We used the Affymetrix® Genome-Wide Human SNP Array 6.0 to identify heterospecific markers and compare copy number and structural genomic variation between humans and rhesus macaques. Over 200,000 human copy number variation (CNV) probes were mapped to a Chinese and an Indian rhesus macaque sample. Observed genomic rearrangements and synteny were in agreement with the results of a previously published genomic comparison between humans and rhesus macaques. Comparisons between each of the two rhesus macaques and humans yielded 206 regions with copy numbers that differed by at least two fold in the Indian rhesus macaque and human, 32 in the Chinese rhesus macaque and human, and 147 in both rhesus macaques. The detailed genomic map and preliminary CNV data are useful for better understanding genetic variation in rhesus macaques, identifying derived changes in human CNVs that may have evolved by selection, and determining the suitability of rhesus macaques as human models for particular biomedical studies.
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- Identifying Rhesus Macaque Gene Orthologs Using Heterospecific Human CNV Probes
- Ng, Jillian (Author)
- Fass, Joseph N. (Author)
- Durbin-Johnson, Blythe (Author)
- Smith, David Glenn (Author)
- Kanthaswamy, Sreetharan (Author)
- New College of Interdisciplinary Arts and Sciences (Contributor)
- Digital object identifier: 10.1016/j.gdata.2015.09.016
- Identifier TypeInternational standard serial numberIdentifier Value2213-5960
- The final version of this article, as published in Genomics Data, can be viewed online at: http://www.sciencedirect.com/science/article/pii/S2213596015300441, opens in a new window
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Ng, J., Fass, J. N., Durbin-Johnson, B., Smith, D. G., & Kanthaswamy, S. (2015). Identifying rhesus macaque gene orthologs using heterospecific human CNV probes. Genomics Data, 6, 202-207. doi:10.1016/j.gdata.2015.09.016