications of the channel and the microfeatures has also been demonstrated. Finally, a pressure driven pumping system with nanoliter per minute flow rate regulation, sub-second response times, and < 3% flow variability has been designed and characterized. The fabrication and assembly of this device is inexpensive and utilizes simple variants of conventional microfluidic fabrication techniques, making it easily accessible to the single cell analysis community.
ContributorsMyers, Jakrey R (Author) / Meldrum, Deirdre (Thesis advisor) / Johnson, Roger (Committee member) / Frakes, David (Committee member) / Arizona State University (Publisher)
Created2012
DescriptionThis research evaluates the national HIV/AIDS policy of Ghana and compares it to the policies of other countries in the Economic Community of West African States.
ContributorsAlcaraz, Hailey Elizabeth (Author) / Alozie, Nicholas (Thesis director) / Fisher, Erik (Committee member) / Rothenberg, Daniel (Committee member) / Barrett, The Honors College (Contributor) / School of Community Resources and Development (Contributor) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2013-05
Description
In the digital humanities, there is a constant need to turn images and PDF files into plain text to apply analyses such as topic modelling, named entity recognition, and other techniques. However, although there exist different solutions to extract text embedded in PDF files or run OCR on images, they typically require additional training (for example, scholars have to learn how to use the command line) or are difficult to automate without programming skills. The Giles Ecosystem is a distributed system based on Apache Kafka that allows users to upload documents for text and image extraction. The system components are implemented using Java and the Spring Framework and are available under an Open Source license on GitHub (https://github.com/diging/).
ContributorsLessios-Damerow, Julia (Contributor) / Peirson, Erick (Contributor) / Laubichler, Manfred (Contributor) / ASU-SFI Center for Biosocial Complex Systems (Contributor)
Created2017-09-28
Description
Background
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are inherently 3D and thus poorly characterized in 2D. Our goal is to quantitatively characterize nuclear structure in 3D, assess its variation with malignancy, and investigate whether such variation correlates with standard nuclear grading criteria.
Methodology
We applied micro-optical computed tomographic imaging and automated 3D nuclear morphometry to quantify and compare morphological variations between human cell lines derived from normal, benign fibrocystic or malignant breast epithelium. To reproduce the appearance and contrast in clinical cytopathology images, we stained cells with hematoxylin and eosin and obtained 3D images of 150 individual stained cells of each cell type at sub-micron, isotropic resolution. Applying volumetric image analyses, we computed 42 3D morphological and textural descriptors of cellular and nuclear structure.
Principal Findings
We observed four distinct nuclear shape categories, the predominant being a mushroom cap shape. Cell and nuclear volumes increased from normal to fibrocystic to metastatic type, but there was little difference in the volume ratio of nucleus to cytoplasm (N/C ratio) between the lines. Abnormal cell nuclei had more nucleoli, markedly higher density and clumpier chromatin organization compared to normal. Nuclei of non-tumorigenic, fibrocystic cells exhibited larger textural variations than metastatic cell nuclei. At p<0.0025 by ANOVA and Kruskal-Wallis tests, 90% of our computed descriptors statistically differentiated control from abnormal cell populations, but only 69% of these features statistically differentiated the fibrocystic from the metastatic cell populations.
Conclusions
Our results provide a new perspective on nuclear structure variations associated with malignancy and point to the value of automated quantitative 3D nuclear morphometry as an objective tool to enable development of sensitive and specific nuclear grade classification in breast cancer diagnosis.
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are inherently 3D and thus poorly characterized in 2D. Our goal is to quantitatively characterize nuclear structure in 3D, assess its variation with malignancy, and investigate whether such variation correlates with standard nuclear grading criteria.
Methodology
We applied micro-optical computed tomographic imaging and automated 3D nuclear morphometry to quantify and compare morphological variations between human cell lines derived from normal, benign fibrocystic or malignant breast epithelium. To reproduce the appearance and contrast in clinical cytopathology images, we stained cells with hematoxylin and eosin and obtained 3D images of 150 individual stained cells of each cell type at sub-micron, isotropic resolution. Applying volumetric image analyses, we computed 42 3D morphological and textural descriptors of cellular and nuclear structure.
