Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

Displaying 1 - 2 of 2
Filtering by

Clear all filters

134059-Thumbnail Image.png

An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer's Disease: Addressing the Critical Window

Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this…

With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
134060-Thumbnail Image.png

Effects of Parental Monitoring, Parental Autonomy-Giving, and Personal Autonomy on Drinking Behaviors during the Transition from High School to College

Description
This study addresses a gap in the literature by examining interactions between parental monitoring and parental autonomy giving/personal autonomy in predicting changes in drinking behavior from high school to college. Using data from two unique studies (study 1 was 62.8% female, n = 425; study 2 was 59.9% female, n…

This study addresses a gap in the literature by examining interactions between parental monitoring and parental autonomy giving/personal autonomy in predicting changes in drinking behavior from high school to college. Using data from two unique studies (study 1 was 62.8% female, n = 425; study 2 was 59.9% female, n = 2245), we analyzed main effects of parental monitoring, parental autonomy-giving, and personal autonomy. We also analyzed interactions between parental monitoring and autonomy-giving, and between parental monitoring and personal autonomy. Analyses found significant main effects of parental monitoring on drinking, with high levels of parental monitoring protecting against heavy drinking. Personal autonomy was a protective factor in both high school and college, whereas parental autonomy-giving did not predict drinking behavior in either high school or during the transition to college. This calls into question the extent to which parental autonomy-giving is a primary influence on personal autonomy. Hypothesized interactions between parental monitoring and parental autonomy giving/personal autonomy were not statistically significant. In summary, parental monitoring seems to be protective in high school, and personal autonomy—but not parental autonomy-giving—is also protective. Whereas the latter finding is well established from previous studies, the protective effect of personal autonomy during the transition to college is a novel finding. This relationship suggests that efforts to identify sources of personal autonomy in early adulthood and methods for increasing autonomy may be warranted.
ContributorsStack, Jaclyn Elaine (Author) / Corbin, William (Thesis director) / Meier, Madeline (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12