Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Genre: Academic theses
- Creators: Li, Baoxin
Description
Beta-Amyloid(Aβ) plaques and tau protein tangles in the brain are now widely recognized as the defining hallmarks of Alzheimer’s disease (AD), followed by structural atrophy detectable on brain magnetic resonance imaging (MRI) scans. However, current methods to detect Aβ/tau pathology are either invasive (lumbar puncture) or quite costly and not widely available (positron emission tomography (PET)). And one of the particular neurodegenerative regions is the hippocampus to which the influence of Aβ/tau on has been one of the research projects focuses in the AD pathophysiological progress.
In this dissertation, I proposed three novel machine learning and statistical models to examine subtle aspects of the hippocampal morphometry from MRI that are associated with Aβ /tau burden in the brain, measured using PET images. The first model is a novel unsupervised feature reduction model to generate a low-dimensional representation of hippocampal morphometry for each individual subject, which has superior performance in predicting Aβ/tau burden in the brain. The second one is an efficient federated group lasso model to identify the hippocampal subregions where atrophy is strongly associated with abnormal Aβ/Tau. The last one is a federated model for imaging genetics, which can identify genetic and transcriptomic influences on hippocampal morphometry. Finally, I stated the results of these three models that have been published or submitted to peer-reviewed conferences and journals.
ContributorsWu, Jianfeng (Author) / Wang, Yalin (Thesis advisor) / Li, Baoxin (Committee member) / Liang, Jianming (Committee member) / Wang, Junwen (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2022
Description
Insufficient training data poses significant challenges to training a deep convolutional neural network (CNN) to solve a target task. One common solution to this problem is to use transfer learning with pre-trained networks to apply knowledge learned from one domain with sufficient data to a new domain with limited data and avoid training a deep network from scratch. However, for such methods to work in a transfer learning setting, learned features from the source domain need to be generalizable to the target domain, which is not guaranteed since the feature space and distributions of the source and target data may be different. This thesis aims to explore and understand the use of orthogonal convolutional neural networks to improve learning of diverse, generic features that are transferable to a novel task.
In this thesis, orthogonal regularization is used to pre-train deep CNNs to investigate if and how orthogonal convolution may improve feature extraction in transfer learning. Experiments using two limited medical image datasets in this thesis suggests that orthogonal regularization improves generality and reduces redundancy of learned features more effectively in certain deep networks for transfer learning. The results on feature selection and classification demonstrate the improvement in transferred features helps select more expressive features that improves generalization performance. To understand the effectiveness of orthogonal regularization on different architectures, this work studies the effects of residual learning on orthogonal convolution. Specifically, this work examines the presence of residual connections and its effects on feature similarities and show residual learning blocks help orthogonal convolution better preserve feature diversity across convolutional layers of a network and alleviate the increase in feature similarities caused by depth, demonstrating the importance of residual learning in making orthogonal convolution more effective.
ContributorsChan, Tsz (Author) / Li, Baoxin (Thesis advisor) / Liang, Jianming (Committee member) / Yang, Yezhou (Committee member) / Arizona State University (Publisher)
Created2023
Description
High-level inference tasks in video applications such as recognition, video retrieval, and zero-shot classification have become an active research area in recent years. One fundamental requirement for such applications is to extract high-quality features that maintain high-level information in the videos.
Many video feature extraction algorithms have been purposed, such as STIP, HOG3D, and Dense Trajectories. These algorithms are often referred to as “handcrafted” features as they were deliberately designed based on some reasonable considerations. However, these algorithms may fail when dealing with high-level tasks or complex scene videos. Due to the success of using deep convolution neural networks (CNNs) to extract global representations for static images, researchers have been using similar techniques to tackle video contents. Typical techniques first extract spatial features by processing raw images using deep convolution architectures designed for static image classifications. Then simple average, concatenation or classifier-based fusion/pooling methods are applied to the extracted features. I argue that features extracted in such ways do not acquire enough representative information since videos, unlike images, should be characterized as a temporal sequence of semantically coherent visual contents and thus need to be represented in a manner considering both semantic and spatio-temporal information.
