Theses and dissertations

This collection includes both ASU Theses and Dissertations, submitted by graduate students, and the Barrett, Honors College theses submitted by undergraduate students. 

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An Evaluation of the Cognitive Effects of a Short-Term and a Long-Term Ovarian Hormone Deprivation in a Transgenic Mouse Model of Alzheimer's Disease: Addressing the Critical Window

Description
With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this…

With no known cure, Alzheimer's disease (AD) is the most common dementia, affecting more than 5.5 million Americans. Research has shown that women who undergo surgical menopause (i.e. removal of the ovaries) before the onset of natural menopause are at a greater risk for AD. It is hypothesized that this greater relative risk of developing AD is linked to ovarian hormone deprivation associated with surgical menopause. The purpose of these studies was to evaluate the behavioral changes that occur after a short-term (ST) and a long-term (LT) ovarian hormone deprivation in a mouse model of AD. Wildtype (Wt) or APP/PS1 (Tg) mutation mice underwent either a sham surgery or an ovariectomy (Ovx) surgery at three months of age. Study 1 consisted of a short-term cohort that was behaviorally tested one month following surgery on a battery of spatial memory tasks including, the Morris water maze, delayed matched-to-sample water maze, and visible platform task. Study 2 consisted of a long-term cohort that was behaviorally tested on the same cognitive battery three months following surgery. Results of Study 1 revealed that genotype interacted with surgical menopause status, such that after a short-term ovarian hormone deprivation, Ovx induced a genotype effect while Sham surgery did not. Results of Study 2 showed a similar pattern of effects, with a comparable interaction between genotypes and surgical menopause status. These findings indicate that the cognitive impact of ovarian hormone deprivation depends on AD-related genotype. Neuropathology evaluations in these mice will be done in the near future and will allow us to test relations between surgical menopause status, cognition, and AD-like neuropathology.
ContributorsPalmer, Justin M. (Author) / Bimonte-Nelson, Heather (Thesis director) / Oddo, Salvatore (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
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Do Awe and Enthusiasm Affect Stereotyping?

Description
Emotions have been defined as coordinated and functional changes in subjective experience, motivation, physiological activation, instrumental behavior, expressive behavior, and cognition that are evoked by important threats or opportunities in the environment. The proposed study looks at cognitive changes associated with the experience of several positive emotions, with a specific…

Emotions have been defined as coordinated and functional changes in subjective experience, motivation, physiological activation, instrumental behavior, expressive behavior, and cognition that are evoked by important threats or opportunities in the environment. The proposed study looks at cognitive changes associated with the experience of several positive emotions, with a specific focus on awe. Prior research shows that positive emotions tend to increase people's use of cognitive heuristics (i.e. mental shortcuts used to simplify information we intake from the environment) and changes how they apply rules of thumb from stored knowledge to make decisions. Stereotypes, or assumptions about the characteristics held by individual members of a group, are one such heuristic. Awe, in contrast to other positive emotions, has been found to reduce people's tendency to rely on heuristics, rather than increasing its use. Thus, awe should tend to reduce stereotyping specifically. Participants made judgments on three characteristics and two types of theoretically valuable true/false statements. However, for both our measures, awe had no significant effect on stereotyping. Participants in the enthusiasm condition were significantly more likely than those in the awe condition to correctly identify stereotype-inconsistent statements present in the biography, which is the opposite of the predicted direction. Patterns for all four emotion conditions trended similarly to our predictions for stereotype-consistent statements correctly marked as being absent in the biography. There were no significant differences in ratings of three traits. Implications for enthusiasm and awe are discussed in the context of stereotypes of social objects and schemas of nonsocial objects.
ContributorsMurwin, Paige Elizabeth (Co-author) / O'Neil, Makenzie (Co-author) / Shiota, Michelle (Thesis director) / Davis, Mary (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12