Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
Displaying 1 - 10 of 30
Filtering by
- Genre: Doctoral Dissertation
Description
The main objective of this research is to develop an approach to PV module lifetime prediction. In doing so, the aim is to move from empirical generalizations to a formal predictive science based on data-driven case studies of the crystalline silicon PV systems. The evaluation of PV systems aged 5 to 30 years old that results in systematic predictive capability that is absent today. The warranty period provided by the manufacturers typically range from 20 to 25 years for crystalline silicon modules. The end of lifetime (for example, the time-to-degrade by 20% from rated power) of PV modules is usually calculated using a simple linear extrapolation based on the annual field degradation rate (say, 0.8% drop in power output per year). It has been 26 years since systematic studies on solar PV module lifetime prediction were undertaken as part of the 11-year flat-plate solar array (FSA) project of the Jet Propulsion Laboratory (JPL) funded by DOE. Since then, PV modules have gone through significant changes in construction materials and design; making most of the field data obsolete, though the effect field stressors on the old designs/materials is valuable to be understood. Efforts have been made to adapt some of the techniques developed to the current technologies, but they are too often limited in scope and too reliant on empirical generalizations of previous results. Some systematic approaches have been proposed based on accelerated testing, but no or little experimental studies have followed. Consequently, the industry does not exactly know today how to test modules for a 20 - 30 years lifetime.
This research study focuses on the behavior of crystalline silicon PV module technology in the dry and hot climatic condition of Tempe/Phoenix, Arizona. A three-phase approach was developed: (1) A quantitative failure modes, effects, and criticality analysis (FMECA) was developed for prioritizing failure modes or mechanisms in a given environment; (2) A time-series approach was used to model environmental stress variables involved and prioritize their effect on the power output drop; and (3) A procedure for developing a prediction model was proposed for the climatic specific condition based on accelerated degradation testing
This research study focuses on the behavior of crystalline silicon PV module technology in the dry and hot climatic condition of Tempe/Phoenix, Arizona. A three-phase approach was developed: (1) A quantitative failure modes, effects, and criticality analysis (FMECA) was developed for prioritizing failure modes or mechanisms in a given environment; (2) A time-series approach was used to model environmental stress variables involved and prioritize their effect on the power output drop; and (3) A procedure for developing a prediction model was proposed for the climatic specific condition based on accelerated degradation testing
ContributorsKuitche, Joseph Mathurin (Author) / Pan, Rong (Thesis advisor) / Tamizhmani, Govindasamy (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2014
Description
One of the greatest 21st century challenges is meeting the needs of a growing world population expected to increase 35% by 2050 given projected trends in diets, consumption and income. This in turn requires a 70-100% improvement on current production capability, even as the world is undergoing systemic climate pattern changes. This growth not only translates to higher demand for staple products, such as rice, wheat, and beans, but also creates demand for high-value products such as fresh fruits and vegetables (FVs), fueled by better economic conditions and a more health conscious consumer. In this case, it would seem that these trends would present opportunities for the economic development of environmentally well-suited regions to produce high-value products. Interestingly, many regions with production potential still exhibit a considerable gap between their current and ‘true’ maximum capability, especially in places where poverty is more common. Paradoxically, often high-value, horticultural products could be produced in these regions, if relatively small capital investments are made and proper marketing and distribution channels are created. The hypothesis is that small farmers within local agricultural systems are well positioned to take advantage of existing sustainable and profitable opportunities, specifically in high-value agricultural production. Unearthing these opportunities can entice investments in small farming development and help them enter the horticultural industry, thus expand the volume, variety and/or quality of products available for global consumption. In this dissertation, the objective is three-fold: (1) to demonstrate the hidden production potential that exist within local agricultural communities, (2) highlight the importance of supply chain modeling tools in the strategic design of local agricultural systems, and (3) demonstrate the application of optimization and machine learning techniques to strategize the implementation of protective agricultural technologies.
As part of this dissertation, a yield approximation method is developed and integrated with a mixed-integer program to estimate a region’s potential to produce non-perennial, vegetable items. This integration offers practical approximations that help decision-makers identify technologies needed to protect agricultural production, alter harvesting patterns to better match market behavior, and provide an analytical framework through which external investment entities can assess different production options.