In this thesis, I propose a novel architecture to learn semantic spatio-temporal embedding for videos to support high-level video analysis. The proposed method encodes video spatial and temporal information separately by employing a deep architecture consisting of two channels of convolutional neural networks (capturing appearance and local motion) followed by their corresponding Fully Connected Gated Recurrent Unit (FC-GRU) encoders for capturing longer-term temporal structure of the CNN features. The resultant spatio-temporal representation (a vector) is used to learn a mapping via a Fully Connected Multilayer Perceptron (FC-MLP) to the word2vec semantic embedding space, leading to a semantic interpretation of the video vector that supports high-level analysis. I evaluate the usefulness and effectiveness of this new video representation by conducting experiments on action recognition, zero-shot video classification, and semantic video retrieval (word-to-video) retrieval, using the UCF101 action recognition dataset.
Many video feature extraction algorithms have been purposed, such as STIP, HOG3D, and Dense Trajectories. These algorithms are often referred to as “handcrafted” features as they were deliberately designed based on some reasonable considerations. However, these algorithms may fail when dealing with high-level tasks or complex scene videos. Due to the success of using deep convolution neural networks (CNNs) to extract global representations for static images, researchers have been using similar techniques to tackle video contents. Typical techniques first extract spatial features by processing raw images using deep convolution architectures designed for static image classifications. Then simple average, concatenation or classifier-based fusion/pooling methods are applied to the extracted features. I argue that features extracted in such ways do not acquire enough representative information since videos, unlike images, should be characterized as a temporal sequence of semantically coherent visual contents and thus need to be represented in a manner considering both semantic and spatio-temporal information.
In this thesis, I propose a novel architecture to learn semantic spatio-temporal embedding for videos to support high-level video analysis. The proposed method encodes video spatial and temporal information separately by employing a deep architecture consisting of two channels of convolutional neural networks (capturing appearance and local motion) followed by their corresponding Fully Connected Gated Recurrent Unit (FC-GRU) encoders for capturing longer-term temporal structure of the CNN features. The resultant spatio-temporal representation (a vector) is used to learn a mapping via a Fully Connected Multilayer Perceptron (FC-MLP) to the word2vec semantic embedding space, leading to a semantic interpretation of the video vector that supports high-level analysis. I evaluate the usefulness and effectiveness of this new video representation by conducting experiments on action recognition, zero-shot video classification, and semantic video retrieval (word-to-video) retrieval, using the UCF101 action recognition dataset.
ContributorsHu, Sheng-Hung (Author) / Li, Baoxin (Thesis advisor) / Turaga, Pavan (Committee member) / Liang, Jianming (Committee member) / Tong, Hanghang (Committee member) / Arizona State University (Publisher)
Created2016
Description
Computational visual aesthetics has recently become an active research area. Existing state-of-art methods formulate this as a binary classification task where a given image is predicted to be beautiful or not. In many applications such as image retrieval and enhancement, it is more important to rank images based on their aesthetic quality instead of binary-categorizing them. Furthermore, in such applications, it may be possible that all images belong to the same category. Hence determining the aesthetic ranking of the images is more appropriate. To this end, a novel problem of ranking images with respect to their aesthetic quality is formulated in this work. A new data-set of image pairs with relative labels is constructed by carefully selecting images from the popular AVA data-set. Unlike in aesthetics classification, there is no single threshold which would determine the ranking order of the images across the entire data-set.
This problem is attempted using a deep neural network based approach that is trained on image pairs by incorporating principles from relative learning. Results show that such relative training procedure allows the network to rank the images with a higher accuracy than a state-of-art network trained on the same set of images using binary labels. Further analyzing the results show that training a model using the image pairs learnt better aesthetic features than training on same number of individual binary labelled images.
