Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: School of Life Sciences
Description
Studies in neocortical neurogenesis have experienced an explosive growth since the early 2000s, measured by the increasing number of publications each year. I examine here the influence of Arnold Kriegstein in the field using Topic Modeling, a set of algorithms that can be applied to a collection of texts to elucidate the central themes of said collection. Using a Java-based software called MALLET, I obtained data for his corpus, and compared it to the texts of other researchers in the field. This latter collection, which I dub "General Corpus", was separated by year from 2000 to 2014. I found that Kriegstein's most frequently discussed topic concerned highly unique terms such as GABA, glutamate, and receptor, which did not appear in any of the primary topics of the General Corpus. This was in contrast to my initial hypothesis that Kriegstein's importance stemmed from his examination of different phenomena that constitute the broader aspect of neocortical neurogenesis. I predicted that the terms in Kriegstein's primary topic would appear many times throughout the topics of the General Corpus, but it was not so, aside from the common ones such as neurons, cortical, and development. Taken in tandem with NIH Reporter data, these results suggest that Kriegstein obtains a large amount of research funding because his studies concern unique topics when compared to others in the field. The implications of these findings are especially relevant in a world where funding is becoming increasingly difficult to come by.
ContributorsChhetri, Chandra Divyash (Author) / Laubichler, Manfred (Thesis director) / Maienschein, Jane (Committee member) / Aiello, Kenneth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
Civil litigation and medical malpractice both seem to be plagued by similar misperceptions. The general public, lawyers, physicians and our elected officials are all in considerable error regarding the reality behind civil litigation. The perception is that there are an increasing number of claims filed, and that in those cases that are filed the plaintiff is likely to win and be awarded a large sum of money. Regarding medical malpractice, in particular, is the belief that such litigation increases the over-all costs of healthcare by a significant dollar amount through the costs of litigation as well as the increasing instances of defensive medicine. Physicians further state that it is the absurd awards all too common in medical malpractice cases that are to blame for the out of control increases seen in medical malpractice premiums. These increases in premiums are said to have forced a large number of physicians out of practice that will hurt the general public's access to health care. These perceptions are at least reinforced by the media coverage that reports on the rare multimillion-dollar cases and from reports by insurance companies and physicians, in their attempt to lower their business costs by decreasing medical malpractice insurance premiums. By understanding the prevalence of such misperceptions, the truth behind the claims, and how such misinformation reaches the public and has spread to all levels of society, empirical data must be presented to the public in order to overcome the misperceptions.
ContributorsKohl, Mitchell Anthony (Author) / Robert, Jason (Thesis director) / Maienschein, Jane (Committee member) / Mossman, Kenneth (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Type-two diabetes represents a pathological state of insulin resistance due to systemic, complex interactions between numerous identified and linked metabolic genes. According to current medical literature, the genetic predisposition to type-two diabetes, coupled with environmental risk-factors, such as poverty and poor dietary habits, further exacerbate the risk of developing the disease. My research investigated the hypothesis that government poverty programs are associated with the surge in type-two diabetes among people of low socioeconomic status. My research suggests that government subsidies for the Commodity Supplemental Food Program, Women Infants and Children, Supplemental Nutrition Assistance Program, National School Lunch Program, and corn production influence individual dietary choices that lead to consumption of excessive amounts of refined sugars and fats and a surge in the prevalence of obesity, known risk-factors for developing type-two diabetes. These policies and programs may directly or indirectly promote and incentivize diets with excessive refined sugars and fats. As such, current programs paradoxically contradict current medical literature and direct individual choices that have increased the known risk-factors for developing type-two diabetes. Future efforts should reassess poverty and agricultural subsidy programs in relation to medical recommendations for diabetes prevention. The enormous societal and economic burden associated with type-two diabetes calls for further research to assess the efficacy of current public policy and the allocation of government funds.
ContributorsCarabajal, Christian James (Author) / Orchinik, Miles (Thesis director) / Maienschein, Jane (Committee member) / Opat, Melissa (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
In 2004, the South Korean geneticist Woo-Suk Hwang published what was widely regarded as the most important research result in biotechnology of the year. In the prestigious American journal Science, he claimed that he had succeeded in cloning a human blastocyst, an embryo in its early stages (Hwang et al. 2004). A year later, in a second Science article, he made the earth-shattering announcement that he had derived eleven embryonic stem cell lines using his cloning technique (Hwang et al. 2005). The international scientific community was stunned. American scientists publicly fretted that President George W. Bush‘s 2001 executive order limiting federal funding for stem-cell research in the United States had put American bioscience behind the Koreans‘ (Paarlberg 2005). These breakthroughs offered potential solutions to immune system rejection of transplanted organs and possible cures for diseases such as rheumatoid arthritis, Parkinson‘s, Down‘s syndrome, and paralysis (Svenaeus 2007). However, within a year, Hwang was exposed as a fraud who had faked his results and pressured his female colleagues to donate eggs without informed consent. Despite protests against his methods from Korean religious and nongovernmental organizations, Hwang had used his prestige to ignore his ethical obligations. The Korean government, too, was slow to investigate Hwang and to subject his work to appropriate regulation.
