Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: Kwan, Virginia
- Creators: Oddo, Salvatore
Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
The purpose of this thesis study is to widen the understanding of the effect culture on self-improvement. Past research found that Japanese students, when compared to their North American counterparts, are more likely to strive for self-improvement by persisting when they encounter academic setbacks. In addition to North Americans and Asians, this thesis examines South Asians as well. It is hypothesized that South Asians will have similar levels of self-improvement as East Asians. This thesis also looks at possible explanations for why culture affects self-improvement. Two variables, future self-connectedness and growth mindset, are proposed as these explanations. It is hypothesized that culture affects future self-connectedness and growth mindset, and those two variables in turn influence self-improvement.
For this thesis, 100 undergraduate and recent college graduates completed online self-report measures. Results of independent t-tests showed that there were no significant differences between South and East Asians in self-improvement, which is consistent with what was hypothesized. There were also no differences between South and East Asians in future self-connectedness or growth mindset. The two Asian groups were then combined and compared to North Americans. Further independent t-tests were run, and results found that while the trend was as expected and Asians exhibited higher levels of self-improvement than North Americans, they did not exhibit significantly higher levels. There were also no significant differences between North Americans and Asians in growth mindset, however, North Americans had significantly higher levels of future self-connectedness than Asians, contrary to expectation. Results of mediation regressions found that neither future self-connectedness nor growth mindset significantly explained the effect of culture on self-improvement.
For this thesis, 100 undergraduate and recent college graduates completed online self-report measures. Results of independent t-tests showed that there were no significant differences between South and East Asians in self-improvement, which is consistent with what was hypothesized. There were also no differences between South and East Asians in future self-connectedness or growth mindset. The two Asian groups were then combined and compared to North Americans. Further independent t-tests were run, and results found that while the trend was as expected and Asians exhibited higher levels of self-improvement than North Americans, they did not exhibit significantly higher levels. There were also no significant differences between North Americans and Asians in growth mindset, however, North Americans had significantly higher levels of future self-connectedness than Asians, contrary to expectation. Results of mediation regressions found that neither future self-connectedness nor growth mindset significantly explained the effect of culture on self-improvement.
ContributorsShaikjamaludeen, Shaikhameedha (Author) / Kwan, Virginia (Thesis director) / Shiota, Michelle (Committee member) / Davis, Mary (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12