As part of this dissertation, a yield approximation method is developed and integrated with a mixed-integer program to estimate a region’s potential to produce non-perennial, vegetable items. This integration offers practical approximations that help decision-makers identify technologies needed to protect agricultural production, alter harvesting patterns to better match market behavior, and provide an analytical framework through which external investment entities can assess different production options.
ContributorsFlores, Hector M. (Author) / Villalobos, Rene (Thesis advisor) / Pan, Rong (Committee member) / Wu, Teresa (Committee member) / Parker, Nathan (Committee member) / Arizona State University (Publisher)
Created2017
Description
This research develops heuristics to manage both mandatory and optional network capacity reductions to better serve the network flows. The main application discussed relates to transportation networks, and flow cost relates to travel cost of users of the network. Temporary mandatory capacity reductions are required by maintenance activities. The objective of managing maintenance activities and the attendant temporary network capacity reductions is to schedule the required segment closures so that all maintenance work can be completed on time, and the total flow cost over the maintenance period is minimized for different types of flows. The goal of optional network capacity reduction is to selectively reduce the capacity of some links to improve the overall efficiency of user-optimized flows, where each traveler takes the route that minimizes the traveler’s trip cost. In this dissertation, both managing mandatory and optional network capacity reductions are addressed with the consideration of network-wide flow diversions due to changed link capacities.
This research first investigates the maintenance scheduling in transportation networks with service vehicles (e.g., truck fleets and passenger transport fleets), where these vehicles are assumed to take the system-optimized routes that minimize the total travel cost of the fleet. This problem is solved with the randomized fixed-and-optimize heuristic developed. This research also investigates the maintenance scheduling in networks with multi-modal traffic that consists of (1) regular human-driven cars with user-optimized routing and (2) self-driving vehicles with system-optimized routing. An iterative mixed flow assignment algorithm is developed to obtain the multi-modal traffic assignment resulting from a maintenance schedule. The genetic algorithm with multi-point crossover is applied to obtain a good schedule.
Based on the Braess’ paradox that removing some links may alleviate the congestion of user-optimized flows, this research generalizes the Braess’ paradox to reduce the capacity of selected links to improve the efficiency of the resultant user-optimized flows. A heuristic is developed to identify links to reduce capacity, and the corresponding capacity reduction amounts, to get more efficient total flows. Experiments on real networks demonstrate the generalized Braess’ paradox exists in reality, and the heuristic developed solves real-world test cases even when commercial solvers fail.
This research first investigates the maintenance scheduling in transportation networks with service vehicles (e.g., truck fleets and passenger transport fleets), where these vehicles are assumed to take the system-optimized routes that minimize the total travel cost of the fleet. This problem is solved with the randomized fixed-and-optimize heuristic developed. This research also investigates the maintenance scheduling in networks with multi-modal traffic that consists of (1) regular human-driven cars with user-optimized routing and (2) self-driving vehicles with system-optimized routing. An iterative mixed flow assignment algorithm is developed to obtain the multi-modal traffic assignment resulting from a maintenance schedule. The genetic algorithm with multi-point crossover is applied to obtain a good schedule.
Based on the Braess’ paradox that removing some links may alleviate the congestion of user-optimized flows, this research generalizes the Braess’ paradox to reduce the capacity of selected links to improve the efficiency of the resultant user-optimized flows. A heuristic is developed to identify links to reduce capacity, and the corresponding capacity reduction amounts, to get more efficient total flows. Experiments on real networks demonstrate the generalized Braess’ paradox exists in reality, and the heuristic developed solves real-world test cases even when commercial solvers fail.
