Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
Displaying 1 - 2 of 2
Filtering by
- Creators: Holloway, Steven
- Creators: Oddo, Salvatore
Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Previous evidence implicating fighting gameplay with markers for cardiovascular changes in response to stress appraisals emphasizes the plausibility of additional biopsychosocial factors varying between players and dictating gameplay changes (Porter & Goolkasian, 2019). The current study builds upon previous research using the Biopsychosocial Model of Challenge and Threat (Blascovich and Tomaka, 1996) alongside the Mental Load Rating Scale (Hughes, 2023) to link perceptions of increased stress during gameplay with increases in gameplay errors. Participants were allotted a set time to acclimate to fighting game mechanics, then began combo trials. The game used in research (Street Fighter 6) requires precise movements in rapid succession completion the completion of a “combo”. Competitive fighting game players were compared to players lacking fighting game experience in post-participation response measuring stress salience or hindrance perception, as well as total input error comparison. Current findings suggest Competitive fighting game players report factors such as spectator viewing and time limits as hindrances capable of being overcome as opposed to Noncompetitor reports of factors and stressors during game acclimation. Findings between Competitor and Noncompetitor groups allude to cultural significance when navigating gameplay. Future research should continue measuring sociocultural perception of stress when navigating specific genres of video game play and avenues for stress reappraisal techniques.
ContributorsDavis, Nicholas (Author) / Holloway, Steven (Thesis director) / Flores, Valerie (Committee member) / Davis, Mary (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2023-12