ContributorsClay, Anne (Author) / Hurlbut, James (Thesis director) / Maienschein, Jane (Committee member) / Marchant, Gary (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2012-12
Description
The use of medical scribes in emergency departments has been associated with faster patient discharge times, increased numbers of patients treated, and improved patient satisfaction ratings in previous research studies and has also been correlated with improved levels of physician satisfaction as well as a high degree of gratification from scribes. For this paper, I examined the nature of scribing, essentially analyzing the role of the scribe in modern healthcare, and the effects of the occupation on the medical field. Though a shortage of prior research regarding medical scribing persisted, the data I received here mirrored some of the results from earlier studies, specifically those which proclaimed that physicians admit to increased work efficiency when accompanied by scribes. Unlike prior studies, however, this thesis presents novel information regarding scribes‘ perspectives of the profession, including some of the complaints they possess, which are most notably long and irregular shifts, far commute distances, and low wages. Through my research, which relied heavily on interviews and surveys and less heavily on EMR-simulating examinations, scribes were discovered to have a greater average typing speed (64 wpm) than physicians (30 wpm) and performed better in three drills that simulated different manners of patient charting. It was the opinion of all physicians that scribes were beneficial—both to them as physicians and to patients. Though scribes represented varying opinions about their role, the majority (9/11) of those who were interviewed classified scribing as a somewhat stressful job but also stated that they were mostly satisfied with their position.
ContributorsAguirre, Abel (Author) / Robert, Jason (Thesis director) / Maienschein, Jane (Committee member) / Ellison, Karin (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Life Sciences (Contributor)
Created2012-12
Description
More than 90 million Americans suffer from low health literacy levels that can lead to detrimental health practices. One of the greatest issues stemming from low health literacy is the misuse of medication, which results in 125,000 deaths per year and close to $200 billion dollars in health care funds (Ngoh 2009). With their implementation into neighborhood settings and consequently the everyday lives of individuals, pharmacies show potential in being great assets towards increasing health literacy on an individual and societal level. However, pharmacists must first be made aware of the opportunities and challenges that exist concerning this effort. Through a three step literature review and corresponding comparative analysis, the results of this study show that pharmacists should focus on four main areas: overall assessment of health literacy in a pharmacy setting, individualization and tailoring of health/ medication plans, development of verbal and written communication tools, and the pharmacist-patient relationship. Each area presents a set of opportunities and challenges that must be accounted for in order to design more effective initiatives and tools in the pharmacists' aim to increase health literacy.
ContributorsMergens, Rianna Lynn (Author) / Robert, Jason Scott (Thesis director) / Maienschein, Jane (Committee member) / Kinzig, Ann (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
The COVID-19 pandemic places significant strain on the U.S. healthcare system due to the high number of coronavirus cases. During the pandemic, there was much unknown about the virus, its course of the disease, COVID-19 diagnosis, treatments, or other imperative information needed to contain the virus. Resources within the healthcare system, such as PPE and healthcare workers, were in short supply and exacerbated the difficulty of managing the viral outbreak. Peer-reviewed articles suggest that telehealth, the application of electronic information and telecommunication technologies in healthcare, proved useful in public health and clinical care during the 2020 public health emergency due to a novel virus. The scoping review broadly assessed themes of telehealth’s strengths and weaknesses during the COVID-19 pandemic. These findings could suggest how virtual medicine may be a helpful tool to improve access in addition to the quality of care in the future of medicine. Assessments of case studies suggest that telehealth helped provide care to large patient volumes by aiding with communication, data collection, triage, remote patient monitoring, and critical care. Limitations of expanding telehealth subsequent to the pandemic include, but not limited to, a lack of national standards for practice and restrictions of utility for certain populations. Populations may include those with low socioeconomic status, specific cultural practices, and beliefs, or physical and cognitive ability barriers. Outlining the benefits and limitations of telehealth may suggest how virtual medicine can provide valuable in day-to-day medical practices and other pathogenic outbreaks.
ContributorsBlock, Andrea (Author) / Tanner, Rene (Thesis director) / Maienschein, Jane (Committee member) / Marvasti, Farshad (Committee member) / School of Life Sciences (Contributor, Contributor) / School of Human Evolution & Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
This thesis examines congressional discussions of media technologies at two distinct historical moments in order to see how Congress evaluated and sought to regulate technologies with the potential to reshape public modes of thought and communication. Specifically, it examines congressional discussions centered around Television and the Fairness Doctrine, as well as Facebook and the recent scandal involving Cambridge Analytica by asking how Congress has understood what is at stake while attempting to regulate emerging media technologies. Specifically, it probes questions such as: What is assumed about the technologies while attempting to legislate them? What is treated as subject to assessment and revision; what is given priority for consideration over other alternate angles? How do the legal and political contexts in which these discussions are framed impact legislative proceedings and society’s ways of knowing and relating to the world?
