Matching Items (139)
Description
In recent years the state of Arizona passed a series of laws affecting undocumented immigrants, including Proposition 300 in 2006 outlawing in-state tuition for undocumented youth. However, there has also been a reaction from these youth who refused to be relegated to the shadows and are demanding rights. Using mixed ethnographic methods, this dissertation research analyzes how undocumented Mexican youth in Arizona have experienced liminality after the passage of Proposition 300 as well as their ability to utilize their increased marginalization in order to build community amongst themselves and fight for basic rights--a process known as cultural citizenship. These immigrant youth are of the 1.5 generation, who are brought to the United States at a young age, grow up in the country and share characteristics with both first and second- generation immigrants. Even though undocumented 1.5 generation immigrants are raised and acculturated within this country and treated the same as other children while in the public school system, they have been denied basic rights upon approaching adulthood because of their illegality. This includes limiting access to affordable higher education as well as public services and legal work. Consequently, they are unable to fully incorporate into U.S. society and they end up transitioning into illegality after leaving school. This is especially true in Arizona, a state that has passed some of the strictest anti-immigrant laws in the country aiming to deter undocumented immigrants from staying in the state. However, I argue that this increased marginalization has had an unintended consequence of creating a space that allowed for these youth to come together and form a community. I further posit that this community provides valuable social capital and access to resources and information that mitigates the possibility of downward assimilation. Moreover, this community offers its members a safety net that allows them to publically claim their undocumented status in order to fight for their right to have a pathway towards citizenship. As a result, they have been able to gain some victories, but are still fighting for their ultimate goal to become citizens.
ContributorsRuth, Alissa (Author) / Tsuda, Takeyuki (Thesis advisor) / Wutich, Amber (Committee member) / Provine, Doris Marie (Committee member) / Arizona State University (Publisher)
Created2014
Description
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by progressive autoimmune destruction of insulin-producing pancreatic β-cells. Genetic, immunological and environmental factors contribute to T1D development. The focus of this dissertation is to track the humoral immune response in T1D by profiling autoantibodies (AAbs) and anti-viral antibodies using an innovative protein array platform called Nucleic Acid Programmable Protein Array (NAPPA).
AAbs provide value in identifying individuals at risk, stratifying patients with different clinical courses, improving our understanding of autoimmune destructions, identifying antigens for cellular immune response and providing candidates for prevention trials in T1D. A two-stage serological AAb screening against 6,000 human proteins was performed. A dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) was validated with 36% sensitivity at 98% specificity by an orthogonal immunoassay. This is the first systematic screening for novel AAbs against large number of human proteins by protein arrays in T1D. A more comprehensive search for novel AAbs was performed using a knowledge-based approach by ELISA and a screening-based approach against 10,000 human proteins by NAPPA. Six AAbs were identified and validated with sensitivities ranged from 16% to 27% at 95% specificity. These two studies enriched the T1D “autoantigenome” and provided insights into T1D pathophysiology in an unprecedented breadth and width.
The rapid rise of T1D incidence suggests the potential involvement of environmental factors including viral infections. Sero-reactivity to 646 viral antigens was assessed in new-onset T1D patients. Antibody positive rate of EBV was significantly higher in cases than controls that suggested a potential role of EBV in T1D development. A high density-NAPPA platform was demonstrated with high reproducibility and sensitivity in profiling anti-viral antibodies.
This dissertation shows the power of a protein-array based immunoproteomics approach to characterize humoral immunoprofile against human and viral proteomes. The identification of novel T1D-specific AAbs and T1D-associated viruses will help to connect the nodes in T1D etiology and provide better understanding of T1D pathophysiology.
AAbs provide value in identifying individuals at risk, stratifying patients with different clinical courses, improving our understanding of autoimmune destructions, identifying antigens for cellular immune response and providing candidates for prevention trials in T1D. A two-stage serological AAb screening against 6,000 human proteins was performed. A dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) was validated with 36% sensitivity at 98% specificity by an orthogonal immunoassay. This is the first systematic screening for novel AAbs against large number of human proteins by protein arrays in T1D. A more comprehensive search for novel AAbs was performed using a knowledge-based approach by ELISA and a screening-based approach against 10,000 human proteins by NAPPA. Six AAbs were identified and validated with sensitivities ranged from 16% to 27% at 95% specificity. These two studies enriched the T1D “autoantigenome” and provided insights into T1D pathophysiology in an unprecedented breadth and width.
