Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer's Disease: Addressing the Critical Window

Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this…

With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Impact of Maternal PTSD on Infant Problem Behaviors: Mediation Through Parenting Stress

Description
Posttraumatic Stress Disorder (PTSD) affects nearly 10% of adult women in general population samples. In populations of impoverished ethnic minority women, those lifetime prevalence rates may possibly exceed national averages due to lack of mental health resources. Mothers with PTSD are more likely to exhibit negative parenting styles and experience…

Posttraumatic Stress Disorder (PTSD) affects nearly 10% of adult women in general population samples. In populations of impoverished ethnic minority women, those lifetime prevalence rates may possibly exceed national averages due to lack of mental health resources. Mothers with PTSD are more likely to exhibit negative parenting styles and experience higher levels of perceived parenting stress, both of which are associated with poor child outcomes. However, there is a lack of evidence on how maternal PTSD may affect parenting for ethnic minority mothers. This study evaluated the prevalence of lifetime PTSD and its effects on parenting stress and infant problem behaviors in a sample of 322 low-income Mexican-American mothers (mean age = 27.8; 86% born in Mexico). Lifetime PTSD diagnoses were assessed at a prenatal home visit (24-36 weeks gestation) using the WHO Composite International Diagnostic Interview (CIDI). Mothers reported parenting hassles at 24-weeks postpartum (PDLH; Crnic & Greenberg, 1990), and child problem behaviors at infant age one-year (BITSEA; Briggs-Gowan et al., 2004). I hypothesized that 1) women with PTSD would report more parenting stress than women without PTSD, 2) women with PTSD would report more infant problem behavior symptoms than women without PTSD, and 3) parenting stress mediates the relationship between PTSD and infant problem behavior. Results found that 16.5% of women met criteria for past or present PTSD. Compared to women without PTSD, women with PTSD reported more parenting stress but a similar level of infant problem behaviors. Parenting stress significantly mediated the relationship between maternal PTSD and infant problem behaviors. Study findings suggest a need for mental health screenings during prenatal care in order to promote the healthy development of high-risk children.
ContributorsPreves, Ashley Maria (Author) / Luecken, Linda (Thesis director) / Davis, Mary (Committee member) / Mauricio, Anne (Committee member) / Department of Psychology (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12