While these moments are only a subset of such moments in US history, and Congress is only one of a range of forums in which such political discussions can take place, the thesis focuses on these cases because not only are they important in themselves, but also they reveal issues and approaches that are not unique to these moments. The thesis draws on the on the work of Neil Postman, who argues that the emergence and subsequent dominance of media like television have the capacity to alter the manner in which we think and thus have profound effects on the texture and character of American civic life. In this vein it uses a comparison of how lawmakers attempted to regulate television and social media platforms like Facebook to explore whether and how lawmakers have attended to the capacity of these media to shape public thought.
The thesis demonstrates that understanding of media’s epistemological influence is only ever tacitly acknowledged by lawmakers and is not regarded as an important consideration during evaluative legislative efforts. Instead, Congress tends to focus on matters that are of immediate concern and pragmatic in nature, eclipsing questions about how these technologies fundamentally alter our perceptions of the world and the ways we as individuals and as a society relate to it. By not taking such questions into account during our legislative proceedings, the thesis argues, we cede opportunities to employ and regulate technologies to better serve our cultural ideals and remain susceptible to unwanted forms of cultural erosion mediated by technologies.
While these moments are only a subset of such moments in US history, and Congress is only one of a range of forums in which such political discussions can take place, the thesis focuses on these cases because not only are they important in themselves, but also they reveal issues and approaches that are not unique to these moments. The thesis draws on the on the work of Neil Postman, who argues that the emergence and subsequent dominance of media like television have the capacity to alter the manner in which we think and thus have profound effects on the texture and character of American civic life. In this vein it uses a comparison of how lawmakers attempted to regulate television and social media platforms like Facebook to explore whether and how lawmakers have attended to the capacity of these media to shape public thought.
The thesis demonstrates that understanding of media’s epistemological influence is only ever tacitly acknowledged by lawmakers and is not regarded as an important consideration during evaluative legislative efforts. Instead, Congress tends to focus on matters that are of immediate concern and pragmatic in nature, eclipsing questions about how these technologies fundamentally alter our perceptions of the world and the ways we as individuals and as a society relate to it. By not taking such questions into account during our legislative proceedings, the thesis argues, we cede opportunities to employ and regulate technologies to better serve our cultural ideals and remain susceptible to unwanted forms of cultural erosion mediated by technologies.
ContributorsOberhaus, Jack M (Author) / Hurlbut, J. Benjamin (Thesis director) / Zachary, Gregg (Committee member) / Maienschein, Jane (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Yuma County, a primarily agricultural community on the border of Mexico and Arizona, has been deemed a “medical island surrounded by a sea of sand.”17 Yuma, Arizona consists of over 200,000 people, with an additional 80,000 to 100,000 winter visitors.17 An extra 41,000 farm workers from California and 50,000 Mexicans on work visas travel to Yuma during the winter harvest season.17 Additionally, approximately 20% of residents live below the poverty line and 60% of the population is Hispanic in 2016.17 Unemployment in Yuma is also 50% higher than the national average, and has a 20% unemployment rate in 2016.17 Because these statistics are higher than the state and national averages, the Department of Health and Human Services have declared Yuma County as a “high needs area.”17 For all of these residents in Yuma County, Yuma Regional Medical Center is the sole healthcare provider.
ContributorsTallman, Hailey Nicole (Author) / Hurlbut, Ben (Thesis director) / Maienschein, Jane (Committee member) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This study investigates the impact of the COVID-19 pandemic on telemedicine-prescribed controlled substances by discussing the opinions of pharmacists holding an Arizona pharmacy license. To accommodate the rapid changes during the COVID-19 pandemic, the federal government adapted pharmacy laws to better support the healthcare community. The use of remote healthcare services such as telemedicine visits and online pharmacy services dramatically increased during the pandemic, so regulators waived tele-health restrictions like the Ryan Haight Act. This study involved structured interviews with 3 participants. The interviews revealed a positive outlook on the future of telehealth and the possibilities of modernizing healthcare and pharmacy. The study suggests that the waiving of the Ryan Haight Act was perceived somewhat positively by pharmacists, although they still had concerns regarding abandoning parts of the Act from a patient safety standpoint. The study concludes that certain pharmacy and telemedicine regulations are outdated given the positive and negative outcomes of these laws during the global pandemic. While this study offers insights on bringing various healthcare and law arguments together, the small sample size results in limited scope. The study still provides points of discussion to offer recommendations for implementation of the Ryan Haight Act and other similar tele-health and online-pharmacy regulations.
ContributorsNawara, Jihan (Author) / Martin, Thomas (Thesis director) / Maienschein, Jane (Committee member) / Ellison, Karin (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor)
Created2023-05