Principal Findings
We observed four distinct nuclear shape categories, the predominant being a mushroom cap shape. Cell and nuclear volumes increased from normal to fibrocystic to metastatic type, but there was little difference in the volume ratio of nucleus to cytoplasm (N/C ratio) between the lines. Abnormal cell nuclei had more nucleoli, markedly higher density and clumpier chromatin organization compared to normal. Nuclei of non-tumorigenic, fibrocystic cells exhibited larger textural variations than metastatic cell nuclei. At p<0.0025 by ANOVA and Kruskal-Wallis tests, 90% of our computed descriptors statistically differentiated control from abnormal cell populations, but only 69% of these features statistically differentiated the fibrocystic from the metastatic cell populations.
Conclusions
Our results provide a new perspective on nuclear structure variations associated with malignancy and point to the value of automated quantitative 3D nuclear morphometry as an objective tool to enable development of sensitive and specific nuclear grade classification in breast cancer diagnosis.
ContributorsNandakumar, Vivek (Author) / Kelbauskas, Laimonas (Author) / Hernandez, Kathryn (Author) / Lintecum, Kelly (Author) / Senechal, Patti (Author) / Bussey, Kimberly (Author) / Davies, Paul (Author) / Johnson, Roger (Author) / Meldrum, Deirdre (Author) / Ira A. Fulton Schools of Engineering (Contributor) / School of Electrical, Computer and Energy Engineering (Contributor) / Biodesign Institute (Contributor) / Center for Biosignatures Discovery Automation (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / Department of Physics (Contributor)
Created2012-01-05
Description
Because collective cognition emerges from local signaling among group members, deciphering communication systems is crucial to understanding the underlying mechanisms. Alarm signals are widespread in the social insects and can elicit a variety of behavioral responses to danger, but the functional plasticity of these signals has not been well studied. Here we report an alarm pheromone in the ant Temnothorax rugatulus that elicits two different behaviors depending on context. When an ant was tethered inside an unfamiliar nest site and unable to move freely, she released a pheromone from her mandibular gland that signaled other ants to reject this nest as a potential new home, presumably to avoid potential danger. When the same pheromone was presented near the ants' home nest, they were instead attracted to it, presumably to respond to a threat to the colony. We used coupled gas chromatography/mass spectrometry to identify candidate compounds from the mandibular gland and tested each one in a nest choice bioassay. We found that 2,5-dimethylpyrazine was sufficient to induce rejection of a marked new nest and also to attract ants when released at the home nest. This is the first detailed investigation of chemical communication in the leptothoracine ants. We discuss the possibility that this pheromone's deterrent function can improve an emigrating colony's nest site selection performance.
ContributorsSasaki, Takao (Author) / Hoelldobler, Bert (Author) / Millar, Jocelyn G. (Author) / Pratt, Stephen (Author) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor) / ASU-SFI Center for Biosocial Complex Systems (Contributor) / Center for Social Dynamics and Complexity (Contributor)
Created2014-09-01
Description
The governance of natural resources often gets implicitly or explicitly shaped by the knowledge systems that are invoked for making decisions. These knowledge systems reflect the underlying notions of how human-nature relationships are conceived and operationalized by different stakeholders in the governance system. Conflicts in the science-policy interface in environmental governance arise when specific conceptions of nature dominate over other ways of knowing, when stakeholders with representing different knowledge systems have disproportionate degrees of influence in policymaking spaces, or when certain stakeholders are deracinated from their resources and long-held knowledge traditions. This dissertation examines the epistemic conflicts that exist in the Indian forestry that have led to a situation of policy stalemate in the governance system and continue to perpetuate colonial systems of scientific forestry and marginalize local knowledge traditions. To do so, this dissertation analyzes three datasets to understand the extent and consequences of this conflict in the forestry sciences in Indian academia. First, scientific discourses on the Indian Forest Rights Act are examined to understand the normative and epistemic practices that lead to differences in perspectives and scientific positions on forest governance. Second, the forest policy literature is analyzed using bibliometrics techniques to identify the intellectual and social silos in forestry sciences in India. Third, interview data from Indian forest scientists is analyzed to understand the inequalities within the science-policy interface in Indian forestry and how these perpetuate colonial legacies of forestry science. This dissertation concludes with recommendations and future pathways for knowledge integration and policy deliberations to make more decolonial, inclusive, and sustainable policies in Indian forestry.
