Embryo Project Encyclopedia

Stephen Jay Gould studied snail fossils and worked at Harvard University in Cambridge, Massachusetts during the latter half of the twentieth century. He contributed to philosophical, historical, and scientific ideas in paleontology, evolutionary theory, and developmental biology. Gould, with Niles Eldredge, proposed the theory of punctuated equilibrium, a view of evolution by which species undergo long periods of stasis followed by rapid changes over relatively short periods instead of continually accumulating slow changes over millions of years. In his 1977 book, Ontogeny and Phylogeny, Gould reconstructed a history of developmental biology and stressed the importance of development to evolutionary biology. In a 1979 paper coauthored with Richard Lewontin, Gould and Lewonitn criticized many evolutionary bioligists for relying solely on adaptive evolution as an explanation for morphological change, and for failing to consider other explanations, such as developmental constraints.

In 1894, William Stewart Halsted published The Results of Operations for the Cure of Cancer of the Breast Performed at the Johns Hopkins Hospital from June, 1889, to January, 1894, in the medical journal Annals of Surgery. In the article, Halsted describes the results from fifty of his operations on women with breast cancer, performed at Johns Hopkins Hospital in Baltimore, Maryland. Those operations involved a surgical procedure Halsted called radical mastectomy, which consists in removing all of the patient’s breast tissue, chest muscle, and underarm lymph nodes. Halsted’s surgery effectively cured breast cancer in a time period when no other effective treatment options were available. The radical mastectomy remained the standard of care from the 1890s to the 1970s as a means of treating a type of reproductive cancer common to women.

During the twentieth century, Austin Bradford Hill researched diseases and their causes in England and developed the Bradford Hill criteria, which comprise the minimal requirements that must be met for a causal relationship to be established between a factor and a disease. Hill also suggested that researchers should randomize clinical trials to evaluate the effects of a drug or treatment by monitoring large groups of people. In addition, Hill advocated for case-control studies, in which researchers compare a group of people with a medical condition to a group without that condition to investigate the condition's possible causes. Hill's own work with clinical trials and case-control studies helped him prove that smoking caused lung cancer. The Bradford Hill criteria have also been used to establish causal links between factors and cancer, including reproductive cancers such as human papillomavirus that causes cervical cancer.

Percivall Pott was a physician in England during the eighteenth century who identified soot as the cause of chimney sweeps' scrotal cancer, later called testicular cancer. In the 1770s, Pott observed that scrotal cancer commonly afflicted chimney sweeps, the young boys sent up into chimneys to clean away the soot left over from fires, and he hypothesized that the soot inside chimneys might cause that type of cancer. Pott was one of the first doctors to identify some environmental factor as causing cancer. Pott's research helped chimney sweeps to prevent scrotal cancer by using protective clothing, and it also allowed for future research on environmental causes of cancers.

Aristotle studied developing organisms, among other things, in ancient Greece, and his writings shaped Western philosophy and natural science for greater than two thousand years. He spent much of his life in Greece and studied with Plato at Plato's Academy in Athens, where he later established his own school called the Lyceum. Aristotle wrote greater than 150 treatises on subjects ranging from aesthetics, politics, ethics, and natural philosophy, which include physics and biology. Less than fifty of Aristotle's treatises persisted into the twenty-first century. In natural philosophy, later called natural science, Aristotle established methods for investigation and reasoning and provided a theory on how embryos generate and develop. He originated the theory that an organism develops gradually from undifferentiated material, later called epigenesis.

David Starr Jordan studied fish and promoted eugenics in the US during the late nineteenth and early twentieth centuries. In his work, he embraced Charles Darwin s theory of evolution and described the importance of embryology in tracing phylogenic relationships. In 1891, he became the president of Stanford University in Stanford, California. Jordan condemned war and promoted conservationist causes for the California wilderness, and he advocated for the eugenic sterilization of thousands of Americans. Like many American eugenicists of the early twentieth century, Jordan combined ideas of Mendelian genetics and of Darwinian natural selection to form a basis for limiting or encouraging reproduction in certain individuals and groups based on their perceived hereditary fitness. Like other eugenicists, Jordan s attempt to control the reproductive fate of entire populations marked an episode in the history of reproduction and biology in which its concepts increasingly influenced the social and cultural contexts.

In 1928 Ezra Seymour Gosney founded the non-profit Human Betterment Foundation (HBF) in Pasadena, California to support the research and publication of the personal and social effects of eugenic sterilizations carried out in California. Led by director Gosney and secretary Paul Popenoe, the HBF collected data on thousands of individuals in California who had been involuntarily sterilized under a California state law enacted in 1909. The Foundation's assets were liquidated following Gosney's death in 1942. In 1943, Gosney's daughter donated the remaining assets to the California Institute of Technology (Caltech) in Pasadena, California to establish the Gosney research fund for biological research. Between 1928 and 1942, the HBF published extensively on what they believed to be the benefits of sterilization to both patient and society. The HBF and its members existed within the larger context of the American eugenics movement and scientific institutions, including the Eugenics Record Office at Cold Spring Harbor Laboratory in Cold Spring Harbor, New York, which bolstered the movement's goals of the control of human reproduction and human heredity. Moreover, the model sterilization legislation written by the HBF was disseminated throughout the world to eugenics enthusiasts eager to pass laws limiting the reproduction of people they considered to be unfit.

Georges Cuvier, baptized Georges Jean-Leopold Nicolas-Frederic Cuvier, was a professor of anatomy at the National Museum of Natural History in Paris, France, through the late eighteenth and early nineteenth centuries. Scholars recognize Cuvier as a founder of modern comparative anatomy, and as an important contributor to vertebrate paleontology and geology. Cuvier studied the form and function of animal anatomy, writing four volumes on quadruped fossils and co-writing eleven volumes on the natural history of fish with Achille Valenciennes. Moreover, Cuvier constructed a system of classification based on specific and well-articulated principles to help anatomists classify animal taxa. Cuvier had public debate in 1830 with Etienne Geoffroy Saint-Hilaire, a dispute centered on whether form or function matters most for the study of anatomy and whether the transmutation of organic forms can occur over time. Cuvier's opinions influenced the development of biology in France, and his arguments against transmutation of types influenced the reception of Charles Darwin's theory of evolution by natural selection among many French naturalists.

Etienne Geoffroy Saint-Hilaire, commonly known as Geoffroy, studied animals, their anatomy and their embryos, and teratogens at the National Museum of Natural History in Paris, France in the eighteenth and nineteenth centuries. Geoffroy also helped develop several specialized fields in the life sciences, including experimental embryology. In his efforts to experimentally demonstrate the theory of recapitulation, Geoffroy developed techniques to intervene in the growth of embryos to see whether they would develop into different kinds of organisms. Moreover, Geoffroy emphasized the concept of l'unite de composition (the unity of plan). Geoffroy disputed in 1830 with Georges Cuvier over whether form or function matters most for the study of anatomy and whether the transformation of organic forms can occur over time. Geoffroy's conceptual contributions, as well as his experimental research, influenced embryological research on animal morphology and teratogens, and later the field of evolutionary paleontology.

The 1973 Supreme Court case Roe v. Wade was a significant event in the story of fetal personhood—the story of whether embryos and fetuses are legal persons. Roe legalized abortion care in the United States (US). However, the story of fetal personhood began long before the 1970s. People have been talking about embryos, fetuses, and their status in science, the law, and society for centuries. I studied the history of fetal personhood in the United States, tracing its origins from Ancient Rome and Medieval England to its first appearance in a US courtroom in 1884 and then to the Supreme Court’s decision in 1973.