ContributorsPeng, Dening (Author) / Mirchandani, Pitu B. (Thesis advisor) / Sefair, Jorge (Committee member) / Wu, Teresa (Committee member) / Zhou, Xuesong (Committee member) / Arizona State University (Publisher)
Created2017
Description
Healthcare operations have enjoyed reduced costs, improved patient safety, and
innovation in healthcare policy over a huge variety of applications by tackling prob-
lems via the creation and optimization of descriptive mathematical models to guide
decision-making. Despite these accomplishments, models are stylized representations
of real-world applications, reliant on accurate estimations from historical data to jus-
tify their underlying assumptions. To protect against unreliable estimations which
can adversely affect the decisions generated from applications dependent on fully-
realized models, techniques that are robust against misspecications are utilized while
still making use of incoming data for learning. Hence, new robust techniques are ap-
plied that (1) allow for the decision-maker to express a spectrum of pessimism against
model uncertainties while (2) still utilizing incoming data for learning. Two main ap-
plications are investigated with respect to these goals, the first being a percentile
optimization technique with respect to a multi-class queueing system for application
in hospital Emergency Departments. The second studies the use of robust forecasting
techniques in improving developing countries’ vaccine supply chains via (1) an inno-
vative outside of cold chain policy and (2) a district-managed approach to inventory
control. Both of these research application areas utilize data-driven approaches that
feature learning and pessimism-controlled robustness.
innovation in healthcare policy over a huge variety of applications by tackling prob-
lems via the creation and optimization of descriptive mathematical models to guide
decision-making. Despite these accomplishments, models are stylized representations
of real-world applications, reliant on accurate estimations from historical data to jus-
tify their underlying assumptions. To protect against unreliable estimations which
can adversely affect the decisions generated from applications dependent on fully-
realized models, techniques that are robust against misspecications are utilized while
still making use of incoming data for learning. Hence, new robust techniques are ap-
plied that (1) allow for the decision-maker to express a spectrum of pessimism against
model uncertainties while (2) still utilizing incoming data for learning. Two main ap-
plications are investigated with respect to these goals, the first being a percentile
optimization technique with respect to a multi-class queueing system for application
in hospital Emergency Departments. The second studies the use of robust forecasting
techniques in improving developing countries’ vaccine supply chains via (1) an inno-
vative outside of cold chain policy and (2) a district-managed approach to inventory
control. Both of these research application areas utilize data-driven approaches that
feature learning and pessimism-controlled robustness.
ContributorsBren, Austin (Author) / Saghafian, Soroush (Thesis advisor) / Mirchandani, Pitu (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2018
Description
Technology advancements in diagnostic imaging, smart sensing, and health information systems have resulted in a data-rich environment in health care, which offers a great opportunity for Precision Medicine. The objective of my research is to develop data fusion and system informatics approaches for quality and performance improvement of health care. In my dissertation, I focus on three emerging problems in health care and develop novel statistical models and machine learning algorithms to tackle these problems from diagnosis to care to system-level decision-making.
The first topic is diagnosis/subtyping of migraine to customize effective treatment to different subtypes of patients. Existing clinical definitions of subtypes use somewhat arbitrary boundaries primarily based on patient self-reported symptoms, which are subjective and error-prone. My research develops a novel Multimodality Factor Mixture Model that discovers subtypes of migraine from multimodality imaging MRI data, which provides complementary accurate measurements of the disease. Patients in the different subtypes show significantly different clinical characteristics of the disease. Treatment tailored and optimized for patients of the same subtype paves the road toward Precision Medicine.
The second topic focuses on coordinated patient care. Care coordination between nurses and with other health care team members is important for providing high-quality and efficient care to patients. The recently developed Nurse Care Coordination Instrument (NCCI) is the first of its kind that enables large-scale quantitative data to be collected. My research develops a novel Multi-response Multi-level Model (M3) that enables transfer learning in NCCI data fusion. M3 identifies key factors that contribute to improving care coordination, and facilitates the design and optimization of nurses’ training, workload assignment, and practice environment, which leads to improved patient outcomes.
The last topic is about system-level decision-making for Alzheimer’s disease early detection at the early stage of Mild Cognitive Impairment (MCI), by predicting each MCI patient’s risk of converting to AD using imaging and proteomic biomarkers. My research proposes a systems engineering approach that integrates the multi-perspectives, including prediction accuracy, biomarker cost/availability, patient heterogeneity and diagnostic efficiency, and allows for system-wide optimized decision regarding the biomarker testing process for prediction of MCI conversion.