The rapid rise of T1D incidence suggests the potential involvement of environmental factors including viral infections. Sero-reactivity to 646 viral antigens was assessed in new-onset T1D patients. Antibody positive rate of EBV was significantly higher in cases than controls that suggested a potential role of EBV in T1D development. A high density-NAPPA platform was demonstrated with high reproducibility and sensitivity in profiling anti-viral antibodies.
This dissertation shows the power of a protein-array based immunoproteomics approach to characterize humoral immunoprofile against human and viral proteomes. The identification of novel T1D-specific AAbs and T1D-associated viruses will help to connect the nodes in T1D etiology and provide better understanding of T1D pathophysiology.
ContributorsBian, Xiaofang (Author) / LaBaer, Joshua (Thesis advisor) / Mandarino, Lawrence (Committee member) / Chang, Yung (Committee member) / Arizona State University (Publisher)
Created2015
Description
The National Research Council 2011 report lists quantifying the extent of de facto (or unplanned) potable reuse in the U.S. as the top research need associated with assessing the potential for expanding the nations water supply through reuse of municipal wastewater. Efforts to identify the significance and potential health impacts of de facto water reuse are impeded by out dated information regarding the contribution of municipal wastewater effluent to potable water supplies. This project aims to answer this research need. The overall goal of the this project is to quantify the extent of de facto reuse by developing a model that estimates the amount of wastewater effluent that is present within drinking water treatment plants; and to use the model in conjunction with a survey to help assess public perceptions. The four-step approach to accomplish this goal includes: (1) creating a GIS-based model coupled with Python programming; (2) validating the model with field studies by analyzing sucralose as a wastewater tracer; (3) estimating the percentage of wastewater in raw drinking water sources under varying streamflow conditions; (4) and assessing through a social survey the perceptions of the general public relating to acceptance and occurrence of de facto reuse. The resulting De Facto Reuse in our Nations Consumable Supply (DRINCS) Model, estimates that treated municipal wastewater is present at nearly 50% of drinking water treatment plant intake sites serving greater than 10,000 people (N=2,056). Contrary to the high frequency of occurrence, the magnitude of occurrence is relatively low with 50% of impacted intakes yielding less than 1% de facto reuse under average streamflow conditions. Model estimates increase under low flow conditions (modeled by Q95), in several cases treated wastewater makes up 100% of the water supply. De facto reuse occurs at levels that surpass what is publically perceived in the three cities of Atlanta, GA, Philadelphia, PA, and Phoenix, AZ. Respondents with knowledge of de facto reuse occurrence are 10 times more likely to have a high acceptance (greater than 75%) of treated wastewater at their home tap.
ContributorsRice, Jacelyn (Author) / Westerhoff, Paul (Thesis advisor) / Abbaszadegan, Morteza (Committee member) / Vivoni, Enrique (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2014
Description
Climate change poses a threat to the emotional well-being and livelihood strategies of individuals in biophysically vulnerable communities. While the biophysical effects and possibilities of climate change are well-documented, understanding the emotional impacts on individuals in these communities is an avenue of research that requires more exploration. Using an ethnographic approach, this study analyzes the emotional responses of individuals, first in three biophysically vulnerable communities in the United States, and second, in island communities. Study sites in the United States include Mobile, Alabama; Kodiak, Alaska; and Phoenix, Arizona, each of which have different vulnerabilities to the effects of climate change. Internationally, we conducted research in Viti Levu, Fiji; Nicosia, Cyprus; Wellington, New Zealand; and London, England. Using the 2014 Global Ethnohydrology Study Protocol respondents were asked about their emotional responses to the current effects of climate change, the effects of climate change on livelihoods in their area, and the effects of climate change on the younger generation. Using cross-cultural data allows for a broader understanding of emotional distress and wellbeing in response to climate change in areas with similar expected climate change outcomes, although with different levels of biophysical vulnerability, as well as understanding emotional distress and wellbeing in areas with different expected climate change outcomes, and similar levels of biophysical vulnerability. Results from this research can be used to understand possible mental health outcomes, the possibilities for political activism, and how to create mitigation strategies that resonate with local community members.
