Theses and Dissertations

Intrauterine devices, or IUDs, are long-lasting forms of birth control that have effectiveness comparable to sterilization, while they can be removed at any time. However, the insertion process can be very painful, especially for individuals who have never given vaginal birth. The most common form of pain management for this procedure is having the patient take an ibuprofen an hour or so before the procedure, but this only helps with cramping afterwards, not the acute pain caused by insertion. Pain, and anxiety and fear regarding potential pain, serve as a barrier between users and this highly effective form of birth control. This report uses COMSOL to model lidocaine diffusion from 4% topical hydrogel into the cervix (the main site of acute pain during IUD insertion) over 180 minutes. The cervix was modeled axisymmetrically, using average experimental values for cervix size. Concentration at four specific probe points were measured over time and compared at different concentrations. A sensitivity analysis was performed by adjusting the diffusion coefficient of the epithelial layer. This model was developed to serve as a predictor for future drug applications across the cervix, to determine in advance whether a novel formulation of drug would be effective to significantly reduce pain. This model may be refined further with experimental values for the constants, and with further testing of different lidocaine concentrations.

With millions of people living with a disease as restraining as migraines, there are no ways to diagnose them before they occur. In this study, a migraine model using nitroglycerin is used in rats to study the awake brain activity during the migraine state. In an attempt to search for a biomarker for the migraine state, we found multiple deviations in EEG brain activity across different bands. Firstly, there was a clear decrease in power in the delta, beta, alpha, and theta bands. A slight increase in power in the gamma and high frequency bands was also found, which is consistent with other pain-related studies12. Additionally, we searched for a decreased pain threshold in this deviation, in which we concluded that more data analysis is needed to eliminate the multiple potential noise influxes throughout each dataset. However, with this study we did find a clear change in brain activity, but a more detailed analysis will narrow down what this change could mean and how it impacts the migraine state.