The first topic is diagnosis/subtyping of migraine to customize effective treatment to different subtypes of patients. Existing clinical definitions of subtypes use somewhat arbitrary boundaries primarily based on patient self-reported symptoms, which are subjective and error-prone. My research develops a novel Multimodality Factor Mixture Model that discovers subtypes of migraine from multimodality imaging MRI data, which provides complementary accurate measurements of the disease. Patients in the different subtypes show significantly different clinical characteristics of the disease. Treatment tailored and optimized for patients of the same subtype paves the road toward Precision Medicine.
The second topic focuses on coordinated patient care. Care coordination between nurses and with other health care team members is important for providing high-quality and efficient care to patients. The recently developed Nurse Care Coordination Instrument (NCCI) is the first of its kind that enables large-scale quantitative data to be collected. My research develops a novel Multi-response Multi-level Model (M3) that enables transfer learning in NCCI data fusion. M3 identifies key factors that contribute to improving care coordination, and facilitates the design and optimization of nurses’ training, workload assignment, and practice environment, which leads to improved patient outcomes.
The last topic is about system-level decision-making for Alzheimer’s disease early detection at the early stage of Mild Cognitive Impairment (MCI), by predicting each MCI patient’s risk of converting to AD using imaging and proteomic biomarkers. My research proposes a systems engineering approach that integrates the multi-perspectives, including prediction accuracy, biomarker cost/availability, patient heterogeneity and diagnostic efficiency, and allows for system-wide optimized decision regarding the biomarker testing process for prediction of MCI conversion.
ContributorsSi, Bing (Author) / Li, Jing (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Schwedt, Todd (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2018
Description
A quantitative analysis of a system that has a complex reliability structure always involves considerable challenges. This dissertation mainly addresses uncertainty in- herent in complicated reliability structures that may cause unexpected and undesired results.
The reliability structure uncertainty cannot be handled by the traditional relia- bility analysis tools such as Fault Tree and Reliability Block Diagram due to their deterministic Boolean logic. Therefore, I employ Bayesian network that provides a flexible modeling method for building a multivariate distribution. By representing a system reliability structure as a joint distribution, the uncertainty and correlations existing between system’s elements can effectively be modeled in a probabilistic man- ner. This dissertation focuses on analyzing system reliability for the entire system life cycle, particularly, production stage and early design stages.
In production stage, the research investigates a system that is continuously mon- itored by on-board sensors. With modeling the complex reliability structure by Bayesian network integrated with various stochastic processes, I propose several methodologies that evaluate system reliability on real-time basis and optimize main- tenance schedules.
In early design stages, the research aims to predict system reliability based on the current system design and to improve the design if necessary. The three main challenges in this research are: 1) the lack of field failure data, 2) the complex reliability structure and 3) how to effectively improve the design. To tackle the difficulties, I present several modeling approaches using Bayesian inference and nonparametric Bayesian network where the system is explicitly analyzed through the sensitivity analysis. In addition, this modeling approach is enhanced by incorporating a temporal dimension. However, the nonparametric Bayesian network approach generally accompanies with high computational efforts, especially, when a complex and large system is modeled. To alleviate this computational burden, I also suggest to building a surrogate model with quantile regression.
In summary, this dissertation studies and explores the use of Bayesian network in analyzing complex systems. All proposed methodologies are demonstrated by case studies.
The reliability structure uncertainty cannot be handled by the traditional relia- bility analysis tools such as Fault Tree and Reliability Block Diagram due to their deterministic Boolean logic. Therefore, I employ Bayesian network that provides a flexible modeling method for building a multivariate distribution. By representing a system reliability structure as a joint distribution, the uncertainty and correlations existing between system’s elements can effectively be modeled in a probabilistic man- ner. This dissertation focuses on analyzing system reliability for the entire system life cycle, particularly, production stage and early design stages.
In production stage, the research investigates a system that is continuously mon- itored by on-board sensors. With modeling the complex reliability structure by Bayesian network integrated with various stochastic processes, I propose several methodologies that evaluate system reliability on real-time basis and optimize main- tenance schedules.