ContributorsBisht, Vanya (Author) / Chhetri, Nalini (Thesis advisor) / Fisher, Erik (Thesis advisor) / Berbés-Blázquez, Marta (Committee member) / Arizona State University (Publisher)
Created2022
Description
ABSTRACT
Despite a recognized need for corporations to take greater social responsibility, such responsibility is often lacking in the decisions of corporate America. This lack of attention to social responsibility has numerous implications, not least for the US workforce. Additionally, the workforce itself has a potential role to play in implementing social responsibility. Workers are partly responsible for actions causing negative effects; however, organizations tend to avoid addressing the negative effects as a form of organized irresponsibility. This dissertation examines decisions and actions related to the worker, their work roles, and within their organization. It aims to understand to what extent workers can function as change agents in aligning their organizations with social responsibility as it relates to organizational missions. The methodological approach used to gather data for this dissertation is Socio-Technical Integration Research (STIR), and the framework used to analyze the data is Midstream Modulation. The dissertation advances the STIR methodology in several respects as a result of studying technology startups with a focus towards organizational effects. These advances include measuring how modulations within individual workers’ decisions have outcomes at the organizational level or across multiple departments. Examples of such “organizational modulations” can be seen in two of the three studies at the core of this dissertation. Additionally, I demonstrate that multiple reflexive modulations can be involved in modulation sequences and that modulation sequences can be nested in relation to one another.
Furthermore, I present the Collaborative Change Agent Model, which may possibly be utilized to further discuss decisions and embed concepts such as social responsibility and Responsible Innovation in an individual worker’s decision-making process.
ContributorsZaveri, Shivam Rajeshbhai (Author) / Fisher, Erik (Thesis advisor) / Nadesan, Majia (Committee member) / Maynard, Andrew (Committee member) / Arizona State University (Publisher)
Created2023
Description
Crises at Teton Dam in 1976, Roosevelt Dam in 1980, Tempe Town Lake Dam in 2010, Oroville Dam in 2017, and the Edenville and Sanford Dams in 2020 prove the substantial and continuing threats to communities posed by major dams. Sociotechnical systems of dams encompass both social or governance characteristics as well as the technical or architectural characteristics. To reduce or overcome chances of failure, experts traditionally focus on making the architectural characteristics of dams safe from potential modes of failure. However, governance characteristics such as laws, building codes, and emergency actions plans also affect the ability of systems of dams that include downstream communities to sustainably adapt to crises. Increasingly, emerging threats such as climate change, earthquakes, terrorism, cyberattacks, or wildfires worsen known modes of failure such as overtopping.Considering these emerging threats, my research assesses whether the architectural and governance characteristics of the aging population of systems of dams in the United States can sustainably adapt to challenges posed by emerging threats. First, by analyzing architectural characteristics of dams, my research provides a useful definition of infrastructures of dams. Next, to assess the governance characteristics of dams, I review institutional documents to heuristically outline seven sociotechnical imaginaries and assess whether an eighth based on resilience is appearing. Further, by analyzing interview transcripts and professional conference presentations, and by conducting case studies, my research reveals ways that experts and stakeholders assess the safety and resilience of systems of dams.
The combined findings of these studies suggest that experts and stakeholders are not sufficiently informed about or focused upon important aspects of the resilience of dams. Therefore, they may not be able to sustainably adapt to crises caused or worsened by emerging threats such as climate change, earthquakes, terrorism, cyberattacks, or wildfires. I offer explanations of why this is so and formulate recommendations.
ContributorsDwyer, Kevin Thomas (Author) / Fisher, Erik (Thesis advisor) / Maynard, Andrew (Committee member) / Allenby, Braden (Committee member) / Arizona State University (Publisher)
Created2022