Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer's Disease: Addressing the Critical Window

Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this…

With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Humor Based Coping: For Which Negative Emotions Do We Use Humor?

Description

People use a variety of emotion regulation strategies to cope with difficult situations. Although there is research supporting humor as an effective emotion regulation strategy, less is known about what circumstances lead people to use humor and what negative emotions humor seems to be the most helpful in mitigating. The…

People use a variety of emotion regulation strategies to cope with difficult situations. Although there is research supporting humor as an effective emotion regulation strategy, less is known about what circumstances lead people to use humor and what negative emotions humor seems to be the most helpful in mitigating. The current study aimed to determine to what extent specific negative emotions lead people to choose humor as an emotion regulation strategy. Participants wrote about a neutral situation and then selected from four card decks with different stimuli (funny, pleasant, awe-inspiring, or neutral). Participants were then randomly assigned to a negative emotion condition (sadness, embarrassment, anxiety, or anger) and wrote about a situation in which they have experienced that specific emotion. They then completed the card selection task again. We compared the number of funny cards chosen between the neutral vs negative emotion trials for each emotion. We found that card selection did not change significantly from the neutral-affect trial to the negative emotion trial across any of the negative emotions. Limitations and future directions are discussed.
ContributorsLigas, Kaitlyn (Author) / Shiota, Michelle (Thesis director) / Corbin, William (Committee member) / Davis, Mary (Committee member) / Pages, Erika (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2021-12