Matching Items (167)
Description
Service based software (SBS) systems are software systems consisting of services based on the service oriented architecture (SOA). Each service in SBS systems provides partial functionalities and collaborates with other services as workflows to provide the functionalities required by the systems. These services may be developed and/or owned by different entities and physically distributed across the Internet. Compared with traditional software system components which are usually specifically designed for the target systems and bound tightly, the interfaces of services and their communication protocols are standardized, which allow SBS systems to support late binding, provide better interoperability, better flexibility in dynamic business logics, and higher fault tolerance. The development process of SBS systems can be divided to three major phases: 1) SBS specification, 2) service discovery and matching, and 3) service composition and workflow execution. This dissertation focuses on the second phase, and presents a privacy preserving service discovery and ranking approach for multiple user QoS requirements. This approach helps service providers to register services and service users to search services through public, but untrusted service directories with the protection of their privacy against the service directories. The service directories can match the registered services with service requests, but do not learn any information about them. Our approach also enforces access control on services during the matching process, which prevents unauthorized users from discovering services. After the service directories match a set of services that satisfy the service users' functionality requirements, the service discovery approach presented in this dissertation further considers service users' QoS requirements in two steps. First, this approach optimizes services' QoS by making tradeoff among various QoS aspects with users' QoS requirements and preferences. Second, this approach ranks services based on how well they satisfy users' QoS requirements to help service users select the most suitable service to develop their SBSs.
ContributorsYin, Yin (Author) / Yau, Stephen S. (Thesis advisor) / Candan, Kasim (Committee member) / Dasgupta, Partha (Committee member) / Santanam, Raghu (Committee member) / Arizona State University (Publisher)
Created2011
Description
Filtration for microfluidic sample-collection devices is desirable for sample selection, concentration, preprocessing, and downstream manipulation, but microfabricating the required sub-micrometer filtration structure is an elaborate process. This thesis presents a simple method to fabricate polydimethylsiloxane (PDMS) devices with an integrated membrane filter that will sample, lyse, and extract the DNA from microorganisms in aqueous environments. An off-the-shelf membrane filter disc was embedded in a PDMS layer and sequentially bound with other PDMS channel layers. No leakage was observed during filtration. This device was validated by concentrating a large amount of cyanobacterium Synechocystis in simulated sample water with consistent performance across devices. After accumulating sufficient biomass on the filter, a sequential electrochemical lysing process was performed by applying 5VDC across the filter. This device was further evaluated by delivering several samples of differing concentrations of cyanobacterium Synechocystis then quantifying the DNA using real-time PCR. Lastly, an environmental sample was run through the device and the amount of photosynthetic microorganisms present in the water was determined. The major breakthroughs in this design are low energy demand, cheap materials, simple design, straightforward fabrication, and robust performance, together enabling wide-utility of similar chip-based devices for field-deployable operations in environmental micro-biotechnology.
ContributorsLecluse, Aurelie (Author) / Meldrum, Deirdre (Thesis advisor) / Chao, Joseph (Thesis advisor) / Westerhoff, Paul (Committee member) / Arizona State University (Publisher)
Created2011
Description
Single cell phenotypic heterogeneity studies reveal more information about the pathogenesis process than conventional bulk methods. Furthermore, investigation of the individual cellular response mechanism during rapid environmental changes can only be achieved at single cell level. By enabling the study of cellular morphology, a single cell three-dimensional (3D) imaging system can be used to diagnose fatal diseases, such as cancer, at an early stage. One proven method, CellCT, accomplishes 3D imaging by rotating a single cell around a fixed axis. However, some existing cell rotating mechanisms require either intricate microfabrication, and some fail to provide a suitable environment for living cells. This thesis develops a microvorterx chamber that allows living cells to be rotated by hydrodynamic alone while facilitating imaging access. In this thesis work, 1) the new chamber design was developed through numerical simulation. Simulations revealed that in order to form a microvortex in the side chamber, the ratio of the chamber opening to the channel width must be smaller than one. After comparing different chamber designs, the trapezoidal side chamber was selected because it demonstrated controllable circulation and met the imaging requirements. Microvortex properties were not sensitive to the chambers with interface angles ranging from 0.32 to 0.64. A similar trend was observed when chamber heights were larger than chamber opening. 2) Micro-particle image velocimetry was used to characterize microvortices and validate simulation results. Agreement between experimentation and simulation confirmed that numerical simulation was an effective method for chamber design. 3) Finally, cell rotation experiments were performed in the trapezoidal side chamber. The experimental results demonstrated cell rotational rates ranging from 12 to 29 rpm for regular cells. With a volumetric flow rate of 0.5 µL/s, an irregular cell rotated at a mean rate of 97 ± 3 rpm. Rotational rates can be changed by altering inlet flow rates.