ContributorsDu Bray, Margaret V (Author) / Wutich, Amber (Thesis advisor) / BurnSilver, Shauna (Thesis advisor) / Bolin, Bob (Committee member) / Arizona State University (Publisher)
Created2017
Description
Suicide is one of the fastest-growing and least-understood causes of death, particularly in low and middle income countries (LMIC). In low-income settings, where the technical capacity for death surveillance is limited, suicides may constitute a significant portion of early deaths, but disappear as they are filtered through reporting systems shaped by social, cultural, and political institutions. These deaths become unknown and unaddressed. This dissertation illuminates how suicide is perceived, contested, experienced, and interpreted in institutions ranging from the local (i.e., family, community) to the professional (i.e., medical, law enforcement) in Nepal, a country purported to have one of the highest suicide rates in the world. Drawing on a critical medical anthropology approach, I bridge public health and anthropological perspectives to better situate the problem of suicide within a greater social-political context. I argue that these complex, contestable deaths, become falsely homogenized, or lost. During 18 months of fieldwork in Nepal, qualitative, data tracing, and psychological autopsy methodologies were conducted. Findings are shared through three lenses: (1) health policy and world systems; (2) epidemiology and (3) socio-cultural. The first investigates how actors representing familial, legal, and medical institutions perceive, contest, and negotiate suicide documentation, ultimately failing to accurately capture a leading cause of death. Using epidemiologic perspectives, surveillance data from medical and legal agencies are analyzed and pragmatic approaches to better detect and prevent suicidal death in the Nepali context are recommended. The third lens provides perceived explanatory models for suicide. These narratives offer important insights into the material, social, and cultural factors that shape suicidal acts in Nepal. Findings are triangulated to inform policy, prevention, and intervention approaches to reduce suicidal behavior and improve health system capabilities to monitor violent deaths. These approaches go beyond typical psychological investigations of suicide by situating self-inflicted death within broader familial, social, and political contexts. Findings contribute to cultural anthropological theories related to suicide and knowledge production, while informing public health solutions. Looking from the margins towards centers of power, this dissertation explicates how varying institutional numbers can obfuscate and invalidate suffering experienced at local levels.
ContributorsHagaman, Ashley (Author) / Wutich, Amber (Thesis advisor) / Hruschka, Daniel (Committee member) / Kohrt, Brandon (Committee member) / Arizona State University (Publisher)
Created2017
Description
Criticisms of technocratic and managerial sustainability responses to global environmental change have led scholars to argue for transformative shifts in ideology, policy, and practice favoring alternative, plural transformation pathways to sustainability. This raises key debates around how we build transformative capacity and who will lead the way. To further this critical dialogue, this dissertation explores the potential for sustainability experiential learning (SEL) to serve as a capacity building mechanism for global ecological citizenship in support of transformation pathways to sustainable wellbeing. In the process it considers how the next generation of those primed for sustainability leadership identify with and negotiate diversity—of perceptions, values, agency, and lived experiences—in what constitutes sustainable wellbeing and the approaches needed to get there.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
Inspired by the STEPS (Social, Technological and Environmental Pathways to Sustainability) Centre’s transformation pathways approach, this research proposes a Transformative Capacity Building model grounded in a Transformation Pathways to Sustainable Wellbeing framework that integrates and builds upon tenets of the original pathways approach with transformative learning, Value-Believe-Norm, and global ecological citizenship (eco-citizenship) theories and concepts. The proposed model and framework were applied to an in-depth ethnographic case study of sustainability experiential learning communities formed within the four Summer 2015 Global Sustainability Studies (GSS) programs at Arizona State University. Using mixed methods, including semi-structured interviews, participant observation, and Photovoice, this study examines the values, perceptions, and perceived agency of participants post-program in relation to the knowledge-making and mobilization processes that unfolded during their international GSS programs. Of particular interest are participants’ cognitive, moral, and affective engagement as SEL community members.
