Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
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- Creators: Blais, Chris
- Creators: Oddo, Salvatore
Description
Recognition memory is examined by exposing a person to a stimulus and later prompting them with the same stimulus to examine their ability to accurately acknowledge that the stimulus was previously encountered (Kahana, 2012). In recognition memory, confidence ratings are taken during the testing phase to assess how confident the participant is that the old-new judgment that they just made is accurate (Busey et al., 2000). Confidence is a metacognitive assessment about the accuracy of perception of decision making based on the amount, speed, and clarity of thoughts that come to mind (Dunlosky and Metcalfe, 2008). The goal of the current study is to better understand how assessing recognition memory using a variety of test procedures influences memory accuracy using the signal detection theory and adding multiple confidence scales that vary in granularity. Based on the previous literature, it is hypothesized that; 1) tasks ordered sequentially will produce greater recognition accuracy (d') than the simultaneous (dual task) condition; 2) confidence scale of 3 points will produce a larger d' than the 7 point scale, and the 7 point scale will produce a larger d' than the 100 point scale; and 3) task mode (ordered vs. sequenced) will interact with confidence scale granularity to predict memory accuracy, such that sequential judgments lessen demands on working memory that come from maintaining an increasing number of decision criteria in comparison to the dual task. Results indicated all hypotheses were not upheld. The findings suggest that taxing working memory may not affect decisional accuracy on a recognition task incorporating confidence judgments.
ContributorsSullivan, Krysten Jennifer (Author) / Brewer, Gene (Thesis director) / Blais, Chris (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12