Embryo Project Encyclopedia
The Embryo Project Encyclopedia (https://embryo.asu.edu) is an open-access digital encyclopedia devoted to recording and contextualizing the science of embryos, development, and reproduction. The collection of documents, images, and multimedia housed here serves as the Encyclopedia's permanent archive.
Jane Maienschein, ASU University Professor, Regents Professor, and Director of the Biology and Society Program, started the Embryo Project Encyclopedia in 2007 with support from the National Science Foundation.
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- All Subjects: Organisms
- Creators: Tantibanchachai, Chanapa
Thalidomide is a sedative drug introduced to European markets on 1 October 1957 after extensive testing on rodent embryos to ensure its safety. Early laboratory tests in rodent populations showed that pregnant rodents could safely use it, so doctors prescribed Thalidomide to treat morning sickness in pregnant women. However, in humans Thalidomide interfered with embryonic and fetal development in ways not observed in rodent tests. Pregnant women who take Thalidomide are at grater than normal risk for spontaneous abortion and for giving birth to children with developmental anomalies such as shortened, absent, or extra limbs, as well as a variety of heart, ear, and internal organ defects. The failure of rodent models to inform scientists of Thalidomide's teratogenicity in humans ignited debate about the proper use of cross-species testing during drug development.