Through multi-level thematic analyses, key values, perceptions, agency and engagement themes are identified and influencing relationships highlighted across the different SEL communities and programs. Implications of these factors and their relationships for capacity building for eco-citizenship and future program development are considered. The dissertation concludes by translating study findings into actionable pathways for future research AND practice, including the proposal of program development and implementation recommendations that could enable future sustainability experiential learning programs to better contribute to transformative capacity building for eco-citizenship.
ContributorsGwiszcz, Julianna Marie (Author) / Eder, James (Thesis advisor) / Haglund, LaDawn (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2018
Description
Under-representation of women doctors in medical work force despite their overwhelming majority in medical schools is an intriguing social issue for Pakistan raising important questions related to evolving gender relations in Pakistani society. Previous research on the broader issue of under-representation of women in science has focused primarily on the structural barriers to women’s advancement. It does not account for the underlying subtle (and changing) gendered power relations that permeate everyday life and which can constrain (or enable) the choices of women. It also does not address how women are not simply constructed as subjects within intersecting power relations, but actively construct meaning in relation to them. It raises interesting questions about the cultural shaping of subjectivities, identities and agency of women within the web of power relations in a society such as Pakistan.
To analyze the underlying dynamics of this issue, this dissertation empirically examines the individual, institutional and social factors which enable or affect the career choices of Pakistani women doctors. Based on the ethnographic data obtained from in-depth, person centered, open ended interviews with sixty women doctors and their families, as well as policy makers and the stake holders in medical education and health administration in Lahore, Pakistan this dissertation seeks to address the complex issues of empowerment and agency in the context of Pakistani women, both in individual and collective sense.
Participation in medical education is ostensibly an empowering act, but dissecting the social relations in which this decision takes place reveals that becoming a doctor actually enmeshes women further in the disciplinary relations within their families and society. Similarly, the medical workplaces of Pakistan are marked by entrenched gendered hierarchies constraining women’s access to resources and their progression through medical career. Finally, the political implications of defining work in medicine, and devaluing care in capitalist economies is explored.
To analyze the underlying dynamics of this issue, this dissertation empirically examines the individual, institutional and social factors which enable or affect the career choices of Pakistani women doctors. Based on the ethnographic data obtained from in-depth, person centered, open ended interviews with sixty women doctors and their families, as well as policy makers and the stake holders in medical education and health administration in Lahore, Pakistan this dissertation seeks to address the complex issues of empowerment and agency in the context of Pakistani women, both in individual and collective sense.
Participation in medical education is ostensibly an empowering act, but dissecting the social relations in which this decision takes place reveals that becoming a doctor actually enmeshes women further in the disciplinary relations within their families and society. Similarly, the medical workplaces of Pakistan are marked by entrenched gendered hierarchies constraining women’s access to resources and their progression through medical career. Finally, the political implications of defining work in medicine, and devaluing care in capitalist economies is explored.
ContributorsMasood, Ayesha (Author) / Tsuda, Takeyuki (Thesis advisor) / Wutich, Amber (Committee member) / Gaughan, Monica (Committee member) / Arizona State University (Publisher)
Created2017
Collective action among non-governmental organizations working in maternal and child health in Haiti
Description
This mixed-methods research study examined the level of collective action that is occurring among non-governmental organizations (NGOs) working in maternal and child health in Haiti. This study takes the view that health, and by extension, maternal and child health, is a global public good; global public goods are most efficiently provided by the means of collective action. Therefore, to the extent that maternal and child health services are provided efficiently in Haiti, collective action should be occurring.
