Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: School of Nutrition and Health Promotion
Description
The aim was to examine the effectiveness of a cycling intervention on body composition in adolescents with Down syndrome (DS). Four participants completed three interventions over eight consecutive weeks. The interventions were: 1) Voluntary Cycling (VC), in which participants cycled at their self-selected pedaling rate 2) Assisted Cycling (AC), in which the participants' voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpms. 3) No cycling (NC), in which the participants acted as controls. Total weight of the participants and percentage body fat of the participants both decreased but not in values that were statistically significant. The only statistically significant value was the ratio of android fat to gynoid fat, which increased. Future research will try to replicate this data with statistically significant values for more cycling adolescents with DS.
ContributorsFankhauser, Kristin Marie (Author) / Ringenbach, Shannon (Thesis director) / Shaibi, Gabriel (Committee member) / Hillman, Charles (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2014-05
Description
The aim of this case study was to help MH, a young adult male with Down syndrome, lose weight and improve his health. Initially he was morbidly obese, suffering from physical, mental, emotional, and health-related side effects. MH and his mother requested help from Dr. Shannon Ringenbach, and resided in Arizona for four months during the process of developing and implementing a program of diet and exercise for him. We created a plan to maximize weight loss in this short period of time. Overall, MH reduced his weight from 276 lbs. to 217 lbs. in four months, his lowest weight being 201 lbs. after he and his mother returned home to Oregon. This is a 75 lb. weight loss and body mass index (BMI) reduction of 13.7 kg/m2. Although to reach a healthy body weight MH would still need to continue his weight loss, this is a significant amount of weight, which is especially difficult for people with Down syndrome to lose. In this case study it was crucial to take into consideration the other aspects that affect weight gain and loss, such as motivation, family life, diet, and lifestyle.
ContributorsBrennan, Julia (Co-author) / Wright, Berlin (Co-author) / Ringenbach, Shannon (Thesis director) / Shaibi, Gabriel (Committee member) / Chen, Chih-Chia (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2013-05
Description
High fat diets (HFD) are known to cause hepatic non-alcoholic steatosis in rats in as few as four weeks. Accumulation of triglycerides in liver and skeletal muscle is associated with insulin resistance and obesity. However, studies of fat accumulation in cardiac muscle are not as prevalent. Therefore, the first hypothesis of this study was that HFD would lead to hepatic steatosis as well as lipid accumulation in pectoralis and cardiac muscles, tissues responsible for the majority of postprandial glucose disposal. Prior studies also indicated that HFD leads to increased inflammation and oxidative stress within the vasculature resulting in impaired endothelium-dependent vasodilation, however biomarkers of immune system reactivity were not assessed. Therefore, the second aim of this study was to explore additional pathways of immune system reactivity and stress (natural antibodies; heat shock protein 60 (HSP60)) in rats fed either a control (chow) or high fat (HFD) diet. HSP60 has also recently been recognized as an early marker of vascular dysfunction in humans. The hypothesis was that immune system reactivity and early vascular dysfunction would be heightened in rats fed a HFD compared to chow-fed controls. Young male Sprague-Dawley rats (140-160g) were maintained on a chow diet (5% fat, 57.33% carbohydrate, 3.4kcal/g) or HFD (60% fat, 20% carbohydrate, 5.24 kcal/g) for 6 weeks. HFD rats developed hepatic steatosis with significantly elevated liver triglyceride concentrations compared to chow-fed controls (20.73±2.09 vs.9.75±0.52 mg triglycerides/g tissue, respectively; p=0.001). While lipid accumulation appeared to be evident in the pectoralis muscle from HFD rats, triglyceride concentrations were not significantly different from controls. Likewise, there was no evidence of lipid infiltration in cardiac muscles of HFD rats. Lipid accumulation in the liver of overweight HFD rats may contribute to the observed insulin resistance in these animals. Contrary to the second hypothesis, there were no significant differences in plasma HSP60 expression between HFD and chow rats (p>0.05). Likewise, hemagglutination and hemolysis responses were similar between HFD and chow-fed rats (p>0.05). These findings suggest that immune system responses may not be affected by 6 weeks of high fat intake and that HSP60 is not an early marker of vascular dysfunction in this rodent model.
ContributorsLiss, Tyler Jessee (Author) / Sweazea, Karen (Thesis director) / Shaibi, Gabriel (Committee member) / Johnston, Carol (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2013-05
Description
The aim of this study is to evaluate whether or not fitness can be determined using a well-researched six minute walk test (6MWT) in a young adult population with Down syndrome (DS). This holds importance in today's health industry because this particular target group is at high risk for several cardiovascular, cognitive and clinical factors that contribute to their well-being and longevity. As well, the findings of this research could potentially contribute to the low volume of research that currently exists regarding fitness and the DS population and provide pertinent knowledge towards intervention programs. Fourteen participants with DS performed one 6MWT at a self-selected rate during an exercise intervention study to assess physical fitness. The results showed that walk distance increased with decreased BMI and walk distance increased with increased walking speed and increased leisure activity. These findings are clear indicators of physical fitness relating to healthy physical behavior. All results were consistent with past research in specific at-risk health related populations. This data suggests that this physical test is an adequate indicator of fitness levels in populations with DS, which may additionally provide explicit avenues for intervention and treatment to improve health.
ContributorsMoss Hunt, Lauren Charlie (Author) / Ringenbach, Shannon (Thesis director) / Shaibi, Gabriel (Committee member) / Maraj, Brian (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor)
Created2013-05