Additionally, an attempt is made at enhancing the performance of the system by incorporating saliency related information. Given an image, humans might fixate their vision on particular parts of the image, which they might be subconsciously intrigued to. I therefore tried to utilize the saliency information both stand-alone as well as in combination with the global and local aesthetic features by performing two separate sets of experiments. In both the cases, a standard saliency model is chosen and the generated saliency maps are convoluted with the images prior to passing them to the network, thus giving higher importance to the salient regions as compared to the remaining. Thus generated saliency-images are either used independently or along with the global and the local features to train the network. Empirical results show that the saliency related aesthetic features might already be learnt by the network as a sub-set of the global features from automatic feature extraction, thus proving the redundancy of the additional saliency module.
This problem is attempted using a deep neural network based approach that is trained on image pairs by incorporating principles from relative learning. Results show that such relative training procedure allows the network to rank the images with a higher accuracy than a state-of-art network trained on the same set of images using binary labels. Further analyzing the results show that training a model using the image pairs learnt better aesthetic features than training on same number of individual binary labelled images.
Additionally, an attempt is made at enhancing the performance of the system by incorporating saliency related information. Given an image, humans might fixate their vision on particular parts of the image, which they might be subconsciously intrigued to. I therefore tried to utilize the saliency information both stand-alone as well as in combination with the global and local aesthetic features by performing two separate sets of experiments. In both the cases, a standard saliency model is chosen and the generated saliency maps are convoluted with the images prior to passing them to the network, thus giving higher importance to the salient regions as compared to the remaining. Thus generated saliency-images are either used independently or along with the global and the local features to train the network. Empirical results show that the saliency related aesthetic features might already be learnt by the network as a sub-set of the global features from automatic feature extraction, thus proving the redundancy of the additional saliency module.
ContributorsGattupalli, Jaya Vijetha (Author) / Li, Baoxin (Thesis advisor) / Davulcu, Hasan (Committee member) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2016
Description
Alzheimer’s Disease (AD), a neurodegenerative disease is a progressive disease that affects the brain gradually with time and worsens. Reliable and early diagnosis of AD and its prodromal stages (i.e. Mild Cognitive Impairment(MCI)) is essential. Fluorodeoxyglucose (FDG) positron emission tomography (PET) measures the decline in the regional cerebral metabolic rate for glucose, offering a reliable metabolic biomarker even on presymptomatic AD patients. PET scans provide functional information that is unique and unavailable using other types of imaging. The computational efficacy of FDG-PET data alone, for the classification of various Alzheimer’s Diagnostic categories (AD, MCI (LMCI, EMCI), Control) has not been studied. This serves as motivation to correctly classify the various diagnostic categories using FDG-PET data. Deep learning has recently been applied to the analysis of structural and functional brain imaging data. This thesis is an introduction to a deep learning based classification technique using neural networks with dimensionality reduction techniques to classify the different stages of AD based on FDG-PET image analysis.
This thesis develops a classification method to investigate the performance of FDG-PET as an effective biomarker for Alzheimer's clinical group classification. This involves dimensionality reduction using Probabilistic Principal Component Analysis on max-pooled data and mean-pooled data, followed by a Multilayer Feed Forward Neural Network which performs binary classification. Max pooled features result into better classification performance compared to results on mean pooled features. Additionally, experiments are done to investigate if the addition of important demographic features such as Functional Activities Questionnaire(FAQ), gene information helps improve performance. Classification results indicate that our designed classifiers achieve competitive results, and better with the additional of demographic features.
This thesis develops a classification method to investigate the performance of FDG-PET as an effective biomarker for Alzheimer's clinical group classification. This involves dimensionality reduction using Probabilistic Principal Component Analysis on max-pooled data and mean-pooled data, followed by a Multilayer Feed Forward Neural Network which performs binary classification. Max pooled features result into better classification performance compared to results on mean pooled features. Additionally, experiments are done to investigate if the addition of important demographic features such as Functional Activities Questionnaire(FAQ), gene information helps improve performance. Classification results indicate that our designed classifiers achieve competitive results, and better with the additional of demographic features.
ContributorsSingh, Shibani (Author) / Wang, Yalin (Thesis advisor) / Li, Baoxin (Committee member) / Liang, Jianming (Committee member) / Arizona State University (Publisher)
Created2017