Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: Braden, B. Blair
- Creators: Davis, Nicholas
Description
Adults with autism spectrum disorder (ASD) face heightened risk of co-occurring psychiatric conditions, especially depression and anxiety disorders, which contribute to seven-fold higher suicide rates than the general population. Mindfulness-based stress reduction (MBSR) is an 8-week meditation intervention centered around training continuous redirection of attention toward present moment experience, and has been shown to improve mental health in autistic adults. However, the underlying therapeutic neural mechanisms and whether behavioral and brain changes are mindfulness-specific have yet to be elucidated. In this randomized clinical trial, I utilized functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) to characterize fMRI functional activity (Study 1) and connectivity (Study 2) and EEG neurophysiological (Study 3) changes between MBSR and a social support/relaxation education (SE) active control group. Study 1 revealed an MBSR-specific increase in the midcingulate cortex fMRI blood oxygen level dependent signal which was associated with reduced depression. Study 2 identified nonspecific intervention improvements in depression, anxiety, and autistic, and MBSR-specific improvements in the mindfulness trait ‘nonjudgment toward experience’ and in the executive functioning domain of working memory. MBSR-specific decreases in insula-thalamus and frontal pole-posterior cingulate functional connectivity was associated with improvements in anxiety, mindfulness traits, and working memory abilities. Both MBSR and SE groups showed decreased amygdala-sensorimotor and frontal pole-insula connectivity which correlated with reduced depression. Study 3 consisted of an EEG spectral power analysis at high-frequency brainwaves associated with default mode network (DMN) activity. Results showed MBSR-specific and nonspecific decreases in beta- and gamma-band power, with effects being generally more robust in the MBSR group; additionally, MBSR-specific decreases in posterior gamma correlated with anxiolytic effects. Collectively, these studies suggest: 1) social support is sufficient for improvements in depression, anxiety, and autistic traits; 2) MBSR provides additional benefits related to mindfulness traits and working memory; and 3) distinct and shared neural mechanisms of mindfulness training in adults with ASD, implicating the salience and default mode networks and high-frequency neurophysiology. Findings bear relevance to the development of personalized medicine approaches for psychiatric co-morbidity in ASD, provide putative targets for neurostimulation research, and warrant replication and extension using advanced multimodal imaging approaches.
ContributorsPagni, Broc (Author) / Braden, B. Blair (Thesis advisor) / Newbern, Jason (Thesis advisor) / Davis, Mary (Committee member) / Brewer, Gene (Committee member) / Arizona State University (Publisher)
Created2022
Description
Previous evidence implicating fighting gameplay with markers for cardiovascular changes in response to stress appraisals emphasizes the plausibility of additional biopsychosocial factors varying between players and dictating gameplay changes (Porter & Goolkasian, 2019). The current study builds upon previous research using the Biopsychosocial Model of Challenge and Threat (Blascovich and Tomaka, 1996) alongside the Mental Load Rating Scale (Hughes, 2023) to link perceptions of increased stress during gameplay with increases in gameplay errors. Participants were allotted a set time to acclimate to fighting game mechanics, then began combo trials. The game used in research (Street Fighter 6) requires precise movements in rapid succession completion the completion of a “combo”. Competitive fighting game players were compared to players lacking fighting game experience in post-participation response measuring stress salience or hindrance perception, as well as total input error comparison. Current findings suggest Competitive fighting game players report factors such as spectator viewing and time limits as hindrances capable of being overcome as opposed to Noncompetitor reports of factors and stressors during game acclimation. Findings between Competitor and Noncompetitor groups allude to cultural significance when navigating gameplay. Future research should continue measuring sociocultural perception of stress when navigating specific genres of video game play and avenues for stress reappraisal techniques.
ContributorsDavis, Nicholas (Author) / Holloway, Steven (Thesis director) / Flores, Valerie (Committee member) / Davis, Mary (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2023-12