ContributorsZhang, Wenjie (Author) / Frakes, David (Thesis advisor) / Meldrum, Deirdre (Thesis advisor) / Chao, Shih-hui (Committee member) / Wang, Xiao (Committee member) / Arizona State University (Publisher)
Created2011
Description
This thesis research attempts to observe, measure and visualize the communication patterns among developers of an open source community and analyze how this can be inferred in terms of progress of that open source project. Here I attempted to analyze the Ubuntu open source project's email data (9 subproject log archives over a period of five years) and focused on drawing more precise metrics from different perspectives of the communication data. Also, I attempted to overcome the scalability issue by using Apache Pig libraries, which run on a MapReduce framework based Hadoop Cluster. I described four metrics based on which I observed and analyzed the data and also presented the results which show the required patterns and anomalies to better understand and infer the communication. Also described the usage experience with Pig Latin (scripting language of Apache Pig Libraries) for this research and how they brought the feature of scalability, simplicity, and visibility in this data intensive research work. These approaches are useful in project monitoring, to augment human observation and reporting, in social network analysis, to track individual contributions.
ContributorsMotamarri, Lakshminarayana (Author) / Santanam, Raghu (Thesis advisor) / Ye, Jieping (Thesis advisor) / Davulcu, Hasan (Committee member) / Arizona State University (Publisher)
Created2011
Description
Laboratory automation systems have seen a lot of technological advances in recent times. As a result, the software that is written for them are becoming increasingly sophisticated. Existing software architectures and standards are targeted to a wider domain of software development and need to be customized in order to use them for developing software for laboratory automation systems. This thesis proposes an architecture that is based on existing software architectural paradigms and is specifically tailored to developing software for a laboratory automation system. The architecture is based on fairly autonomous software components that can be distributed across multiple computers. The components in the architecture make use of asynchronous communication methodologies that are facilitated by passing messages between one another. The architecture can be used to develop software that is distributed, responsive and thread-safe. The thesis also proposes a framework that has been developed to implement the ideas proposed by the architecture. The framework is used to develop software that is scalable, distributed, responsive and thread-safe. The framework currently has components to control very commonly used laboratory automation devices such as mechanical stages, cameras, and also to do common laboratory automation functionalities such as imaging.
ContributorsKuppuswamy, Venkataramanan (Author) / Meldrum, Deirdre (Thesis advisor) / Collofello, James (Thesis advisor) / Sarjoughian, Hessam S. (Committee member) / Johnson, Roger (Committee member) / Arizona State University (Publisher)
Created2012
Description
In this dissertation, two interrelated problems of service-based systems (SBS) are addressed: protecting users' data confidentiality from service providers, and managing performance of multiple workflows in SBS. Current SBSs pose serious limitations to protecting users' data confidentiality. Since users' sensitive data is sent in unencrypted forms to remote machines owned and operated by third-party service providers, there are risks of unauthorized use of the users' sensitive data by service providers. Although there are many techniques for protecting users' data from outside attackers, currently there is no effective way to protect users' sensitive data from service providers. In this dissertation, an approach is presented to protecting the confidentiality of users' data from service providers, and ensuring that service providers cannot collect users' confidential data while the data is processed or stored in cloud computing systems. The approach has four major features: (1) separation of software service providers and infrastructure service providers, (2) hiding the information of the owners of data, (3) data obfuscation, and (4) software module decomposition and distributed execution. Since the approach to protecting users' data confidentiality includes software module decomposition and distributed execution, it is very important to effectively allocate the resource of servers in SBS to each of the software module to manage the overall performance of workflows in SBS. An approach is presented to resource allocation for SBS to adaptively allocating the system resources of servers to their software modules in runtime in order to satisfy the performance requirements of multiple workflows in SBS. Experimental results show that the dynamic resource allocation approach can substantially increase the throughput of a SBS and the optimal resource allocation can be found in polynomial time
ContributorsAn, Ho Geun (Author) / Yau, Sik-Sang (Thesis advisor) / Huang, Dijiang (Committee member) / Ahn, Gail-Joon (Committee member) / Santanam, Raghu (Committee member) / Arizona State University (Publisher)
Created2012
Description
Single cell analysis has become increasingly important in understanding disease onset, progression, treatment and prognosis, especially when applied to cancer where cellular responses are highly heterogeneous. Through the advent of single cell computerized tomography (Cell-CT), researchers and clinicians now have the ability to obtain high resolution three-dimensional (3D) reconstructions of single cells. Yet to date, no live-cell compatible version of the technology exists. In this thesis, a microfluidic chip with the ability to rotate live single cells in hydrodynamic microvortices about an axis parallel to the optical focal plane has been demonstrated. The chip utilizes a novel 3D microchamber design arranged beneath a main channel creating flow detachment into the chamber, producing recirculating flow conditions. Single cells are flowed through the main channel, held in the center of the microvortex by an optical trap, and rotated by the forces induced by the recirculating fluid flow. Computational fluid dynamics (CFD) was employed to optimize the geometry of the microchamber. Two methods for the fabrication of the 3D microchamber were devised: anisotropic etching of silicon and backside diffuser photolithography (BDPL). First, the optimization of the silicon etching conditions was demonstrated through design of experiment (DOE). In addition, a non-conventional method of soft-lithography was demonstrated which incorporates the use of two positive molds, one of the main channel and the other of the microchambers, compressed together during replication to produce a single ultra-thin (<200 µm) negative used for device assembly. Second, methods for using thick negative photoresists such as SU-8 with BDPL have been developed which include a new simple and effective method for promoting the adhesion of SU-8 to glass. An assembly method that bonds two individual ultra-thin (<100 µm) replications of the channel and the microfeatures has also been demonstrated. Finally, a pressure driven pumping system with nanoliter per minute flow rate regulation, sub-second response times, and < 3% flow variability has been designed and characterized. The fabrication and assembly of this device is inexpensive and utilizes simple variants of conventional microfluidic fabrication techniques, making it easily accessible to the single cell analysis community.