In early design stages, the research aims to predict system reliability based on the current system design and to improve the design if necessary. The three main challenges in this research are: 1) the lack of field failure data, 2) the complex reliability structure and 3) how to effectively improve the design. To tackle the difficulties, I present several modeling approaches using Bayesian inference and nonparametric Bayesian network where the system is explicitly analyzed through the sensitivity analysis. In addition, this modeling approach is enhanced by incorporating a temporal dimension. However, the nonparametric Bayesian network approach generally accompanies with high computational efforts, especially, when a complex and large system is modeled. To alleviate this computational burden, I also suggest to building a surrogate model with quantile regression.
In summary, this dissertation studies and explores the use of Bayesian network in analyzing complex systems. All proposed methodologies are demonstrated by case studies.
ContributorsLee, Dongjin (Author) / Pan, Rong (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Wu, Teresa (Committee member) / Du, Xiaoping (Committee member) / Arizona State University (Publisher)
Created2018
Description
Under different environmental conditions, the relationship between the design and operational variables of a system and the system’s performance is likely to vary and is difficult to be described by a single model. The environmental variables (e.g., temperature, humidity) are not controllable while the variables of the system (e.g. heating, cooling) are mostly controllable. This phenomenon has been widely seen in the areas of building energy management, mobile communication networks, and wind energy. To account for the complicated interaction between a system and the multivariate environment under which it operates, a Sparse Partitioned-Regression (SPR) model is proposed, which automatically searches for a partition of the environmental variables and fits a sparse regression within each subdivision of the partition. SPR is an innovative approach that integrates recursive partitioning and high-dimensional regression model fitting within a single framework. Moreover, theoretical studies of SPR are explicitly conducted to derive the oracle inequalities for the SPR estimators which could provide a bound for the difference between the risk of SPR estimators and Bayes’ risk. These theoretical studies show that the performance of SPR estimator is almost (up to numerical constants) as good as of an ideal estimator that can be theoretically achieved but is not available in practice. Finally, a Tree-Based Structure-Regularized Regression (TBSR) approach is proposed by considering the fact that the model performance can be improved by a joint estimation on different subdivisions in certain scenarios. It leverages the idea that models for different subdivisions may share some similarities and can borrow strength from each other. The proposed approaches are applied to two real datasets in the domain of building energy. (1) SPR is used in an application of adopting building design and operational variables, outdoor environmental variables, and their interactions to predict energy consumption based on the Department of Energy’s EnergyPlus data sets. SPR produces a high level of prediction accuracy and provides insights into the design, operation, and management of energy-efficient buildings. (2) TBSR is used in an application of predicting future temperature condition which could help to decide whether to activate or not the Heating, Ventilation, and Air Conditioning (HVAC) systems in an energy-efficient manner.
ContributorsNing, Shuluo (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Rafi, Tanveer A (Committee member) / Arizona State University (Publisher)
Created2018
Description
In healthcare facilities, health information systems (HISs) are used to serve different purposes. The radiology department adopts multiple HISs in managing their operations and patient care. In general, the HISs that touch radiology fall into two categories: tracking HISs and archive HISs. Electronic Health Records (EHR) is a typical tracking HIS, which tracks the care each patient receives at multiple encounters and facilities. Archive HISs are typically specialized databases to store large-size data collected as part of the patient care. A typical example of an archive HIS is the Picture Archive and Communication System (PACS), which provides economical storage and convenient access to diagnostic images from multiple modalities. How to integrate such HISs and best utilize their data remains a challenging problem due to the disparity of HISs as well as high-dimensionality and heterogeneity of the data. My PhD dissertation research includes three inter-connected and integrated topics and focuses on designing integrated HISs and further developing statistical models and machine learning algorithms for process and patient care improvement.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
Topic 1: Design of super-HIS and tracking of quality of care (QoC). My research developed an information technology that integrates multiple HISs in radiology, and proposed QoC metrics defined upon the data that measure various dimensions of care. The DDD assisted the clinical practices and enabled an effective intervention for reducing lengthy radiologist turnaround times for patients.
Topic 2: Monitoring and change detection of QoC data streams for process improvement. With the super-HIS in place, high-dimensional data streams of QoC metrics are generated. I developed a statistical model for monitoring high- dimensional data streams that integrated Singular Vector Decomposition (SVD) and process control. The algorithm was applied to QoC metrics data, and additionally extended to another application of monitoring traffic data in communication networks.