This study utilized a semi-structured interview approach to gather both qualitative and quantitative data. A total of 17 participants who were managers or executives of NGOs working in maternal and child health in Haiti were interviewed. The interviews also gathered quantitative data that characterized types of cooperation that were occurring among NGOs. The qualitative data that were collected in these interviews were analyzed using thematic analysis, and quantitative data were analyzed using social network analysis. The findings concluded that while there is cooperation occurring among NGOs in Haiti, the cooperation levels are low, networks are not very dense and there is overall general consensus that more cooperation is needed
This study utilized a semi-structured interview approach to gather both qualitative and quantitative data. A total of 17 participants who were managers or executives of NGOs working in maternal and child health in Haiti were interviewed. The interviews also gathered quantitative data that characterized types of cooperation that were occurring among NGOs. The qualitative data that were collected in these interviews were analyzed using thematic analysis, and quantitative data were analyzed using social network analysis. The findings concluded that while there is cooperation occurring among NGOs in Haiti, the cooperation levels are low, networks are not very dense and there is overall general consensus that more cooperation is needed
ContributorsMcCool, Sarah (Author) / Gaughan, Monica (Thesis advisor) / Wutich, Amber (Committee member) / York, Abigail (Committee member) / Arizona State University (Publisher)
Created2017
Description
This dissertation combines three research projects to examine the people affecting and affected by urban environmental change across multiple scales of decision making. In the Phoenix Metropolitan area and the Colorado River Basin, I study the social influence around the implementation of water use innovations among city-level stakeholders (Chapter 2) and I emphasize that water insecurity still exists in wealthy cities (Chapter 3). In Chapter 4, I ultimately consider grassroots solutions for achieving resource security alongside positive social change in a historically underserved community. In this dissertation, I have conceptualized my research questions by envisioning urban change as an opportunity for actors, at multiple scales, to simultaneously reduce resource waste and promote positive social change.
ContributorsDeMyers, Christine (Author) / Wutich, Amber (Thesis advisor) / White, Dave (Committee member) / BurnSilver, Shauna (Committee member) / Glegziabher, Meskerem (Committee member) / Arizona State University (Publisher)
Created2019
Description
This dissertation provides a foundation for understanding who decides and proceed local climate change policymaking, how race and ethnicity, class, and political ideology inform climate beliefs, the role of personal exposure to heat-related illnesses in climate change beliefs, and finally differences in perceptions of local extreme heat and global manifestations of climate change. The first focus examines urban climate governance, the influence of state policy, and stakeholders’ climate agenda-setting in a state-centric urban governance structure. A new conceptual model is developed to explore climate governance in Istanbul, a Turkish megacity, under a unitary system of government, in a transcontinental country straddling Europe (in candidate status with the European Union) and Asia. The qualitative analyses show that swings in political leadership, the divergence between the existing laws and newly adopted urban climate agenda, and conflicting priorities between policy entrepreneurs generate barriers to long-run and tangible climate change actions in Istanbul. The second focus unveils the influence of personal heat exposure and sociodemographic characteristics affecting climate change perceptions in a large American city facing substantial climate change impacts, Phoenix, Arizona. Using the 2011 Phoenix Metropolitan Area Social Survey, a two-level logistic model examines what factors influence a belief that “global warming and climate change are already occurring.” The integrated econometric model of climate beliefs and justice shows that climate change and global warming are positively associated with non-white race and non-Latinx ethnicity, high levels of education, personal experience with heat-related illnesses, and liberal beliefs. The last focus of this dissertation explores how threats of extreme local weather conditions and global climate change are perceived differently by individuals depending on their vulnerability and adaptive capacity to the changing climate. Using the 2017 Phoenix Social Survey, the individual-level regression models demonstrate that greenspace and tight-knit communities, aspects of adaptive capacity, serve as protective elements reducing the perception of climate risk. Factors such as ethnic identity and connection to place are more closely associated with local versus global risks. In contrast, political ideology and personal experiences moderate perception of both local and global risks.
ContributorsYazar, Mahir (Author) / York, Abigail (Thesis advisor) / BurnSilver, Shauna (Committee member) / Wutich, Amber (Committee member) / Arizona State University (Publisher)
Created2021