Theses and Dissertations
This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students.
Displaying 1 - 2 of 2
Filtering by
- Creators: Blais, Chris
- Creators: Finan, Patrick Hamilton
Description
Fibromyalgia (FM) is a chronic musculoskeletal disorder characterized by widespread pain, fatigue, and a variety of other comorbid physiological and psychological characteristics, including a deficit of positive affect. Recently, the focus of research on the pathophysiology of FM has considered the role of a number of genomic variants. In the current manuscript, case-control analyses did not support the hypothesis that FM patients would differ from other chronic pain groups in catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genotype. However, evidence is provided in support of the hypothesis that functional single nucleotide polymorphisms on the COMT and OPRM1 genes would be associated with risk and resilience, respectively, in a dual processing model of pain-related positive affective regulation in FM. Forty-six female patients with a physician-confirmed diagnosis of FM completed an electronic diary that included once-daily assessments of positive affect and soft tissue pain. Multilevel modeling yielded a significant gene X environment interaction, such that individuals with met/met genotype on COMT experienced a greater decline in positive affect as daily pain increased than did either val/met or val/val individuals. A gene X environment interaction for OPRM1 also emerged, indicating that individuals with at least one asp allele were more resilient to elevations in daily pain than those homozygous for the asn allele. In sum, the findings offer researchers ample reason to further investigate the contribution of the catecholamine and opioid systems, and their associated genomic variants, to the still poorly understood experience of FM.
ContributorsFinan, Patrick Hamilton (Author) / Zautra, Alex (Thesis advisor) / Davis, Mary (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / Presson, Clark (Committee member) / Arizona State University (Publisher)
Created2011
Description
Recognition memory is examined by exposing a person to a stimulus and later prompting them with the same stimulus to examine their ability to accurately acknowledge that the stimulus was previously encountered (Kahana, 2012). In recognition memory, confidence ratings are taken during the testing phase to assess how confident the participant is that the old-new judgment that they just made is accurate (Busey et al., 2000). Confidence is a metacognitive assessment about the accuracy of perception of decision making based on the amount, speed, and clarity of thoughts that come to mind (Dunlosky and Metcalfe, 2008). The goal of the current study is to better understand how assessing recognition memory using a variety of test procedures influences memory accuracy using the signal detection theory and adding multiple confidence scales that vary in granularity. Based on the previous literature, it is hypothesized that; 1) tasks ordered sequentially will produce greater recognition accuracy (d') than the simultaneous (dual task) condition; 2) confidence scale of 3 points will produce a larger d' than the 7 point scale, and the 7 point scale will produce a larger d' than the 100 point scale; and 3) task mode (ordered vs. sequenced) will interact with confidence scale granularity to predict memory accuracy, such that sequential judgments lessen demands on working memory that come from maintaining an increasing number of decision criteria in comparison to the dual task. Results indicated all hypotheses were not upheld. The findings suggest that taxing working memory may not affect decisional accuracy on a recognition task incorporating confidence judgments.
ContributorsSullivan, Krysten Jennifer (Author) / Brewer, Gene (Thesis director) / Blais, Chris (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12