Embryo Project Encyclopedia Articles

Menstrual hygiene management, or MHM, is a concept that concerns girls' and women’s access to the appropriate information and resources to manage menstruation. In December 2012, the Joint Monitoring Program, or JMP, was one of the first organizations to define MHM as a global development goal. Since then, other organizations like WaterAid and the United Nations have expanded MHM’s definition to include menstrual education that is biologically accurate and free of taboo and stigma. Many women in low-income countries lack those necessities for MHM due to high prices of menstrual sanitary products, lack of access to clean water and sanitation facilities, and social stigma surrounding menstruation that prevents it from being talked about. However, as more organizations began to frame MHM as an issue of public concern rather than a woman’s private problem, more researchers, organizations, and governmental bodies have begun to address issues at the root of inadequate MHM.

In 2008, Celeste Mergens founded the organization Days for Girls to address obstacles impeding women’s and girls’ access to sustainable hygiene and health education by enlisting volunteers around the world to construct reusable menstrual hygiene products for girls in low-income countries. Mergens founded Days for Girls in the US in 2008 after learning that an orphanage she was working with in Kenya did not have resources for girls to manage their menstrual cycles. She provided those girls with reusable sanitary pads, and later that year, she decided to provide Days for Girls Kits, or DfG Kits, that volunteers from around the world made for women and girls in parts of the world lacking access to menstrual hygiene products. By 2012, Mergens launched chapters across the United States to allow volunteers to hand-sew the DfG Kits, and by 2019, the organization expanded to include chapters in Zimbabwe, Ghana, and Uganda. Days for Girls provides women and girls with education and resources necessary to manage menstruation, which can help reduce the instances of absenteeism for girls in schools and reduce the risk of contracting infectious diseases.

Revive and Restore is a California-based nonprofit that uses genetic engineering to help solve conservation problems, such as saving endangered species and increasing the biodiversity of ecosystems. To facilitate their solutions, Revive and Restore utilizes genetic engineering, which is the process of making changes to an organism’s DNA, or the set of instructions for how an organism develops and functions. One of their broad solutions is genetic rescue, which involves imbuing populations of endangered species with a wider variety of traits to make them more adaptable to a changing environment. Their other solution is de-extinction, which takes a more radical approach by attempting to recreate extinct species that performed important roles in their ecosystems. While scientists working with Revive and Restore have helped advance genome editing technology on a theoretical and technical level, their research has also prompted practical and ethical concerns over the extent of permissible human interference with nature, even when attempting to conserve it.

Stanley Paul Leibo studied the cryopreservation of embryos in the US in the twentieth century. Cryopreservation is a method of preserving biological material through freezing. Early in his career, Leibo collaborated with other scientists to study why cells were oftentimes injured during freezing. Later, Leibo and his team accomplished one of the first successful births using previously-frozen mammalian embryos. Leibo continued evolving simpler and more reliable methods of cryopreservation and embryo transfer for many different species over the course of his career, such as the development of a one-step procedure of transferring fertilized embryos between cattle. Leibo’s work to develop simple and reliable ways to cryopreserve cells and embryos enabled its use in a wider scope of research, including agriculture, reproductive medicine, and conservation.

In 2015, Revive & Restore launched the Woolly Mammoth Revival Project with a goal of engineering a creature with genes from the woolly mammoth and introducing it back into the tundra to combat climate change. Revive & Restore is a nonprofit in California that uses genome editing technologies to enhance conservation efforts in sometimes controversial ways. In order to de-extinct the woolly mammoth, researchers theorize that they can manipulate the genome of the Asian elephant, which is the mammoth’s closest living evolutionary relative, to make it resemble the genome of the extinct woolly mammoth. While their goal is to create a new elephant-mammoth hybrid species, or a mammophant, that looks and functions like the extinct woolly mammoth, critics have suggested researchers involved in the project have misled and exaggerated the process. As of 2021, researchers have not yet succeeded in their efforts to de-extinct the woolly mammoth, but have expressed that it may become a reality within a decade.

