Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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Genetic influences on the dynamics of pain and affect in fibromyalgia

Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the…

Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
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Impact of Maternal PTSD on Infant Problem Behaviors: Mediation Through Parenting Stress

Description
Posttraumatic Stress Disorder (PTSD) affects nearly 10% of adult women in general population samples. In populations of impoverished ethnic minority women, those lifetime prevalence rates may possibly exceed national averages due to lack of mental health resources. Mothers with PTSD are more likely to exhibit negative parenting styles and experience…

Posttraumatic Stress Disorder (PTSD) affects nearly 10% of adult women in general population samples. In populations of impoverished ethnic minority women, those lifetime prevalence rates may possibly exceed national averages due to lack of mental health resources. Mothers with PTSD are more likely to exhibit negative parenting styles and experience higher levels of perceived parenting stress, both of which are associated with poor child outcomes. However, there is a lack of evidence on how maternal PTSD may affect parenting for ethnic minority mothers. This study evaluated the prevalence of lifetime PTSD and its effects on parenting stress and infant problem behaviors in a sample of 322 low-income Mexican-American mothers (mean age = 27.8; 86% born in Mexico). Lifetime PTSD diagnoses were assessed at a prenatal home visit (24-36 weeks gestation) using the WHO Composite International Diagnostic Interview (CIDI). Mothers reported parenting hassles at 24-weeks postpartum (PDLH; Crnic & Greenberg, 1990), and child problem behaviors at infant age one-year (BITSEA; Briggs-Gowan et al., 2004). I hypothesized that 1) women with PTSD would report more parenting stress than women without PTSD, 2) women with PTSD would report more infant problem behavior symptoms than women without PTSD, and 3) parenting stress mediates the relationship between PTSD and infant problem behavior. Results found that 16.5% of women met criteria for past or present PTSD. Compared to women without PTSD, women with PTSD reported more parenting stress but a similar level of infant problem behaviors. Parenting stress significantly mediated the relationship between maternal PTSD and infant problem behaviors. Study findings suggest a need for mental health screenings during prenatal care in order to promote the healthy development of high-risk children.
ContributorsPreves, Ashley Maria (Author) / Luecken, Linda (Thesis director) / Davis, Mary (Committee member) / Mauricio, Anne (Committee member) / Department of Psychology (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12