ContributorsMyers, Jakrey R (Author) / Meldrum, Deirdre (Thesis advisor) / Johnson, Roger (Committee member) / Frakes, David (Committee member) / Arizona State University (Publisher)
Created2012
Description
Information technology (IT) outsourcing, including foreign or offshore outsourcing, has been steadily growing over the last two decades. This growth in IT outsourcing has led to the development of different hubs of services across nations, and has resulted in increased competition among service providers. Firms have been using IT outsourcing to not only leverage advanced technologies and services at lower costs, but also to maintain their competitive edge and grow. Furthermore, as prior studies have shown, there are systematic differences among industries in terms of the degree and impact of IT outsourcing. This dissertation uses a three-study approach to investigate issues related to IT outsourcing at the macro and micro levels, and provides different perspectives for understanding the issues associated with IT outsourcing at a firm and industry level. The first study evaluates the diffusion patterns of IT outsourcing across industries at aggregate level and within industries at a firm level. In addition, it analyzes the factors that influence the diffusion of IT outsourcing and tests models that help us understand the rate and patterns of diffusion at the industry level. This study establishes the presence of hierarchical contagion effects in the diffusion of IT outsourcing. The second study explores the role of location and proximity of industries to understand the diffusion patterns of IT outsourcing within clusters using the spatial analysis technique of space-time clustering. It establishes the presence of simultaneous space and time interactions at the global level in the diffusion of IT outsourcing. The third study examines the development of specialized hubs for IT outsourcing services in four developing economies: Brazil, Russia, India, and China (BRIC). In this study, I adopt a theory-building approach involving the identification of explanatory anomalies, and propose a new hybrid theory called- knowledge network theory. The proposed theory suggests that the growth and development of the IT and related services sector is a result of close interactions among adaptive institutions. It is also based on new knowledge that is created, and which flows through a country's national diaspora of expatriate entrepreneurs, technologists and business leaders. In addition, relevant economic history and regional geography factors are important. This view diverges from the traditional view, wherein effective institutions are considered to be the key determinants of long-term economic growth.
ContributorsMann, Arti (Author) / Kauffman, Robert J. (Thesis advisor) / Santanam, Raghu (Thesis advisor) / St. Louis, Robert (Committee member) / Anselin, Luc (Committee member) / Nault, Barrie R (Committee member) / Arizona State University (Publisher)
Created2012
Description
Cyber-weapons and the rapid progression of utilizing cyberspace in conflict poses several risks to states and their ability to maintain control of their respective technological infrastructures. Susceptibility to these weapons extend to virtually all existing nations, and indicates a critical need for transnational organizations and their members to establish collective strategies for governing cyber-arms. In this paper, the United Nations, as a prime example of an influential transnational organization, is utilized as a case study for a framework that seeks to define and establish guidelines for arms control policy as it relates to cyber-weapons. Presented is a strategy that seeks to define cyber-warfare and cyber-weapons, distinguish it from other existing forms of weapons and warfare, and outline recommended actions for the United Nations and its affiliates, including the United Nations Office for Disarmament Affairs and United Nations Security Council.
ContributorsSidhu, Arman Singh (Author) / Berliner, Daniel (Thesis director) / Santanam, Raghu (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / Department of Information Systems (Contributor)
Created2015-12
Description
Considering the overwhelming prevalence of BPH, how can it best be managed in light of the aging population? The purpose of this investigation is to illustrate that BPH and LUTS are conditions that are highly conducive to health literacy technology interventions. This objective will be met by: a) Providing an overview of the clinically relevant information regarding BPH, including anatomy, physiology, epidemiology, symptoms, and medical treatment for the disease; b) Establishing the necessity for novel health care delivery solutions by identifying past successes and challenges associated with technologic advances in related fields; c) Providing evidence of a lack of a systematic approach to BPH education, especially as it relates to health literacy. The relative successes and failures of previously established clinical decision aids will be discussed, leading to recommendations on how to improve upon these standards. Finally, the procedures and results of a pilot study will be analyzed in an effort to further highlight the necessity of engaging patients in the clinical decision making process.
ContributorsMelikian, Robert Jeffrey (Author) / Santanam, Raghu (Thesis director) / Humphreys, Mitchell (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School for the Science of Health Care Delivery (Contributor)
Created2014-12