George Frederic Still studied pediatrics and childhood conditions in England during the early twentieth century. In Still’s time, pediatrics, or the branch of medicine that focuses on treating and caring for children, remained largely unexplored according to biographer Joseph deBettencourt. Still helped advance pediatrics as a field by classifying and writing about diseases and conditions that arose in children. In 1897, he discovered a unique type of arthritis in children, now referred to as Still’s disease. Still also was one of the first to correctly describe what is now known as attention deficit hyperactivity disorder, or ADHD, a disorder that can cause children to act impulsively and have trouble focusing, among other behaviors. He shared his understanding of those conditions and pediatrics as a whole in a popular textbook called Common Disorders and Diseases of Childhood. Still’s work helped establish pediatrics as a separate field of medicine and provide a foundation for pediatricians throughout the twentieth century to understand and expand on a variety of conditions developing children can face.

In 1972, David Whittingham, Stanley Leibo, and Peter Mazur published the paper, “Survival of Mouse Embryos Frozen to -196 ° and -269 °C,” hereafter, “Survival of Mouse Embryos,” in the journal Science. The study marked one of the first times that researchers had successfully cryopreserved, or preserved and stored by freezing, a mammalian embryo and later transferred that embryo to a live mouse who gave birth to viable offspring. Previously, scientists had only been successful cryopreserving single cells, like red blood cells. Mammalian embryos, on the other hand, were more difficult to cryopreserve because they are more complex and therefore more easily weakened or destroyed by the formation of ice within its cells. Whittingham, Leibo, and Mazur’s work provided a successful model for mammalian embryo cryopreservation, a technology that later expanded to cryopreserve more complex embryos, such as human embryos.

Peter Mazur was a researcher in the US who developed new ways of preserving biological material by freezing it, a process called cryopreservation. If done correctly, cryopreservation enables scientists to store or study biological material for an extended period of time. If done incorrectly, cryopreservation can easily harm or destroy biological material. Mazur worked to find the best ways to cryopreserve different cells, embryos, and organs in order to minimize the damage caused by freezing. Throughout the 1960s and 1970s, Mazur and his colleagues published a series of papers that ultimately led to the discovery of previously unexplored factors that can cause harm to cells during the cryopreservation process. He called that discovery the two-factor hypothesis. That same year, Mazur also contributed to one of the first successful attempts at cryopreserving viable mouse embryos. Mazur’s work to improve the cryopreservation process helped to establish foundational knowledge that was later used in many different fields, such as reproductive health and conservation.

Multiplex Automated Genome Engineering, or MAGE, is a genome editing technique that enables scientists to quickly edit an organism’s DNA to produce multiple changes across the genome. In 2009, two genetic researchers at the Wyss Institute at Harvard Medical School in Boston, Massachusetts, Harris Wang and George Church, developed the technology during a time when researchers could only edit one site in an organism’s genome at a time. Wang and Church called MAGE a form of accelerated evolution because it creates different cells with many variations of the same original genome over multiple generations. MAGE made genome editing much faster, cheaper, and easier for genetic researchers to create organisms with novel functions that they can use for a variety of purposes, such as making chemicals and medicine, developing biofuels, or further studying and understanding the genes that can cause harmful mutations in humans.

In 1916, eugenicist Madison Grant published the book The Passing of the Great Race; or The Racial Basis of European History, hereafter The Passing of the Great Race, where he claimed that northern Europeans, or Nordics, are biologically and culturally superior to the rest of humanity. Charles Scribner’s Sons in New York City, New York, published the volume. Grant claimed that the Nordic race was at risk of extinction and advocated for the creation of laws in the US to decrease the population of people he considered inferior. According to Grant’s biographer Jonathan Spiro, Grant’s book synthesized a range of racist and pseudoscientific eugenics claims in prose that was accessible to the public. In the US, The Passing of the Great Race was praised by politicians, including former presidents Theodore Roosevelt and Calvin Coolidge, and cited as justification for laws that restricted immigration based on ethnicity and nationality. Adolf Hitler referred to The Passing of the Great Race as his Bible, and during the Nuremberg Trials in the 1940s, Nazi leaders who were prosecuted for war crimes committed during World War II presented the book as evidence that eugenics did not solely originate in Germany but rather had deep roots in the United States.