Topic 3: Deep transfer learning of archive HIS data for computer-aided diagnosis (CAD). The novelty of the CAD system is the development of a deep transfer learning algorithm that combines the ideas of transfer learning and multi- modality image integration under the deep learning framework. Our system achieved high accuracy in breast cancer diagnosis compared with conventional machine learning algorithms.
ContributorsWang, Kun (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Zwart, Christine M. (Committee member) / Arizona State University (Publisher)
Created2018
Description
With the development of computer and sensing technology, rich datasets have become available in many fields such as health care, manufacturing, transportation, just to name a few. Also, data come from multiple heterogeneous sources or modalities. This is a common phenomenon in health care systems. While multi-modality data fusion is a promising research area, there are several special challenges in health care applications. (1) The integration of biological and statistical model is a big challenge; (2) It is commonplace that data from various modalities is not available for every patient due to cost, accessibility, and other reasons. This results in a special missing data structure in which different modalities may be missed in “blocks”. Therefore, how to train a predictive model using such a dataset poses a significant challenge to statistical learning. (3) It is well known that different modality data may contain different aspects of information about the response. The current studies cannot afford to solve this problem. My dissertation includes new statistical learning model development to address each of the aforementioned challenges as well as application case studies using real health care datasets, included in three chapters (Chapter 2, 3, and 4), respectively. Collectively, it is expected that my dissertation could provide a new sets of statistical learning models, algorithms, and theory contributed to multi-modality heterogeneous data fusion driven by the unique challenges in this area. Also, application of these new methods to important medical problems using real-world datasets is expected to provide solutions to these problems, and therefore contributing to the application domains.
ContributorsLiu, Xiaonan (Ph.D.) (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Fatyga, Mirek (Committee member) / Arizona State University (Publisher)
Created2019
Description
Transfer learning is a sub-field of statistical modeling and machine learning. It refers to methods that integrate the knowledge of other domains (called source domains) and the data of the target domain in a mathematically rigorous and intelligent way, to develop a better model for the target domain than a model using the data of the target domain alone. While transfer learning is a promising approach in various application domains, my dissertation research focuses on the particular application in health care, including telemonitoring of Parkinson’s Disease (PD) and radiomics for glioblastoma.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.
The first topic is a Mixed Effects Transfer Learning (METL) model that can flexibly incorporate mixed effects and a general-form covariance matrix to better account for similarity and heterogeneity across subjects. I further develop computationally efficient procedures to handle unknown parameters and large covariance structures. Domain relations, such as domain similarity and domain covariance structure, are automatically quantified in the estimation steps. I demonstrate METL in an application of smartphone-based telemonitoring of PD.
The second topic focuses on an MRI-based transfer learning algorithm for non-invasive surgical guidance of glioblastoma patients. Limited biopsy samples per patient create a challenge to build a patient-specific model for glioblastoma. A transfer learning framework helps to leverage other patient’s knowledge for building a better predictive model. When modeling a target patient, not every patient’s information is helpful. Deciding the subset of other patients from which to transfer information to the modeling of the target patient is an important task to build an accurate predictive model. I define the subset of “transferrable” patients as those who have a positive rCBV-cell density correlation, because a positive correlation is confirmed by imaging theory and the its respective literature.
The last topic is a Privacy-Preserving Positive Transfer Learning (P3TL) model. Although negative transfer has been recognized as an important issue by the transfer learning research community, there is a lack of theoretical studies in evaluating the risk of negative transfer for a transfer learning method and identifying what causes the negative transfer. My work addresses this issue. Driven by the theoretical insights, I extend Bayesian Parameter Transfer (BPT) to a new method, i.e., P3TL. The unique features of P3TL include intelligent selection of patients to transfer in order to avoid negative transfer and maintain patient privacy. These features make P3TL an excellent model for telemonitoring of PD using an At-Home Testing Device.
ContributorsYoon, Hyunsoo (Author) / Li, Jing (Thesis advisor) / Wu, Teresa (Committee member) / Yan, Hao (Committee member) / Hu, Leland S. (Committee member) / Arizona State University (Publisher)
Created2018