Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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Observing effects of drug modulation on electrophysiological response of Aplysia neurons

Description
The effect of three different drug modulators on the electrophysiological response of Aplysia neurons was observed through the use of extracellular and intracellular recordings. Extracellular recordings captured the effects of magnesium chloride and glutamate at a variety of concentrations for each. Intracellular recordings displayed the effects of magnesium chloride, glutamate,…

The effect of three different drug modulators on the electrophysiological response of Aplysia neurons was observed through the use of extracellular and intracellular recordings. Extracellular recordings captured the effects of magnesium chloride and glutamate at a variety of concentrations for each. Intracellular recordings displayed the effects of magnesium chloride, glutamate, and GABA for two concentrations each. For extracellular recordings, the average firing rate, average peak-to-peak voltage, average SNR, and sorted units were considered. For intracellular recordings, average firing rate, average peak voltage, and average resting potential were considered. Significance of data could not be determined using statistical analysis due to having a sample size of 1 for every experiment.
ContributorsEyster, Kyle (Co-author) / Moore, Amanda (Co-author) / Muthuswamy, Jitendran (Thesis director) / Sadleir, Rosalind (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
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Modeling the Effect of Mechanical Deformation on Electrical Stimulation of Peripheral Nerve Fibers

Description

There are many challenges in designing neuroprostheses and one of them is to maintain proper axon selectivity in all situations. This project is based on an electrode that is implanted into a fascicle in a peripheral nerve and used to provide tactile sensory feedback of a prosthetic arm. This fascicle…

There are many challenges in designing neuroprostheses and one of them is to maintain proper axon selectivity in all situations. This project is based on an electrode that is implanted into a fascicle in a peripheral nerve and used to provide tactile sensory feedback of a prosthetic arm. This fascicle can undergo mechanical deformation during every day motion. This work aims to characterize the effect of fascicle deformation on axon selectivity and recruitment when electrically stimulated using hybrid modeling. The main framework consists of combining finite element modeling (FEM) and simulation environment NEURON. A suite of programs was developed to first populate a fascicle with axons followed by deforming the fascicle and rearranging axons accordingly. A model of the fascicle with an implanted electrode is simulated to find the electrical potential profile through FEM. The potential profile is then used to compare which axons are activated in the two conformations of the fascicle using NERUON.
ContributorsDileep, Devika (Author) / Abbas, James (Thesis director) / Sadleir, Rosalind (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05